Optic neuritis

H7_OPTNEURITIS

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H46
  • Hospital discharge: ICD-9 3773
  • Hospital discharge: ICD-8 3670[2-9]
  • Cause of death: ICD-10 H46
  • Cause of death: ICD-9 3773
  • Cause of death: ICD-8 3670[2-9]

2 out of 7 registries used, show all original rules.

1513

4. Check minimum number of events

None

1513

5. Include endpoints

None

1513

6. Filter based on genotype QC (FinnGen only)

1438

Control definitions (FinnGen only)

Control exclude
H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H46-H48
Name in latin
Neuritis optica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10403 6920 3413
Only index persons 9515 6484 3031
Unadjusted period prevalence (%)
Whole population 0.16 0.20 0.10
Only index persons 0.20 0.24 0.12
Median age at first event (years)
Whole population 36.47 35.70 38.00
Only index persons 35.76 35.17 37.00

-FinnGen-

Key figures

All Female Male
Number of individuals 1438 1087 351
Unadjusted period prevalence (%) 0.37 0.43 0.18
Median age at first event (years) 36.60 35.78 39.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1513
Matched controls
15131
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
182.7
323.0
564
49
G35
ICD-10 Finland
Multiple sclerosis
180.5
323.0
773
87
109
Kela drug reimbursment
Multiple sclerosis
178.0
323.0
634
61
H46
ICD-10 Finland
Optic neuritis
4503599627370496.0
323.0
1304
*
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
181.1
323.0
531
45
L03AB07
ATC
interferon beta-1a; parenteral
167.1
323.0
338
26
XCK00
NOMESCO Finland
Perimetry
19.3
291.3
468
343
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
14.1
282.5
526
550
L03AX13
ATC
glatiramer acetate; parenteral
187.7
245.4
251
16
TAB00
NOMESCO Finland
Lumbar puncture
16.7
228.9
386
304
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
77.7
205.3
231
35
N86
ICPC
Multiple sclerosis
83.6
199.3
222
31
164
Kela drug reimbursment
Fingolimod
117.0
172.6
185
18
L04AX07
ATC
dimethyl fumarate; oral
135.7
159.9
169
14
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.7
150.9
516
1256
353
Kela drug reimbursment
Cladribine and fingolimod
100.7
148.5
162
18
L04AA31
ATC
teriflunomide; oral
121.3
133.6
143
13
L04AA27
ATC
fingolimod; oral
119.5
131.6
141
13
N04BB01
ATC
amantadine; oral
33.5
131.0
173
58
L03AB08
ATC
interferon beta-1b; parenteral
176.1
124.5
129
8
N07XX09
ATC
[U] dimethyl fumarate; oral
139.4
109.7
116
9
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
+∞
109.7
104
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
17.4
101.5
164
105
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
99.1
94
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.3
95.9
188
187
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
13.7
93.0
166
135
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.4
90.7
302
665
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
12.9
87.0
159
136
H53.1
ICD-10 Finland
Subjective visual disturbances
6.5
85.4
240
426
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.0
81.3
244
470
XA800
NOMESCO Finland
Neuropsychological investigation
8.7
79.7
181
233
2AB04
NOMESCO Finland
NA
144.4
77.8
82
6
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
42.9
71.6
89
22
H47.2
ICD-10 Finland
Optic atrophy
+∞
71.4
68
*
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
720.7
70.7
69
*
M03BX01
ATC
baclofen; systemic
13.1
69.8
126
104
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
21.1
67.5
101
51
XKD06
NOMESCO Finland
Physiologic investigation of micturition
10.9
65.3
129
128
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
+∞
65.1
62
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.6
64.8
245
604
H47.1
ICD-10 Finland
Papilloedema, unspecified
655.0
64.4
63
*
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
64.0
61
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.3
61.5
252
671
H53.4
ICD-10 Finland
Visual field defects
15.0
59.0
100
71
ZX120
NOMESCO Finland
Intravenous
4.1
55.6
241
672
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
286.3
54.5
55
*
XKD00
NOMESCO Finland
Uroflowmetry
4.0
52.5
233
662
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
134.5
49.1
52
*
N06BA07
ATC
modafinil; oral
41.6
48.2
60
15
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
46.3
47.6
58
13
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
10.1
47.6
97
102
Z3231
NOMESCO Finland
Registered nurse
2.4
45.3
481
2436
L03AB13
ATC
peginterferon beta-1a; parenteral
84.4
44.1
49
6
36702
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica. Papillitis
+∞
44.0
42
*
G04BD09
ATC
trospium; oral
9.2
42.9
92
106
XCK10
NOMESCO Finland
Photography of fundus of eye
3.7
42.4
203
610
N03AX12
ATC
gabapentin; oral
2.8
41.3
305
1249
H53.9
ICD-10 Finland
Visual disturbance, unspecified
7.4
41.1
101
145
4AA23
NOMESCO Finland
NA
143.9
39.9
42
*
G04BD12
ATC
mirabegron; oral
3.8
39.8
181
519
R20.2
ICD-10 Finland
Paraesthesia of skin
3.7
38.9
182
535
H57.1
ICD-10 Finland
Ocular pain
5.7
38.1
115
217
R1250
NOMESCO Finland
Evaluation of functional capability
8.6
36.0
80
98
CS494
NOMESCO Finland
Other visual field testing
8.9
35.1
76
89
XKC03
NOMESCO Finland
Water cystometry
6.3
34.8
95
158
UKC02
NOMESCO Finland
Cystoscopy
2.9
34.5
238
925
3773A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[PAPILLITIS OPTICA]
+∞
34.5
33
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
7.8
33.6
79
106
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.1
31.9
131
342
H02AB04
ATC
methylprednisolone; systemic
2.6
31.6
269
1179
H53.2
ICD-10 Finland
Diplopia
5.9
29.0
83
147
A02BC02
ATC
pantoprazole; systemic
1.9
28.7
943
7137
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
7.6
28.6
68
93
TKC22
NOMESCO Finland
Catheterisation instruction
9.5
28.6
59
64
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
65.3
28.0
32
5
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
18.4
28.0
43
24
G04BD07
ATC
tolterodine; oral
4.8
27.8
95
207
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.8
27.7
125
354
G04BD04
ATC
oxybutynin; oral, transdermal
4.1
27.5
111
285
H02AB06
ATC
prednisolone; systemic
1.8
27.4
695
4791
Z3229
NOMESCO Finland
Other healthcare associate professional
3.1
27.2
156
533
N03AX16
ATC
pregabalin; oral
2.1
27.0
368
2009
N03AE01
ATC
clonazepam; systemic
3.5
26.9
132
401
L04AA40
ATC
cladribine; oral
76.6
26.8
30
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.1
26.7
161
567
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
14.5
26.7
45
32
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
16.6
26.3
42
26
G04BD08
ATC
solifenacin; oral
3.8
25.9
115
321
34099
ICD-8 Finland
Multiple sclerosis
95.1
25.7
28
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
9.1
25.6
54
61
Z3226
NOMESCO Finland
Physiotherapist
2.2
25.1
301
1550
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
25.1
191
781
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
14.4
24.9
42
30
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.0
24.1
101
269
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
27.2
23.6
32
12
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.3
23.3
124
400
Z2445
NOMESCO Finland
Psychologist
3.6
22.8
106
308
R33
ICD-10 Finland
Retention of urine
3.7
22.6
103
295
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
11.4
22.0
41
37
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
9.4
21.9
45
49
R35
ICD-10 Finland
Polyuria
3.6
21.6
102
300
R4150
NOMESCO Finland
Neuropsychological rehabilitation
12.1
21.1
38
32
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
28.5
21.0
28
10
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
20.8
539
3644
TKC20
NOMESCO Finland
Catheterisation of bladder
3.1
19.0
108
366
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
5.0
18.6
60
124
H53.8
ICD-10 Finland
Other visual disturbances
11.2
18.2
34
31
SPAT1229
SPAT
Assessment of need for aid
3.0
18.1
109
383
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
7.2
17.9
43
61
J01EA01
ATC
trimethoprim; systemic
1.8
17.8
392
2498
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
17.7
17
*
H02AB07
ATC
prednisone; oral
2.1
17.5
213
1089
R51.80
ICD-10 Finland
Headache
1.9
17.4
268
1508
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
8.4
17.0
37
45
N03AF01
ATC
carbamazepine; oral, rectal
3.3
16.7
87
277
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
16.7
16
*
R4110
NOMESCO Finland
Physiotherapy
1.8
16.3
357
2262
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
7.1
16.2
39
56
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
16.9
16.1
25
15
L28
ICPC
Limited function/disability (L)
2.2
16.1
181
896
C10AC01
ATC
colestyramine; oral
4.3
15.9
59
141
N05CF01
ATC
zopiclone; oral
1.7
15.9
428
2876
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
15.8
388
2539
N28
ICPC
Limited function/disability (N)
7.4
15.8
37
51
H30.2
ICD-10 Finland
Posterior cyclitis
22.3
15.5
22
10
L04AX01
ATC
azathioprine; systemic
3.0
15.3
90
313
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
3.7
15.1
67
189
AA1AD
NOMESCO Finland
CT of head and brain
1.8
15.1
278
1657
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
5.4
14.3
42
79
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
14.2
199
1073
XKD03
NOMESCO Finland
Urethral pressure profilometry
4.5
14.1
50
115
G04BD11
ATC
fesoterodine; oral
4.4
13.9
50
117
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
8.7
13.8
29
34
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
13.7
194
1051
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
9.8
13.7
27
28
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
13.7
210
1172
36709
ICD-8 Finland
Inflammation of optic nerve and retina, Unspecified
+∞
13.6
13
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
13.3
521
3823
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
11.6
13.3
24
21
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
9.8
13.2
26
27
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
13.2
115
502
Z2446
NOMESCO Finland
Social worker
2.4
13.2
113
492
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.0
13.2
77
268
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
13.1
12.9
22
17
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
50.4
12.9
15
*
XCH00
NOMESCO Finland
Eye pressure measurement
3.6
12.8
58
167
R42
ICD-10 Finland
Dizziness and giddiness
1.7
12.6
263
1628
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
12.5
106
459
M03BX02
ATC
tizanidine; oral
1.5
12.5
926
7782
G50.0
ICD-10 Finland
Trigeminal neuralgia
5.0
12.4
39
80
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.3
12.3
117
533
N06AX16
ATC
venlafaxine; oral
1.8
12.1
241
1467
H54.4
ICD-10 Finland
Blindness, monocular
26.9
12.1
16
6
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
11.5
264
1678
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
7.9
11.4
25
32
N06AA09
ATC
amitriptyline; systemic
2.1
11.3
138
703
N03AF02
ATC
oxcarbazepine; oral
3.3
11.3
56
174
RF120
NOMESCO Finland
NA
5.7
11.2
31
55
F05
ICPC
Visual disturbance other
3.6
11.0
49
140
R4120
NOMESCO Finland
Occupational therapy
2.4
11.0
93
401
G04CA02
ATC
tamsulosin; oral
1.9
11.0
161
882
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
10.9
530
4037
R50.9
ICD-10 Finland
Fever, unspecified
1.8
10.9
196
1154
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
10.7
365
2564
A28
ICPC
Limited function/disability NOS
2.0
10.7
136
707
J01CA08
ATC
pivmecillinam; oral
1.5
10.6
629
4978
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.2
10.6
106
496
Z2221
NOMESCO Finland
Medical doctor
1.5
10.5
406
2938
ZXA10
NOMESCO Finland
Bilateral
1.7
10.5
232
1456
N30.0
ICD-10 Finland
Acute cystitis
1.8
10.4
202
1216
N02BE01
ATC
paracetamol; systemic, rectal
1.5
10.4
1213
10965
H20.1
ICD-10 Finland
Chronic iridocyclitis
5.2
10.3
31
61
S06.0
ICD-10 Finland
Concussion
1.9
10.2
144
778
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.6
10.1
44
124
G51.0
ICD-10 Finland
Bell palsy
3.6
10.1
44
125
N99
ICPC
Neurological disease other
5.6
10.0
28
51
SPAT1216
SPAT
Assessment of functional ability
1.8
9.8
163
933
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
9.6
346
2455
N29
ICPC
Neurological sympt/complt other
4.1
9.6
36
90
N06AB04
ATC
citalopram; systemic
1.6
9.5
302
2079
G04BD01
ATC
emepronium; systemic
9.1
9.5
19
21
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.5
9.4
72
297
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.0
9.3
51
172
SPAT1231
SPAT
Assessment of adjustments needed in living environment
5.5
9.2
26
48
N05BA01
ATC
diazepam; systemic, rectal
1.8
9.2
171
1017
J01MA02
ATC
ciprofloxacin; systemic
1.4
9.1
470
3594
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
9.1
172
1030
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.4
9.0
77
334
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
36.9
9.0
11
*
L01BB04
ATC
cladribine; systemic
36.9
9.0
11
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
8.9
143
810
A02BA02
ATC
ranitidine; systemic
1.6
8.9
222
1439
H34.2
ICD-10 Finland
Other retinal artery occlusions
16.4
8.6
13
8
U13
ICPC
Bladder symptom/complaint other
3.0
8.5
47
160
G04CA01
ATC
alfuzosin; oral
2.2
8.5
89
425
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
8.5
458
3523
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
8.5
130
725
N02AX02
ATC
tramadol; systemic, rectal
1.4
8.5
506
3966
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
8.4
384
2857
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
6.7
8.4
20
30
R06.0
ICD-10 Finland
Dyspnoea
1.5
8.4
277
1924
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.8
8.4
34
92
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
8.2
57
223
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
4.7
8.1
26
56
G81.9
ICD-10 Finland
Hemiplegia, unspecified
4.9
8.1
25
52
RF420
NOMESCO Finland
NA
4.1
8.1
30
75
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.8
7.9
136
789
A02BC03
ATC
lansoprazole; oral
1.5
7.8
345
2545
H52.1
ICD-10 Finland
Myopia
2.5
7.8
61
255
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
7.7
286
2032
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.1
7.7
90
452
H54.0
ICD-10 Finland
Blindness, binocular
45.2
7.7
9
*
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
15.1
7.7
12
8
RF410
NOMESCO Finland
NA
4.6
7.7
25
55
ZXY02
NOMESCO Finland
Neuropsychologist
7.5
7.7
17
23
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
7.6
221
1483
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
7.6
342
2532
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
7.6
157
963
NA1BM
NOMESCO Finland
Cervical spine MRI examination with 3 Tesla magnet
11.9
7.6
13
11
R39.1
ICD-10 Finland
Other difficulties with micturition
3.2
7.5
37
117
A02BC01
ATC
omeprazole; systemic
1.5
7.5
336
2485
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.9
7.5
29
76
XA412
NOMESCO Finland
VEP
80.5
7.4
8
*
RS221
NOMESCO Finland
NA
3.8
7.4
29
77
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
8.4
7.3
15
18
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
10.9
7.3
13
12
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
+∞
7.3
7
*
3773X
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS OPTICA ALIA SEU NUD]
+∞
7.3
7
*
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
6.9
7.3
17
25
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
7.3
131
773
J01AA02
ATC
doxycycline; systemic
1.4
7.3
1068
9627
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
7.3
127
742
N06AX21
ATC
duloxetine; oral
1.7
7.1
157
982
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
6.1
7.1
18
30
A04
ICPC
Weakness/tiredness general
1.6
7.1
166
1057
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
7.0
109
612
U07
ICPC
Urine symptom/complaint other
2.1
6.9
71
340
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
6.9
779
6709
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
4.6
6.9
22
48
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
6.9
272
1957
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
6.9
492
3950
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
4.5
6.8
22
49
H54.7
ICD-10 Finland
Unspecified visual loss
6.1
6.8
17
28
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
6.1
6.8
17
28
4AA36
NOMESCO Finland
NA
40.2
6.8
8
*
S01EC01
ATC
acetazolamide; systemic
3.4
6.7
30
89
N03AX09
ATC
lamotrigine; oral
1.9
6.7
87
459
Z43.5
ICD-10 Finland
Attention to cystostomy
22.6
6.7
9
*
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.7
6.6
141
878
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
8.7
6.6
13
15
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
10.1
6.5
12
12
J01XE01
ATC
nitrofurantoin; oral
3.2
6.5
31
97
F01
ICPC
Eye pain
2.6
6.5
44
173
H52.5
ICD-10 Finland
Disorders of accommodation
14.4
6.4
10
7
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.4
6.4
21
48
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
6.3
684
5827
H53
ICD-10 Finland
Visual disturbances
5.5
6.3
17
31
R03CA02
ATC
ephedrine; oral
18.1
6.3
9
5
SPAT1325
SPAT
Vaccination
1.4
6.2
372
2889
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
2.4
6.2
51
221
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
26.8
6.2
8
*
R51.81
ICD-10 Finland
Facial pain NOS
2.8
6.2
37
135
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
6.2
148
948
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
4.5
6.2
20
45
Z50.1
ICD-10 Finland
Other physical therapy
2.1
6.2
66
324
A06AD11
ATC
lactulose; oral
1.7
6.1
132
821
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.1
6.1
61
290
H34.1
ICD-10 Finland
Central retinal artery occlusion
12.6
6.1
10
8
6BA02
NOMESCO Finland
NA
8.6
6.1
12
14
WX892
NOMESCO Finland
Monitored bed care
1.9
6.1
78
412
WW400
NOMESCO Finland
Plasmaferesis
10.1
6.0
11
11
N07AA03
ATC
distigmine; systemic
10.1
6.0
11
11
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
2.9
6.0
33
115

Mortality – FinRegistry

Association

Association between endpoint H7_OPTNEURITIS and mortality.

Females

Parameter HR [95% CI] p-value
H7_OPTNEURITIS 1.515 [1.3, 1.76] < 0.001
Birth year 0.997 [0.99, 1.01] 0.525

During the follow-up period (1.1.1998 — 31.12.2019), 352 out of 4881 females with H7_OPTNEURITIS died.

Males

Parameter HR [95% CI] p-value
H7_OPTNEURITIS 1.457 [1.25, 1.69] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 331 out of 2288 males with H7_OPTNEURITIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_OPTNEURITIS.

N-year risk Females Males
1 0.204% 0.266%
5 0.939% 1.733%
10 2.566% 4.544%
15 4.917% 8.48%
20 8.402% 13.804%

Relationships between endpoints

Index endpoint: H7_OPTNEURITIS – Optic neuritis

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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