Choroidal haemorrhage and rupture

H7_CHORHAEMORRHAGE

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H31.3 Hospital discharge: ICD-9 — 3636 Cause of death: ICD-10 — H31.3 Cause of death: ICD-9 — 3636 2 out of 7 registries used, show all original rules.	114
4. Check minimum number of events None	114
5. Include endpoints None	114
6. Filter based on genotype QC (FinnGen only)	114

Control definitions (FinnGen only)

Control exclude: H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H31
Name in latin: Haemorrhagia chorioideae

NAME	H7_CHORHAEMORRHAGE
CONTROL_EXCLUDE	H7_CHOROIDRETINA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H313
HD_ICD_9	3636
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H313
COD_ICD_9	3636
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Choroidal haemorrhage and rupture based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1087	570	511
Only index persons	959	503	456
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	70.48	75.66	64.66
Only index persons	69.40	75.24	62.96

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	114	47	67
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	65.58	64.25	66.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
101: Matched controls
1011

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H31.3

ICD-10 Finland

Choroidal haemorrhage and rupture

+∞

128.3

WX140

NOMESCO Finland

Parabulbar anesthesy

115.1

25.0

CKD05

NOMESCO Finland

Puncture of vitreous body with injection of medication

+∞

22.8

H35.31

ICD-10 Finland

Senile macular degeneration (atrophic)(exudative)

+∞

22.8

CKD65

NOMESCO Finland

Pars plana or pars plicata vitrectomy

246.3

20.3

XCW99

NOMESCO Finland

Other investigative procedure of eye

12.3

16.5

H43.1

ICD-10 Finland

Vitreous haemorrhage

46.2

16.0

XCK10

NOMESCO Finland

Photography of fundus of eye

12.2

15.6

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

5.7

15.3

242

CKD10

NOMESCO Finland

Insufflation of vitreous cavity

+∞

15.0

H35.30

ICD-10 Finland

Kuhnt-Junius degeneration

+∞

15.0

H33.0

ICD-10 Finland

Retinal detachment with retinal break

+∞

13.9

Z96.1

ICD-10 Finland

Presence of intraocular lens

7.2

13.5

D31.3

ICD-10 Finland

Benign neoplasm: Choroid

58.0

13.2

H33.3

ICD-10 Finland

Retinal breaks without detachment

+∞

12.8

S01ED51

ATC

timolol, combinations; ophthalmic

10.3

12.5

Z01.0

ICD-10 Finland

Examination of eyes and vision

6.8

11.9

H35.6

ICD-10 Finland

Retinal haemorrhage

+∞

11.7

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

11.7

11.4

S01EC01

ATC

acetazolamide; systemic

18.7

10.8

CKC10

NOMESCO Finland

Local photocoagulation of retina

122.2

10.6

CKD40

NOMESCO Finland

Endophotocoagulation of retina

+∞

10.6

114

Kela drug reimbursment

Glaucoma

7.1

10.3

CA1AE

NOMESCO Finland

Eye and orbita ultrasound examination

+∞

8.4

CKD94

NOMESCO Finland

Combined vitrectomy and procedure on lens through pars plana

+∞

8.4

H25.1

ICD-10 Finland

Senile nuclear cataract

3.6

7.9

192

CKC12

NOMESCO Finland

Photocoagulation of retina

48.9

7.8

S01EA05

ATC

brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)

9.6

7.6

XCD20

NOMESCO Finland

Photoangiography of eye

86.1

7.5

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

86.1

7.5

CKD60

NOMESCO Finland

Anterior vitrectomy

86.1

7.5

S01EE05

ATC

tafluprost; ophthalmic

17.4

7.4

CKD92

NOMESCO Finland

Combined vitrectomy and retinal procedure

+∞

7.4

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

3.3

7.2

233

XCK00

NOMESCO Finland

Perimetry

7.8

6.8

CKD91

NOMESCO Finland

Extended vitrectomy through pars plana

74.3

6.5

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

3.0

6.4

246

CKD20

NOMESCO Finland

Removal of vitreous body substitute

+∞

6.3

CKD70

NOMESCO Finland

Excision of preretinal or epiretinal membrane

+∞

6.3

H35.38

ICD-10 Finland

Preretinal fibrosis of the macula

+∞

6.3

3636A

ICD-9 Finland

Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture

+∞

6.3

CHB10

NOMESCO Finland

Puncture of anterior chamber of eye with irrigation

+∞

6.3

H26.4

ICD-10 Finland

After-cataract

4.9

6.3

XCD10

NOMESCO Finland

Electrophysiological examination of eye

9.6

6.3

CK2S4

NOMESCO Finland

Plain photography of ocular fundus

11.0

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3001122) Ferritin [Mass/volume] in Serum or Plasma

297

2.30

4.46

3.5

2.6

ug/l

136.5

152.7

0.15

262

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

197

2.39

4.31

2.4

2.1

mg/l

3.0

3.4

0.56

174

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.73

4.04

1.3

1.2

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

104

866

3.29

3.49

22.5

18.8

umol/l

85.4

83.0

0.31

104

866

(3000963) Hemoglobin [Mass/volume] in Blood

105

908

2.98

3.16

27.5

23.4

g/l

130.7

134.8

1.91

105

886

(3035941) MCH [Entitic mass]

105

908

2.98

3.16

27.0

23.2

30.3

30.4

0.21

105

888

(3024731) MCV [Entitic volume]

105

908

2.98

3.16

27.1

23.2

91.3

91.4

0.06

105

888

(3035350) Ketones [Presence] in Urine by Test strip

412

1.96

3.11

4.3

4.0

estimate

0.0

0.00

(3030905) Polymorphonuclear cells [#/volume] in Blood

6.13

3.07

3.6

1.5

e9/l

4.0

4.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

6.13

3.07

3.6

1.5

59.0

61.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

264

2.01

3.07

4.7

3.8

mg/mmol

9.1

6.5

0.26

179

(3009261) Glucose [Presence] in Urine by Test strip

417

1.93

2.96

4.6

4.0

estimate

0.0

0.00

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

765

2.30

2.95

6.9

6.2

mmol/mol

43.2

41.0

1.11

701

(3023103) Potassium [Moles/volume] in Serum or Plasma

102

861

2.75

2.93

23.1

18.9

mmol/l

4.0

0.20

102

833

(3021601) Nitrite [Presence] in Urine by Test strip

409

1.92

2.92

5.6

5.4

estimate

0.0

0.00

(3012516) Albumin [Mass/volume] in Urine

245

1.97

2.84

3.6

3.0

mg/l

1267.7

46.4

0.48

171

(1616796) Gas panel - Central venous blood

4.44

2.73

2.6

2.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

185

2.01

2.65

5.0

4.8

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

801

2.26

2.62

4.7

4.6

mmol/l

4.4

4.5

0.55

717

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

411

1.84

2.59

7.5

7.1

mmol/l

1.2

0.01

334

(3021589) Normoblasts [#/volume] in Blood

358

1.83

2.54

13.9

9.7

e9/l

0.0

0.71

302

(3000850) Epithelial cells [#/volume] in Urine

204

1.95

2.53

3.1

2.5

e6/l

3.0

4.4

1.20

180

(3026008) Bacteria identified in Urine by Culture

263

1.87

2.50

2.8

3.6

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

740

2.03

2.45

4.1

4.5

mu/l

2.1

2.0

0.16

647

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

798

2.14

2.41

4.6

mmol/l

1.4

0.09

714

(3030467) Casts [#/volume] in Urine by Automated count

242

1.86

2.35

3.4

3.0

e6/l

0.2

0.4

0.93

189

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

825

2.18

2.32

18.4

16.5

mg/l

23.4

24.7

0.17

661

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

597

1.82

2.32

3.5

3.7

pmol/l

15.0

15.1

0.13

527

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

771

2.00

2.25

16.8

14.3

ml/min/173m2

72.6

75.8

0.62

634

(3044889) 12 lead EKG panel

560

1.78

2.24

4.4

—

(3018095) Leukocytes [#/volume] in Urine

306

1.78

2.23

3.8

3.4

e6/l

97.7

56.1

0.23

231

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

370

1.75

2.20

4.1

4.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

572

1.77

2.19

4.1

4.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.43

2.18

1.4

1.6

—

(3012544) pH of Venous blood

2.19

2.15

3.2

3.8

—

(3017732) Neutrophils [#/volume] in Blood

0.00

2.13

0.0

2.2

—

3.9

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

765

1.94

2.13

4.3

4.2

mmol/l

1.3

0.06

681

(3013290) Carbon dioxide [Partial pressure] in Blood

3.66

2.09

4.0

2.3

kpa

5.8

4.9

—

(3027315) Oxygen [Partial pressure] in Blood

3.66

2.09

4.0

2.3

kpa

6.7

8.9

—

(3009508) Creatinine [Moles/volume] in Urine

252

1.76

2.02

3.8

2.9

mmol/l

6.5

7.7

1.25

215

(3029937) Albumin [Presence] in Urine by Test strip

244

1.76

2.01

5.0

4.2

estimate

0.0

0.00

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

100

2.08

2.00

3.6

3.1

—

(3001604) Monocytes [#/volume] in Blood

387

1.69

2.00

5.6

e9/l

0.6

0.06

342

(3006315) Basophils [#/volume] in Blood

387

1.69

2.00

5.6

e9/l

0.0

0.19

344

(3002582) Erythrocytes [#/volume] in Urine

262

1.74

1.98

3.7

3.1

e6/l

92.5

295.3

0.39

211

(3002385) Erythrocyte distribution width [Ratio]

665

1.75

1.95

22.7

19.1

14.1

13.9

0.34

649

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

831

1.98

1.92

5.2

5.0

mmol/l

2.5

2.7

0.68

739

(3013115) Eosinophils [#/volume] in Blood

400

1.67

1.90

5.6

5.9

e9/l

0.2

0.88

358

(3031040) Bacteria [#/volume] in Urine by Automated count

556

1.67

1.87

4.5

4.9

—

3902.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

174

1.81

1.83

4.5

4.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

376

1.64

1.81

5.3

4.8

ng/l

34.1

58.3

0.94

279

(3000330) Specific gravity of Urine by Test strip

2.58

1.81

3.8

5.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

791

1.85

1.80

4.8

5.0

mmol/l

6.4

6.0

1.70

707

(40761536) Microorganisms panel - Urine sediment

2.11

1.80

5.3

3.3

—

(3021901) Oxygen saturation in Capillary blood

3.04

1.75

3.7

2.4

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

2.24

1.73

3.0

3.3

ml/min/173m2

57.2

65.4

—

(3013512) EKG study

281

1.65

1.69

4.9

4.4

—

(3010421) pH of Blood

2.91

1.68

4.0

2.2

7.4

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.61

1.63

3.8

2.3

mmol/l

23.4

24.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

320

1.61

3.9

3.2

—

(3044640) Blood type and Crossmatch panel - Blood

260

1.63

1.55

2.1

2.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

343

1.57

1.50

5.2

4.3

—

(36304419) Bacteria [Presence] in Urine

227

1.64

1.50

3.6

3.0

—

(40761511) CBC panel - Blood by Automated count

864

1.82

1.47

19.8

15.9

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

648

1.58

1.45

7.8

7.4

u/l

90.4

82.4

0.18

597

(1761868) Lipid panel - Serum or Plasma

274

1.58

1.42

3.7

3.2

—

(3020891) Body temperature

2.24

1.38

2.8

3.8

—

(3018418) pH of Serum or Plasma

258

1.58

1.38

6.1

4.2

7.4

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.11

1.32

2.1

2.9

0.9

1.4

1.25

(4034850)

2.45

1.32

9.1

15.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

616

1.51

1.29

4.0

mm/h

15.0

13.7

0.20

556

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

196

1.57

1.17

1.9

2.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

306

1.47

1.11

3.5

ng/l

2410.4

1739.4

0.60

251

(3045414) Leukocytes [Presence] in Urine

2.33

1.04

1.4

1.6

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.33

1.04

2.8

4.8

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

494

1.40

0.98

3.0

u/l

47.9

58.7

0.50

456

(3020779) Urea [Moles/volume] in Serum or Plasma

1.80

0.97

5.3

6.1

mmol/l

17.5

9.7

1.97

(3049717) Cytology report of Urine Cyto stain

1.95

0.96

2.6

3.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

188

1.50

0.94

1.4

1.8

mg/l

0.8

1.4

1.33

148

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

215

1.47

0.93

2.1

1.8

pmol/l

436.9

451.3

0.09

181

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.97

0.91

4.1

6.0

mmol/l

26.8

24.3

—

(3000991) Gas panel - Venous blood

1.75

0.89

4.1

7.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

200

1.46

0.87

2.6

2.9

ug/l

1.9

0.8

0.66

133

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.99

0.85

1.2

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

183

1.47

0.85

1.6

1.7

mmol/l

1.1

1.4

1.25

149

(3032080) INR in Blood by Coagulation assay

367

1.37

0.85

12.6

11.0

inr

1.4

1.3

0.14

116

(3023368) Bacteria identified in Blood by Culture

265

1.40

0.84

4.3

4.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

141

1.51

0.81

2.1

2.0

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.86

0.80

5.0

6.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

133

1.51

0.80

2.4

2.7

e6/l

1.0

0.9

0.11

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.04

0.73

1.4

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

1.96

0.71

1.2

1.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.96

0.71

1.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

1.96

0.71

1.2

1.5

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

339

1.33

0.69

1.9

2.0

pmol/l

91.1

92.8

0.09

169

(3009542) Hematocrit [Volume Fraction] of Blood

696

1.33

0.68

19.2

16.7

36.0

39.6

1.14

466

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.67

0.68

2.3

2.5

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.82

0.67

2.0

1.6

—

(3002256) Pathology report gross observation

104

1.51

0.66

1.3

1.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.61

0.62

2.4

3.0

e6/l

0.3

0.1

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

373

1.29

0.61

5.3

4.7

ug/l

4.2

2.2

0.76

321

(3022621) pH of Urine by Test strip

1.58

0.61

3.4

2.3

—

(40768793) Breast Pathology biopsy report

0.00

0.61

0.0

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.60

0.0

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.60

0.0

1.4

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

115

1.46

0.60

2.6

2.9

e6/l

2.3

2.7

0.08

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

279

1.31

0.60

4.9

4.6

23.6

21.8

0.24

149

(3003396) Base excess in Arterial blood by calculation

124

1.44

0.60

4.2

6.0

mmol/l

0.5

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.55

0.60

1.1

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

244

1.31

0.56

4.6

3.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.57

0.54

1.0

—

(42870588) Differential panel, method unspecified - Blood

256

1.29

0.52

6.0

5.5

—

(3019060) Gas panel - Arterial blood

1.48

0.51

4.7

3.3

—

(3009343) pH of Capillary blood

1.52

0.49

3.2

7.4

7.5

—

(3003694) ABO and Rh group [Type] in Blood

193

1.31

0.49

1.5

1.4

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.58

0.47

1.4

1.6

—

(3022145) Colonoscopy Study observation

1.47

0.47

1.2

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

1.49

0.46

3.2

kpa

5.0

—

(40761535) Cells panel - Urine sediment

1.42

0.44

4.1

3.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.47

0.43

1.5

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

436

1.22

0.43

3.0

2.8

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.54

0.42

2.6

2.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.54

0.42

2.2

3.5

pmol/l

4.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.0

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.39

0.0

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

193

1.24

0.34

2.0

1.7

nmol/l

949.1

1311.3

1.29

142

(3004588) Protein electrophoresis panel - Serum or Plasma

1.27

0.30

2.7

—

(40768797) Stomach Pathology biopsy report

114

1.26

0.26

1.2

1.3

—

(40758558) Short blood count panel - Blood

209

1.19

0.25

4.2

6.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

386

1.14

0.23

4.7

4.4

g/l

33.7

34.7

0.44

360

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.21

0.0

1.1

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.21

0.0

1.3

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.21

0.0

1.4

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.21

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

4.1

—

4.1

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

112.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.20

0.0

1.4

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.20

0.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

100

1.22

0.19

1.8

1.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

100

1.22

0.19

1.8

2.0

—

(3000494) Fungus identified in Specimen by Culture

102

1.20

0.16

2.1

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.82

0.14

1.4

1.5

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.09

0.10

10.2

7.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

155

1.11

0.09

1.5

1.1

u/ml

0.8

2.2

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.07

0.09

1.0

1.2

u/ml

75.2

178.9

—

(3025941) Bacteria identified in Stool by Culture

1.04

0.09

1.2

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.10

0.09

4.2

8.2

mmol/l

20.2

24.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.83

0.08

3.8

2.5

g/l

10.1

9.8

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.10

0.08

2.8

2.9

g/l

63.2

66.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

104

0.85

0.06

1.7

—

(40768804) Tissue Pathology biopsy report

316

1.06

0.06

2.1

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

121

0.90

0.06

10.4

9.1

—

(3042936) Bacteria identified in Isolate by Culture

119

0.92

0.04

1.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

101

0.99

0.00

2.6

1.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

109

1.01

0.00

1.7

1.5

—

(3007164) IgA [Mass/volume] in Serum or Plasma

146

1.03

0.00

1.3

1.4

g/l

2.8

3.0

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(4024509)

0.00

0.0

1.4

—

(3020650) Glucose [Presence] in Urine

0.00

0.0

1.2

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

9.2

—

0.5

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.6

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1776.6

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.4

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.0

—

1.2

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.5

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.6

—

(3022313) Gas panel - Capillary blood

1.02

0.00

4.2

3.4

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.4

—

323.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(4281824)

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

6.0

—

47.4

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.1

—

(36660697) Celiac disease serology panel - Serum

0.92

0.00

1.4

1.1

—

(3000492) Spirometry study

1.00

0.00

1.2

1.4

—

(3035880) pH of Pleural fluid

0.00

0.0

1.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.95

0.00

3.1

1.8

nmol/l

400.4

378.4

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.8

—

(3020876) Protein [Mass/time] in 24 hour Urine

0.00

0.0

2.4

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.7

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

0.8

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.7

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.6

—

4.9

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

4.3

—

247.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.8

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

6.2

—

51.9

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

1196.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.86

0.00

3.0

1.9

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

1.8

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.7

—

23.0

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.2

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.0

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.6

—

(21494755) Public health laboratory ask at order entry panel

0.86

0.00

1.4

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.7

—

(3037522) Nuclear Ab [Titer] in Serum

0.93

0.00

1.1

1.2

—

295.2

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.7

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3019225) pH of Specimen

0.94

0.00

4.3

4.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.92

0.00

1.6

1.4

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

3.7

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.3

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_CHORHAEMORRHAGE and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_CHORHAEMORRHAGE	1.035 [0.83, 1.28]	0.757
Birth year	0.994 [0.99, 1.0]	0.161

During the follow-up period (1.1.1998 — 31.12.2019), 194 out of 506 females with H7_CHORHAEMORRHAGE died.

Males

Parameter	HR [95% CI]	p-value
H7_CHORHAEMORRHAGE	1.019 [0.79, 1.31]	0.884
Birth year	0.992 [0.98, 1.0]	0.089

During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 419 males with H7_CHORHAEMORRHAGE died.

Mortality risk

Mortality risk for people of age

years, who have H7_CHORHAEMORRHAGE.

N-year risk	Females	Males
1	0.075%	0.219%
5	0.534%	1.415%
10	1.286%	3.496%
15	2.713%	6.676%
20	4.845%	11.232%

Relationships between endpoints

↥

Index endpoint: H7_CHORHAEMORRHAGE – Choroidal haemorrhage and rupture

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Choroidal haemorrhage and rupture

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints