vestibular disease: Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls. [database_cross_reference: MESH:D015837]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
138194 |
4. Check minimum number of eventsNone |
138194 |
5. Include endpointsNone |
138194 |
6. Filter based on genotype QC (FinnGen only) |
138194 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF3
Falls/tendency to fall
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1433862 | 732590 | 694287 |
| Only index persons | 1260084 | 647587 | 612497 |
| Unadjusted period prevalence (%) | |||
| Whole population | 20.15 | 20.98 | 19.40 |
| Only index persons | 23.60 | 23.81 | 23.38 |
| Median age at first event (years) | |||
| Whole population | 52.20 | 59.28 | 44.66 |
| Only index persons | 51.98 | 58.61 | 44.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138194 | 77300 | 60894 |
| Unadjusted period prevalence (%) | 26.57 | 26.35 | 26.84 |
| Median age at first event (years) | 57.04 | 56.19 | 58.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1913
- Matched controls
- 9800
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1514.4
323.0
1166
10
W00
ICD-10 Finland
Fall on same level involving ice and snow
766.8
323.0
457
*
W19
ICD-10 Finland
Unspecified fall
1977.9
266.5
328
*
W17
ICD-10 Finland
Other fall from one level to another
1157.2
165.7
208
*
S93.4
ICD-10 Finland
Sprain and strain of ankle
5.2
110.2
439
530
W10
ICD-10 Finland
Fall on and from stairs and steps
262.8
109.0
143
*
X59
ICD-10 Finland
Exposure to unspecified factor
4.2
88.4
434
639
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
13.9
85.8
181
73
S06.0
ICD-10 Finland
Concussion
5.4
79.4
296
320
X58
ICD-10 Finland
Exposure to other specified factors
4.2
69.7
334
470
NHJ10
NOMESCO Finland
Internal fixation of fracture of ankle using wire, rod, cerclage or pin
36.6
67.5
108
16
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
9.6
62.6
156
90
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
6.9
54.3
165
133
S83.2
ICD-10 Finland
Tear of meniscus, current
7.9
50.7
140
97
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.2
50.0
851
2629
N02AX02
ATC
tramadol; systemic, rectal
2.5
48.5
534
1329
S80.0
ICD-10 Finland
Contusion of knee
5.1
47.0
180
196
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
14.2
45.9
95
36
ND1AA
NOMESCO Finland
Wrist X-ray examination
9.4
45.3
113
65
S52.5
ICD-10 Finland
Fracture of lower end of radius
6.2
44.7
144
126
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
44.6
667
1915
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
9.1
40.4
102
60
S82.6
ICD-10 Finland
Fracture of lateral malleolus
7.9
39.0
107
73
M79.6
ICD-10 Finland
Pain in limb
2.1
39.0
598
1714
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
8.7
38.3
99
61
N02BE01
ATC
paracetamol; systemic, rectal
2.1
37.7
1527
6378
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
13.9
36.7
76
29
M54.5
ICD-10 Finland
Low back pain
2.0
34.7
656
2030
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
5.5
34.6
122
120
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.4
34.4
148
182
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
9.5
34.2
84
47
M03BX02
ATC
tizanidine; oral
1.9
33.7
1100
4136
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
14.4
33.3
68
25
AA1AD
NOMESCO Finland
CT of head and brain
3.2
33.0
210
363
M01AB05
ATC
diclofenac; systemic, rectal
1.8
30.2
1066
4045
M25.5
ICD-10 Finland
Pain in joint
2.0
30.2
488
1402
M01AH05
ATC
etoricoxib; oral
1.8
29.3
829
2917
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
6.7
28.7
86
68
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
28.6
799
2793
S60.2
ICD-10 Finland
Contusion of other parts of wrist and hand
4.2
28.6
130
169
S92.3
ICD-10 Finland
Fracture of metatarsal bone
5.9
27.4
90
81
Z09.4
ICD-10 Finland
Follow-up examination after treatment of fracture
8.8
26.7
68
41
R51.80
ICD-10 Finland
Headache
2.1
26.6
388
1060
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
5.8
26.1
87
80
L16
ICPC
Ankle symptom/complaint
3.1
25.9
168
292
NG4AA
NOMESCO Finland
Lower leg X-ray examination
9.5
25.9
63
35
S63.5
ICD-10 Finland
Sprain and strain of wrist
4.5
25.1
104
123
TNX99
NOMESCO Finland
Other orthopaedic minor procedure
12.3
25.1
54
23
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.3
25.0
109
136
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
4.9
24.1
93
102
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
6.1
24.1
77
67
ZXA05
NOMESCO Finland
Left side
2.6
23.6
206
434
TQW40
NOMESCO Finland
Remowal of suture of skin
4.4
23.0
97
117
S89.9
ICD-10 Finland
Unspecified injury of lower leg
5.5
22.6
78
75
S83.0
ICD-10 Finland
Dislocation of patella
4.8
22.5
88
98
NCJ62
NOMESCO Finland
Internal fixation of fracture of forearm using plate
19.5
22.4
41
11
S18
ICPC
Laceration/cut
1.8
22.2
488
1546
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
5.1
22.1
81
84
S63.6
ICD-10 Finland
Sprain and strain of finger(s)
3.6
22.1
116
171
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.2
22.0
98
125
S13.4
ICD-10 Finland
Sprain and strain of cervical spine
3.3
21.9
129
210
ZXA00
NOMESCO Finland
Right side
2.3
21.8
231
541
NH1AD
NOMESCO Finland
Ankle and foot CT
10.5
21.7
50
25
S82.3
ICD-10 Finland
Fracture of lower end of tibia
13.1
21.5
45
18
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
9.0
21.3
53
31
S50.0
ICD-10 Finland
Contusion of elbow
4.9
20.7
79
86
N03AX16
ATC
pregabalin; oral
2.2
20.6
245
606
J01AA02
ATC
doxycycline; systemic
1.6
19.8
1128
4636
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.0
19.8
93
125
S43.4
ICD-10 Finland
Sprain and strain of shoulder joint
4.7
19.5
76
85
S52.1
ICD-10 Finland
Fracture of upper end of radius
13.6
19.0
39
15
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
10.7
18.9
43
21
L15
ICPC
Knee symptom/complaint
2.2
18.9
224
552
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
14.2
18.8
38
14
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.8
18.7
143
279
W22
ICD-10 Finland
Striking against or struck by other object(s)
3.1
18.6
119
206
N06AX11
ATC
mirtazapine; oral
1.7
18.5
491
1637
B01AB05
ATC
enoxaparin; parenteral
1.9
18.4
358
1076
N05AH04
ATC
quetiapine; oral
1.9
18.2
358
1082
M01AE01
ATC
ibuprofen; systemic, rectal
2.0
18.2
1735
8129
A02BC02
ATC
pantoprazole; systemic
1.6
18.1
845
3274
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.8
18.0
135
259
S82.2
ICD-10 Finland
Fracture of shaft of tibia
12.9
17.7
37
15
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
17.6
540
1872
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
17.3
378
1180
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
6.9
17.3
50
38
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
17.2
248
665
R03AC02
ATC
salbutamol; inhalant
1.5
17.1
973
3935
S70.0
ICD-10 Finland
Contusion of hip
7.2
17.1
48
35
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
17.0
646
2367
S01.0
ICD-10 Finland
Open wound of scalp
4.7
16.9
65
72
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.5
16.8
90
136
S62.6
ICD-10 Finland
Fracture of other finger
3.7
16.7
84
121
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
7.0
16.5
47
35
S82.1
ICD-10 Finland
Fracture of upper end of tibia
14.3
16.5
33
12
N05BA04
ATC
oxazepam; oral
1.7
16.1
445
1491
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
16.1
1158
4911
Z04.3
ICD-10 Finland
Examination and observation following other accident
10.4
15.8
36
18
H02AB06
ATC
prednisolone; systemic
1.6
15.7
629
2325
S40.0
ICD-10 Finland
Contusion of shoulder and upper arm
4.4
15.4
64
77
S93.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of foot
6.1
15.4
48
41
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
15.2
397
1306
NCU20
NOMESCO Finland
Removal of internal fixation device from elbow or forearm
18.2
15.2
28
8
N06AX16
ATC
venlafaxine; oral
1.8
15.2
297
892
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.6
15.1
60
69
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.6
14.9
122
247
S20.2
ICD-10 Finland
Contusion of thorax
4.1
14.9
66
85
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.9
14.8
101
183
R4110
NOMESCO Finland
Physiotherapy
1.8
14.8
295
891
N02AA05
ATC
oxycodone; systemic
3.3
14.8
84
133
TNH33
NOMESCO Finland
Custom moulded brace, ankle or foot
12.4
14.7
31
13
SPAT1153
SPAT
Removal of sutures
1.7
14.7
365
1182
ND1BA
NOMESCO Finland
Wrist extensive X-ray examination
8.9
14.7
36
21
J01FF01
ATC
clindamycin; systemic
1.7
14.5
399
1331
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
14.4
443
1524
R02
ICPC
Shortness of breath/dyspnoea
2.2
14.3
168
412
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
14.2
167
408
S82.7
ICD-10 Finland
Multiple fractures of lower leg
38.0
14.2
22
*
L17
ICPC
Foot/toe symptom/complaint
1.8
14.0
307
955
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
4.6
13.9
54
61
S52.0
ICD-10 Finland
Fracture of upper end of ulna
14.0
13.5
27
10
M22.0
ICD-10 Finland
Recurrent dislocation of patella
4.5
13.5
54
63
N03AX12
ATC
gabapentin; oral
2.1
13.4
166
416
S42.2
ICD-10 Finland
Fracture of upper end of humerus
6.3
13.3
40
33
J01DB01
ATC
cefalexin; oral
1.5
13.2
1498
6853
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.2
13.1
56
70
N06AB10
ATC
escitalopram; oral
1.6
13.1
495
1789
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
12.7
13.0
27
11
NGD25
NOMESCO Finland
Reinsertion of meniscus of knee, arthroscopic
6.9
13.0
37
28
S93.2
ICD-10 Finland
Rupture of ligaments at ankle and foot level
4.7
12.9
49
54
M01AE02
ATC
naproxen; oral, rectal
1.5
12.9
956
3993
NG2AA
NOMESCO Finland
Patella X-ray examination
13.5
12.8
26
10
NGJ62
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using plate and screws, other or unspecified
49.1
12.8
19
*
N05CF01
ATC
zopiclone; oral
1.7
12.5
330
1083
L03
ICPC
Low back symptom/complaint
1.6
12.5
446
1587
S53.1
ICD-10 Finland
Dislocation of elbow, unspecified
17.0
12.3
23
7
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
12.3
410
1432
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
3.2
12.3
73
121
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
12.2
268
833
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
12.2
366
1244
S69.9
ICD-10 Finland
Unspecified injury of wrist and hand
5.1
12.1
43
44
S22.3
ICD-10 Finland
Fracture of rib
4.2
12.1
51
63
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
12.0
182
495
WX320
NOMESCO Finland
Spinalanesthesy
1.6
12.0
346
1164
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
11.9
262
815
E66.01
ICD-10 Finland
Obesity due to excess calories
1.9
11.7
204
586
S53.4
ICD-10 Finland
Sprain and strain of elbow
9.1
11.7
28
16
S62.3
ICD-10 Finland
Fracture of other metacarpal bone
5.3
11.5
39
38
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
11.5
134
328
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.2
11.4
127
303
S72.3
ICD-10 Finland
Fracture of shaft of femur
20.7
11.4
20
5
Z00.0
ICD-10 Finland
General medical examination
1.7
11.4
270
858
V49.9
ICD-10 Finland
Car occupant [any] injured in unspecified traffic accident
2.5
11.4
96
199
NC2AA
NOMESCO Finland
Forearm X-ray examination
13.2
11.4
23
9
NB3AA
NOMESCO Finland
Clavicle X-ray examination
13.2
11.4
23
9
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
10.8
11.3
25
12
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
2.8
11.2
83
158
TNG34
NOMESCO Finland
Major custom moulded orthopaedic cast, knee or lower leg
7.9
11.2
29
19
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.3
11.2
38
37
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
7.4
11.2
30
21
L08
ICPC
Shoulder symptom/complaint
2.0
11.1
166
451
NHF25
NOMESCO Finland
Operation for debridement of ankle joint, arthroscopic
8.7
11.1
27
16
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.1
10.9
140
357
S42.0
ICD-10 Finland
Fracture of clavicle
5.5
10.9
36
34
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
10.9
142
365
A01
ICPC
Pain general/multiple sites
2.3
10.9
110
251
WX702
NOMESCO Finland
Supraglottic ventilation device
2.7
10.9
81
156
N03AX09
ATC
lamotrigine; oral
2.1
10.8
135
340
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
10.7
884
3715
S82.4
ICD-10 Finland
Fracture of fibula alone
8.2
10.7
27
17
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
10.7
275
893
S63.3
ICD-10 Finland
Traumatic rupture of ligament of wrist and carpus
4.9
10.6
38
40
TNH31
NOMESCO Finland
Prefabricated orthosis, ankle or foot
13.6
10.5
21
8
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.6
10.5
289
957
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
8.4
10.5
26
16
NHE15
NOMESCO Finland
Suture or reinsertion of ligament of ankle
8.4
10.5
26
16
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
10.5
346
1202
S43.0
ICD-10 Finland
Dislocation of shoulder joint
4.4
10.4
42
50
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
7.8
10.4
27
18
P01AB01
ATC
metronidazole; oral, rectal
1.4
10.4
666
2668
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
10.4
302
1014
W52
ICD-10 Finland
Crushed, pushed or stepped on by crowd or human stampede
4.4
10.4
41
48
S60.0
ICD-10 Finland
Contusion of finger(s) without damage to nail
2.8
10.4
75
142
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
10.3
191
559
TND32
NOMESCO Finland
Custom moulded splint, wrist or hand
9.6
10.3
24
13
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.9
10.2
159
437
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
3.0
10.2
66
117
N03AG01
ATC
valproic acid; systemic, rectal
2.2
10.2
110
260
NGJ60
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using intramedullary nail, other or unspecified
16.4
10.2
19
6
L12
ICPC
Hand/finger symptom/complaint
1.8
10.2
201
602
WX002
NOMESCO Finland
Sedation and analgesia
1.9
10.1
179
516
J01MA02
ATC
ciprofloxacin; systemic
1.5
10.1
445
1650
N01
ICPC
Headache
1.7
10.1
250
803
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
10.0
256
830
R05
ICPC
Cough
1.5
10.0
379
1360
M02AA07
ATC
piroxicam; topical
1.6
9.9
310
1060
S90.0
ICD-10 Finland
Contusion of ankle
4.1
9.9
42
53
TNX30
NOMESCO Finland
Soft bandage, unspecified region
8.1
9.9
25
16
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.9
9.8
156
432
F10.09
ICD-10 Finland
Alcohol intoxication UNS
4.8
9.8
36
39
J01MA12
ATC
levofloxacin; systemic
1.9
9.7
169
486
R01AD09
ATC
mometasone; nasal
1.4
9.7
861
3646
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.6
9.7
48
70
S99.9
ICD-10 Finland
Unspecified injury of ankle and foot
3.6
9.6
47
68
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.9
9.5
159
449
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.5
9.5
459
1733
N05CF02
ATC
zolpidem; oral
1.7
9.5
249
813
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
2.9
9.5
62
111
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
9.5
150
416
S83.3
ICD-10 Finland
Tear of articular cartilage of knee, current
6.7
9.5
27
21
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
9.5
9.5
22
12
R42
ICD-10 Finland
Dizziness and giddiness
1.7
9.5
231
739
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
9.5
1390
6399
N05BA01
ATC
diazepam; systemic, rectal
2.0
9.5
129
337
W06
ICD-10 Finland
Fall involving bed
+∞
9.5
12
*
NF1AA
NOMESCO Finland
Hip X-ray examination
4.7
9.3
35
39
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
7.8
9.3
24
16
N05AH03
ATC
olanzapine; systemic
2.1
9.3
110
271
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
9.3
930
4006
N06AB04
ATC
citalopram; systemic
1.5
9.2
355
1276
J46
ICD-10 Finland
Status asthmaticus
4.0
9.2
40
52
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.7
9.2
205
639
G56.2
ICD-10 Finland
Lesion of ulnar nerve
3.7
9.1
43
60
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
9.1
882
3772
S42.4
ICD-10 Finland
Fracture of lower end of humerus
8.7
9.1
22
13
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.3
9.0
36
43
A10BA02
ATC
metformin; oral
1.8
9.0
176
525
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
8.9
592
2371
S80.1
ICD-10 Finland
Contusion of other and unspecified parts of lower leg
3.2
8.9
50
81
NCJ64
NOMESCO Finland
Other internal fixation of fracture of forearm
14.6
8.8
17
6
NHE20
NOMESCO Finland
Plastic repair of capsule or ligament of ankle joint with transplant
14.6
8.8
17
6
S93.5
ICD-10 Finland
Sprain and strain of toe(s)
5.2
8.8
30
30
J01DA01
ATC
[U] cefalexin; systemic
1.4
8.8
977
4265
S90.3
ICD-10 Finland
Contusion of other and unspecified parts of foot
3.0
8.8
56
98
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.8
8.8
184
561
S83
ICD-10 Finland
Dislocation, sprain and strain of joints and ligaments of knee
4.4
8.7
34
40
R06.0
ICD-10 Finland
Dyspnoea
1.6
8.6
259
876
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.7
8.6
183
562
M22.4
ICD-10 Finland
Chondromalacia patellae
2.5
8.6
73
152
F43.1
ICD-10 Finland
Post-traumatic stress disorder
2.2
8.6
97
235
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.0
8.6
55
97
NF3AA
NOMESCO Finland
Femur X-ray examination
11.6
8.6
18
8
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
11.6
8.6
18
8
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
5.2
8.5
29
29
NC1BA
NOMESCO Finland
Elbow extensive X-ray examination
19.3
8.5
15
*
S92.5
ICD-10 Finland
Fracture of other toe
2.8
8.5
58
107
J01FA10
ATC
azithromycin; systemic
1.3
8.5
1050
4651
NGE60
NOMESCO Finland
Plastic repair of patellar ligaments, open
6.5
8.4
24
19
NFJ60
NOMESCO Finland
Internal fixation of fracture of other parts of femur with intramedullary nail
24.0
8.4
14
*
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.8
8.4
171
517
S72.0
ICD-10 Finland
Fracture of neck of femur
12.5
8.4
17
7
NG1AD
NOMESCO Finland
Knee CT examination
33.5
8.4
13
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
8.4
256
870
T82
ICPC
Obesity
2.4
8.3
79
175
WX290
NOMESCO Finland
Other blockade of nerve
1.3
8.3
991
4357
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
8.6
8.3
20
12
Z71.8
ICD-10 Finland
Other specified counselling
1.4
8.3
513
2026
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.4
8.2
77
171
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
8.2
112
294
M54.8
ICD-10 Finland
Other dorsalgia
2.4
8.1
74
162
OAA65
SPAT
NA
1.6
8.1
252
857
R51
ICD-10 Finland
Headache
2.0
8.1
117
314
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
8.1
243
823
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
8.0
193
615
NGJ40
NOMESCO Finland
Closed reduction of fracture of knee or lower leg, other or unspecified
15.5
8.0
15
5
L11
ICPC
Wrist symptom/complaint
1.9
8.0
134
380
S62.0
ICD-10 Finland
Fracture of navicular [scaphoid] bone of hand
11.0
7.9
17
8
G43.9
ICD-10 Finland
Migraine, unspecified
1.7
7.9
179
561
M75.9
ICD-10 Finland
Shoulder lesion, unspecified
2.6
7.8
63
128
S52.2
ICD-10 Finland
Fracture of shaft of ulna
18.0
7.8
14
*
R60.0
ICD-10 Finland
Localized oedema
2.1
7.8
91
223
T93.2
ICD-10 Finland
Sequelae of other fractures of lower limb
9.3
7.8
18
10
S82.0
ICD-10 Finland
Fracture of patella
9.3
7.8
18
10
C07AB07
ATC
bisoprolol; oral
1.6
7.8
234
790
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.7
7.7
176
550
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
7.7
118
324
N05AA02
ATC
levomepromazine; systemic
3.0
7.7
48
84
S90.1
ICD-10 Finland
Contusion of toe(s) without damage to nail
3.1
7.7
46
77
X50
ICD-10 Finland
Overexertion and strenuous or repetitive movements
3.8
7.7
35
48
NGE30
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, open
56.6
7.7
11
*
NDJ40
NOMESCO Finland
Closed reduction of fracture of wrist or hand
7.4
7.6
20
14
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
7.6
108
288
SPAT1210
SPAT
Application of cast or individual aid
2.7
7.6
57
112
R55
ICD-10 Finland
Syncope and collapse
2.1
7.6
94
236
ND1AD
NOMESCO Finland
Wrist CT examination
9.7
7.6
17
9
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
7.5
216
721
NBU20
NOMESCO Finland
Removal of internal fixation device from shoulder or upper arm
12.9
7.5
15
6
S82.5
ICD-10 Finland
Fracture of medial malleolus
8.4
7.4
18
11
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.9
7.4
124
351
L28
ICPC
Limited function/disability (L)
2.0
7.4
106
284
Y04.8
ICD-10 Finland
Assault by bodily force by other known person
14.4
7.3
14
5
S89.8
ICD-10 Finland
Other specified injuries of lower leg
10.3
7.3
16
8
K92.1
ICD-10 Finland
Melaena
4.0
7.3
31
40
D11
ICPC
Diarrhoea
1.5
7.3
277
988
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.4
7.3
396
1520
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.3
277
989
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
3.7
7.3
34
48
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.3
7.2
68
152
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
4.1
7.2
30
38
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.3
7.2
74
171
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
1.4
7.2
377
1438
M01AC06
ATC
meloxicam; systemic, rectal
1.5
7.2
329
1222
N03AE01
ATC
clonazepam; systemic
2.4
7.2
64
138
NHA30
NOMESCO Finland
Exploration of joint of ankle or foot, arthroscopic
16.7
7.1
13
*
WX212
NOMESCO Finland
Femoral plexus blockade
16.7
7.1
13
*
TNH32
NOMESCO Finland
Custom moulded split, ankle or foot
16.7
7.1
13
*
F51.0
ICD-10 Finland
Nonorganic insomnia
1.5
7.1
271
968
S86.0
ICD-10 Finland
Injury of Achilles tendon
6.5
7.1
20
16
J02AC01
ATC
fluconazole; systemic
1.3
7.1
859
3754
L01
ICPC
Neck symptom/complaint
1.5
7.0
233
805
N07BB01
ATC
disulfiram; oral
2.9
7.0
46
83
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
7.0
523
2121
N06AB06
ATC
sertraline; oral
1.5
7.0
234
811
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
7.0
124
360
WX110
NOMESCO Finland
Local anesthesy
1.3
6.9
1279
5920
T84.1
ICD-10 Finland
Mechanical complication of internal fixation device of bones of limb
28.3
6.9
11
*
S82.9
ICD-10 Finland
Fracture of lower leg, part unspecified
28.3
6.9
11
*
P76
ICPC
Depressive disorder
1.7
6.9
168
536
M24.2
ICD-10 Finland
Disorder of ligament
3.9
6.9
30
40
T00.9
ICD-10 Finland
Multiple superficial injuries, unspecified
12.0
6.9
14
6
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
12.0
6.9
14
6
S32.5
ICD-10 Finland
Fracture of pubis
12.0
6.9
14
6
NHJ50
NOMESCO Finland
Open reduction of fracture of foot or toe
12.0
6.9
14
6
Y94.8
ICD-10 Finland
Other leisure activity accident
3.0
6.8
42
73
SPAT1197
SPAT
Extensive health check-up of expecting family
0.8
6.8
798
4729
A46
ICD-10 Finland
Erysipelas
2.3
6.8
69
159
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
1.7
6.8
149
463
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
2.9
6.8
43
77
TLC02
NOMESCO Finland
Simple extraction of IUD
1.9
6.8
105
291
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
6.8
285
1039
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.5
6.7
33
49
NB6AA
NOMESCO Finland
Humerus X-ray examination
9.7
6.7
15
8
S00.0
ICD-10 Finland
Superficial injury of scalp
4.0
6.7
28
36
R06AE07
ATC
cetirizine; oral
1.3
6.7
820
3576
N06BA04
ATC
methylphenidate; oral
2.1
6.6
77
190
L02
ICPC
Back symptom/complaint
1.6
6.6
179
588
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
4.1
6.6
27
34
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
6.6
314
1175
T93.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of lower limb
5.7
6.5
20
18
SFA00
NOMESCO Finland
Small filling
1.6
6.5
187
625
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.6
6.5
24
27
R03BA05
ATC
fluticasone; inhalant
1.5
6.5
289
1065
NDJ64
NOMESCO Finland
Internal fixation of fracture of wrist or hand wire, rod, cerclage or pin
6.1
6.5
19
16
W64
ICD-10 Finland
Exposure to other and unspecified animate mechanical forces
6.6
6.5
18
14
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.8
6.5
110
314
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
2.9
6.5
41
73
M79.1
ICD-10 Finland
Myalgia
1.5
6.5
216
747
N89
ICPC
Migraine
1.8
6.5
108
307
L73
ICPC
Fracture: tibia/fibula
15.4
6.5
12
*
SPAT1260
SPAT
Consultation of another employee
1.5
6.5
270
984
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
4.8
6.5
23
25
T78.4
ICD-10 Finland
Allergy, unspecified
1.9
6.5
104
292
WX203
NOMESCO Finland
Infraclavicular plexus blockade
4.3
6.4
25
30
L02.8
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of other sites
3.2
6.4
35
56
D10
ICPC
Vomiting
1.6
6.4
178
590
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
2.3
6.4
62
141
L13
ICPC
Hip symptom/complaint
1.9
6.4
100
278
A02BC03
ATC
lansoprazole; oral
1.5
6.4
242
863
H02AB07
ATC
prednisone; oral
1.7
6.4
130
394
QCB00
NOMESCO Finland
Suture of skin of upper limb
5.2
6.4
21
21
T74.1
ICD-10 Finland
Physical abuse
2.6
6.3
49
99
V19
ICD-10 Finland
Pedal cyclist injured in other and unspecified transport accidents
3.1
6.3
36
60
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.8
6.3
115
338
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
2.8
6.3
43
81
M89.0
ICD-10 Finland
Algoneurodystrophy
5.8
6.3
19
17
S91.3
ICD-10 Finland
Open wound of other parts of foot
3.3
6.3
34
54
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.4
6.3
54
116
SPAT1211
SPAT
Application of soft bandage
1.9
6.3
90
243
S52.6
ICD-10 Finland
Fracture of lower end of both ulna and radius
6.7
6.3
17
13
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
6.2
6.3
18
15
R21
ICPC
Throat symptom/complaint
1.3
6.3
573
2391
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
3.9
6.3
27
36
L10
ICPC
Elbow symptom/complaint
2.6
6.3
48
96
F90.0
ICD-10 Finland
Disturbance of activity and attention
1.9
6.3
99
277
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.2
192
653
C03CA01
ATC
furosemide; systemic
2.0
6.2
82
214
N05AX12
ATC
aripiprazole; systemic
1.9
6.2
97
270
G44.2
ICD-10 Finland
Tension-type headache
1.5
6.2
248
895
S92.7
ICD-10 Finland
Multiple fractures of foot
25.7
6.2
10
*
M01AH01
ATC
celecoxib; oral (coxibs)
1.7
6.2
122
367
SPAT1380
SPAT
Postpartum check-up
0.8
6.2
570
3492
S30.1
ICD-10 Finland
Contusion of abdominal wall
4.0
6.2
26
34
S54.0
ICD-10 Finland
Injury of ulnar nerve at forearm level
46.3
6.2
9
*
R11
ICD-10 Finland
Nausea and vomiting
1.7
6.2
147
467
S29
ICPC
Skin symptom/complaint other
1.5
6.1
201
694
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
3.6
6.1
29
42
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.8
6.1
118
352
S06.9
ICD-10 Finland
Intracranial injury, unspecified
9.0
6.1
14
8
A02BC05
ATC
esomeprazole; systemic
1.4
6.1
433
1739
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.6
6.1
170
565
M02AA10
ATC
ketoprofen; topical
1.7
6.0
132
409
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.0
6.0
75
192
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
7.7
6.0
15
10
ACC53
NOMESCO Finland
Release of ulnar nerve
5.8
6.0
18
16
Mortality – FinRegistry
↥Association
Association between endpoint FALLS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FALLS | 1.899 [1.77, 2.04] | < 0.001 |
| Birth year | 0.982 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 152425 out of 619961 females with FALLS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FALLS | 2.001 [1.84, 2.18] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 108021 out of 588969 males with FALLS died.
Mortality risk
Mortality risk for people of age
years, who have FALLS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.207% |
| 5 | 0.473% | 1.465% |
| 10 | 1.189% | 3.543% |
| 15 | 2.338% | 6.56% |
| 20 | 4.001% | 11.249% |
Relationships between endpoints
↥Index endpoint: FALLS – Falls/tendency to fall
GWS hits: 16
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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