Risteys · H8_ACOUSNERVDIS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H93.3 Cause of death: ICD-10 — H93.3 2 out of 7 registries used, show all original rules.	31
4. Check minimum number of events None	31
5. Include endpoints None	31
6. Filter based on genotype QC (FinnGen only)	31

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	220	113	106
Only index persons	202	106	96
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	57.91	57.86	57.77
Only index persons	57.59	57.98	57.16

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	31	16	15
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	60.48	59.99	61.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

5.90

2.53

1.5

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

109

2.92

2.12

3.7

3.4

—

(3023368) Bacteria identified in Blood by Culture

2.79

1.98

2.3

4.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.72

1.31

2.7

1.6

—

(3003694) ABO and Rh group [Type] in Blood

2.29

1.22

1.1

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

2.19

1.19

2.0

2.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

104

0.38

1.17

4.0

3.2

—

(3026008) Bacteria identified in Urine by Culture

2.15

1.14

2.8

2.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

282

+∞

1.04

14.9

17.6

umol/l

76.3

79.6

0.50

282

(3019550) Sodium [Moles/volume] in Serum or Plasma

278

+∞

1.01

15.8

16.9

mmol/l

139.3

139.8

0.33

272

(3023103) Potassium [Moles/volume] in Serum or Plasma

278

+∞

1.01

15.7

17.0

mmol/l

3.9

4.0

0.35

272

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

138

1.97

0.96

1.6

2.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.98

0.86

2.0

2.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

104

1.86

0.84

2.1

1.8

pmol/l

94.3

88.5

—

(3012544) pH of Venous blood

2.28

0.78

1.8

3.9

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.00

0.63

0.0

4.6

—

66.2

—

(3000963) Hemoglobin [Mass/volume] in Blood

291

+∞

0.62

20.5

21.6

g/l

135.3

135.2

0.01

285

(3010813) Leukocytes [#/volume] in Blood

291

+∞

0.62

20.4

21.5

e9/l

6.7

6.6

0.06

281

(3035941) MCH [Entitic mass]

291

+∞

0.62

20.4

21.4

30.1

30.4

0.31

286

(3007461) Platelets [#/volume] in Blood

291

+∞

0.62

20.5

21.5

e9/l

260.7

245.5

0.64

284

(3026361) Erythrocytes [#/volume] in Blood

291

+∞

0.62

20.4

21.5

e12/l

4.5

0.29

280

(3024731) MCV [Entitic volume]

291

+∞

0.62

20.4

21.5

90.1

91.5

1.05

286

(3037467) Urinalysis macro (dipstick) panel - Urine

175

1.62

0.51

4.0

3.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.59

0.51

1.4

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.67

0.45

1.2

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.61

0.44

1.2

1.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

119

1.50

0.43

4.3

g/l

33.8

34.4

0.28

114

(40768797) Stomach Pathology biopsy report

1.51

0.41

1.0

1.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

0.64

0.40

1.7

3.1

ng/l

1553.0

1083.7

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

1.49

0.36

2.0

1.6

mmol/l

1.3

—

(3018010) Neutrophils/100 leukocytes in Blood

114

1.42

0.33

3.1

5.6

55.7

59.2

0.46

105

(40758558) Short blood count panel - Blood

1.33

0.29

4.6

7.2

—

(3002030) Lymphocytes/100 leukocytes in Blood

116

1.38

0.29

3.1

5.8

30.0

25.4

0.71

104

(3021589) Normoblasts [#/volume] in Blood

123

0.72

0.27

4.9

9.7

e9/l

0.0

—

106

(3044889) 12 lead EKG panel

202

1.31

0.25

3.3

4.0

—

(3042936) Bacteria identified in Isolate by Culture

1.42

0.25

3.2

1.5

—

(42870588) Differential panel, method unspecified - Blood

1.35

0.22

3.6

5.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.22

0.0

1.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.22

0.0

1.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.22

0.0

1.7

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.22

0.0

1.4

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.22

0.0

1.1

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.22

0.0

1.7

—

(3019198) Lymphocytes [#/volume] in Blood

120

1.30

0.21

3.1

5.5

e9/l

2.1

1.7

0.67

108

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.22

0.21

2.8

2.7

—

(3019069) Monocytes/100 leukocytes in Blood

112

1.28

0.18

3.5

5.9

8.4

8.7

0.09

103

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

152

1.26

0.17

3.4

6.7

umol/l

12.0

12.2

0.02

142

(3003338) MCHC [Mass/volume]

215

1.27

0.16

18.1

19.3

g/l

333.0

331.4

0.42

215

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

106

1.22

0.12

3.0

2.2

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.80

0.09

2.0

1.8

pmol/l

366.0

428.4

—

(3001604) Monocytes [#/volume] in Blood

118

1.18

0.09

3.3

5.2

e9/l

0.6

0.30

102

(3006315) Basophils [#/volume] in Blood

118

1.18

0.09

3.3

5.4

e9/l

0.0

0.05

104

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.12

0.08

3.0

1.9

u/l

85.1

50.7

—

(3002385) Erythrocyte distribution width [Ratio]

220

1.18

0.08

17.8

17.9

13.5

13.7

0.37

215

(3015736) pH of Urine

0.85

0.08

3.6

2.7

—

(36304419) Bacteria [Presence] in Urine

1.16

0.06

2.8

2.2

—

(3022096) Basophils/100 leukocytes in Blood

110

1.15

0.06

3.5

5.9

0.6

0.01

101

(40768804) Tissue Pathology biopsy report

108

0.89

0.03

2.0

2.2

—

(3013115) Eosinophils [#/volume] in Blood

122

1.11

0.03

3.4

5.4

e9/l

0.2

0.01

107

(3001122) Ferritin [Mass/volume] in Serum or Plasma

107

0.90

0.02

1.9

2.1

ug/l

82.8

132.6

—

(3031040) Bacteria [#/volume] in Urine by Automated count

174

0.95

0.00

4.9

3.5

—

22.7

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

0.94

0.00

2.2

1.8

mg/l

3.8

3.5

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

215

1.08

0.00

5.7

7.6

u/l

71.8

81.5

0.75

198

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

2.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.0

—

4.8

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.0

2.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

6.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(4034850)

0.00

0.0

34.8

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.7

—

1.7

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.0

2.3

—

5.7

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.0

—

(4094501)

0.00

0.0

1.2

—

(1761868) Lipid panel - Serum or Plasma

0.92

0.00

3.5

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.2

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

4.2

—

7.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3028626) Oxygen [Partial pressure] in Capillary blood

0.00

0.0

6.2

—

8.0

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.0

—

88.5

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.0

—

7.8

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

5.2

—

134.2

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.0

—

60.4

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

0.84

0.00

1.2

3.5

mmol/l

0.9

0.8

—

(3013512) EKG study

0.92

0.00

3.7

3.9

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.0

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.2

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.02

0.00

2.0

2.9

mmol/l

2.4

2.5

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.0

1.7

—

5.5

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.4

—

(1616796) Gas panel - Central venous blood

0.00

0.0

4.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.0

—

184.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.0

1.7

—

63.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.0

3.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.4

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

83.4

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

5.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_ACOUSNERVDIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_ACOUSNERVDIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_ACOUSNERVDIS – Disorders of acoustic nerve

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H8_ACOUSNERVDIS
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H933
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H933
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Disorders of acoustic nerve

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints