Hyperkinetic disorders (excl. ADHD)

F5_HYPERKIN

attention deficit hyperactivity disorder: A mental disorder characterized by inattention, easy distraction, careless mistakes and avoidance of tasks that require sustained mental focus. These behaviors can lead to maladaptive consequences in the affected individual's life.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F90
  • Hospital discharge: ICD-9 3141
  • Hospital discharge: excluded ICD-10 F90.0
  • Cause of death: ICD-10 F90
  • Cause of death: ICD-9 3141
  • Cause of death: excluded ICD-10 F90.0

2 out of 7 registries used, show all original rules.

647

4. Check minimum number of events

None

647

5. Include endpoints

None

647

6. Filter based on genotype QC (FinnGen only)

595

Control definitions (FinnGen only)

Control exclude
F5_BEHEMOCHILD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F90-F98
Name in latin
Perturbationes hyperkineticae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19442 4593 14832
Only index persons 15443 3764 11679
Unadjusted period prevalence (%)
Whole population 0.35 0.13 0.41
Only index persons 0.37 0.14 0.45
Median age at first event (years)
Whole population 9.79 12.16 9.04
Only index persons 11.14 14.77 9.98

-FinnGen-

Key figures

All Female Male
Number of individuals 595 226 369
Unadjusted period prevalence (%) 0.15 0.09 0.19
Median age at first event (years) 16.23 23.86 11.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
647
Matched controls
6412
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F90.0
ICD-10 Finland
Disturbance of activity and attention
131.5
323.0
388
72
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
1164.8
323.0
368
7
N06BA04
ATC
methylphenidate; oral
99.3
312.7
334
68
F90.1
ICD-10 Finland
Hyperkinetic conduct disorder
+∞
120.3
112
*
3141A
ICD-9 Finland
Hyperkinetic syndrome of childhood, Hyperkinesis with developmental delay
+∞
103.7
97
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
7.9
95.3
256
491
F90.8
ICD-10 Finland
Other hyperkinetic disorders
265.2
91.8
92
*
N05AH04
ATC
quetiapine; oral
6.5
80.5
250
565
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
69.4
70.1
80
13
N05AX08
ATC
risperidone; systemic
9.9
66.6
143
178
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
9.6
60.6
132
167
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
214.1
57.9
59
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
10.7
57.5
117
130
ZY010
NOMESCO Finland
Hospital outpatient
6.6
49.5
139
255
N06AX12
ATC
bupropion; oral
7.4
49.3
127
206
Z2445
NOMESCO Finland
Psychologist
6.0
47.2
143
288
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
+∞
46.3
44
*
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
12.6
45.6
84
75
N05AH03
ATC
olanzapine; systemic
6.6
43.6
121
216
F93.89
ICD-10 Finland
Other childhood emotional disorders
98.1
42.2
46
5
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.5
41.7
170
471
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
10.9
41.0
81
83
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
13.0
41.0
74
63
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
10.4
40.5
82
88
IGY99
NOMESCO Finland
Other psychiatric treatment contact
9.0
40.2
89
112
IGV01
NOMESCO Finland
Psychiatric network contact
16.2
39.1
64
43
N06BA12
ATC
lisdexamfetamine; oral
59.8
38.7
45
8
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.8
38.3
117
234
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
6.0
37.9
113
219
N03AG01
ATC
valproic acid; systemic, rectal
6.4
37.8
106
190
IGY02
NOMESCO Finland
Psychiatric monitoring contact
7.6
37.6
92
136
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.3
37.2
157
445
N06AB04
ATC
citalopram; systemic
4.3
36.2
152
427
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.6
35.9
139
361
IGP01
NOMESCO Finland
Psychiatric family contact
12.2
35.7
66
59
Z3231
NOMESCO Finland
Registered nurse
3.1
35.5
269
1209
N05BA04
ATC
oxazepam; oral
3.8
35.4
177
581
N06BA09
ATC
atomoxetine; oral
82.3
35.1
39
5
F29
ICD-10 Finland
Unspecified nonorganic psychosis
6.3
34.6
98
177
N05AX12
ATC
aripiprazole; systemic
6.3
34.3
97
175
N05BA01
ATC
diazepam; systemic, rectal
5.1
33.7
116
265
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.6
33.6
129
330
N06AB03
ATC
fluoxetine; oral
5.1
33.6
115
261
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.6
33.6
91
155
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
5.8
31.5
95
185
F92.8
ICD-10 Finland
Other mixed disorders of conduct and emotions
325.1
31.0
31
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
4.9
30.8
108
250
N06AX16
ATC
venlafaxine; oral
4.0
30.6
138
409
F90
ICD-10 Finland
Hyperkinetic disorders
86.1
29.9
33
*
P29
ICPC
Psychological sympt/compl other
4.7
29.6
110
270
F92.0
ICD-10 Finland
Depressive conduct disorder
+∞
29.3
28
*
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
+∞
29.3
28
*
Z2446
NOMESCO Finland
Social worker
3.8
29.2
140
436
T36
ICD-10 Finland
Poisoning by systemic antibiotics
6.7
29.1
77
126
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
8.9
28.8
63
77
N06AB06
ATC
sertraline; oral
4.0
28.5
128
376
F81.3
ICD-10 Finland
Mixed disorder of scholastic skills
15.9
27.6
45
30
P81
ICPC
Hyperkinetic disorder
18.5
27.3
42
24
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
5.4
27.0
86
178
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
7.6
27.0
65
93
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.5
26.4
82
165
IEV99
NOMESCO Finland
Other psychiatric network intervention
14.5
26.1
44
32
F81.9
ICD-10 Finland
Developmental disorder of scholastic skills, unspecified
18.3
25.9
40
23
N06AX11
ATC
mirtazapine; oral
2.9
25.9
192
816
F61.0
ICD-10 Finland
Mixed personality disorders
11.1
25.6
49
47
ZYC01
NOMESCO Finland
Remote contact by phone
5.8
25.5
75
141
F60.9
ICD-10 Finland
Personality disorder, unspecified
13.7
25.4
44
34
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
23.5
25.4
36
16
F84.5
ICD-10 Finland
Asperger syndrome
16.0
25.3
41
27
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
9.3
25.1
53
61
P99
ICPC
Psychological disorders other
8.3
24.9
56
72
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
7.6
24.6
59
84
N06AB10
ATC
escitalopram; oral
2.9
24.5
172
702
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.7
24.5
89
212
N03AX09
ATC
lamotrigine; oral
5.3
24.3
77
158
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
4.9
23.9
82
184
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
32.2
23.8
31
10
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
10.2
23.5
47
49
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
6.2
23.2
64
111
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
6.7
22.9
60
97
Z2221
NOMESCO Finland
Medical doctor
2.6
22.6
213
1030
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
5.3
22.6
72
149
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
7.7
22.5
53
73
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
6.0
22.2
63
113
F91.9
ICD-10 Finland
Conduct disorder, unspecified
+∞
21.9
21
*
F83
ICD-10 Finland
Mixed specific developmental disorders
6.9
21.7
55
85
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
5.4
21.1
66
133
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
12.9
21.0
37
30
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.2
20.9
67
139
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.6
20.8
76
182
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
3.2
20.3
116
405
C07AA05
ATC
propranolol; systemic
2.9
20.0
138
549
XA800
NOMESCO Finland
Neuropsychological investigation
4.1
19.9
81
215
F39
ICD-10 Finland
Unspecified mood [affective] disorder
8.9
18.8
40
47
F51.0
ICD-10 Finland
Nonorganic insomnia
3.1
18.6
112
404
N05AA02
ATC
levomepromazine; systemic
6.6
18.4
48
77
N07BB01
ATC
disulfiram; oral
5.6
18.3
54
102
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
8.4
18.1
40
50
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
9.0
18.0
38
44
F82
ICD-10 Finland
Specific developmental disorder of motor function
7.4
18.0
43
61
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
4.8
17.7
61
137
F91.3
ICD-10 Finland
Oppositional defiant disorder
+∞
17.7
17
*
N05CF01
ATC
zopiclone; oral
2.8
17.6
125
502
F33.4
ICD-10 Finland
Recurrent depressive disorder, currently in remission
7.3
17.5
42
60
R5599
NOMESCO Finland
Other rehabilitation service
7.8
17.3
40
54
Z3226
NOMESCO Finland
Physiotherapist
2.5
17.1
158
737
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.2
16.9
96
334
P01
ICPC
Feeling anxious/nervous/tense
2.5
16.8
148
674
N05AN01
ATC
lithium; oral
7.9
16.7
38
50
F84.8
ICD-10 Finland
Other pervasive developmental disorders
91.7
16.6
18
*
SAA01
NOMESCO Finland
Simple examination of mouth
2.2
16.4
514
4071
F99
ICD-10 Finland
Mental disorder, not otherwise specified
6.6
16.2
42
67
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.1
16.1
96
344
K02.1
ICD-10 Finland
Caries of dentine
2.0
15.9
439
3266
IEP01
NOMESCO Finland
Psychoeducation, family
16.1
15.7
25
16
F81.0
ICD-10 Finland
Specific reading disorder
10.7
15.3
29
28
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
15.2
202
1117
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
9.7
15.0
30
32
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.7
14.9
68
199
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
9.4
14.7
30
33
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.8
14.7
63
175
IEP99
NOMESCO Finland
Other psychiatric family intervention
9.7
14.5
29
31
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
5.2
14.5
45
91
F31.8
ICD-10 Finland
Other bipolar affective disorders
7.6
14.3
33
45
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.6
14.1
30
36
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.9
14.0
91
342
N05AF03
ATC
chlorprothixene; systemic
7.1
14.0
34
50
ZXY82
NOMESCO Finland
Nurse in multidisciplinary team
10.3
14.0
27
27
N03AX16
ATC
pregabalin; oral
2.8
14.0
96
377
N05AD01
ATC
haloperidol; systemic
8.8
13.8
29
34
F13.1
ICD-10 Finland
Mental and behavioural disorders due to use of sedatives or hypnotics, harmful use
20.4
13.8
20
10
F40.1
ICD-10 Finland
Social phobias
4.5
13.6
48
111
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.1
13.6
79
278
N03AF02
ATC
oxcarbazepine; oral
5.3
13.5
41
81
F88
ICD-10 Finland
Other disorders of psychological development
14.1
13.2
22
16
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.8
13.2
37
66
F89
ICD-10 Finland
Unspecified disorder of psychological development
40.6
13.1
16
*
F98.9
ICD-10 Finland
Unspecified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
40.6
13.1
16
*
IEP03
NOMESCO Finland
Focused parental counselling
8.1
13.1
29
37
P15
ICPC
Chronic alcohol abuse
5.9
13.1
36
63
EBA00
NOMESCO Finland
Extraction of tooth
1.9
13.1
264
1701
-1
NOMESCO Finland
NA
1.9
13.1
318
2189
F81.8
ICD-10 Finland
Other developmental disorders of scholastic skills
11.2
13.0
24
22
N05AH02
ATC
clozapine; systemic
5.0
12.9
41
85
Z63.5
ICD-10 Finland
Disruption of family by separation and divorce
19.4
12.9
19
10
A02BC02
ATC
pantoprazole; systemic
1.9
12.8
253
1614
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
11.8
12.8
23
20
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
12.8
116
529
F20.9
ICD-10 Finland
Schizophrenia, unspecified
6.0
12.8
35
61
R51.80
ICD-10 Finland
Headache
2.3
12.7
125
595
N06BA02
ATC
dexamfetamine; oral
70.7
12.6
14
*
R05
ICPC
Cough
2.1
12.6
172
949
P19
ICPC
Drug abuse
6.8
12.6
31
47
F91.1
ICD-10 Finland
Unsocialized conduct disorder
131.3
12.4
13
*
L17
ICPC
Foot/toe symptom/complaint
2.1
12.4
162
876
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.8
12.4
335
2375
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
10.7
12.3
23
22
WX110
NOMESCO Finland
Local anesthesy
1.9
12.2
474
3786
N06AA12
ATC
doxepin; systemic
7.9
12.1
27
35
F34.1
ICD-10 Finland
Dysthymia
5.2
12.1
37
74
SPAT1240
SPAT
Therapeutic discussion
2.4
12.0
110
505
N05CD07
ATC
temazepam; oral
4.9
12.0
39
83
N05AB03
ATC
perphenazine; systemic, rectal
5.5
12.0
35
66
IER01
NOMESCO Finland
Psychoeducation, group
10.2
12.0
23
23
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
9.5
12.0
24
26
T74.1
ICD-10 Finland
Physical abuse
5.0
12.0
38
79
N05BA12
ATC
alprazolam; oral
3.7
11.9
53
153
R53
ICD-10 Finland
Malaise and fatigue
2.3
11.6
118
567
N06AB05
ATC
paroxetine; oral
4.1
11.6
45
115
N06AX22
ATC
agomelatine; oral
5.8
11.5
32
57
Z06
ICPC
Unemployment problem
10.2
11.5
22
22
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
121.0
11.4
12
*
N04AA02
ATC
biperiden; systemic
9.1
11.3
23
26
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
9.8
11.2
22
23
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.3
11.2
113
541
F51.9
ICD-10 Finland
Nonorganic sleep disorder, unspecified
6.9
11.2
27
40
N01
ICPC
Headache
2.1
11.1
145
782
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
20.3
11.1
16
8
Z72.2
ICD-10 Finland
Drug use
11.3
11.0
20
18
N05BE01
ATC
buspirone; oral
6.1
10.9
29
49
P76
ICPC
Depressive disorder
3.0
10.9
66
237
F15.2
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, dependence syndrome
12.1
10.8
19
16
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
10.7
296
2074
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
10.7
311
2217
C07AB07
ATC
bisoprolol; oral
2.2
10.7
121
614
RT420
NOMESCO Finland
NA
21.7
10.7
15
7
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
3.6
10.6
47
135
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
10.6
126
650
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
6.1
10.6
28
47
ZXY60
NOMESCO Finland
2-person team, nurses
8.1
10.6
23
29
IEP02
NOMESCO Finland
Child-centred family therapy
7.1
10.6
25
36
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
5.7
10.4
29
52
RT390
NOMESCO Finland
NA
+∞
10.4
10
*
N06BA07
ATC
modafinil; oral
32.8
10.3
13
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
4.9
10.3
33
70
M54.5
ICD-10 Finland
Low back pain
1.9
10.3
172
1016
F60.8
ICD-10 Finland
Other specific personality disorders
9.7
10.3
20
21
EBA05
NOMESCO Finland
Complicated extraction of tooth
2.2
10.2
109
538
S29
ICPC
Skin symptom/complaint other
2.2
10.1
106
517
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
11.4
10.0
18
16
P74
ICPC
Anxiety disorder/anxiety state
3.2
10.0
51
165
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
5.1
9.9
30
60
SGA01
NOMESCO Finland
Tooth opening as first aid
2.1
9.9
121
632
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.5
9.9
34
78
N06AX21
ATC
duloxetine; oral
3.0
9.8
58
207
IBB01
NOMESCO Finland
Psychiatric functioning capacity evaluation
20.2
9.8
14
7
A04
ICPC
Weakness/tiredness general
2.3
9.8
98
470
N03AF01
ATC
carbamazepine; oral, rectal
5.2
9.7
29
57
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
9.7
64
244
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.2
9.7
36
89
F10.20
ICD-10 Finland
Alcohol dependence currently independent
6.2
9.7
25
41
Z61.8
ICD-10 Finland
Other negative life events in childhood
13.5
9.7
16
12
34408
ICD-8 Finland
Other cerebral paralysis, Alia definita
55.4
9.6
11
*
IEY01
NOMESCO Finland
Psychoeducation, individual
7.9
9.6
21
27
W0A12
NOMESCO Finland
Planned therapy visit for psychiatric disease
11.5
9.6
17
15
B18.2
ICD-10 Finland
Chronic viral hepatitis C
6.1
9.5
25
42
ZXY80
NOMESCO Finland
Doctor in multidisciplinary team
9.2
9.5
19
21
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
9.5
206
1329
G44.2
ICD-10 Finland
Tension-type headache
2.5
9.5
78
337
D01
ICPC
Abdominal pain/cramps general
2.2
9.4
106
534
S10
ICPC
Boil/carbuncle
3.6
9.4
41
117
30920
ICD-8 Finland
Mental disorders not specified as psychotic associated with physical conditions, Brain trauma
100.6
9.4
10
*
F91.0
ICD-10 Finland
Conduct disorder confined to the family context
+∞
9.4
9
*
F43.1
ICD-10 Finland
Post-traumatic stress disorder
4.4
9.3
33
78
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
9.3
49
162
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
9.3
107
544
SPAT1307
SPAT
Psychosocial counselling and guidance
2.3
9.3
90
424
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
9.3
181
1123
X78
ICD-10 Finland
Intentional self-harm by sharp object
10.8
9.3
17
16
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
6.5
9.3
23
36
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
4.6
9.2
31
70
ZY000
NOMESCO Finland
Hospital inpatient
5.4
9.1
26
49
F80.2
ICD-10 Finland
Receptive language disorder
5.7
9.1
25
45
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
7.1
9.0
21
30
ICC03
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric ward
15.7
9.0
14
9
W0A10
NOMESCO Finland
Mapping of psychosocial situation
15.7
9.0
14
9
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
10.1
9.0
17
17
K08.3
ICD-10 Finland
Retained dental root
3.7
9.0
38
106
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
8.9
118
634
ZXE00
NOMESCO Finland
One hour or less
1.7
8.9
237
1616
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
8.9
104
530
3153X
ICD-9 Finland
Specific delays in development, Developmental speech or language disorder[PUHEEN KEHITYKSEN ERITYISVAIKEUS]
24.2
8.9
12
5
J01DB01
ATC
cefalexin; oral
1.7
8.9
487
4074
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
5.0
8.8
27
55
N06AX26
ATC
vortioxetine; oral
2.8
8.8
55
203
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.6
8.8
38
108
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
3.6
8.8
38
108
N03AE01
ATC
clonazepam; systemic
3.9
8.8
35
93
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
6.0
8.8
23
39
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
8.8
109
571
SPAT1389
SPAT
Visit based on need for special support
2.5
8.7
69
294
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
3.0
8.7
49
168
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.6
8.6
64
260
ZXY02
NOMESCO Finland
Neuropsychologist
16.4
8.5
13
8
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
9.1
8.5
17
19
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
5.2
8.5
25
49
A46
ICD-10 Finland
Erysipelas
3.1
8.5
46
156
F10.25
ICD-10 Finland
Alcohol dependence continuous use
7.4
8.4
19
26
R4170
NOMESCO Finland
Therapy forms involving educational rehabilitation
90.4
8.4
9
*
N02BE01
ATC
paracetamol; systemic, rectal
1.6
8.4
403
3220
WX290
NOMESCO Finland
Other blockade of nerve
1.6
8.4
330
2498
ZXY81
NOMESCO Finland
Psychologist in multidisciplinary team
12.9
8.4
14
11
L12
ICPC
Hand/finger symptom/complaint
2.0
8.4
114
621
F98.2
ICD-10 Finland
Feeding disorder of infancy and childhood
+∞
8.3
8
*
F91.8
ICD-10 Finland
Other conduct disorders
+∞
8.3
8
*
R1270
NOMESCO Finland
Evaluation of the need for educational rehabilitation
+∞
8.3
8
*
T90.5
ICD-10 Finland
Sequelae of intracranial injury
8.6
8.3
17
20
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
8.3
94
474
F19.20
ICD-10 Finland
Addiction relationship caused by several drugs in combination and by other psychoactive substances currently independent
10.8
8.3
15
14
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
8.2
68
295
N05BA06
ATC
lorazepam; systemic, sublingual
4.2
8.2
30
74
TKC20
NOMESCO Finland
Catheterisation of bladder
4.2
8.2
30
74
A03
ICPC
Fever
1.7
8.2
181
1165
M79.6
ICD-10 Finland
Pain in limb
1.8
8.2
162
1007
P03
ICPC
Feeling depressed
2.1
8.2
101
526
Z71.8
ICD-10 Finland
Other specified counselling
1.8
8.2
157
964
N06AA06
ATC
trimipramine; systemic
7.6
8.1
18
24
Y07
ICD-10 Finland
Other maltreatment
8.2
8.1
17
21
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.6
8.1
352
2727
3094A
ICD-9 Finland
Adjustment reaction, With mixed disturbance of emotions and conduct
33.5
8.1
10
*
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
6.9
8.1
19
28
F12.1
ICD-10 Finland
Mental and behavioural disorders due to use of cannabinoids, harmful use
6.9
8.1
19
28
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.1
8.0
24
48
F41.1
ICD-10 Finland
Generalized anxiety disorder
2.7
8.0
52
199
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
7.8
7.9
17
22
IEY08
NOMESCO Finland
Psychiatric coaching, domestic and community skills
13.1
7.9
13
10
F32
ICD-10 Finland
Depressive episode
2.9
7.8
47
171
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.0
7.8
110
607
R05
ICD-10 Finland
Cough
1.9
7.8
113
628
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.6
7.7
57
234
F80.1
ICD-10 Finland
Expressive language disorder
4.3
7.7
27
64
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
7.7
222
1536
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
7.7
209
1423
F80.8
ICD-10 Finland
Other developmental disorders of speech and language
7.5
7.7
17
23
RS310
NOMESCO Finland
NA
18.5
7.6
11
6
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
6.8
7.6
18
27
L03
ICPC
Low back symptom/complaint
1.9
7.6
130
767
F32.1
ICD-10 Finland
Moderate depressive episode
2.6
7.6
52
205
N06AX05
ATC
trazodone; oral
5.2
7.5
22
43
E66.8
ICD-10 Finland
Other obesity
3.5
7.5
34
101
K85
ICPC
Elevated blood pressure
3.5
7.5
34
101
F10.09
ICD-10 Finland
Alcohol intoxication UNS
4.4
7.5
26
61
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.5
93
487
N05CF02
ATC
zolpidem; oral
2.2
7.5
73
344
P23
ICPC
Adolescent behaviour sympt/compl
7.2
7.5
17
24
RS220
NOMESCO Finland
NA
4.3
7.4
26
62
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
7.4
37
119
RT260
NOMESCO Finland
NA
80.3
7.4
8
*
N06AB08
ATC
fluvoxamine; oral
7.7
7.4
16
21
G47.9
ICD-10 Finland
Sleep disorder, unspecified
5.6
7.4
20
36
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
7.4
103
566
R21
ICPC
Throat symptom/complaint
1.7
7.3
211
1454
R41.0
ICD-10 Finland
Disorientation, unspecified
8.4
7.3
15
18
F15.1
ICD-10 Finland
Mental and behavioural disorders due to use of other stimulants, including caffeine, harmful use
8.4
7.3
15
18
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
+∞
7.3
7
*
30088
ICD-8 Finland
Neuroses, Other
+∞
7.3
7
*
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
+∞
7.3
7
*
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
5.0
7.3
22
45
F11.22
ICD-10 Finland
Addiction-induced dependence is currently independent but uses substitute intermittent medication
9.4
7.3
14
15
F33.8
ICD-10 Finland
Other recurrent depressive disorders
9.4
7.3
14
15
WX002
NOMESCO Finland
Sedation and analgesia
2.2
7.3
74
356
K04.08
ICD-10 Finland
Other specified pulpit
2.5
7.2
56
235
Z72.0
ICD-10 Finland
Tobacco use
6.3
7.2
18
29
R03AC02
ATC
salbutamol; inhalant
1.6
7.2
325
2511
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.7
7.2
176
1159
R42
ICD-10 Finland
Dizziness and giddiness
2.2
7.2
74
360
WX110
SPAT
NA
2.8
7.1
45
167
K10.3
ICD-10 Finland
Alveolitis of jaws
3.2
7.1
36
117
AA1AD
NOMESCO Finland
CT of head and brain
2.1
7.1
76
375
ZXY49
NOMESCO Finland
Other health care provider
8.0
7.1
15
19
P22
ICPC
Child behaviour symptom/complaint
3.2
7.1
35
112
U07
ICPC
Urine symptom/complaint other
4.1
7.1
26
65
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.8
7.1
28
75
Z72.8
ICD-10 Finland
Other problems related to lifestyle
12.1
7.1
12
10
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
12.1
7.1
12
10
IBC98
NOMESCO Finland
Other child protection assessment
12.1
7.1
12
10
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
7.0
95
514
Z00.0
ICD-10 Finland
General medical examination
1.8
7.0
121
714
F98.00
ICD-10 Finland
Nonorganic enuresis nocturna
10.1
7.0
13
13
S20
ICPC
Corn/callosity
10.1
7.0
13
13
ZXY03
NOMESCO Finland
Occupational therapist
10.1
7.0
13
13
A10BA02
ATC
metformin; oral
2.4
7.0
60
265
I10
ICD-10 Finland
Essential (primary) hypertension
2.0
7.0
95
517
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.6
7.0
51
207
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.7
6.9
45
172
N06AX03
ATC
mianserin; oral
5.2
6.9
20
39
L01
ICPC
Neck symptom/complaint
2.1
6.9
76
377
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
2.1
6.9
78
391
S18
ICPC
Laceration/cut
1.6
6.9
190
1292
S00.0
ICD-10 Finland
Superficial injury of scalp
5.9
6.9
18
31
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
3.0
6.9
39
135
F19.29
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances UNS
7.6
6.9
15
20
N03AX12
ATC
gabapentin; oral
2.4
6.9
59
260
RS312
NOMESCO Finland
NA
13.8
6.9
11
8
A06AD11
ATC
lactulose; oral
2.7
6.8
45
174
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
6.8
73
357
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.8
6.8
129
787
R4110
NOMESCO Finland
Physiotherapy
1.8
6.7
136
845
XA820
NOMESCO Finland
NA
16.8
6.7
10
6
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.7
6.7
43
163
R62.0
ICD-10 Finland
Delayed milestone
3.3
6.7
31
95
EBA30
NOMESCO Finland
Excision of root of tooth
3.8
6.7
26
69
D10
ICPC
Vomiting
2.1
6.7
79
407
T83
ICPC
Overweight
5.0
6.7
20
41
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
6.5
6.6
16
25
Z07
ICPC
Education problem
4.1
6.6
24
60
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
6.5
179
1217
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
5.7
6.4
17
30
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.4
139
881
F84.0
ICD-10 Finland
Childhood autism
14.4
6.4
10
7
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
4.9
6.3
19
39
L14
ICPC
Leg/thigh symptom/complaint
2.6
6.3
44
174
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
1.6
6.3
179
1224
K59.09
ICD-10 Finland
Constipation, unspecified
3.1
6.3
33
111
F11.29
ICD-10 Finland
Addiction caused by opiates UNS
11.1
6.3
11
10
R4120
NOMESCO Finland
Occupational therapy
2.6
6.3
42
165
Z63.8
ICD-10 Finland
Other specified problems related to primary support group
18.1
6.2
9
5
L28
ICPC
Limited function/disability (L)
2.5
6.2
47
195
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
6.2
119
723
F95.1
ICD-10 Finland
Chronic motor or vocal tic disorder
+∞
6.2
6
*
F94.1
ICD-10 Finland
Reactive attachment disorder of childhood
+∞
6.2
6
*
SFA40
NOMESCO Finland
Replacement of krone of tooth
2.1
6.2
69
344
F80.9
ICD-10 Finland
Developmental disorder of speech and language, unspecified
4.4
6.2
21
49
Z61.2
ICD-10 Finland
Altered pattern of family relationships in childhood
26.7
6.2
8
*
F95.9
ICD-10 Finland
Tic disorder, unspecified
26.7
6.2
8
*
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
7.1
6.2
14
20
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
4.0
6.2
23
59
SPAT1243
SPAT
Psychiatric/psychological examination
2.6
6.2
41
160
P16
ICPC
Acute alcohol abuse
5.1
6.2
18
36
F22.0
ICD-10 Finland
Delusional disorder
6.3
6.1
15
24
F10.24
ICD-10 Finland
Alcohol depence active use
5.8
6.1
16
28
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.1
6.1
31
102
R06.5
ICD-10 Finland
Mouth breathing
2.3
6.1
55
251
P17
ICPC
Tobacco abuse
7.7
6.1
13
17
L08
ICPC
Shoulder symptom/complaint
2.0
6.1
75
393
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
3.3
6.1
28
86
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
3.9
6.1
23
60
Z03
ICPC
Housing/neighbourhood problem
12.6
6.1
10
8
F05.9
ICD-10 Finland
Delirium, unspecified
12.6
6.1
10
8
WZA90
NOMESCO Finland
Other doctors statement
1.6
6.1
179
1234
F33.1
ICD-10 Finland
Recurrent depressive disorder, current episode moderate
3.4
6.0
27
81
ZXY57
NOMESCO Finland
2-person team, nurse-social worker
10.1
6.0
11
11
F60.6
ICD-10 Finland
Anxious [avoidant] personality disorder
10.1
6.0
11
11
F60.2
ICD-10 Finland
Dissocial personality disorder
10.1
6.0
11
11
F61
ICD-10 Finland
Mixed and other personality disorders
10.1
6.0
11
11
F19.25
ICD-10 Finland
Addiction caused by several drugs in combination and by other psychoactive substances continuously used
10.1
6.0
11
11
R44.0
ICD-10 Finland
Auditory hallucinations
10.1
6.0
11
11

Mortality – FinRegistry

Association

Association between endpoint F5_HYPERKIN and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
F5_HYPERKIN 3.079 [2.45, 3.88] < 0.001
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 133 out of 11270 males with F5_HYPERKIN died.

Mortality risk

Mortality risk for people of age

years, who have F5_HYPERKIN.

N-year risk Females Males
1 No data 0.595%
5 No data 3.574%
10 No data 8.962%
15 No data 15.978%
20 No data 26.045%

Relationships between endpoints

Index endpoint: F5_HYPERKIN – Hyperkinetic disorders (excl. ADHD)

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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