Risteys · H7_IRIDOCYCLITISINOTH

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H22[0-1] Cause of death: ICD-10 — H22[0-1] 2 out of 7 registries used, show all original rules.	659
4. Check minimum number of events None	659
5. Include endpoints None	659
6. Filter based on genotype QC (FinnGen only)	659

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3920	2066	1843
Only index persons	3697	1955	1742
Unadjusted period prevalence (%)
Whole population	0.06	0.06	0.05
Only index persons	0.07	0.07	0.07
Median age at first event (years)
Whole population	53.62	55.44	51.59
Only index persons	53.59	55.89	51.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	659	367	292
Unadjusted period prevalence (%)	0.13	0.13	0.13
Median age at first event (years)	54.69	52.90	56.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
585: Matched controls
5851

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

+∞

322.8

279

H22.1*M45

ICD-10 Finland

Iridocyclitis in ankylosing spondylitis

+∞

215.3

193

M45

ICD-10 Finland

Ankylosing spondylitis

90.8

175.9

191

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

175.0

159

H22.0*B02.3

ICD-10 Finland

Zoster iridocyclitis

+∞

153.0

140

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

15.5

149.7

277

321

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

13.8

116.8

221

247

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

48.5

116.3

141

A07EC01

ATC

sulfasalazine; oral, rectal

14.9

111.1

200

197

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

44.7

103.0

127

S01BA04

ATC

prednisolone; ophthalmic (corticosteroids, plain)

37.0

92.6

119

S01AD03

ATC

aciclovir; ophthalmic

25.2

91.5

131

H22.0*B00.5

ICD-10 Finland

Herpesviral iridocyclitis

+∞

89.9

S01BA01

ATC

dexamethasone; ophthalmic (corticosteroids, plain)

23.0

89.4

132

H22.1*D86.8

ICD-10 Finland

Iridocyclitis in sarcoidosis

+∞

83.3

L04AB04

ATC

adalimumab; parenteral

40.5

82.7

104

H22.1

ICD-10 Finland

Iridocyclitis in other diseases classified elsewhere

+∞

77.9

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

16.1

73.1

123

S01ED51

ATC

timolol, combinations; ophthalmic

10.8

70.4

145

173

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

10.5

67.4

141

172

H19.2*B02.3

ICD-10 Finland

Keratitis and keratoconjunctivitis (interstitial) in zoster

+∞

63.7

H19.1*B00.5

ICD-10 Finland

Herpesviral keratoconjunctivitis

+∞

63.7

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

9.8

62.8

136

175

S01CA02

ATC

prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

52.0

57.9

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

4.2

57.1

334

1416

H02AB06

ATC

prednisolone; systemic

3.9

52.5

381

1896

D86.8

ICD-10 Finland

Sarcoidosis of other and combined sites

101.0

50.8

S01FA04

ATC

cyclopentolate; ophthalmic

48.5

50.6

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

65.9

47.2

L04AB01

ATC

etanercept; parenteral

33.9

46.9

J05AB11

ATC

valaciclovir; oral

5.3

46.4

161

390

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.7

46.0

185

525

J05AB01

ATC

aciclovir; systemic

4.2

45.2

211

690

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

3.7

45.1

283

1193

H22.0

ICD-10 Finland

Iridocyclitis in infectious and parasitic diseases classified elsewhere

+∞

44.3

M08.4

ICD-10 Finland

Pauciarticular juvenile arthritis

118.7

41.3

S01ED01

ATC

timolol; ophthalmic

12.0

40.9

B02.3

ICD-10 Finland

Zoster ocular disease

90.4

38.3

L04AA13

ATC

leflunomide; oral

16.1

37.2

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.3

36.6

256

1123

L04AB06

ATC

golimumab; parenteral

73.2

36.5

H26.2

ICD-10 Finland

Complicated cataract

29.9

35.2

D86.0

ICD-10 Finland

Sarcoidosis of lung

27.6

33.7

H221, M084

ICD-10 Finland

+∞

33.7

H30.2

ICD-10 Finland

Posterior cyclitis

345.5

33.2

Z96.1

ICD-10 Finland

Presence of intraocular lens

4.8

33.1

123

310

H20.9

ICD-10 Finland

Iridocyclitis, unspecified

123.8

33.0

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.9

32.1

313

1671

7200A

ICD-9 Finland

Ankylosing spondylitis and other inflammatory spondylopathies, Ankylosing spondylitis

120.1

32.0

XCW99

NOMESCO Finland

Other investigative procedure of eye

4.5

30.0

117

308

114

Kela drug reimbursment

Glaucoma

5.4

29.8

201

M08.3

ICD-10 Finland

Juvenile polyarthritis (seronegative)

60.0

29.4

H02AB07

ATC

prednisone; oral

3.8

29.0

138

435

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

4.8

28.8

104

252

P01BA02

ATC

hydroxychloroquine; oral

5.2

28.4

212

H40.4

ICD-10 Finland

Glaucoma secondary to eye inflammation

+∞

28.4

B02.9

ICD-10 Finland

Zoster without complication

6.6

27.9

128

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

13.7

27.6

H16.0

ICD-10 Finland

Corneal ulcer

15.6

27.4

H16.9

ICD-10 Finland

Keratitis, unspecified

101.5

26.9

H221, M083

ICD-10 Finland

+∞

26.2

H19.1

ICD-10 Finland

Herpesviral keratitis and keratoconjunctivitis

+∞

26.2

M46.1

ICD-10 Finland

Sacroiliitis, not elsewhere classified

23.1

26.0

B00.5

ICD-10 Finland

Herpesviral ocular disease

141.2

25.8

S01EA03

ATC

apraclonidine; ophthalmic

34.9

25.8

S01BA07

ATC

fluorometholone; ophthalmic (corticosteroids, plain)

16.4

25.0

S01EC01

ATC

acetazolamide; systemic

11.8

24.8

D86.9

ICD-10 Finland

Sarcoidosis, unspecified

29.0

24.7

L88

ICPC

Rheumatoid/seropositive arthritis

7.4

24.6

NA6BG

NOMESCO Finland

Sacro-iliac joint MRI examination with high intensity magnet

16.6

24.5

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

11.2

24.3

L04AX01

ATC

azathioprine; systemic

6.3

23.4

111

S01FA02

ATC

scopolamine; ophthalmic

21.1

23.3

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

2.7

23.2

202

958

L04AA11

ATC

[U] etanercept; parenteral

47.0

22.5

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

19.4

22.0

H04.10

ICD-10 Finland

Dry eye syndrome

3.8

20.3

273

M08.0

ICD-10 Finland

Juvenile rheumatoid arthritis

37.2

20.0

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

4.8

19.7

160

TCA20

NOMESCO Finland

Peribulbar therapeutic injection into orbit

206.6

19.7

S01BC03

ATC

diclofenac; ophthalmic

9.1

19.5

S01EE01

ATC

latanoprost; ophthalmic

5.4

19.3

122

M13.9

ICD-10 Finland

Arthritis, unspecified

4.2

18.7

194

S01EC04

ATC

brinzolamide; ophthalmic

7.0

18.5

ZXA10

NOMESCO Finland

Bilateral

2.7

18.3

142

615

H57.1

ICD-10 Finland

Ocular pain

7.7

17.6

D86.2

ICD-10 Finland

Sarcoidosis of lung with sarcoidosis of lymph nodes

21.7

17.4

L04AA01

ATC

[U] ciclosporin; systemic

12.1

17.2

Z3229

NOMESCO Finland

Other healthcare associate professional

3.5

17.2

270

L04AB05

ATC

certolizumab pegol; parenteral

32.6

17.1

H20

ICD-10 Finland

Iridocyclitis

65.3

16.8

36400

ICD-8 Finland

Iritis, Iridocyclitis acuta

+∞

16.7

CG2S4

NOMESCO Finland

Photography of cornea

174.7

16.6

XCK10

NOMESCO Finland

Photography of fundus of eye

3.3

16.1

299

H40.0

ICD-10 Finland

Glaucoma suspect

4.0

15.9

176

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

4.5

15.7

133

L04AA17

ATC

[U] adalimumab; parenteral

39.2

15.5

ZXE00

NOMESCO Finland

One hour or less

2.1

15.3

257

1604

4AA12

NOMESCO Finland

29.5

15.3

CJB10

NOMESCO Finland

Laser discission of secondary cataract

3.7

15.2

204

A02BC02

ATC

pantoprazole; systemic

2.1

15.2

385

2829

TCF00

NOMESCO Finland

Subconjunctival therapeutic injection

58.2

14.9

N03AX16

ATC

pregabalin; oral

2.3

14.8

160

819

H03.1*B02.3

ICD-10 Finland

Zoster blepharitis

25.8

14.8

WZA10

NOMESCO Finland

Long statement of health and health related matters

12.3

14.7

3640A

ICD-9 Finland

Disorders of iris and ciliary body, Acute and subacute iridocyclitis

+∞

14.6

H20.8

ICD-10 Finland

Other iridocyclitis

+∞

14.6

71240

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Spondylitis ankylopoietica

37.0

14.5

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.2

13.9

183

1018

D86

ICD-10 Finland

Sarcoidosis

+∞

13.6

132

Kela drug reimbursment

Sarcoidosis

16.7

13.5

H19.2

ICD-10 Finland

Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere

143.1

13.5

N02AX02

ATC

tramadol; systemic, rectal

2.0

13.4

251

1606

H26.4

ICD-10 Finland

After-cataract

3.3

13.4

231

H25.1

ICD-10 Finland

Senile nuclear cataract

2.3

13.2

146

748

UJF32

NOMESCO Finland

Coloscopy

2.2

13.1

162

874

S01EE04

ATC

travoprost; ophthalmic

8.3

12.9

TNH11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in ankle joint or foot joint

17.8

12.6

ZX120

NOMESCO Finland

Intravenous

2.9

12.3

300

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

8.7

11.9

B02

ICD-10 Finland

Zoster [herpes zoster]

5.3

11.9

XCK00

NOMESCO Finland

Perimetry

3.6

11.8

161

4AB02

NOMESCO Finland

30.7

11.7

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.0

11.7

243

S01EE05

ATC

tafluprost; ophthalmic

5.7

11.7

M01AH01

ATC

celecoxib; oral (coxibs)

2.3

11.6

117

570

S01BC05

ATC

ketorolac; ophthalmic

4.5

11.4

M01CB01

ATC

sodium aurothiomalate; parenteral

10.8

11.3

H26.3

ICD-10 Finland

Drug-induced cataract

13.0

11.2

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

3.5

11.2

163

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.9

11.1

268

TCG10

NOMESCO Finland

Removal of sutures from cornea

44.2

11.0

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

44.2

11.0

S01FA06

ATC

tropicamide; ophthalmic

44.2

11.0

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

3.3

10.5

171

M05BA04

ATC

alendronic acid; oral

3.0

10.5

218

WX100

NOMESCO Finland

Conjunctival surface anesthesia

2.7

10.4

306

H10.3

ICD-10 Finland

Acute conjunctivitis, unspecified

3.5

10.4

145

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

4.9

10.1

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.8

10.1

244

1664

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

5.2

10.0

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

5.8

9.9

NA1CG

NOMESCO Finland

Cervical spine extensive MRI examination with high intensity magnet

7.2

9.9

NK5AT

NOMESCO Finland

Joint injection with ultrasound guidance not elsewhere classified

13.7

9.7

M01AX01

ATC

nabumetone; oral

4.2

9.7

ZXE10

NOMESCO Finland

More than one and less than three hours

1.8

9.7

215

1420

Z3231

NOMESCO Finland

Registered nurse

1.9

9.6

170

1042

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.7

9.4

246

G53.0*B02.20

ICD-10 Finland

Trigeminal neuralgia after shingles

30.6

9.4

TNG11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in knee

12.6

9.4

H21.1

ICD-10 Finland

Other vascular disorders of iris and ciliary body

+∞

9.4

K50.8

ICD-10 Finland

Other Crohn disease

7.1

9.4

L04AC10

ATC

secukinumab; parenteral

22.1

9.4

B02.8

ICD-10 Finland

Zoster with other complications

22.1

9.4

N02BE01

ATC

paracetamol; systemic, rectal

2.0

9.3

487

4191

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

7.5

9.3

ZXD10

NOMESCO Finland

Scheduled procedure

1.8

9.2

224

1522

G53.0

ICD-10 Finland

Postzoster neuralgia

15.9

9.1

D86.3

ICD-10 Finland

Sarcoidosis of skin

37.3

9.0

R4110

NOMESCO Finland

Physiotherapy

1.9

9.0

165

1017

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.0

8.9

133

759

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

3.5

8.9

124

M01AC06

ATC

meloxicam; systemic, rectal

1.8

8.9

208

1391

N03AX12

ATC

gabapentin; oral

2.2

8.8

448

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

4.6

8.8

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

3.5

8.7

121

CFW99

NOMESCO Finland

Other operation on conjunctiva

50.7

8.7

S01EC03

ATC

dorzolamide; ophthalmic

7.1

8.6

J01FA06

ATC

roxithromycin; oral

1.7

8.6

229

1588

ZXX01

NOMESCO Finland

Extent of proceudre, 1 unit

9.2

8.6

H10.8

ICD-10 Finland

Other conjunctivitis

20.4

8.5

NAJ12

NOMESCO Finland

Posterior reduction of fracture of cervical spine

91.3

8.4

H22.0*A69.2

ICD-10 Finland

Iridocyclitis in Lyme disease

+∞

8.3

3641A

ICD-9 Finland

Disorders of iris and ciliary body, Chronic iridocyclitis

+∞

8.3

Z3226

NOMESCO Finland

Physiotherapist

2.0

8.3

120

675

TND11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in joint, wrist or hand

9.6

8.3

L04AD01

ATC

ciclosporin; systemic

5.5

8.2

M02.9

ICD-10 Finland

Reactive arthropathy, unspecified

6.2

8.2

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.8

8.2

162

1022

K50.0

ICD-10 Finland

Crohn disease of small intestine

8.3

8.1

TNG10

NOMESCO Finland

Puncture of knee

8.3

8.1

CHC05

NOMESCO Finland

Iridotomy

8.3

8.1

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.3

8.1

336

H15.1

ICD-10 Finland

Episcleritis

17.5

8.1

WX140

NOMESCO Finland

Parabulbar anesthesy

3.9

8.1

NF1AA

NOMESCO Finland

Hip X-ray examination

2.7

8.0

211

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

3.8

8.0

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.6

8.0

239

M01AE02

ATC

naproxen; oral, rectal

1.6

7.9

329

2565

D86.1

ICD-10 Finland

Sarcoidosis of lymph nodes

11.0

7.8

M01AH02

ATC

rofecoxib; oral

2.2

7.8

391

J01DB01

ATC

cefalexin; oral

1.8

7.8

468

4041

S01EE03

ATC

bimatoprost; ophthalmic

5.2

7.8

R05

ICD-10 Finland

Cough

2.0

7.8

114

644

WX408

NOMESCO Finland

General anesthesy, balanced

1.8

7.7

159

1014

WX002

NOMESCO Finland

Sedation and analgesia

1.9

7.6

115

657

ZXA05

NOMESCO Finland

Left side

1.8

7.6

147

914

NG1AE

NOMESCO Finland

Knee joint ultrasound exmination

8.2

7.6

ZXA00

NOMESCO Finland

Right side

1.8

7.6

154

973

M08.9

ICD-10 Finland

Juvenile arthritis, unspecified

25.4

7.6

L04AA24

ATC

abatacept; parenteral

25.4

7.6

XCD10

NOMESCO Finland

Electrophysiological examination of eye

5.2

7.5

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

4.7

7.5

ZXD05

NOMESCO Finland

Urgent procedure

1.7

7.5

180

1203

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

2.5

7.4

260

H30.9

ICD-10 Finland

Chorioretinal inflammation, unspecified

81.1

7.4

H13.1*B02.3

ICD-10 Finland

Zoster conjunctivitis

81.1

7.4

208

Kela drug reimbursment

Ulcerative colitis and Crohn's disease

3.3

7.3

110

H21.0

ICD-10 Finland

Hyphaema

+∞

7.3

H16.8

ICD-10 Finland

Other keratitis

+∞

7.3

H17.9

ICD-10 Finland

Corneal scar and opacity, unspecified

+∞

7.3

NH3EA

NOMESCO Finland

Feet X-ray examination with load

5.6

7.3

CHD65

NOMESCO Finland

Nonpenetrating glaucoma surgery

16.0

7.2

E0000UV

ATC

1.7

7.2

218

1547

K07.60

ICD-10 Finland

Snapping jaw

3.2

7.2

118

EG1AA

NOMESCO Finland

Mandibular joint X-ray examination

20.3

7.1

CS5Z4

NOMESCO Finland

Specialised imaging for glaucoma

5.7

7.1

SBB10

NOMESCO Finland

Teeth copy

2.6

7.1

214

NH1AE

NOMESCO Finland

Ankle joint ultrasound examination

12.2

7.1

Z2221

NOMESCO Finland

Medical doctor

1.7

7.1

163

1072

CS424

NOMESCO Finland

Visual field testing with Goldmann perimetry

10.2

7.1

A04AA01

ATC

ondansetron; systemic, rectal

2.6

7.0

197

K50.1

ICD-10 Finland

Crohn disease of large intestine

7.1

7.0

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

3.6

7.0

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.6

6.9

222

1601

RT160

NOMESCO Finland

16.9

6.8

Z2446

NOMESCO Finland

Social worker

2.5

6.7

216

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

5.0

6.7

CD2S4

NOMESCO Finland

Photography of eye

22.8

6.7

NA6AA

NOMESCO Finland

Sacro-iliac joint X-ray examination

22.8

6.7

WZC05

NOMESCO Finland

Specialty-specific consultation based on referral by dentist or doctor

2.8

6.7

148

H33.0

ICD-10 Finland

Retinal detachment with retinal break

4.4

6.6

N02AJ06

ATC

codeine and paracetamol; systemic

1.6

6.6

197

1387

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.6

6.5

250

1875

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

2.6

6.5

180

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.4

6.5

227

H40.6

ICD-10 Finland

Glaucoma secondary to drugs

70.6

6.4

NHG24

NOMESCO Finland

Fusion of subtalar joint and between bones of ankle

14.5

6.4

NG1DA

NOMESCO Finland

X-ray of knees

5.3

6.4

XX9XE

NOMESCO Finland

Other ultrasound examination

8.3

6.4

XCH00

NOMESCO Finland

Eye pressure measurement

3.3

6.3

NHG20

NOMESCO Finland

Fusion of talocrural joint

18.2

6.3

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

4.9

6.3

7143D

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[OLIGARTHRITIS JUVENILIS]

+∞

6.3

H20.2

ICD-10 Finland

Lens-induced iridocyclitis

+∞

6.3

CGG31

NOMESCO Finland

Posterior corneal lamellar transplantation

+∞

6.3

H18.1

ICD-10 Finland

Bullous keratopathy

+∞

6.3

H16.3

ICD-10 Finland

Interstitial and deep keratitis

+∞

6.3

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

3.0

6.2

113

CG2T4

NOMESCO Finland

Topography assessment of cornea

27.0

6.2

A02BC03

ATC

lansoprazole; oral

1.7

6.2

160

1081

H43.1

ICD-10 Finland

Vitreous haemorrhage

4.5

6.1

UJF30

NOMESCO Finland

Ileoscopy through colon

2.3

6.1

256

H35.9

ICD-10 Finland

Retinal disorder, unspecified

10.2

6.1

H11.3

ICD-10 Finland

Conjunctival haemorrhage

3.4

6.0

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

6.1

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint H7_IRIDOCYCLITISINOTH and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_IRIDOCYCLITISINOTH	1.095 [0.91, 1.31]	0.326
Birth year	0.994 [0.99, 1.0]	0.156

During the follow-up period (1.1.1998 — 31.12.2019), 252 out of 1718 females with H7_IRIDOCYCLITISINOTH died.

Males

Parameter	HR [95% CI]	p-value
H7_IRIDOCYCLITISINOTH	1.374 [1.14, 1.66]	0.001
Birth year	0.985 [0.98, 0.99]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 266 out of 1621 males with H7_IRIDOCYCLITISINOTH died.

Mortality risk

Mortality risk for people of age

years, who have H7_IRIDOCYCLITISINOTH.

N-year risk	Females	Males
1	0.099%	0.265%
5	0.543%	1.506%
10	1.49%	3.577%
15	2.793%	6.832%
20	5.292%	11.356%

Relationships between endpoints

↥

Index endpoint: H7_IRIDOCYCLITISINOTH – Iridocyclitis in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	H7_IRIDOCYCLITISINOTH
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H22[0-1]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H22[0-1]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Iridocyclitis in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints