Risteys · H7_VASCCILIARY

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H21.0, H21.1 Hospital discharge: ICD-9 — 3644 Cause of death: ICD-10 — H21.0, H21.1 Cause of death: ICD-9 — 3644 2 out of 7 registries used, show all original rules.	693
4. Check minimum number of events None	693
5. Include endpoints None	693
6. Filter based on genotype QC (FinnGen only)	693

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	5991	2454	3510
Only index persons	5469	2239	3230
Unadjusted period prevalence (%)
Whole population	0.09	0.07	0.10
Only index persons	0.11	0.08	0.12
Median age at first event (years)
Whole population	60.60	71.92	52.62
Only index persons	59.68	71.26	51.65

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	693	301	392
Unadjusted period prevalence (%)	0.14	0.10	0.17
Median age at first event (years)	65.10	65.44	64.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
616: Matched controls
6160

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H21.0

ICD-10 Finland

Hyphaema

+∞

323.0

422

H21.1

ICD-10 Finland

Other vascular disorders of iris and ciliary body

+∞

227.6

204

S01ED51

ATC

timolol, combinations; ophthalmic

24.5

199.9

305

237

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

108.0

132.9

142

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

1454.3

125.6

118

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

31.8

108.1

145

H43.1

ICD-10 Finland

Vitreous haemorrhage

34.2

105.8

139

S01EC01

ATC

acetazolamide; systemic

29.1

94.8

130

114

Kela drug reimbursment

Glaucoma

9.9

91.1

204

294

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

87.6

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

5.4

83.8

387

1458

CKC12

NOMESCO Finland

Photocoagulation of retina

17.4

82.0

134

WX140

NOMESCO Finland

Parabulbar anesthesy

14.0

81.5

147

135

S01EE01

ATC

latanoprost; ophthalmic

11.2

80.1

163

192

Z96.1

ICD-10 Finland

Presence of intraocular lens

6.9

78.9

232

495

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

11.8

70.1

137

146

XCW99

NOMESCO Finland

Other investigative procedure of eye

6.9

66.1

187

366

S01EA03

ATC

apraclonidine; ophthalmic

55.0

61.8

S01ED01

ATC

timolol; ophthalmic

12.3

60.2

114

112

CHB10

NOMESCO Finland

Puncture of anterior chamber of eye with irrigation

221.1

59.2

S05.1

ICD-10 Finland

Contusion of eyeball and orbital tissues

28.6

58.6

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

7.4

57.2

150

258

XCK10

NOMESCO Finland

Photography of fundus of eye

6.3

55.0

165

340

S01EC04

ATC

brinzolamide; ophthalmic

11.3

49.6

100

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

3.6

48.6

318

1396

H3603, E113

ICD-10 Finland

39.8

46.3

CHF05

NOMESCO Finland

Transscleral laser coagulation of ciliary body

64.2

46.1

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

14.2

45.9

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.6

45.9

189

544

H16.0

ICD-10 Finland

Corneal ulcer

22.5

44.6

CKC15

NOMESCO Finland

Panretinal photocoagulation

37.6

43.3

CKC20

NOMESCO Finland

Cryopexy of undetached retina

97.0

41.4

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

3.2

40.2

331

1648

XCK00

NOMESCO Finland

Perimetry

6.6

39.8

110

197

CKD40

NOMESCO Finland

Endophotocoagulation of retina

17.0

39.2

S01EC54

ATC

brinzolamide, combinations; ophthalmic

21.5

37.3

H3603, E103

ICD-10 Finland

34.6

37.2

S01EC03

ATC

dorzolamide; ophthalmic

16.7

34.1

H40.0

ICD-10 Finland

Glaucoma suspect

5.8

33.8

103

207

S01EE03

ATC

bimatoprost; ophthalmic

12.0

33.3

H36.03

ICD-10 Finland

Proliferative diabetic retinopathy

26.0

33.2

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

6.4

32.6

163

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

11.8

32.0

H20.9

ICD-10 Finland

Iridocyclitis, unspecified

328.7

31.1

H40.10

ICD-10 Finland

Capsular glaucoma with pseudoexfoliation on the anterior lens capsule

8.6

30.3

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

112.3

29.9

A10AE04

ATC

insulin glargine; parenteral

4.4

29.9

120

323

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

4.8

29.7

108

263

CJB10

NOMESCO Finland

Laser discission of secondary cataract

4.4

28.3

111

291

H25.1

ICD-10 Finland

Senile nuclear cataract

2.8

28.2

240

1140

S01BA01

ATC

dexamethasone; ophthalmic (corticosteroids, plain)

8.9

28.1

H34.8

ICD-10 Finland

Other retinal vascular occlusions

11.0

27.5

A10AB01

ATC

insulin (human); parenteral (insulins and analog. for injection, fast-acting)

8.1

26.9

CKC10

NOMESCO Finland

Local photocoagulation of retina

11.2

26.8

XCH00

NOMESCO Finland

Eye pressure measurement

6.9

26.3

109

A10AA02

ATC

7.6

26.2

CA1AE

NOMESCO Finland

Eye and orbita ultrasound examination

42.1

26.1

S01BA04

ATC

prednisolone; ophthalmic (corticosteroids, plain)

15.3

26.1

CKD92

NOMESCO Finland

Combined vitrectomy and retinal procedure

15.3

26.1

XCD10

NOMESCO Finland

Electrophysiological examination of eye

9.3

25.6

WX100

NOMESCO Finland

Conjunctival surface anesthesia

3.8

25.2

119

368

S01BC03

ATC

diclofenac; ophthalmic

11.5

25.0

WX002

NOMESCO Finland

Sedation and analgesia

2.9

24.9

178

747

H26.4

ICD-10 Finland

After-cataract

3.8

24.8

116

355

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

4.4

24.7

243

H26.2

ICD-10 Finland

Complicated cataract

19.6

24.6

CKD15

NOMESCO Finland

Injection of vitreous substitute

50.6

24.5

E10.3

ICD-10 Finland

Type 1 diabetes mellitus, With ophthalmic complications

10.1

24.5

A10AA01

ATC

9.1

23.0

ZXA00

NOMESCO Finland

Right side

2.6

23.0

218

1075

CKD91

NOMESCO Finland

Extended vitrectomy through pars plana

14.4

22.6

H33.0

ICD-10 Finland

Retinal detachment with retinal break

7.3

22.4

CHC05

NOMESCO Finland

Iridotomy

13.4

21.9

T89

ICPC

Diabetes insulin dependent

6.9

21.7

H40.9

ICD-10 Finland

Glaucoma, unspecified

12.2

21.5

S01BC05

ATC

ketorolac; ophthalmic

5.5

21.0

127

A10AB04

ATC

insulin lispro; parenteral (insulins and analog. for injection, fast-acting)

7.6

20.7

CKD20

NOMESCO Finland

Removal of vitreous body substitute

28.1

20.2

H36.09*E10.3

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic retinopathy

19.6

20.1

H40.4

ICD-10 Finland

Glaucoma secondary to eye inflammation

+∞

19.9

S01EX03

ATC

7.3

19.9

S01EE05

ATC

tafluprost; ophthalmic

7.0

19.6

ZXA10

NOMESCO Finland

Bilateral

2.7

19.6

156

687

S01BA07

ATC

fluorometholone; ophthalmic (corticosteroids, plain)

13.9

19.4

E11.3

ICD-10 Finland

Type 2 diabetes mellitus, with ophthalmic complications

6.7

19.4

S01CA02

ATC

prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

15.5

19.1

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

5.2

18.8

126

25000

ICD-8 Finland

Diabetes mellitus, Sine complicatione

8.1

18.7

CHF15

NOMESCO Finland

Cryotherapy of ciliary body

195.7

18.6

H3601, E113

ICD-10 Finland

8.5

18.3

CKD93

NOMESCO Finland

Extended combined procedure on vitreous body and retina

34.0

18.1

H36.09*E11.3

ICD-10 Finland

Non-insulin-dependent diabetes mellitus - Diabetic retinopathy

17.2

18.0

M08.4

ICD-10 Finland

Pauciarticular juvenile arthritis

68.7

17.8

XCD20

NOMESCO Finland

Photoangiography of eye

10.0

17.6

S01EE04

ATC

travoprost; ophthalmic

8.3

17.6

CKD94

NOMESCO Finland

Combined vitrectomy and procedure on lens through pars plana

13.1

17.3

H3601, E103

ICD-10 Finland

15.6

16.8

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

3.9

16.7

198

2500B

ICD-9 Finland

Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]

9.9

16.6

H36.01

ICD-10 Finland

Diabetic maculopathy

10.2

16.3

T85.2

ICD-10 Finland

Mechanical complication of intraocular lens

31.0

16.2

ZXA05

NOMESCO Finland

Left side

2.2

16.2

197

1068

S01FA04

ATC

cyclopentolate; ophthalmic

19.2

16.1

S05.9

ICD-10 Finland

Injury of eye and orbit, unspecified

25.3

16.1

A10AE05

ATC

insulin detemir; parenteral

3.9

15.7

182

H54.2

ICD-10 Finland

Moderate visual impairment, binocular

13.5

15.3

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

6.3

15.1

Z3229

NOMESCO Finland

Other healthcare associate professional

3.3

14.9

263

W22

ICD-10 Finland

Striking against or struck by other object(s)

3.9

14.9

170

CHD15

NOMESCO Finland

Trabeculectomy and iridectomy

25.8

14.8

CKD10

NOMESCO Finland

Insufflation of vitreous cavity

8.4

14.7

ZXE10

NOMESCO Finland

More than one and less than three hours

2.0

14.4

243

1495

WX142

NOMESCO Finland

Sub-tenon anesthesy

17.5

14.4

CHD65

NOMESCO Finland

Nonpenetrating glaucoma surgery

22.9

14.3

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.9

14.2

349

M08.3

ICD-10 Finland

Juvenile polyarthritis (seronegative)

30.8

13.9

S01FA02

ATC

scopolamine; ophthalmic

18.1

13.9

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

4.5

13.6

117

TCA20

NOMESCO Finland

Peribulbar therapeutic injection into orbit

143.0

13.5

CG2S4

NOMESCO Finland

Photography of cornea

143.0

13.5

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

4.6

13.5

109

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

8.4

13.4

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

6.6

13.4

103

Kela drug reimbursment

Diabetes, insulin-treated

2.1

13.4

195

1125

H26.02

ICD-10 Finland

Presenil cataract

7.1

13.3

NHQ40

NOMESCO Finland

Amputation of toe

7.8

13.3

H04AA01

ATC

glucagon; nasal, parenteral

7.0

13.1

Z3231

NOMESCO Finland

Registered nurse

2.1

13.0

189

1086

H16.9

ICD-10 Finland

Keratitis, unspecified

132.6

12.5

TCG10

NOMESCO Finland

Removal of sutures from cornea

38.4

12.3

H26.3

ICD-10 Finland

Drug-induced cataract

27.3

12.1

H04.10

ICD-10 Finland

Dry eye syndrome

3.1

12.0

243

N08.39*E10.2

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic nephropathy

12.0

11.9

ZXD05

NOMESCO Finland

Urgent procedure

1.9

11.9

212

1313

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

4.7

11.9

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

7.9

11.7

M08.0

ICD-10 Finland

Juvenile rheumatoid arthritis

66.2

11.6

H3600, E103

ICD-10 Finland

11.4

11.6

3644A

ICD-9 Finland

Disorders of iris and ciliary body, Vascular disorders of iris and ciliary body

+∞

11.5

H20.8

ICD-10 Finland

Other iridocyclitis

+∞

11.5

CHD05

NOMESCO Finland

Selective lasertrabeculoplasty

5.2

11.4

L04AB04

ATC

adalimumab; parenteral

10.8

11.3

H57.1

ICD-10 Finland

Ocular pain

6.3

11.2

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.0

11.2

165

946

L04AA01

ATC

[U] ciclosporin; systemic

8.8

11.1

Z49.1

ICD-10 Finland

Extracorporeal dialysis

10.3

11.1

E10.1

ICD-10 Finland

Type 1 diabetes mellitus, With ketoacidosis

10.3

11.1

CS494

NOMESCO Finland

Other visual field testing

6.2

11.0

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

3.0

10.9

223

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

3.5

10.9

155

H53.1

ICD-10 Finland

Subjective visual disturbances

3.3

10.9

172

CKD70

NOMESCO Finland

Excision of preretinal or epiretinal membrane

6.9

10.8

H27.1

ICD-10 Finland

Dislocation of lens

18.2

10.8

H3600, E113

ICD-10 Finland

7.8

10.8

J01FF01

ATC

clindamycin; systemic

2.0

10.7

172

1017

C03CA01

ATC

furosemide; systemic

1.9

10.6

214

1373

I65.2

ICD-10 Finland

Occlusion and stenosis of carotid artery

5.2

10.6

ZX198

NOMESCO Finland

Other local administration

10.3

10.6

W44

ICD-10 Finland

Foreign body entering into or through eye or natural orifice

7.3

10.4

TK800

NOMESCO Finland

Hemodialysis

5.8

10.2

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

3.4

10.0

149

CG2T4

NOMESCO Finland

Topography assessment of cornea

40.8

10.0

E10.00

ICD-10 Finland

Insulin-dependent diabetes diabetic hypoglycemic coma

9.8

TCW99

NOMESCO Finland

Other minor procedure in eye surgery

7.6

9.8

S01FA01

ATC

atropine; ophthalmic

13.6

9.7

PA6DE

NOMESCO Finland

Neck artery ultrasound examination with Doppler method

3.3

9.7

159

L04AD01

ATC

ciclosporin; systemic

8.6

9.6

H43.8

ICD-10 Finland

Other disorders of vitreous body

2.9

9.6

224

H30.2

ICD-10 Finland

Posterior cyclitis

101.5

9.4

H18.8

ICD-10 Finland

Other specified disorders of cornea

101.5

9.4

I25.1

ICD-10 Finland

Atherosclerotic heart disease

1.9

9.4

162

977

CK2K4

NOMESCO Finland

Red-free imaging of ocular fundus

+∞

9.4

H19.1*B00.5

ICD-10 Finland

Herpesviral keratoconjunctivitis

+∞

9.4

TCG00

NOMESCO Finland

Protection of cornea and sclera with soft lens

+∞

9.4

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.8

9.4

200

1298

E11.5

ICD-10 Finland

Type 2 diabetes mellitus, with peripheral circulatory complications

5.2

9.4

CHD00

NOMESCO Finland

Laser trabeculoplasty

7.5

9.3

A10AE06

ATC

insulin degludec; parenteral

4.9

9.3

SPAT1262

SPAT

Handing over of treatment supplies

2.1

9.2

120

650

C08CA01

ATC

amlodipine; oral

1.7

9.1

227

1543

CKD60

NOMESCO Finland

Anterior vitrectomy

9.2

9.1

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

4.0

9.1

E10

ICD-10 Finland

Type 1 diabetes mellitus

6.7

9.0

CS5Z4

NOMESCO Finland

Specialised imaging for glaucoma

5.9

9.0

A10AD01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)

4.9

9.0

XCH05

NOMESCO Finland

Eye pressure longterm registration

12.8

8.9

I50.9

ICD-10 Finland

Heart failure, unspecified

2.1

8.9

110

584

H34.1

ICD-10 Finland

Central retinal artery occlusion

9.7

8.8

CHD99

NOMESCO Finland

Other filtering operation

14.3

8.7

C10AA05

ATC

atorvastatin; oral

1.7

8.6

233

1617

H40.3

ICD-10 Finland

Glaucoma secondary to eye trauma

16.6

8.6

L04AB06

ATC

golimumab; parenteral

16.6

8.6

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

2.4

8.6

326

H35.38

ICD-10 Finland

Preretinal fibrosis of the macula

3.9

8.6

H54.4

ICD-10 Finland

Blindness, monocular

27.9

8.5

H26.1

ICD-10 Finland

Traumatic cataract

20.4

8.5

N08.39

ICD-10 Finland

Glomerular disorders in diabetes mellitus microalbuminuria

20.4

8.5

H53.9

ICD-10 Finland

Visual disturbance, unspecified

4.6

8.5

Z94.7

ICD-10 Finland

Corneal transplant status

91.2

8.4

H3603, E107

ICD-10 Finland

91.2

8.4

S05.0

ICD-10 Finland

Injury of conjunctiva and corneal abrasion without mention of foreign body

6.0

8.4

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

5.1

8.3

Z2221

NOMESCO Finland

Medical doctor

1.8

8.2

163

1027

H40.20

ICD-10 Finland

Acute glaucoma with closed ventricular angle

11.9

8.1

R1220

NOMESCO Finland

Psychological examination of need and possibilities to rehabilitation

17.4

8.1

B03XA02

ATC

darbepoetin alfa; parenteral

5.4

8.1

AA1AD

NOMESCO Finland

CT of head and brain

1.8

8.0

152

941

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.0

8.0

100

533

N18.0

ICD-10 Finland

End-stage renal disease

7.9

190

Kela drug reimbursment

Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide

13.2

7.9

A11CC03

ATC

alfacalcidol; systemic

4.8

7.9

A02BC02

ATC

pantoprazole; systemic

1.6

7.9

375

3009

Z2446

NOMESCO Finland

Social worker

3.0

7.9

159

E10.2

ICD-10 Finland

Type 1 diabetes mellitus, With renal complications

8.6

7.8

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

2.3

7.8

341

C07AB07

ATC

bisoprolol; oral

1.6

7.8

287

2150

L04AB05

ATC

certolizumab pegol; parenteral

45.6

7.7

127

Kela drug reimbursment

Transplant complication

7.6

7.7

E10.8

ICD-10 Finland

Type 1 diabetes mellitus, With unspecified complications

7.6

7.7

CS424

NOMESCO Finland

Visual field testing with Goldmann perimetry

8.2

7.6

H10.3

ICD-10 Finland

Acute conjunctivitis, unspecified

3.2

7.6

129

KAS10

NOMESCO Finland

Allogenic transplantation of kidney from cadaver donor

10.2

7.6

ZXD30

NOMESCO Finland

Difficulties in perfomrming procedure

3.3

7.5

113

TCF00

NOMESCO Finland

Subconjunctival therapeutic injection

81.0

7.4

H36.00

ICD-10 Finland

Diabetic background retinopathy

5.7

7.4

PBL10

NOMESCO Finland

Construction of arteriovenous fistula from radial artery

7.8

7.4

H40.8

ICD-10 Finland

Other glaucoma

13.6

7.4

I50.0

ICD-10 Finland

Congestive heart failure

2.4

7.4

294

S01AD03

ATC

aciclovir; ophthalmic

4.3

7.4

I69.3

ICD-10 Finland

Sequelae of cerebral infarction

2.4

7.4

273

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.7

7.3

198

L04AA06

ATC

mycophenolic acid; systemic

5.9

7.3

H25.8

ICD-10 Finland

Other senile cataract

2.1

7.2

417

B01AC04

ATC

clopidogrel; oral

1.9

7.2

110

630

N08.39*E11.2

ICD-10 Finland

Non-insulin-dependent diabetes mellitus - Diabetic nephropathy

5.4

7.1

ZXE00

NOMESCO Finland

One hour or less

1.6

7.1

227

1628

1LA05

NOMESCO Finland

12.2

7.1

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

2.4

6.9

252

H28.0*E10.3

ICD-10 Finland

Other specified diabetes mellitus - Diabetic cataract

40.5

6.8

CA1AD

NOMESCO Finland

Orbita CT

40.5

6.8

H54.1

ICD-10 Finland

Severe visual impairment, binocular

40.5

6.8

CKD95

NOMESCO Finland

Extended combined vitectomy and lens procedure through pars plana

16.9

6.8

L04AA17

ATC

[U] adalimumab; parenteral

16.9

6.8

C09AA02

ATC

enalapril; systemic

1.8

6.7

132

820

H44.5

ICD-10 Finland

Degenerated conditions of globe

22.8

6.7

CKD50

NOMESCO Finland

Endodiathermy of retina

22.8

6.7

CS1H4

NOMESCO Finland

Retinal nerve fibre layer imaging

6.0

6.6

H35.6

ICD-10 Finland

Retinal haemorrhage

12.4

6.6

CS3P4

NOMESCO Finland

Optic nerve head stereophotography

8.8

6.6

Z94.0

ICD-10 Finland

Kidney transplant status

8.8

6.6

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

10.2

6.6

A10AA03

ATC

7.0

6.5

SPAT1009

SPAT

Measurement of intraocular pressure

7.0

6.5

A10AD05

ATC

insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)

4.0

6.4

H40

ICD-10 Finland

Glaucoma

7.5

6.4

CH2S4

NOMESCO Finland

Photography of iris

70.5

6.4

S18

ICPC

Laceration/cut

1.6

6.4

236

1744

N02BE01

ATC

paracetamol; systemic, rectal

1.7

6.4

494

4358

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

14.5

6.4

I10

ICD-10 Finland

Essential (primary) hypertension

1.5

6.4

335

2691

M45

ICD-10 Finland

Ankylosing spondylitis

5.3

6.4

V03AE01

ATC

polystyrene sulfonate; oral

5.6

6.3

PAF14

NOMESCO Finland

Thrombendarterectomy of internal carotid artery

4.7

6.3

Z49.2

ICD-10 Finland

Other dialysis

11.2

6.3

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

2.4

6.3

215

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.6

6.3

183

1274

H18.6

ICD-10 Finland

Keratoconus

+∞

6.3

H22.1*M45

ICD-10 Finland

Iridocyclitis in ankylosing spondylitis

+∞

6.3

H18.1

ICD-10 Finland

Bullous keratopathy

+∞

6.3

TCA15

NOMESCO Finland

Retrobulbar therapeutic injection into orbit

+∞

6.3

H221, M084

ICD-10 Finland

+∞

6.3

H17.9

ICD-10 Finland

Corneal scar and opacity, unspecified

+∞

6.3

CWW99

NOMESCO Finland

Other reoperation on eye and adjacent structures

+∞

6.3

TJA35

NOMESCO Finland

Removal of peritoneal dialysis catheter

27.0

6.2

2504B

ICD-9 Finland

Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]

27.0

6.2

N18.8

ICD-10 Finland

Other chronic renal failure

3.6

6.2

FN1AC

NOMESCO Finland

Angiography of heart and/or coronary arteries

1.7

6.1

135

870

E10.4

ICD-10 Finland

Type 1 diabetes mellitus, With neurological complications

6.8

6.1

S01ED02

ATC

betaxolol; ophthalmic

5.6

6.0

A12AA04

ATC

calcium carbonate; oral

5.6

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_VASCCILIARY and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_VASCCILIARY	1.43 [1.22, 1.67]	< 0.001
Birth year	0.998 [0.99, 1.01]	0.646

During the follow-up period (1.1.1998 — 31.12.2019), 674 out of 2047 females with H7_VASCCILIARY died.

Males

Parameter	HR [95% CI]	p-value
H7_VASCCILIARY	1.647 [1.36, 1.99]	< 0.001
Birth year	0.986 [0.98, 0.99]	0.002

During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 2837 males with H7_VASCCILIARY died.

Mortality risk

Mortality risk for people of age

years, who have H7_VASCCILIARY.

N-year risk	Females	Males
1	0.142%	0.259%
5	0.861%	1.779%
10	2.386%	4.403%
15	4.604%	8.327%
20	8.298%	13.714%

NAME	H7_VASCCILIARY
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H21[0-1]
HD_ICD_9	3644
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H21[0-1]
COD_ICD_9	3644
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Hyphaema and other vascular disorders of iris and ciliary body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints