Femoral hernia, bilateral

FEMHER_BILATERAL

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — K41.0, K41.1, K41.2 Cause of death: ICD-10 — K41.0, K41.1, K41.2 2 out of 7 registries used, show all original rules.	112
4. Check minimum number of events None	112
5. Include endpoints None	112
6. Filter based on genotype QC (FinnGen only)	112

Control definitions (FinnGen only)

Control exclude: K11_HERNIA

Extra metadata

First used in FinnGen datafreeze: DF3

NAME	FEMHER_BILATERAL
CONTROL_EXCLUDE	K11_HERNIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K41[0-2]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K41[0-2]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Femoral hernia, bilateral based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	879	487	390
Only index persons	757	427	330
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.02	0.01
Median age at first event (years)
Whole population	64.25	66.06	61.96
Only index persons	62.17	63.86	59.99

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	112	68	44
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	60.92	60.53	61.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
97: Matched controls
968

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K41.2

ICD-10 Finland

Bilateral femoral hernia, without obstruction or gangrene

+∞

55.7

K41.0

ICD-10 Finland

Bilateral femoral hernia, with obstruction, without gangrene

+∞

47.9

K40.9

ICD-10 Finland

Unilateral or unspecified inguinal hernia, without obstruction or gangrene

+∞

44.2

JAB30

NOMESCO Finland

Repair of inguinal hernia using prosthetic material

+∞

25.1

JAB11

NOMESCO Finland

Laparoscopic repair of inguinal hernia

+∞

18.3

K40.2

ICD-10 Finland

Bilateral inguinal hernia, without obstruction or gangrene

218.0

18.2

K43.9

ICD-10 Finland

Other and unspecified ventral hernia without obstruction or gangrene

148.2

12.8

JAC11

NOMESCO Finland

Laparoscopic repair of femoral hernia

+∞

10.6

K41.9

ICD-10 Finland

Unilateral or unspecified femoral hernia, without obstruction or gangrene

+∞

10.6

JAB10

NOMESCO Finland

Repair of inguinal hernia

+∞

9.5

K41.1

ICD-10 Finland

Bilateral femoral hernia, with gangrene

+∞

8.4

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

24.5

8.2

A06AD11

ATC

lactulose; oral

4.5

7.7

K40.3

ICD-10 Finland

Unilateral or unspecified inguinal hernia, with obstruction, without gangrene

86.3

7.5

JAC10

NOMESCO Finland

Repair of femoral hernia

+∞

7.4

R51.80

ICD-10 Finland

Headache

4.8

7.0

JA1AE

NOMESCO Finland

Ultrasound examination of groin and abdominal wall

28.7

6.3

D01

ICPC

Abdominal pain/cramps general

5.1

6.2

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

375

2.38

4.81

4.2

3.7

—

(3044640) Blood type and Crossmatch panel - Blood

253

2.30

4.25

3.0

2.1

—

(3044941) Cell count panel - Synovial fluid

9.23

3.83

1.3

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

657

2.33

3.56

4.1

pmol/l

14.9

15.0

0.10

581

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

327

2.03

3.28

4.4

2.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

364

2.00

3.22

1.9

pmol/l

99.1

95.7

0.20

163

(3019198) Lymphocytes [#/volume] in Blood

440

1.99

3.14

6.6

5.9

e9/l

2.0

1.7

0.78

389

(3002582) Erythrocytes [#/volume] in Urine

280

2.01

3.11

3.9

3.1

e6/l

19.3

39.0

0.74

212

(36304419) Bacteria [Presence] in Urine

258

2.00

2.99

4.1

2.8

—

(3013115) Eosinophils [#/volume] in Blood

446

1.94

2.96

6.8

6.0

e9/l

0.2

0.00

387

(3001604) Monocytes [#/volume] in Blood

429

1.93

2.91

6.7

5.8

e9/l

0.6

0.40

373

(3006315) Basophils [#/volume] in Blood

430

1.92

2.88

6.7

5.8

e9/l

0.0

0.15

374

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

180

2.09

2.88

3.1

2.0

—

(42870588) Differential panel, method unspecified - Blood

288

1.94

2.82

6.4

5.3

—

(3018095) Leukocytes [#/volume] in Urine

325

1.90

2.75

4.4

3.6

e6/l

57.9

71.2

0.14

232

(3030467) Casts [#/volume] in Urine by Automated count

265

1.94

2.73

3.9

2.9

e6/l

0.2

0.5

0.86

197

(3037467) Urinalysis macro (dipstick) panel - Urine

604

1.96

2.70

4.8

4.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.87

2.54

1.7

2.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

798

2.25

2.51

5.3

4.8

mu/l

1.9

0.12

706

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

686

1.99

2.50

7.4

7.9

u/l

70.7

80.5

2.66

635

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

150

2.05

2.49

1.3

iu/ml

20.0

44.2

1.30

(3023368) Bacteria identified in Blood by Culture

225

1.88

2.37

5.3

4.5

—

(3032080) INR in Blood by Coagulation assay

357

1.79

2.32

6.0

8.2

inr

1.2

1.3

0.52

128

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

189

1.89

2.18

2.0

1.8

mg/l

0.8

1.2

1.23

158

(3014111) Lactate [Moles/volume] in Serum or Plasma

2.29

2.15

4.2

5.7

mmol/l

1.3

1.2

0.09

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

292

1.77

2.14

3.3

ng/l

4168.3

1779.5

0.70

246

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

420

1.73

2.12

8.5

5.1

mmol/l

1.2

0.30

376

(3026008) Bacteria identified in Urine by Culture

302

1.75

2.10

3.3

2.9

—

(40758558) Short blood count panel - Blood

233

1.80

2.09

6.2

8.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.66

2.09

1.1

1.4

—

(40768797) Stomach Pathology biopsy report

114

2.04

1.5

1.2

—

(3000492) Spirometry study

2.28

2.03

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

153

1.91

2.02

3.5

2.6

e6/l

1.3

0.9

0.29

(3000494) Fungus identified in Specimen by Culture

107

2.06

2.02

1.8

1.3

—

(3002030) Lymphocytes/100 leukocytes in Blood

426

1.69

1.98

6.7

5.9

27.1

26.6

0.09

394

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

163

1.86

1.95

3.2

3.6

ng/l

113.5

122.4

0.03

134

(3052851) Hemolysis interference index of Serum or Plasma

3.00

1.90

7.9

4.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.00

1.90

1.3

1.1

—

(3018418) pH of Serum or Plasma

293

1.69

1.86

6.1

4.1

7.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

519

1.66

1.84

9.0

9.9

e9/l

4.2

4.1

0.08

451

(3006504) Eosinophils/100 leukocytes in Blood

413

1.65

1.83

6.8

5.7

2.5

2.6

0.30

380

(3011397) Hemoglobin [Presence] in Urine by Test strip

195

1.74

1.69

5.0

3.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

857

1.98

1.69

23.1

15.0

mg/l

27.3

22.7

0.64

661

(3022096) Basophils/100 leukocytes in Blood

403

1.60

1.63

6.8

5.6

0.7

0.06

369

(3018010) Neutrophils/100 leukocytes in Blood

422

1.60

1.63

6.7

5.7

57.5

58.5

0.20

391

(3037756) Immunofixation for Serum or Plasma

2.96

1.52

1.2

—

(3019069) Monocytes/100 leukocytes in Blood

418

1.56

1.51

7.2

6.0

8.8

8.7

0.03

388

(3007853) Bacteria identified in Skin by Aerobe culture

1.95

1.51

3.3

1.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

227

1.64

1.50

2.1

2.7

umol/l

15462.8

8908.8

0.17

189

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

145

1.74

1.43

3.5

2.9

e6/l

1.7

2.7

0.32

(3019309) Folate [Moles/volume] in Red Blood Cells

188

1.65

1.39

2.0

1.8

nmol/l

934.7

1257.3

0.94

134

(40761511) CBC panel - Blood by Automated count

100

908

1.95

1.36

21.6

13.3

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

182

1.64

1.32

1.9

3.6

mmol/l

2.5

0.12

154

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.58

1.32

1.3

1.7

—

(1616796) Gas panel - Central venous blood

2.86

1.30

5.6

3.4

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.86

1.30

2.0

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

477

1.50

1.29

2.9

2.8

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

369

1.47

1.16

5.7

4.1

ng/l

102.2

40.1

0.45

267

(3014007) Fractional oxyhemoglobin in Arterial blood

2.05

1.15

12.4

8.1

94.6

94.2

—

(3044889) 12 lead EKG panel

636

1.48

1.14

4.2

4.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.02

1.11

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.19

1.07

1.1

1.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

777

1.54

1.07

26.5

15.1

38.6

39.2

0.30

551

(3015736) pH of Urine

346

1.45

1.06

5.3

3.6

—

(3042936) Bacteria identified in Isolate by Culture

124

1.64

1.05

3.1

2.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.33

1.04

1.4

—

(3021901) Oxygen saturation in Capillary blood

2.33

1.04

1.8

2.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

472

1.42

1.04

9.0

5.4

mmol/l

1.2

0.05

390

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

802

1.53

1.01

3.9

4.1

mmol/l

1.2

0.08

720

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.94

1.00

12.4

7.2

1.6

1.3

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.94

1.00

12.4

7.7

0.7

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.99

0.0

1.3

—

(3022621) pH of Urine by Test strip

1.86

0.98

3.3

2.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

916

1.70

0.98

25.2

17.4

umol/l

85.7

77.9

0.81

916

(4010399)

1.83

0.97

1.3

—

(3000991) Gas panel - Venous blood

1.80

0.97

8.8

6.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.79

0.95

1.1

1.2

—

(3035941) MCH [Entitic mass]

102

954

1.77

0.92

33.4

21.0

30.5

30.4

0.16

102

937

(3024731) MCV [Entitic volume]

102

954

1.77

0.92

33.4

21.1

92.0

91.5

0.46

102

937

(3000963) Hemoglobin [Mass/volume] in Blood

102

955

1.76

0.90

34.0

21.2

g/l

131.1

133.7

0.89

102

937

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

374

1.39

0.90

2.2

2.1

nmol/l

84.9

77.5

1.58

317

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

831

1.51

0.90

4.4

4.6

mmol/l

1.6

1.5

0.56

749

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

147

1.53

0.88

1.6

1.8

—

(3045414) Leukocytes [Presence] in Urine

1.99

0.86

3.0

1.7

—

(3021589) Normoblasts [#/volume] in Blood

416

1.36

0.84

9.8

10.2

e9/l

0.0

0.00

347

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

804

1.44

0.81

5.5

6.1

mmol/mol

40.5

40.2

0.07

736

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.72

0.80

3.5

2.5

2.0

1.2

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.80

0.0

1.7

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

870

1.50

0.80

5.0

5.1

mmol/l

2.7

0.21

785

(1761868) Lipid panel - Serum or Plasma

304

0.69

0.79

2.5

3.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.76

0.78

1.1

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.81

0.77

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.72

0.77

1.7

1.6

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.13

0.75

2.4

3.3

mmol/l

22.2

27.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

118

1.52

0.75

1.5

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

280

1.36

0.74

2.0

2.2

u/l

129.4

232.0

0.75

263

(4034850)

2.05

0.73

6.0

8.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.63

0.73

1.2

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

102

1.54

0.72

1.7

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

844

1.42

0.69

4.6

4.5

mmol/l

5.9

6.0

0.04

757

(3022313) Gas panel - Capillary blood

1.89

0.69

1.4

2.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.61

0.0

1.5

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.60

0.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.75

0.59

1.2

—

(3012516) Albumin [Mass/volume] in Urine

245

1.31

0.55

2.2

2.9

mg/l

44.6

57.9

0.19

140

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.57

0.54

1.7

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

447

1.26

0.54

5.3

3.8

estimate

0.0

0.00

(3012544) pH of Venous blood

1.48

0.52

6.3

3.0

—

(3029937) Albumin [Presence] in Urine by Test strip

257

1.29

0.51

5.5

4.1

estimate

0.0

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.59

0.50

6.1

7.8

mmol/l

24.7

25.0

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

324

1.26

0.50

2.5

3.4

mmol/l

2.3

2.4

0.65

271

(3041096) Erythrocytes [Presence] in Urine by Automated

271

0.77

0.47

3.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.42

0.46

4.7

3.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.49

0.44

1.5

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

105

1.38

0.43

1.8

1.7

—

(3025941) Bacteria identified in Stool by Culture

1.43

0.43

1.5

1.2

—

(3020891) Body temperature

1.59

0.43

21.6

4.8

—

(40768443) Skin Pathology biopsy report

1.54

0.42

1.2

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.54

0.42

2.2

1.9

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.38

0.41

1.7

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(40768800) Prostate Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

1.49

0.41

17.6

3.2

mmol/l

1.2

1.3

—

(3009261) Glucose [Presence] in Urine by Test strip

458

1.21

0.40

4.9

3.8

estimate

0.0

—

(3019060) Gas panel - Arterial blood

1.34

0.40

12.3

3.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.40

0.0

1.1

—

(40761536) Microorganisms panel - Urine sediment

1.42

0.40

3.5

3.8

—

(3049717) Cytology report of Urine Cyto stain

1.45

0.40

4.0

2.5

—

(3009508) Creatinine [Moles/volume] in Urine

256

1.23

0.39

2.1

2.8

mmol/l

6.6

7.2

0.30

200

(3004588) Protein electrophoresis panel - Serum or Plasma

1.33

0.38

1.7

2.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

267

1.22

0.37

2.6

3.8

mg/mmol

12.7

9.0

0.20

150

(3003694) ABO and Rh group [Type] in Blood

221

1.23

0.35

1.5

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

101

1.32

0.33

17.2

7.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.37

0.32

2.4

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.34

0.31

6.4

4.1

mmol/l

26.1

24.7

—

(40768804) Tissue Pathology biopsy report

361

1.17

0.28

1.8

2.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

113

1.27

0.28

2.1

1.5

—

(3027801) Oxygen [Partial pressure] in Arterial blood

104

1.28

0.28

10.3

5.7

kpa

13.2

11.5

0.47

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

104

1.28

0.28

10.3

5.7

kpa

5.3

5.1

0.29

(3007164) IgA [Mass/volume] in Serum or Plasma

179

1.21

0.27

1.4

g/l

2.4

2.8

0.63

101

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.33

0.23

1.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

250

1.16

0.22

4.4

4.8

ug/l

2.4

2.1

0.18

219

(3021601) Nitrite [Presence] in Urine by Test strip

456

1.13

0.22

6.6

5.1

estimate

0.0

0.00

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

4.7

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(3019225) pH of Specimen

1.27

0.21

4.7

3.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.2

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.21

0.0

3.2

—

32.5

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.26

0.20

6.5

6.7

—

(3022145) Colonoscopy Study observation

1.25

0.20

1.5

1.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

832

1.14

0.19

20.3

14.2

ml/min/173m2

77.3

78.1

0.11

682

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

195

1.16

0.19

4.9

4.5

25.9

22.4

—

(36660697) Celiac disease serology panel - Serum

0.75

0.17

1.0

1.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.17

0.17

1.6

2.4

g/l

11.3

10.0

—

(40761535) Cells panel - Urine sediment

1.15

0.17

6.3

4.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

190

1.13

0.14

4.0

6.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.12

0.10

3.4

2.9

e6/l

0.4

0.1

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.12

0.09

1.8

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.04

0.07

2.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

364

0.94

0.06

6.4

4.0

—

(3013512) EKG study

267

1.06

0.06

5.4

3.8

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

129

1.10

0.06

1.8

1.4

—

(3002256) Pathology report gross observation

117

0.93

0.02

1.4

1.2

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.3

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

2.5

—

(3006270) Folate [Moles/volume] in Blood

0.00

0.0

1.4

—

305.1

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.95

0.00

2.2

1.6

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.3

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(44806420)

0.00

0.0

2.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

0.0

2.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.6

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

34.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

9.2

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

1.8

—

7.4

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

22.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.8

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.2

—

(4035726)

0.90

0.00

1.1

1.4

—

(3035880) pH of Pleural fluid

0.00

0.0

1.0

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

3.9

—

59.9

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.2

—

(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid

0.00

0.0

1.6

—

61.9

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.3

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.8

—

14.4

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(4027681)

0.00

0.0

1.1

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(4146454)

0.00

0.0

4.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.97

0.00

1.8

2.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.6

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

13.8

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

2.0

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

3.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.2

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint FEMHER_BILATERAL and mortality.

Females

Parameter	HR [95% CI]	p-value
FEMHER_BILATERAL	1.462 [1.18, 1.81]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.999

During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 427 females with FEMHER_BILATERAL died.

Males

Parameter	HR [95% CI]	p-value
FEMHER_BILATERAL	1.338 [1.05, 1.71]	0.021
Birth year	0.989 [0.98, 1.0]	0.022

During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 348 males with FEMHER_BILATERAL died.

Mortality risk

Mortality risk for people of age

years, who have FEMHER_BILATERAL.

N-year risk	Females	Males
1	0.167%	0.245%
5	0.996%	1.493%
10	2.343%	3.873%
15	4.664%	7.459%
20	7.967%	12.692%

Relationships between endpoints

↥

Index endpoint: FEMHER_BILATERAL – Femoral hernia, bilateral

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Femoral hernia, bilateral

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints