No definition available.
Pupillary membranes and other adhesions and disruptions of iris and ciliary body
DOID EFO Endpoint Browser PheWeb
H7_ADHESIOIRIS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
72 |
4. Check minimum number of eventsNone |
72 |
5. Include endpointsNone |
72 |
6. Filter based on genotype QC (FinnGen only) |
72 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Pupillary membranes and other adhesions and disruptions of iris and ciliary body
based on the number of shared cases.
Similar with more cases:
- Other disorders of iris and ciliary body
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 849 | 383 | 459 |
| Only index persons | 678 | 307 | 371 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.21 | 67.48 | 50.24 |
| Only index persons | 57.65 | 67.48 | 49.52 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 72 | 33 | 39 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 64.68 | 68.98 | 61.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 66
- Matched controls
- 659
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H21.5
ICD-10 Finland
Other adhesions and disruptions of iris and ciliary body
+∞
55.1
45
*
H21.4
ICD-10 Finland
Pupillary membranes
+∞
14.0
13
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
11.8
11
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
72.0
11.0
12
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
10.7
10
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.3
9.9
26
54
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
4.8
8.4
39
152
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.6
8.0
41
174
S01ED51
ATC
timolol, combinations; ophthalmic
7.2
7.7
19
35
CHC05
NOMESCO Finland
Iridotomy
+∞
7.4
7
*
H25.1
ICD-10 Finland
Senile nuclear cataract
3.8
6.1
33
136
Mortality – FinRegistry
↥Association
Association between endpoint H7_ADHESIOIRIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ADHESIOIRIS | 1.018 [0.78, 1.33] | 0.893 |
| Birth year | 0.993 [0.98, 1.0] | 0.116 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 298 females with H7_ADHESIOIRIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_ADHESIOIRIS | 1.279 [0.92, 1.78] | 0.144 |
| Birth year | 0.987 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 348 males with H7_ADHESIOIRIS died.
Mortality risk
Mortality risk for people of age
years, who have H7_ADHESIOIRIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.236% |
| 5 | 0.665% | 1.563% |
| 10 | 1.45% | 3.976% |
| 15 | 2.724% | 7.568% |
| 20 | 4.764% | 12.717% |
Relationships between endpoints
↥Index endpoint: H7_ADHESIOIRIS – Pupillary membranes and other adhesions and disruptions of iris and ciliary body
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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