Deaf mutism, not elsewhere classified

H8_HL_DEAFMUT

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H91.3 Hospital discharge: ICD-9 — 3897 Hospital discharge: ICD-8 — 388 Cause of death: ICD-10 — H91.3 Cause of death: ICD-9 — 3897 Cause of death: ICD-8 — 388 2 out of 7 registries used, show all original rules.	189
4. Check minimum number of events None	189
5. Include endpoints None	189
6. Filter based on genotype QC (FinnGen only)	189

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H91
Name in latin: Surdomutitas non alibi classificata

NAME	H8_HL_DEAFMUT
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H913
HD_ICD_9	3897
HD_ICD_8	388
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H913
COD_ICD_9	3897
COD_ICD_8	388
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Deaf mutism, not elsewhere classified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2290	1093	1167
Only index persons	1776	903	873
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	43.90	44.20	43.06
Only index persons	35.92	40.27	31.41

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	189	101	88
Unadjusted period prevalence (%)	0.04	0.03	0.04
Median age at first event (years)	46.97	42.74	51.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
180: Matched controls
1799

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H91.3

ICD-10 Finland

Deaf mutism, not elsewhere classified

+∞

110.0

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

210.7

106.3

102

3897A

ICD-9 Finland

Deafness, Deaf mutism, not elsewhere classifiable[SURDITAS]

+∞

62.1

H90.5

ICD-10 Finland

Sensorineural hearing loss, unspecified

+∞

23.4

N07CA01

ATC

betahistine; oral

13.0

23.2

38801

ICD-8 Finland

Deaf mutism, Congenita

+∞

22.4

DFF00

NOMESCO Finland

Pure tone audiometry

17.1

22.0

H93.1

ICD-10 Finland

Tinnitus

31.4

20.7

Z97.4

ICD-10 Finland

Presence of external hearing-aid

45.7

20.1

R5430

NOMESCO Finland

Interpreter's services

211.1

18.9

Z46.1

ICD-10 Finland

Fitting and adjustment of hearing aid

19.6

18.1

DAX00

NOMESCO Finland

Adjustment or review of hearing aid

186.6

16.8

Z3229

NOMESCO Finland

Other healthcare associate professional

7.4

15.0

H91.2

ICD-10 Finland

Sudden idiopathic hearing loss

162.7

14.7

Z01.1

ICD-10 Finland

Examination of ears and hearing

6.7

14.0

38900

ICD-8 Finland

Other deafness, Deafness, both ears

+∞

13.7

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

13.7

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

6.0

13.5

DFF15

NOMESCO Finland

Speech audiometry

22.0

12.7

DFE00

NOMESCO Finland

Insertion of cochlear implant

+∞

12.6

3891A

ICD-9 Finland

Deafness, Sensorineural deafness

+∞

11.6

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

+∞

11.6

R5120

NOMESCO Finland

Preparation of an aid

27.1

11.3

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

7.4

11.3

38809

ICD-8 Finland

Deaf mutism, Unspecified

+∞

10.5

DFX00

NOMESCO Finland

Connecting cochlear implant

+∞

10.5

R5130

NOMESCO Finland

Repair work or maintenance done on the aid

34.8

10.5

H91.9

ICD-10 Finland

Hearing loss, unspecified

20.3

10.5

UDC00

NOMESCO Finland

Ear microscopy

8.5

10.3

DFF30

NOMESCO Finland

Loudness discomfort Level (LDL)

31.9

9.5

3897B

ICD-9 Finland

Deafness, Deaf mutism, not elsewhere classifiable[SURDOMUTITAS]

+∞

9.5

38990

ICD-8 Finland

Other deafness, Partialis uni-sive bilateralis

+∞

9.5

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

9.5

RK520

NOMESCO Finland

+∞

8.4

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

4.9

8.3

DC1AD

NOMESCO Finland

Temporalbone CT

83.4

7.5

38800

ICD-8 Finland

Deaf mutism, Acquisita

+∞

7.3

3882A

ICD-9 Finland

Other disorders of ear, Sudden hearing loss, unspecified

+∞

7.3

R42

ICD-10 Finland

Dizziness and giddiness

2.9

7.3

200

DAX08

NOMESCO Finland

Fitting of hearing aid

21.0

7.2

RK320

NOMESCO Finland

23.5

6.7

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.9

6.3

155

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

161

2.98

7.93

5.3

4.2

30.8

32.4

0.33

104

(3013512) EKG study

411

2.37

7.33

4.5

3.8

—

(3019309) Folate [Moles/volume] in Red Blood Cells

232

2.50

6.52

2.1

1.6

nmol/l

1375.9

1184.9

0.62

187

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

269

2.41

6.43

1.8

1.7

pmol/l

147500462.3

441.1

0.49

233

(3019225) pH of Specimen

120

2.89

6.09

4.2

4.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

538

2.05

5.46

4.7

3.7

ng/l

31.3

32.0

0.04

384

(3032080) INR in Blood by Coagulation assay

545

2.02

5.21

10.3

8.0

inr

1.4

1.2

1.02

157

(4146454)

10.37

4.56

1.8

2.5

—

(3044640) Blood type and Crossmatch panel - Blood

432

1.94

4.37

2.2

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

420

1.92

4.21

2.3

2.0

u/l

154.1

216.3

0.69

399

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

158

2.32

4.19

6.1

8.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

638

1.78

3.72

4.2

3.5

—

(3007853) Bacteria identified in Skin by Aerobe culture

143

2.21

3.43

2.4

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

330

1.84

3.30

2.4

2.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

323

1.84

3.26

3.6

1.9

mg/l

3.3

3.1

0.21

277

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

704

1.70

3.22

6.7

6.4

mmol/l

1.2

0.40

603

(3022313) Gas panel - Capillary blood

2.82

3.14

7.1

5.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

414

1.74

3.03

5.0

3.7

mg/mmol

18.1

8.7

0.92

263

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

638

1.67

3.01

11.7

5.3

mmol/l

1.2

0.51

587

(3012516) Albumin [Mass/volume] in Urine

392

1.73

2.92

3.7

2.9

mg/l

123.9

50.1

1.29

258

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

135

1117

1.73

2.90

7.7

7.2

u/l

76.6

79.1

0.41

122

1049

(3009508) Creatinine [Moles/volume] in Urine

410

1.72

2.90

3.8

2.9

mmol/l

6.7

7.6

1.02

352

(3024561) Albumin [Mass/volume] in Serum or Plasma

592

1.64

2.79

5.6

4.2

g/l

35.9

35.5

0.27

561

(40761536) Microorganisms panel - Urine sediment

106

2.22

2.76

6.6

3.9

—

(3026008) Bacteria identified in Urine by Culture

416

1.69

2.73

3.3

2.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.43

2.67

1.7

1.3

—

(3012544) pH of Venous blood

137

2.04

2.61

8.5

3.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

415

1.65

2.52

2.9

ng/l

3565.6

1241.1

0.93

354

(3037467) Urinalysis macro (dipstick) panel - Urine

117

952

1.60

2.50

5.6

4.1

—

(3017732) Neutrophils [#/volume] in Blood

2.19

2.48

2.4

2.9

e9/l

3.8

0.06

(3026389) Candida sp identified in Specimen by Organism specific culture

5.12

2.42

1.5

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.72

2.41

2.4

1.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.66

2.32

2.4

1.9

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

441

1.60

2.30

2.6

2.4

u/l

53.2

55.1

0.18

411

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

568

1.57

2.29

2.5

1.9

pmol/l

97.1

97.5

0.02

288

(40761535) Cells panel - Urine sediment

108

2.06

2.26

3.6

3.2

—

(42870588) Differential panel, method unspecified - Blood

462

1.58

2.23

5.3

5.4

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

126

1059

1.57

2.21

4.4

3.8

pmol/l

14.9

0.01

103

966

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.00

2.10

3.7

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

148

1301

1.63

2.05

5.4

4.5

mu/l

1.9

0.01

126

1187

(3019550) Sodium [Moles/volume] in Serum or Plasma

161

1447

1.76

2.04

22.1

15.3

mmol/l

139.6

139.7

0.33

153

1406

(3023103) Potassium [Moles/volume] in Serum or Plasma

161

1451

1.74

1.97

22.2

15.5

mmol/l

4.0

0.60

154

1409

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

3.05

1.96

2.3

1.1

—

(3000991) Gas panel - Venous blood

115

1.93

1.92

11.2

7.6

—

(3023368) Bacteria identified in Blood by Culture

388

1.55

1.89

4.6

4.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

3.41

1.76

1.0

1.2

—

(3042936) Bacteria identified in Isolate by Culture

190

1.69

1.73

2.4

1.7

—

(3017181) Myelocytes/100 leukocytes in Blood

127

1.83

1.73

3.0

4.6

0.7

0.6

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

111

935

1.45

1.73

4.1

2.9

u/l

52.7

47.6

0.31

882

(3021440) Promyelocytes/100 leukocytes in Blood

120

1.84

1.70

3.1

4.8

0.0

0.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

347

1.51

1.62

1.7

1.5

nmol/l

22.5

22.1

0.04

295

(3004789) Transferrin [Mass/volume] in Serum or Plasma

188

1.64

1.54

3.6

2.1

g/l

2.4

2.3

0.40

171

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.23

1.54

2.3

2.8

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

754

1.40

1.47

5.3

6.3

umol/l

9.2

11.1

1.97

717

(3022948) Iron [Moles/volume] in Serum or Plasma

207

1.60

1.47

3.6

2.2

umol/l

12.5

13.8

0.50

191

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

2.56

1.46

5.0

3.6

56.1

59.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

2.56

1.46

4.1

2.8

e9/l

3.3

4.8

—

(3021788) Differential panel - Synovial fluid

3.18

1.44

2.2

1.4

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

577

1.40

4.1

2.5

ug/l

100.3

113.5

0.28

532

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

177

1.61

1.38

4.0

2.2

21.4

23.3

0.31

158

(3027945) Reticulocytes/100 erythrocytes in Blood

155

1.63

1.31

1.5

2.7

1.6

1.7

0.39

143

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

163

1513

1.56

1.30

12.4

10.2

u/l

25.3

25.9

0.19

151

1472

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

145

1317

1.43

1.28

7.2

5.5

mmol/mol

40.6

40.0

0.27

127

1238

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.97

1.26

2.5

2.2

—

(4010399)

101

1.75

1.24

1.6

1.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

477

1.38

1.20

2.9

3.5

mmol/l

2.3

2.4

0.43

431

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

143

1.61

1.18

4.2

3.3

—

(3022096) Basophils/100 leukocytes in Blood

670

1.34

1.14

5.6

5.8

0.7

0.10

626

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

120

1.65

1.13

1.9

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

129

1.62

1.11

2.4

2.5

ug/l

3.8

6.1

0.50

114

(3020891) Body temperature

1.92

1.10

24.8

4.5

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.42

1.09

1.6

4.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.16

1.06

1.1

1.4

—

(3037522) Nuclear Ab [Titer] in Serum

198

1.49

1.05

1.4

titre

640.0

594.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

224

1.46

1.05

2.2

1.7

—

(3029937) Albumin [Presence] in Urine by Test strip

358

1.38

1.04

6.0

4.0

estimate

0.0

0.00

123

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

146

1346

1.37

1.02

15.7

12.8

ml/min/173m2

77.1

80.2

0.89

123

1108

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.88

1.00

2.4

1.8

g/l

0.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.93

0.95

1.6

1.2

—

(3002030) Lymphocytes/100 leukocytes in Blood

704

1.29

0.94

5.6

5.9

24.9

28.1

1.72

657

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.68

0.94

2.1

1.5

—

(3006504) Eosinophils/100 leukocytes in Blood

688

1.28

0.90

5.6

5.7

2.8

0.01

645

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.94

0.90

1.5

1.6

—

(3044889) 12 lead EKG panel

1005

0.78

0.89

4.4

3.7

—

(21494755) Public health laboratory ask at order entry panel

137

0.57

0.87

1.5

1.4

—

(3000963) Hemoglobin [Mass/volume] in Blood

166

1575

1.44

0.87

26.6

19.9

g/l

133.7

135.6

0.95

160

1550

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

518

1.29

0.87

5.6

3.9

—

(3019069) Monocytes/100 leukocytes in Blood

691

1.27

0.86

5.7

6.0

8.5

0.04

651

(3018010) Neutrophils/100 leukocytes in Blood

695

1.26

0.81

5.5

5.7

59.3

57.2

0.72

657

(40768800) Prostate Pathology biopsy report

0.00

0.80

0.0

1.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.84

0.79

1.5

1.3

—

(36660697) Celiac disease serology panel - Serum

1.56

0.78

1.3

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.78

0.0

2.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

118

1076

1.26

0.78

4.5

4.0

mm/h

13.5

12.8

0.21

102

989

(3007461) Platelets [#/volume] in Blood

165

1571

1.40

0.77

26.7

19.9

e9/l

258.2

247.8

1.11

159

1529

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.79

0.77

1.0

1.1

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.73

0.76

2.4

1.7

g/l

1.0

1.2

—

(3044290) Cell count panel - Cerebral spinal fluid

2.11

0.75

1.0

1.2

—

(3019230) Fractional oxyhemoglobin in Venous blood

2.11

0.75

1.2

1.9

56.8

64.5

—

(3035941) MCH [Entitic mass]

165

1573

1.39

0.74

26.5

19.7

30.3

0.02

160

1550

(3010813) Leukocytes [#/volume] in Blood

165

1574

1.38

0.73

26.7

19.9

e9/l

6.9

6.6

0.74

158

1528

(3026361) Erythrocytes [#/volume] in Blood

165

1574

1.38

0.73

26.7

19.8

e12/l

4.4

4.5

0.86

157

1528

(3024731) MCV [Entitic volume]

165

1574

1.38

0.73

26.6

19.8

91.4

91.2

0.14

160

1552

(3024928) Oxygen saturation in Venous blood

2.03

0.73

1.2

2.9

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.03

0.73

12.8

2.3

kpa

5.1

5.0

—

(3027315) Oxygen [Partial pressure] in Blood

2.03

0.73

12.8

2.3

kpa

8.7

8.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

110

1.50

0.71

1.9

1.8

—

(4034850)

1.73

0.70

9.4

13.4

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.81

0.66

1.4

1.3

u/l

4.1

10.4

—

(3035350) Ketones [Presence] in Urine by Test strip

679

1.23

0.66

5.1

3.7

estimate

0.0

0.00

131

(3002256) Pathology report gross observation

182

1.37

0.65

1.3

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

1.68

0.62

2.4

1.2

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.68

0.62

1.0

1.1

—

3.9

—

(40768804) Tissue Pathology biopsy report

577

1.22

0.61

2.2

2.0

—

(4306422)

0.00

0.60

0.0

1.2

—

(3045414) Leukocytes [Presence] in Urine

1.56

0.60

1.6

1.7

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.59

0.60

5.7

4.0

mmol/l

24.0

24.4

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.59

0.0

1.2

—

1.4

—

(3013115) Eosinophils [#/volume] in Blood

754

1.21

0.59

6.0

5.9

e9/l

0.2

0.24

667

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.58

0.0

1.2

—

4.8

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.58

0.0

1.0

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.50

0.54

1.2

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

691

1.19

0.54

5.4

3.7

estimate

0.0

0.00

125

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.56

0.53

1.8

1.2

—

(40761511) CBC panel - Blood by Automated count

155

1483

1.25

0.53

19.3

11.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

384

1.23

0.52

5.0

3.2

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

588

1.19

0.49

3.3

2.1

nmol/l

76.5

76.2

0.03

531

(40768797) Stomach Pathology biopsy report

173

1.31

0.49

1.2

—

(3001604) Monocytes [#/volume] in Blood

735

1.18

0.49

5.9

5.6

e9/l

0.6

0.28

639

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

445

1.20

0.48

4.1

4.6

ug/l

1.8

2.4

0.43

395

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

274

0.78

0.47

2.4

2.7

ug/l

0.8

0.9

0.05

176

(3006315) Basophils [#/volume] in Blood

737

1.17

0.47

5.9

5.6

e9/l

0.0

0.04

644

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.48

0.47

2.0

2.6

—

(3019198) Lymphocytes [#/volume] in Blood

748

1.17

0.46

5.8

5.7

e9/l

1.7

1.9

1.22

664

(3021601) Nitrite [Presence] in Urine by Test strip

680

1.17

0.45

6.6

5.1

estimate

0.0

0.00

130

(3021589) Normoblasts [#/volume] in Blood

641

1.17

0.45

12.1

9.2

e9/l

0.0

0.27

531

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

148

1417

1.20

0.45

18.7

13.6

mg/l

23.3

22.5

0.09

124

1121

(3017143) Hepatitis C virus Ab [Presence] in Serum

149

1.31

0.44

2.2

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

850

1.16

0.43

3.3

3.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.41

0.43

2.0

1.8

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

298

1.21

0.42

2.0

1.8

mg/l

1.0

1.1

0.22

225

(4268621)

0.00

0.41

0.0

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

178

1.27

0.41

2.1

1.5

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.40

0.0

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.39

0.0

1.6

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.39

0.0

1.3

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.37

0.39

1.0

1.2

iu/ml

121.7

143.8

—

(40758558) Short blood count panel - Blood

372

0.83

0.38

6.0

7.3

—

(3000492) Spirometry study

123

0.72

0.36

1.6

1.5

—

(3034770) Mitochondria Ab [Titer] in Serum

1.48

0.36

1.7

1.2

titre

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.44

0.36

2.5

1.4

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

228

1.21

0.36

2.2

1.9

29.9

29.7

0.09

221

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.39

0.35

9.2

7.2

mmol/l

25.7

25.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.36

0.35

1.1

1.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

208

0.80

0.33

1.1

1.4

—

(3000494) Fungus identified in Specimen by Culture

165

1.24

0.33

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

143

1379

1.15

0.32

5.4

4.4

mmol/l

6.0

0.19

120

1263

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

148

1431

1.16

0.32

5.5

4.8

mmol/l

2.6

2.8

1.04

126

1317

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

277

0.85

0.27

2.8

3.0

mmol/l

2.4

0.26

248

(3002582) Erythrocytes [#/volume] in Urine

443

0.88

0.27

4.8

2.9

e6/l

39.6

27.0

0.18

334

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.22

0.27

3.1

9.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

160

1.21

0.26

1.9

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

349

0.87

0.26

3.3

4.1

24.9

22.2

0.32

155

(3007164) IgA [Mass/volume] in Serum or Plasma

274

1.16

0.26

1.5

1.3

g/l

2.3

2.5

0.19

168

(3000330) Specific gravity of Urine by Test strip

1.26

0.26

5.2

3.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

317

0.86

0.25

5.5

3.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.26

0.22

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.23

0.22

1.0

1.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

2.4

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.21

0.0

2.4

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.3

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

288.8

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.21

0.0

1.1

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

522.8

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.21

0.0

2.3

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.21

0.0

1.0

—

38.7

—

(4281824)

0.00

0.21

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3051014) Leukocytes [#/area] in Urine sediment by Automated count

0.00

0.21

0.0

1.8

—

5.0

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

289

1.13

0.20

1.5

1.2

u/ml

1.1

1.6

—

(3020630) Protein [Mass/volume] in Serum or Plasma

111

0.80

0.20

2.2

g/l

68.0

67.0

—

105

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.20

0.0

1.3

—

(3049717) Cytology report of Urine Cyto stain

1.21

0.20

2.3

2.9

—

(40768443) Skin Pathology biopsy report

1.14

0.19

1.7

1.2

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

163

0.85

0.18

1.9

4.6

ug/l

3.1

48.3

—

142

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

509

1.09

0.16

5.1

2.9

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

846

1.08

0.16

8.3

9.7

e9/l

4.1

4.0

0.34

747

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

226

1.12

0.16

1.4

1.5

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.22

0.16

3.5

3.3

pmol/l

4.4

4.5

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.19

0.15

1.8

g/l

1.1

1.6

0.77

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

143

1402

1.08

0.14

5.2

4.4

mmol/l

4.5

4.7

0.84

121

1306

(3009542) Hematocrit [Volume Fraction] of Blood

126

1288

0.93

0.13

15.2

14.3

38.8

39.9

0.48

964

(3000850) Epithelial cells [#/volume] in Urine

298

1.09

0.12

4.0

2.5

e6/l

5.6

4.0

0.46

264

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

240

1.10

0.12

1.2

u/ml

3.8

9.8

0.68

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

261

1.09

0.10

3.1

3.3

ng/l

1156.5

134.9

0.45

201

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

242

1.09

0.10

3.9

2.6

e6/l

1.2

0.9

0.33

132

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.16

0.09

3.4

6.9

mmol/l

25.1

24.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

331

1.07

0.09

6.6

5.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.07

0.09

1.2

1.1

—

(3018095) Leukocytes [#/volume] in Urine

511

0.94

0.09

4.9

3.5

e6/l

120.9

46.1

0.47

357

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.07

0.09

1.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.07

0.09

1.0

1.2

—

(3026493) Urate [Moles/volume] in Serum or Plasma

352

1.06

0.08

1.9

2.8

umol/l

348.5

9789.0

2.20

313

(42529406) Shigella sp [Presence] in Stool by Culture

1.05

0.08

1.0

1.2

—

(1002224) Polysomnography panel

1.05

0.08

1.0

1.1

—

(3030467) Casts [#/volume] in Urine by Automated count

398

0.94

0.08

4.9

2.9

e6/l

0.4

0.05

290

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

166

1.09

0.08

2.0

1.6

—

(3018418) pH of Serum or Plasma

452

1.05

0.08

5.2

3.6

7.4

0.19

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

458

0.95

0.08

3.5

2.9

u/l

28.7

29.4

0.14

438

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

141

1392

1.05

0.07

5.3

4.3

mmol/l

1.5

0.04

120

1284

(3019060) Gas panel - Arterial blood

1.13

0.07

2.0

3.9

—

(3003694) ABO and Rh group [Type] in Blood

347

1.05

0.05

1.3

1.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

130

0.92

0.05

1.2

1.7

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

241

0.95

0.04

1.2

1.3

iu/ml

48.0

39.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

136

1348

1.03

0.04

4.8

3.9

mmol/l

1.3

0.09

115

1235

(3022621) pH of Urine by Test strip

104

1.06

0.01

1.5

2.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.04

0.00

1.1

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

134

0.97

0.00

1.5

1.6

—

(3022145) Colonoscopy Study observation

154

0.97

0.00

1.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

111

0.99

0.00

1.7

2.6

g/l

11.8

10.4

0.75

103

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

229

1.00

0.00

3.7

2.8

e6/l

1.9

2.4

0.27

122

(1761868) Lipid panel - Serum or Plasma

532

0.99

0.00

3.6

2.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

113

0.97

0.00

1.2

1.4

—

(36304419) Bacteria [Presence] in Urine

393

0.99

0.00

4.1

2.8

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

383

0.99

0.00

1.8

1.7

mmol/l

1.5

1.4

0.17

322

(4035726)

142

0.98

0.00

1.3

1.4

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

105

1.05

0.00

2.0

3.1

ml/min/173m2

45.2

63.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

212

0.99

0.00

2.4

1.7

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.97

0.00

1.7

2.1

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.94

0.00

1.0

1.1

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.2

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.5

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3026782) Osmolality of Urine

280

1.00

0.00

4.1

2.8

mosm/kgh2o

492.0

558.6

1.03

234

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.9

—

956.1

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.9

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.8

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

7.2

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.3

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(4027681)

0.00

0.0

1.1

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.6

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

16.0

—

898.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

9.4

—

0.6

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.98

0.00

1.0

1.8

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.92

0.00

1.3

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

19.1

—

1338.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.94

0.00

2.1

1.5

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.1

—

321.8

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.96

0.00

1.6

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.99

0.00

1.1

1.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

-0.00

0.0

2.4

—

1.2

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

0.3

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.0

—

(44816808) CXCL13 Ag [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.0

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.4

—

(3017704) Immunofixation for Urine

0.00

-0.00

0.0

1.8

—

(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

-0.00

0.0

1.6

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.0

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_HL_DEAFMUT and mortality.

Females

Parameter	HR [95% CI]	p-value
H8_HL_DEAFMUT	0.972 [0.76, 1.25]	0.828
Birth year	0.994 [0.99, 1.0]	0.144

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 364 females with H8_HL_DEAFMUT died.

Males

Parameter	HR [95% CI]	p-value
H8_HL_DEAFMUT	1.274 [0.94, 1.72]	0.117
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 329 males with H8_HL_DEAFMUT died.

Mortality risk

Mortality risk for people of age

years, who have H8_HL_DEAFMUT.

N-year risk	Females	Males
1	0.062%	0.198%
5	0.475%	1.537%
10	1.164%	3.742%
15	2.581%	6.891%
20	4.467%	12.099%

Relationships between endpoints

↥

Index endpoint: H8_HL_DEAFMUT – Deaf mutism, not elsewhere classified

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Deaf mutism, not elsewhere classified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints