Physiological and behavioural disorders associated with sexual development and orientation

F5_SEXUAL

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — F66 Hospital discharge: ICD-9 — 3020 Cause of death: ICD-10 — F66 Cause of death: ICD-9 — 3020 2 out of 7 registries used, show all original rules.	62
4. Check minimum number of events None	62
5. Include endpoints None	62
6. Filter based on genotype QC (FinnGen only)	62

Control definitions (FinnGen only)

Control exclude: F5_PERSOBEH

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: F63-F69
Name in latin: Perturbationes psychologicae et modi se gerendi ad formationem et orientationem sexualem adjunctae

NAME	F5_SEXUAL
CONTROL_EXCLUDE	F5_PERSOBEH
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	F66
HD_ICD_9	3020
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	F66
COD_ICD_9	3020
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Physiological and behavioural disorders associated with sexual development and orientation based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	587	240	347
Only index persons	527	218	309
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	-	35.04	23.08
Only index persons	26.20	32.73	21.59

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	62	38	24
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	33.13	35.76	28.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
57: Matched controls
570

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

N05AH04

ATC

quetiapine; oral

18.9

21.0

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

23.3

19.3

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

46.1

17.7

E66.01

ICD-10 Finland

Obesity due to excess calories

18.4

15.6

E66.9

ICD-10 Finland

Obesity, unspecified

51.2

15.6

F66.9

ICD-10 Finland

Psychosexual development disorder, unspecified

+∞

14.1

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

16.7

13.9

E66.8

ICD-10 Finland

Other obesity

18.8

13.5

F60.30

ICD-10 Finland

Emotionally unstable personality disorder, impulsive

+∞

11.9

F60.31

ICD-10 Finland

Emotionally unstable personality disorder, borderline condition

+∞

11.9

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

21.3

11.7

N06AB04

ATC

citalopram; systemic

7.8

10.9

ICZ03

NOMESCO Finland

Participation in compiling a psychiatric treatment plan

41.1

10.9

F32.3

ICD-10 Finland

Severe depressive episode with psychotic symptoms

30.2

10.9

N05AA02

ATC

levomepromazine; systemic

19.6

10.8

ZY010

NOMESCO Finland

Hospital outpatient

14.9

10.8

N05AX12

ATC

aripiprazole; systemic

18.0

10.4

R4160

NOMESCO Finland

Other therapy enhancing rehabilitation

49.6

10.4

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

9.0

9.8

F32.9

ICD-10 Finland

Depressive episode, unspecified

8.0

9.7

F61.0

ICD-10 Finland

Mixed personality disorders

+∞

9.6

F66.01

ICD-10 Finland

Disorder in sexual maturity homosexual

+∞

9.6

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

14.3

9.5

E66.00

ICD-10 Finland

Metabolic syndrome

23.5

9.4

IEY05

NOMESCO Finland

Dedicated profession-specific psychiatric intervention, individual

29.7

9.4

N06AB03

ATC

fluoxetine; oral

8.6

9.2

Z2446

NOMESCO Finland

Social worker

11.6

9.1

N05AF03

ATC

chlorprothixene; systemic

20.5

9.1

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

11.0

8.9

N05BA04

ATC

oxazepam; oral

6.1

8.7

N05AH03

ATC

olanzapine; systemic

9.6

8.7

F31.8

ICD-10 Finland

Other bipolar affective disorders

21.2

8.5

Z3226

NOMESCO Finland

Physiotherapist

7.3

8.5

N05AX08

ATC

risperidone; systemic

10.0

8.5

F34.1

ICD-10 Finland

Dysthymia

39.6

8.4

N05AH02

ATC

clozapine; systemic

26.7

8.4

ICB01

NOMESCO Finland

Psychiatric treatment plan, standard

26.7

8.4

Z2445

NOMESCO Finland

Psychologist

13.8

8.4

F29

ICD-10 Finland

Unspecified nonorganic psychosis

22.2

8.0

N05BE01

ATC

buspirone; oral

22.2

8.0

N06AX12

ATC

bupropion; oral

10.3

7.7

IGY02

NOMESCO Finland

Psychiatric monitoring contact

91.5

7.6

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

14.8

7.5

3020A

ICD-9 Finland

Sexual deviations and disorders, Ego-dystonic homosexuality

+∞

7.4

F66.00

ICD-10 Finland

Disorder in sexual maturity heterosexual

+∞

7.4

F33.30

ICD-10 Finland

Recurrent depression, severe episode without somatic syndrome

+∞

7.4

F66.80

ICD-10 Finland

Other specified disorder of psychosexual development heterosexual

+∞

7.4

A10BA02

ATC

metformin; oral

6.1

7.4

ZXY51

NOMESCO Finland

2-person team, doctor-nurse

23.7

7.4

IGY99

NOMESCO Finland

Other psychiatric treatment contact

34.9

7.4

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

7.9

7.3

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

11.6

7.2

F31.9

ICD-10 Finland

Bipolar affective disorder, unspecified

16.6

7.2

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

13.4

7.2

N06AX16

ATC

venlafaxine; oral

6.3

7.1

IFA01

NOMESCO Finland

Psychiatric pharmacotherapy plan, not specified

45.6

6.9

IGY01

NOMESCO Finland

Accelerated psychiatric treatment contact

26.2

6.9

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

10.2

6.8

IAA01

NOMESCO Finland

Assessment of need for psychiatric treatment

16.9

6.7

ZXE02

NOMESCO Finland

Procedure duration 10 to 19 minutes

13.3

6.6

N06AX03

ATC

mianserin; oral

13.3

6.6

JDF11

NOMESCO Finland

Laparoscopic gastric bypass

30.4

6.4

F20.9

ICD-10 Finland

Schizophrenia, unspecified

12.0

6.4

F66.09

ICD-10 Finland

Disorder of sexual maturity other or indefinite

+∞

6.4

N06AB06

ATC

sertraline; oral

6.7

6.3

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

9.8

6.2

ZXE13

NOMESCO Finland

Procedure duration 90 to 119 minutes

9.8

6.2

N05CF01

ATC

zopiclone; oral

4.6

6.2

F31.4

ICD-10 Finland

Bipolar affective disorder, current episode severe depression without psychotic symptoms

17.4

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(40768797) Stomach Pathology biopsy report

4.88

6.66

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

113

3.46

5.25

3.2

3.0

mmol/l

7.1

8.7

0.77

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

15.02

5.23

20.8

9.5

nmol/l

919.5

1249.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

174

3.32

5.12

15.0

5.5

mmol/l

1.2

0.29

150

(3028707) Methadone [Presence] in Urine by Screen method

12.86

4.93

1.8

1.7

—

(3027008) Opiates [Presence] in Urine

5.49

4.71

1.6

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

137

3.10

4.50

3.0

1.6

pmol/l

91.3

98.5

0.38

(3028300) Cannabinoids [Presence] in Urine

5.23

4.48

1.6

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

5.23

4.48

1.6

1.4

—

(3027944) Amphetamines [Presence] in Urine

5.23

4.48

1.6

1.4

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

169

3.04

4.43

8.5

4.1

g/l

34.8

37.7

2.93

164

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

4.74

4.37

1.5

1.4

—

(3012516) Albumin [Mass/volume] in Urine

3.14

4.22

3.4

3.3

mg/l

47.2

62.8

0.14

(3012544) pH of Venous blood

4.01

3.84

5.2

3.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

143

2.75

3.62

4.8

2.6

—

(3002582) Erythrocytes [#/volume] in Urine

122

2.76

3.51

4.2

2.4

e6/l

117.2

12.1

0.80

(3001604) Monocytes [#/volume] in Blood

230

2.68

3.47

8.0

5.9

e9/l

0.6

0.5

0.38

204

(3006315) Basophils [#/volume] in Blood

231

2.67

3.42

8.0

5.9

e9/l

0.0

0.26

206

(40758558) Short blood count panel - Blood

117

2.72

3.35

9.5

6.9

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

5.95

3.31

1.6

1.5

—

(3016879) Cocaine [Presence] in Urine

5.07

3.26

1.7

1.5

—

(3019198) Lymphocytes [#/volume] in Blood

237

2.56

3.16

8.8

5.9

e9/l

2.0

1.8

0.69

213

(3020682) Albumin/Creatinine [Ratio] in Urine

106

2.67

3.12

3.8

3.9

mg/mmol

9.2

0.00

(3013115) Eosinophils [#/volume] in Blood

239

2.52

3.08

10.4

6.1

e9/l

0.2

0.21

215

(3018095) Leukocytes [#/volume] in Urine

150

2.42

2.81

5.1

2.9

e6/l

41.3

19.6

0.56

(3000991) Gas panel - Venous blood

3.72

2.51

3.8

5.1

—

(42870588) Differential panel, method unspecified - Blood

140

2.32

2.50

7.9

5.2

—

(3023368) Bacteria identified in Blood by Culture

2.47

2.49

10.3

4.1

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

3.83

2.36

1.9

2.0

mg/l

2.0

1.8

—

(3011288) Drugs identified in Urine by Screen method

4.98

2.33

2.5

1.3

—

(3026008) Bacteria identified in Urine by Culture

116

2.23

2.13

6.3

2.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

117

2.20

2.08

1.4

1.3

g/l

1.9

2.3

0.85

(3037467) Urinalysis macro (dipstick) panel - Urine

337

2.22

2.06

5.7

3.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.52

2.01

2.0

1.4

—

(3020779) Urea [Moles/volume] in Serum or Plasma

3.45

1.94

31.0

7.5

mmol/l

9.1

7.3

—

(3021589) Normoblasts [#/volume] in Blood

197

2.01

1.91

16.9

6.9

e9/l

0.0

0.00

155

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.32

1.89

5.7

3.5

ng/l

830.0

99.3

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.79

1.88

1.8

1.2

—

(3052851) Hemolysis interference index of Serum or Plasma

4.43

1.86

6.6

2.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

3.57

1.79

1.3

2.2

0.7

0.9

—

(3027945) Reticulocytes/100 erythrocytes in Blood

3.15

1.78

3.1

2.6

1.9

1.8

—

(3032080) INR in Blood by Coagulation assay

152

1.94

1.65

8.5

7.6

inr

1.0

1.2

—

(1002224) Polysomnography panel

2.90

1.63

1.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.46

1.56

6.4

1.9

—

(3022313) Gas panel - Capillary blood

3.53

1.55

6.4

1.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

3.53

1.55

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

2.19

1.52

2.5

1.7

—

(36304419) Bacteria [Presence] in Urine

122

1.94

1.51

4.3

2.1

—

(3044889) 12 lead EKG panel

326

1.89

1.50

5.1

3.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.69

1.50

1.1

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

352

1.86

1.37

12.2

6.8

u/l

84.1

73.9

1.00

322

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.17

1.31

6.3

2.1

—

(3000494) Fungus identified in Specimen by Culture

2.13

1.26

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

472

2.11

1.25

21.1

8.6

ml/min/173m2

91.0

92.2

0.12

373

(3015736) pH of Urine

183

1.72

1.22

3.7

3.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

106

0.43

1.15

1.6

1.4

—

(3025941) Bacteria identified in Stool by Culture

2.41

1.14

1.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.83

1.14

3.9

2.3

—

(40761536) Microorganisms panel - Urine sediment

2.06

1.00

3.9

2.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.79

0.93

3.3

1.7

—

(3021601) Nitrite [Presence] in Urine by Test strip

232

1.57

0.92

6.3

4.5

estimate

0.0

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

149

1.62

0.92

4.6

2.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.85

0.86

3.1

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

237

1.52

0.81

5.0

3.3

estimate

0.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

111

1.59

0.75

6.0

4.3

—

(3022621) pH of Urine by Test strip

1.89

0.75

6.1

2.1

—

(40768804) Tissue Pathology biopsy report

195

1.47

0.70

2.4

1.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.92

0.70

1.2

1.3

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.92

0.70

3.6

5.0

mmol/l

1.0

1.6

—

(3019150) Specific gravity of Urine by Refractometry

105

1.57

0.68

4.2

4.0

kg/l

1.0

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

132

1.51

0.67

1.6

1.3

u/ml

0.6

0.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.72

0.63

11.0

3.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

116

1.51

0.62

4.3

2.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.61

0.0

1.3

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.60

0.0

1.9

—

5.4

—

(3019225) pH of Specimen

1.79

0.60

11.2

3.4

—

(3044640) Blood type and Crossmatch panel - Blood

154

1.44

0.58

2.8

1.8

—

(3003694) ABO and Rh group [Type] in Blood

166

0.66

0.58

1.4

1.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.59

0.58

1.3

1.4

—

(1761868) Lipid panel - Serum or Plasma

219

0.69

0.57

1.9

2.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.59

0.54

1.2

1.0

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.62

0.51

1.7

1.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

0.58

0.50

3.2

4.0

—

20.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.55

0.49

3.7

1.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.54

0.48

3.2

1.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

217

1.34

0.46

6.1

2.6

ug/l

144.4

81.6

0.52

209

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

518

1.55

0.44

28.5

10.5

mg/l

22.1

20.5

0.16

389

(3013512) EKG study

106

1.41

0.44

3.0

2.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

191

1.32

0.42

4.5

3.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.42

0.0

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.42

0.0

1.1

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.6

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.41

0.0

1.0

—

1.8

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.40

0.0

2.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

154

1.34

0.40

3.9

3.4

ng/l

35.3

21.8

0.31

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

1.40

0.37

2.8

3.1

ng/l

533.8

768.9

0.32

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

425

0.78

0.35

3.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

101

1.36

0.35

3.9

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

140

1.30

0.32

3.2

2.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

112

1.32

0.32

4.7

4.0

—

(3002256) Pathology report gross observation

1.33

0.32

1.0

1.2

—

(3022145) Colonoscopy Study observation

1.28

0.30

1.0

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

113

1.31

0.30

2.6

1.8

—

(3009542) Hematocrit [Volume Fraction] of Blood

507

1.31

0.22

23.8

11.3

41.1

41.0

0.05

432

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

234

1.19

0.22

5.4

3.8

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(4268621)

0.00

0.21

0.0

1.9

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.0

—

(3000492) Spirometry study

1.31

0.21

1.2

1.4

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.20

0.0

1.5

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.1

—

1.8

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(3029937) Albumin [Presence] in Urine by Test strip

129

1.21

0.19

3.1

3.8

estimate

0.0

—

(36660697) Celiac disease serology panel - Serum

1.19

0.18

1.6

1.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

149

0.92

0.04

1.6

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

125

1.05

0.00

2.5

1.7

—

(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen

0.00

0.0

5.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

7.5

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.5

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

6.4

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(44806118)

0.00

0.0

1.6

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

29.6

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

142.6

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.6

—

(44790047)

0.00

0.0

1.6

—

(44790048)

0.00

0.0

1.6

—

(44790049)

0.00

0.0

1.6

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.4

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

0.0

2.6

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.2

—

13.2

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.0

3.7

—

1.4

—

(40761511) CBC panel - Blood by Automated count

550

1.00

0.00

26.7

9.3

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint F5_SEXUAL and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have F5_SEXUAL.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: F5_SEXUAL – Physiological and behavioural disorders associated with sexual development and orientation

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Physiological and behavioural disorders associated with sexual development and orientation

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints