Glaucoma secondary to drugs

H7_GLAUCSECDRUG

glaucoma: Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H40.6# Hospital discharge: ICD-9 — 3653A Cause of death: ICD-10 — H40.6# Cause of death: ICD-9 — 3653A 2 out of 7 registries used, show all original rules.	111
4. Check minimum number of events None	111
5. Include endpoints None	111
6. Filter based on genotype QC (FinnGen only)	111

Control definitions (FinnGen only)

Control exclude: H7_GLAUCOMA

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H40
Name in latin: Glaucoma ex usu medicamenti

NAME	H7_GLAUCSECDRUG
CONTROL_EXCLUDE	H7_GLAUCOMA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H406
HD_ICD_9	3653A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H406
COD_ICD_9	3653A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Glaucoma secondary to drugs based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	667	340	320
Only index persons	593	307	286
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.35	54.38	54.37
Only index persons	52.80	52.63	52.98

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	111	52	59
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	52.09	51.13	52.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
100: Matched controls
1001

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H40.6

ICD-10 Finland

Glaucoma secondary to drugs

+∞

116.8

S01ED51

ATC

timolol, combinations; ophthalmic

258.3

69.8

114

Kela drug reimbursment

Glaucoma

237.0

67.0

H40.0

ICD-10 Finland

Glaucoma suspect

+∞

44.1

S01ED01

ATC

timolol; ophthalmic

163.7

40.3

S01EE01

ATC

latanoprost; ophthalmic

132.4

34.3

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

+∞

33.2

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

+∞

28.5

S01EC04

ATC

brinzolamide; ophthalmic

328.9

26.0

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

35.4

25.0

S01EC01

ATC

acetazolamide; systemic

164.5

24.9

XCW99

NOMESCO Finland

Other investigative procedure of eye

17.0

24.5

H20.1

ICD-10 Finland

Chronic iridocyclitis

147.5

22.6

Z96.1

ICD-10 Finland

Presence of intraocular lens

13.4

21.9

XCK00

NOMESCO Finland

Perimetry

46.8

21.0

H40.13

ICD-10 Finland

Chronic glaucoma with open ventricular angle

+∞

18.3

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

10.3

18.2

S01BA04

ATC

prednisolone; ophthalmic (corticosteroids, plain)

61.7

17.7

S01BA01

ATC

dexamethasone; ophthalmic (corticosteroids, plain)

23.8

17.0

S01EX03

ATC

+∞

16.1

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

5.8

15.5

249

Z01.0

ICD-10 Finland

Examination of eyes and vision

7.4

14.7

S01BA07

ATC

fluorometholone; ophthalmic (corticosteroids, plain)

40.4

14.0

S01EE05

ATC

tafluprost; ophthalmic

40.4

14.0

3653A

ICD-9 Finland

Glaucoma, Corticosteroid-induced glaucoma

+∞

13.9

H26.3

ICD-10 Finland

Drug-induced cataract

80.4

12.9

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

5.1

12.2

153

S01EE03

ATC

bimatoprost; ophthalmic

134.9

11.7

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

7.3

11.5

CJB10

NOMESCO Finland

Laser discission of secondary cataract

10.0

11.4

S01CA02

ATC

prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

49.3

11.2

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

14.3

10.9

S01EE04

ATC

travoprost; ophthalmic

122.3

10.6

S01EC03

ATC

dorzolamide; ophthalmic

122.3

10.6

L04AX01

ATC

azathioprine; systemic

13.4

10.6

H02AB06

ATC

prednisolone; systemic

4.2

10.5

316

A07EC01

ATC

sulfasalazine; oral, rectal

7.3

10.5

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

8.5

10.4

XCK10

NOMESCO Finland

Photography of fundus of eye

8.0

10.4

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

4.2

10.0

193

S01EC54

ATC

brinzolamide, combinations; ophthalmic

61.1

9.9

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

12.5

9.7

H40.4

ICD-10 Finland

Glaucoma secondary to eye inflammation

+∞

9.5

CHD05

NOMESCO Finland

Selective lasertrabeculoplasty

+∞

9.5

S01ED02

ATC

betaxolol; ophthalmic

+∞

9.5

H26.4

ICD-10 Finland

After-cataract

7.8

9.1

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

22.4

8.7

CHD50

NOMESCO Finland

Shunt operation on anterior chamber

+∞

8.4

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

7.6

8.2

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

16.8

7.9

S01FA02

ATC

scopolamine; ophthalmic

49.0

7.8

WX140

NOMESCO Finland

Parabulbar anesthesy

9.6

7.6

M05BA04

ATC

alendronic acid; oral

9.6

7.6

CHD65

NOMESCO Finland

Nonpenetrating glaucoma surgery

+∞

7.4

S01FA01

ATC

atropine; ophthalmic

+∞

7.4

S01EA02

ATC

dipivefrine; ophthalmic

+∞

7.4

L04AB04

ATC

adalimumab; parenteral

32.6

7.3

S01FA04

ATC

cyclopentolate; ophthalmic

32.6

7.3

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

8.2

7.0

H04.10

ICD-10 Finland

Dry eye syndrome

5.0

6.9

H26.2

ICD-10 Finland

Complicated cataract

43.1

6.9

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

5.6

6.7

D86.8

ICD-10 Finland

Sarcoidosis of other and combined sites

74.4

6.5

S01EA03

ATC

apraclonidine; ophthalmic

74.4

6.5

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.1

6.4

194

CS434

NOMESCO Finland

Visual field testing with Humphrey automated perimetry

+∞

6.3

H40.9

ICD-10 Finland

Glaucoma, unspecified

+∞

6.3

S01EB01

ATC

pilocarpine; ophthalmic

+∞

6.3

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

13.7

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

120

3.64

8.30

1.6

1.4

titre

471.1

406.2

—

(42870588) Differential panel, method unspecified - Blood

295

3.13

8.11

14.4

5.7

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

4.29

6.69

3.3

1.9

u/l

40.7

41.8

0.09

(3000494) Fungus identified in Specimen by Culture

118

3.11

6.01

1.9

1.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

433

2.67

5.82

10.0

6.3

mmol/l

1.2

0.11

366

(3021589) Normoblasts [#/volume] in Blood

420

2.41

4.84

17.4

9.6

e9/l

0.0

0.51

342

(3012516) Albumin [Mass/volume] in Urine

251

2.42

4.75

4.6

3.0

mg/l

122.0

66.3

0.33

153

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

4.77

4.68

1.2

—

(3017181) Myelocytes/100 leukocytes in Blood

3.06

4.66

6.5

3.6

1.4

1.3

—

(3025159) Blasts/100 leukocytes in Blood

3.17

4.57

6.5

3.8

0.0

0.4

—

(3002179) Metamyelocytes/100 leukocytes in Blood

3.12

4.47

6.8

3.5

0.5

0.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

8.05

4.45

4.0

2.8

56.2

62.1

—

(3018418) pH of Serum or Plasma

253

2.31

4.26

3.8

3.7

7.4

0.10

(3021440) Promyelocytes/100 leukocytes in Blood

2.95

4.07

6.9

3.8

0.0

0.3

—

(1616796) Gas panel - Central venous blood

6.42

3.90

1.8

3.6

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

7.08

3.74

2.8

2.6

e9/l

3.3

5.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

273

2.17

3.73

5.5

3.8

mg/mmol

15.2

10.1

0.24

169

(40758558) Short blood count panel - Blood

234

2.19

3.66

11.4

6.4

—

(3008898) HLA-B27 [Presence]

3.62

3.59

1.2

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

213

2.19

3.53

9.6

4.7

—

(3009508) Creatinine [Moles/volume] in Urine

273

2.09

3.39

4.7

3.0

mmol/l

8.0

7.8

0.09

231

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

4.57

3.07

1.4

2.0

—

(1175556) inFLIXimab Ab [Units/volume] in Serum by Immunoassay

10.38

3.00

6.2

5.8

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

194

2.08

2.96

1.8

pmol/l

400.5

474.8

1.26

164

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.35

2.95

1.0

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

100

2.36

2.81

2.5

1.6

—

(40760888) Immunoglobulin light chains.free panel - Serum

5.26

2.77

4.3

2.4

—

(3021788) Differential panel - Synovial fluid

6.27

2.73

1.0

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

451

1.85

2.57

4.6

3.8

estimate

0.0

0.00

(40761535) Cells panel - Urine sediment

2.50

2.55

4.4

3.6

—

(3009261) Glucose [Presence] in Urine by Test strip

456

1.81

2.43

5.0

3.9

estimate

0.0

0.00

(3037467) Urinalysis macro (dipstick) panel - Urine

609

1.86

2.34

6.8

4.2

—

(3021901) Oxygen saturation in Capillary blood

4.81

2.30

2.8

2.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.50

2.14

3.4

4.2

ng/l

72.3

75.2

0.04

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.40

2.11

1.5

1.3

—

18.9

—

(3048689) Calprotectin [Mass/mass] in Stool

128

2.01

2.10

5.9

2.4

ug/g

282.7

127.0

0.71

108

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.67

2.08

3.0

2.0

—

(3019309) Folate [Moles/volume] in Red Blood Cells

168

1.89

2.06

1.8

1.6

nmol/l

1171.2

1181.4

0.02

123

(3021601) Nitrite [Presence] in Urine by Test strip

452

1.71

2.05

6.1

5.2

estimate

0.0

0.00

(3022145) Colonoscopy Study observation

114

2.04

2.05

1.6

1.3

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

3.48

2.00

1.1

1.6

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.72

1.98

7.4

4.4

59.1

53.6

—

(3012544) pH of Venous blood

2.15

1.98

4.3

3.2

—

(40767503) Oxygen content in Capillary blood by calculation

3.90

1.96

1.8

3.0

20.7

17.0

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.47

1.95

4.3

3.0

g/l

136.1

133.9

0.10

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

4.31

1.84

1.4

3.2

nmol/l

12.6

22.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.33

1.74

2.9

1.5

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.33

1.74

3.6

2.8

kpa

5.2

5.1

0.09

(3011397) Hemoglobin [Presence] in Urine by Test strip

205

1.71

1.65

4.2

3.7

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

2.80

1.61

1.3

1.2

g/l

0.3

0.2

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.11

1.60

2.8

2.2

mmol/l

25.2

25.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

686

1.67

1.58

4.6

4.0

pmol/l

15.0

14.8

0.31

621

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.53

1.57

4.9

3.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

110

1.88

1.55

1.5

—

(40761536) Microorganisms panel - Urine sediment

2.05

1.52

3.6

3.8

—

(3025941) Bacteria identified in Stool by Culture

2.24

1.50

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

308

1.58

1.48

2.3

3.4

mmol/l

2.3

2.4

0.53

270

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

2.60

1.48

1.3

1.2

g/l

1.4

1.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

256

1.60

1.44

3.6

2.9

ng/l

991.8

988.0

0.00

214

(3034770) Mitochondria Ab [Titer] in Serum

2.51

1.41

1.3

—

(3026782) Osmolality of Urine

179

1.67

1.41

5.3

2.7

mosm/kgh2o

644.9

589.1

0.58

150

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

367

1.54

1.40

4.6

3.9

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.58

1.32

1.0

1.3

—

(3038515) Glucose [Moles/volume] in Venous blood

2.86

1.30

7.2

4.9

mmol/l

5.8

7.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

109

1.78

1.28

11.3

7.1

—

(3028626) Oxygen [Partial pressure] in Capillary blood

2.48

1.26

2.8

2.1

kpa

9.9

8.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

847

1.72

1.22

5.6

4.6

mu/l

2.1

1.9

0.79

773

(3023368) Bacteria identified in Blood by Culture

221

1.56

1.21

4.3

4.6

—

(3008037) Lactate [Moles/volume] in Venous blood

2.57

1.16

7.2

4.5

mmol/l

1.0

1.5

—

(3030467) Casts [#/volume] in Urine by Automated count

260

1.51

1.13

5.7

2.9

e6/l

0.1

0.3

2.08

183

(3029937) Albumin [Presence] in Urine by Test strip

251

1.51

1.13

5.4

4.1

estimate

0.0

0.00

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

166

1.57

1.06

1.8

3.1

mmol/l

2.4

2.5

0.45

141

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.33

1.04

1.4

1.5

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

2.07

1.02

1.0

1.4

u/l

7.7

8.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

127

1.60

0.96

1.5

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

324

1.42

0.95

2.5

1.9

pmol/l

96.0

91.5

0.31

166

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.29

0.95

3.0

2.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.70

0.93

3.2

3.4

—

(3045414) Leukocytes [Presence] in Urine

2.13

0.91

3.2

1.7

—

(36304419) Bacteria [Presence] in Urine

253

1.43

0.90

5.3

2.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

113

1.60

0.88

1.3

1.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

414

1.38

0.87

5.8

4.2

g/l

35.1

35.7

0.25

393

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.84

0.86

3.8

2.4

1.3

1.2

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.84

0.86

16.6

8.0

94.5

94.3

—

(3020891) Body temperature

1.99

0.86

6.7

3.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

194

1.44

0.81

1.8

mg/l

1.1

1.6

0.38

163

(3021960) Folate [Moles/volume] in Serum or Plasma

194

1.44

0.81

1.7

1.5

nmol/l

21.1

20.6

0.06

166

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.80

0.0

1.9

—

994.7

—

(3003694) ABO and Rh group [Type] in Blood

238

0.66

0.78

1.4

—

(3000991) Gas panel - Venous blood

1.67

0.78

11.6

5.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.71

0.78

1.4

1.7

—

(4034850)

1.81

0.77

39.8

9.5

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.23

0.77

1.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.23

0.77

2.0

1.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

499

1.34

0.77

6.2

6.9

umol/l

14.5

10.7

0.40

476

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

336

1.35

0.75

6.4

3.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

931

1.59

0.74

23.7

13.7

mg/l

18.7

22.1

0.54

719

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.63

0.73

3.2

2.9

pmol/l

4.8

4.6

—

(3042936) Bacteria identified in Isolate by Culture

136

1.48

0.73

2.5

2.0

—

(3019225) pH of Specimen

1.60

0.73

9.9

4.2

—

(3018095) Leukocytes [#/volume] in Urine

328

1.34

0.72

6.3

3.8

e6/l

6.9

35.3

2.18

231

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.97

0.71

1.8

2.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.97

0.71

3.4

1.9

185.0

175.5

—

(40768797) Stomach Pathology biopsy report

128

1.48

0.71

1.3

1.2

—

(3022313) Gas panel - Capillary blood

1.71

0.70

4.7

2.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.71

0.70

1.7

1.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.82

0.67

2.4

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

258

1.34

0.64

4.1

3.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

871

1.42

0.63

17.2

12.8

ml/min/173m2

81.3

82.0

0.11

708

(3002582) Erythrocytes [#/volume] in Urine

287

1.32

0.62

5.9

3.1

e6/l

13.5

31.6

0.65

212

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.70

0.62

5.8

1.1

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.60

0.0

1.5

—

557.7

—

(3032080) INR in Blood by Coagulation assay

355

1.29

0.60

8.1

7.9

inr

1.3

1.2

—

110

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

170

1.37

0.57

1.3

iu/ml

35.2

40.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

152

1.39

0.57

2.0

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.42

0.52

1.2

1.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

211

1.30

0.50

1.8

1.3

g/l

2.3

2.5

0.31

128

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

315

1.26

0.49

2.2

2.3

u/l

54.9

56.2

0.13

289

(3009542) Hematocrit [Volume Fraction] of Blood

850

0.79

0.46

25.6

13.3

38.7

40.0

0.44

633

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.43

0.46

3.9

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.41

0.42

2.3

1.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

566

1.22

0.42

6.2

4.4

—

325.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

235

1.26

0.42

1.4

1.3

u/ml

1.1

1.7

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

3.6

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.6

—

(3044640) Blood type and Crossmatch panel - Blood

287

0.79

0.41

3.7

2.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.41

0.0

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.37

0.39

2.3

1.4

—

(3002385) Erythrocyte distribution width [Ratio]

804

1.24

0.39

25.6

16.0

13.8

13.7

0.19

797

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

164

1.27

0.36

1.2

u/ml

8.0

12.5

—

(40768443) Skin Pathology biopsy report

1.42

0.35

1.2

—

(3013512) EKG study

279

1.21

0.34

5.8

3.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

358

1.18

0.32

4.9

3.7

ng/l

30.2

30.7

0.01

236

(3000330) Specific gravity of Urine by Test strip

1.37

0.32

4.1

3.8

—

(36660697) Celiac disease serology panel - Serum

1.34

0.31

1.4

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

278

0.83

0.31

3.2

4.5

21.7

21.3

0.07

141

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

557

1.17

0.30

3.5

3.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

421

0.85

0.29

5.1

4.1

—

(3026361) Erythrocytes [#/volume] in Blood

102

1038

0.79

0.26

36.9

19.8

e12/l

4.5

0.02

102

1020

(3035941) MCH [Entitic mass]

102

1038

0.79

0.26

36.7

19.7

30.2

30.3

0.31

102

1028

(3024731) MCV [Entitic volume]

102

1038

0.79

0.26

36.7

19.7

91.1

91.0

0.09

102

1028

(3000963) Hemoglobin [Mass/volume] in Blood

102

1038

0.79

0.26

37.2

19.9

g/l

136.6

137.1

0.12

102

1028

(3010813) Leukocytes [#/volume] in Blood

102

1038

0.79

0.26

36.9

19.8

e9/l

6.5

6.6

0.11

102

1020

(4010399)

1.25

0.26

2.4

1.4

—

(3007461) Platelets [#/volume] in Blood

102

1037

0.80

0.26

37.0

19.8

e9/l

253.4

250.6

0.16

102

1021

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

211

0.82

0.26

3.8

2.3

—

(40768804) Tissue Pathology biopsy report

364

1.15

0.25

2.4

2.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.30

0.23

1.8

1.9

—

(3000492) Spirometry study

1.25

0.22

1.8

1.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

102

0.77

0.22

2.6

1.8

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

2.2

—

91.2

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.21

0.0

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

2.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.7

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.21

0.0

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.21

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.21

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.21

0.0

1.5

—

(4281824)

0.00

0.21

0.0

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.2

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

233

1.15

0.20

2.2

1.7

mmol/l

1.7

1.3

0.94

194

(3026008) Bacteria identified in Urine by Culture

236

1.13

0.17

4.8

3.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.21

0.14

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.80

0.14

2.6

1.7

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

881

0.89

0.14

4.8

4.0

mmol/l

1.3

0.21

816

(3044889) 12 lead EKG panel

646

1.09

0.13

3.4

3.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

638

1.09

0.12

3.9

3.1

u/l

69.0

49.4

0.74

604

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.14

0.10

1.4

1.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.12

0.10

1.6

1.1

—

(3002256) Pathology report gross observation

124

0.87

0.09

1.0

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

342

1.08

0.09

4.4

5.0

ug/l

1.3

2.9

1.07

308

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

1.15

0.09

13.1

7.0

kpa

5.3

5.1

0.16

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

136

1.12

0.09

2.7

1.9

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

885

0.92

0.08

5.2

4.6

mmol/l

6.0

5.9

0.33

817

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.07

0.07

2.4

1.4

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.04

0.07

1.9

2.4

ug/l

8.3

6.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

100

0.89

0.06

27.9

25.5

—

1.6

—

(1761868) Lipid panel - Serum or Plasma

346

1.06

0.06

3.3

2.8

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

110

1.10

0.05

7.1

4.3

26.9

32.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.11

0.04

1.7

1.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

909

0.95

0.03

5.5

4.4

mmol/l

1.5

0.21

847

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

913

1.04

0.01

5.3

4.5

mmol/l

4.6

4.7

0.43

851

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

934

1.04

0.00

6.0

5.0

mmol/l

2.6

2.8

1.16

871

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

182

0.99

0.00

2.1

1.4

—

(40761511) CBC panel - Blood by Automated count

989

1.01

0.00

20.1

12.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.94

0.00

7.0

5.1

mmol/l

24.1

24.9

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.94

0.00

1.9

1.8

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.98

0.00

2.9

1.6

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.1

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4035726)

1.00

0.00

1.2

1.3

—

(3020961) Endomysium IgA Ab [Titer] in Serum

0.98

0.00

2.4

1.2

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.8

—

32.0

—

(3000060) B lymphocytes [#/volume] in Blood

0.00

0.0

1.4

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

11.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

3.5

—

2.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.7

—

5.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.92

0.00

1.0

1.1

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.0

—

131.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.4

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

33.4

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

2.2

—

6.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.4

—

(3019060) Gas panel - Arterial blood

0.95

0.00

5.0

4.1

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.5

—

13.7

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.4

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.7

—

2.9

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.1

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.8

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

2.8

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

3.4

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

9.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_GLAUCSECDRUG and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_GLAUCSECDRUG	1.913 [1.39, 2.64]	< 0.001
Birth year	0.994 [0.98, 1.0]	0.14

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 267 females with H7_GLAUCSECDRUG died.

Males

Parameter	HR [95% CI]	p-value
H7_GLAUCSECDRUG	1.552 [1.14, 2.11]	0.005
Birth year	0.988 [0.98, 1.0]	0.018

During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 245 males with H7_GLAUCSECDRUG died.

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCSECDRUG.

N-year risk	Females	Males
1	0.161%	0.328%
5	1.124%	1.904%
10	2.803%	4.702%
15	5.382%	8.75%
20	9.14%	14.514%

Relationships between endpoints

↥

Index endpoint: H7_GLAUCSECDRUG – Glaucoma secondary to drugs

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Glaucoma secondary to drugs

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints