Frontotemporal dementia

FTD

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F020&G310 Cause of death: ICD-10 — F020&G310 2 out of 7 registries used, show all original rules.	180
4. Check minimum number of events None	180
5. Include endpoints None	180
6. Filter based on genotype QC (FinnGen only)	180

Control definitions (FinnGen only)

Control exclude: F5_DEMENTIA, G6_ALZHEIMER, G6_AD_WIDE

Extra metadata

First used in FinnGen datafreeze: DF2

NAME	FTD
CONTROL_EXCLUDE	F5_DEMENTIA\|G6_ALZHEIMER\|G6_AD_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F020&G310
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F020&G310
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Frontotemporal dementia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	2112	1189	909
Only index persons	1877	1084	793
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.03
Only index persons	0.04	0.04	0.03
Median age at first event (years)
Whole population	71.43	72.17	70.41
Only index persons	71.37	72.13	70.33

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	180	79	101
Unadjusted period prevalence (%)	0.04	0.03	0.04
Median age at first event (years)	69.65	70.57	68.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
148: Matched controls
1480

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

F02.09*G31.0

ICD-10 Finland

Dementia in Pick's disease without information on additional symptoms

+∞

141.1

112

G31.0

ICD-10 Finland

Circumscribed brain atrophy

619.6

74.8

F03

ICD-10 Finland

Unspecified dementia

94.0

43.0

N05AX08

ATC

risperidone; systemic

28.2

40.3

N05AH04

ATC

quetiapine; oral

17.0

39.8

N05AH03

ATC

olanzapine; systemic

28.8

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

12.3

27.3

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

10.9

27.2

N03AG01

ATC

valproic acid; systemic, rectal

17.3

26.5

F02.09

ICD-10 Finland

Dementia in Pick's disease without information on additional symptoms

+∞

25.8

TAB00

NOMESCO Finland

Lumbar puncture

17.8

25.1

Z2445

NOMESCO Finland

Psychologist

33.5

24.8

N06DA02

ATC

donepezil; oral

283.5

24.4

P70

ICPC

Dementia

148.9

24.4

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

15.1

22.4

N06DX01

ATC

memantine; oral

255.8

22.2

XA800

NOMESCO Finland

Neuropsychological investigation

21.1

21.7

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

14.9

20.6

N05BA06

ATC

lorazepam; systemic, sublingual

18.2

20.5

ZY010

NOMESCO Finland

Hospital outpatient

20.3

18.2

F0203, G310

ICD-10 Finland

+∞

18.1

IBZ01

NOMESCO Finland

Profession-specific psychiatric evaluation

101.6

16.9

F06.7

ICD-10 Finland

Mild cognitive disorder

24.4

16.6

P20

ICPC

Memory disturbance

5.9

15.9

118

A28

ICPC

Limited function/disability NOS

5.1

15.6

171

F0204, G310

ICD-10 Finland

+∞

14.8

F0200, G310

ICD-10 Finland

+∞

13.7

N06DA03

ATC

rivastigmine; oral, transdermal

153.2

13.7

ZXE15

NOMESCO Finland

Procedure duration 120 to 149 minutes

31.6

13.3

N06AX11

ATC

mirtazapine; oral

4.0

13.0

261

ZXY51

NOMESCO Finland

2-person team, doctor-nurse

76.5

12.8

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

16.3

12.7

307

Kela drug reimbursment

Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease

+∞

12.7

IGY02

NOMESCO Finland

Psychiatric monitoring contact

51.1

12.1

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

12.0

11.7

G30.9

ICD-10 Finland

Alzheimer disease, unspecified

+∞

11.6

ZXE17

NOMESCO Finland

Procedure duration 150 to 179 minutes

+∞

11.6

ZY000

NOMESCO Finland

Hospital inpatient

129.4

11.6

N05BA04

ATC

oxazepam; oral

3.8

11.0

204

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

9.7

11.0

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

8.9

10.9

IAB14

NOMESCO Finland

Geriatric psychiatry consultation

117.8

10.6

IEY05

NOMESCO Finland

Dedicated profession-specific psychiatric intervention, individual

25.5

10.4

N06AB10

ATC

escitalopram; oral

4.4

10.0

111

IGY99

NOMESCO Finland

Other psychiatric treatment contact

58.8

9.8

RT250

NOMESCO Finland

106.3

9.5

F0202, G310

ICD-10 Finland

+∞

9.5

IBZ07

NOMESCO Finland

Neurological assessment in psychiatry

+∞

9.5

N06AX16

ATC

venlafaxine; oral

4.8

9.3

ICB03

NOMESCO Finland

Psychiatric treatment plan, monitoring

39.2

9.1

R41.0

ICD-10 Finland

Disorientation, unspecified

9.6

9.1

G30.1

ICD-10 Finland

Alzheimer disease with late onset

25.9

9.1

F32.9

ICD-10 Finland

Depressive episode, unspecified

5.7

9.0

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

5.9

9.0

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

8.5

9.0

F00.10*G30.1

ICD-10 Finland

Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms

53.1

8.8

P99

ICPC

Psychological disorders other

29.4

8.6

F06.4

ICD-10 Finland

Organic anxiety disorder

95.1

8.5

RT150

NOMESCO Finland

95.1

8.5

F0201, G310

ICD-10 Finland

+∞

8.4

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

7.3

8.2

Z2446

NOMESCO Finland

Social worker

5.7

8.1

N05AD01

ATC

haloperidol; systemic

10.3

8.0

SPAT1217

SPAT

Assessment of need for services (elderly/care support)

4.5

7.8

G31.8

ICD-10 Finland

Other specified degenerative diseases of nervous system

47.4

7.8

G31.9

ICD-10 Finland

Degenerative disease of nervous system, unspecified

47.4

7.8

F05.9

ICD-10 Finland

Delirium, unspecified

10.9

7.7

N05AX12

ATC

aripiprazole; systemic

26.5

7.7

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

0.1

7.5

271

G30.8

ICD-10 Finland

Other Alzheimer disease

84.0

7.5

R41.3

ICD-10 Finland

Other amnesia

10.2

7.5

G30.0

ICD-10 Finland

Alzheimer disease with early onset

+∞

7.3

ZXY01

NOMESCO Finland

Chief Physician, Head of Department or Deputy Chief Physician

+∞

7.3

F064, G310

ICD-10 Finland

+∞

7.3

F22.0

ICD-10 Finland

Delusional disorder

16.8

7.3

SPAT1234

SPAT

Support of social functional capacity

5.5

7.3

F32.3

ICD-10 Finland

Severe depressive episode with psychotic symptoms

21.2

7.2

ICB01

NOMESCO Finland

Psychiatric treatment plan, standard

31.6

7.2

Z03.2

ICD-10 Finland

Observation for suspected mental and behavioural disorders

41.9

6.8

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

8.4

6.8

AA1AD

NOMESCO Finland

CT of head and brain

2.6

6.6

304

N06AB04

ATC

citalopram; systemic

3.0

6.6

171

IGY01

NOMESCO Finland

Accelerated psychiatric treatment contact

72.7

6.5

SPAT1245

SPAT

Provision of support and information to patient’s family members

5.4

6.3

P72

ICPC

Schizophrenia

27.9

6.3

G12.2

ICD-10 Finland

Motor neuron disease

+∞

6.3

F060, G310

ICD-10 Finland

+∞

6.3

F020, G310

ICD-10 Finland

+∞

6.3

F02.00

ICD-10 Finland

Dementia in Pick's disease without additional symptoms

+∞

6.3

N05AH02

ATC

clozapine; systemic

+∞

6.3

N03AX09

ATC

lamotrigine; oral

8.2

6.3

R53

ICD-10 Finland

Malaise and fatigue

2.8

6.3

193

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

5.0

6.2

F29

ICD-10 Finland

Unspecified nonorganic psychosis

13.3

6.2

A04

ICPC

Weakness/tiredness general

3.3

6.2

119

P76

ICPC

Depressive disorder

10.7

6.1

SPAT1216

SPAT

Assessment of functional ability

2.8

6.0

190

Mortality – FinRegistry

↥

Association

Association between endpoint FTD and mortality.

Females

Parameter	HR [95% CI]	p-value
FTD	3.562 [2.87, 4.42]	< 0.001
Birth year	0.995 [0.99, 1.0]	0.253

During the follow-up period (1.1.1998 — 31.12.2019), 577 out of 1114 females with FTD died.

Males

Parameter	HR [95% CI]	p-value
FTD	4.074 [3.11, 5.33]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.017

During the follow-up period (1.1.1998 — 31.12.2019), 493 out of 822 males with FTD died.

Mortality risk

Mortality risk for people of age

years, who have FTD.

N-year risk	Females	Males
1	0.343%	0.872%
5	2.068%	5.012%
10	5.094%	12.523%
15	9.351%	21.829%
20	15.906%	34.13%

Relationships between endpoints

↥

Index endpoint: FTD – Frontotemporal dementia

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Frontotemporal dementia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints