epilepsy: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
212 |
4. Check minimum number of eventsNone |
212 |
5. Include endpointsNone |
212 |
6. Filter based on genotype QC (FinnGen only) |
212 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G405
- Name in latin
- Ictus epileptici ex usu alcohol
Similar endpoints
↥List of similar endpoints to
Epileptic seizures related to alcohol
based on the number of shared cases.
Similar with more cases:
- Epilepsy
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Episodal and paroxysmal disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3694 | 714 | 2952 |
| Only index persons | 2804 | 567 | 2237 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.02 | 0.08 |
| Only index persons | 0.07 | 0.02 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 51.19 | 51.05 | 51.18 |
| Only index persons | 51.40 | 51.11 | 51.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 212 | 44 | 168 |
| Unadjusted period prevalence (%) | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | 51.72 | 47.35 | 52.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 191
- Matched controls
- 1908
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G40.51
ICD-10 Finland
Epileptic seizures related to alcohol
+∞
276.4
191
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
86.4
119.9
133
49
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
45.5
103.0
138
103
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
118.7
66.5
69
9
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
35.3
55.2
72
32
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
27.7
46.0
64
34
G40.9
ICD-10 Finland
Epilepsy, unspecified
31.4
45.6
61
28
P15
ICPC
Chronic alcohol abuse
18.0
36.0
58
45
F10.25
ICD-10 Finland
Alcohol dependence continuous use
24.0
34.1
49
27
AA1AD
NOMESCO Finland
CT of head and brain
7.4
34.1
105
270
F10.20
ICD-10 Finland
Alcohol dependence currently independent
25.2
34.0
48
25
N07BB01
ATC
disulfiram; oral
13.4
30.7
56
57
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
27.1
29.8
41
19
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
32.3
29.8
39
15
N03AX14
ATC
levetiracetam; systemic
25.7
29.4
41
20
F10.09
ICD-10 Finland
Alcohol intoxication UNS
20.0
29.0
44
28
N03AG01
ATC
valproic acid; systemic, rectal
13.2
28.9
53
54
F10.24
ICD-10 Finland
Alcohol depence active use
29.3
28.3
38
16
N03AF01
ATC
carbamazepine; oral, rectal
14.9
27.9
48
42
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
27.5
27.9
38
17
N05BA01
ATC
diazepam; systemic, rectal
8.6
26.9
64
105
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
31.5
25.9
34
13
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
5.4
25.2
102
335
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
54.3
24.1
28
6
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
22.7
23.6
34
18
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
23.2
23.1
33
17
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
52.0
23.0
27
6
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
26.1
22.6
31
14
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
91.1
22.2
24
*
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
39.0
21.8
27
8
T36
ICD-10 Finland
Poisoning by systemic antibiotics
12.6
21.4
39
38
N05BA02
ATC
chlordiazepoxide; systemic
18.1
20.6
32
21
G41.9
ICD-10 Finland
Status epilepticus, unspecified
117.3
20.0
21
*
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
25.9
18.3
25
11
N03AF02
ATC
oxcarbazepine; oral
17.0
17.8
28
19
W19
ICD-10 Finland
Unspecified fall
7.7
17.8
43
69
P16
ICPC
Acute alcohol abuse
19.8
17.5
26
15
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.0
17.3
63
170
S06.0
ICD-10 Finland
Concussion
7.4
17.2
43
72
F10.06
ICD-10 Finland
Alcohol-related acute intoxication with seizures
69.9
17.1
19
*
S01.0
ICD-10 Finland
Open wound of scalp
6.7
17.1
46
86
N06AX11
ATC
mirtazapine; oral
3.9
16.7
91
359
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
14.1
16.5
28
23
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
11.6
16.1
30
30
N03AB02
ATC
phenytoin; systemic
26.0
15.5
21
9
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
11.9
15.3
28
27
G40
ICD-10 Finland
Epilepsy
46.4
14.4
17
*
N05CF01
ATC
zopiclone; oral
3.5
14.2
86
358
Z72.1
ICD-10 Finland
Alcohol use
24.7
13.2
18
8
N05AB01
ATC
dixyrazine; systemic
24.7
13.2
18
8
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
15.6
13.1
21
15
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
15.8
12.6
20
14
A98
ICPC
Health maint/preventive medicine
0.3
12.4
131
1705
K70.1
ICD-10 Finland
Alcoholic hepatitis
32.3
11.8
15
5
N05AH04
ATC
quetiapine; oral
3.9
11.7
54
176
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
+∞
11.6
11
*
G72.8
ICD-10 Finland
Other specified myopathies
26.9
11.3
15
6
N05CD07
ATC
temazepam; oral
4.8
11.3
39
96
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
14.1
10.9
18
14
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
30.0
10.9
14
5
N06AB04
ATC
citalopram; systemic
3.4
10.8
61
232
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
116.1
10.5
11
*
R41.0
ICD-10 Finland
Disorientation, unspecified
12.3
10.3
18
16
N05AA02
ATC
levomepromazine; systemic
6.7
10.3
26
44
X59
ICD-10 Finland
Exposure to unspecified factor
3.3
10.2
61
240
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
16.1
9.7
15
10
S06.3
ICD-10 Finland
Focal brain injury
16.1
9.7
15
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
9.7
55
207
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
31.8
9.5
12
*
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
10.3
9.5
18
19
R53
ICD-10 Finland
Malaise and fatigue
3.5
9.5
47
161
V03AA01
ATC
NA
8.1
9.2
20
27
Y04.9
ICD-10 Finland
Assault by bodily force by unknown person
19.8
9.1
13
7
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
13.4
9.0
15
12
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
10.2
9.0
17
18
C07AA05
ATC
propranolol; systemic
3.4
8.8
47
168
S62.3
ICD-10 Finland
Fracture of other metacarpal bone
10.8
8.7
16
16
E87.6
ICD-10 Finland
Hypokalaemia
8.0
8.7
19
26
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.7
8.7
39
123
T90.5
ICD-10 Finland
Sequelae of intracranial injury
21.2
8.6
12
6
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
29.0
8.6
11
*
G40.50
ICD-10 Finland
Epilepsia partialis continua [Kozhevnikof]
+∞
8.4
8
*
S42.2
ICD-10 Finland
Fracture of upper end of humerus
9.6
8.2
16
18
WX730
NOMESCO Finland
Conventional respirator
11.5
7.9
14
13
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
7.9
58
256
G40.6
ICD-10 Finland
Grand mal seizures, unspecified (with or without petit mal)
46.9
7.8
9
*
K29.2
ICD-10 Finland
Alcoholic gastritis
46.9
7.8
9
*
183
Kela drug reimbursment
Lamotrigin and topiramate
19.3
7.7
11
6
F05.9
ICD-10 Finland
Delirium, unspecified
10.7
7.7
14
14
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
26.2
7.7
10
*
G41.0
ICD-10 Finland
Grand mal status epilepticus
83.2
7.5
8
*
N07
ICPC
Convulsion/seizure
83.2
7.5
8
*
F10.05
ICD-10 Finland
Alcohol-related acute intoxication with coma
83.2
7.5
8
*
NA1AD
NOMESCO Finland
Cervical spine CT examination
7.8
7.4
16
22
G40.89
ICD-10 Finland
Other epilepsy
+∞
7.3
7
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
+∞
7.3
7
*
N88
ICPC
Epilepsy
31.3
7.2
9
*
N06AX16
ATC
venlafaxine; oral
3.5
7.2
34
112
W10
ICD-10 Finland
Fall on and from stairs and steps
6.3
7.1
18
31
N06AB03
ATC
fluoxetine; oral
3.7
7.0
31
96
N05BA04
ATC
oxazepam; oral
2.7
7.0
56
258
K70.0
ICD-10 Finland
Alcoholic fatty liver
17.5
6.8
10
6
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.4
6.8
24
61
C03CA01
ATC
furosemide; systemic
2.5
6.7
57
273
R55
ICD-10 Finland
Syncope and collapse
3.6
6.5
29
91
SPAT1227
SPAT
Substance abuse rehabilitation
15.0
6.5
10
7
N05AD03
ATC
melperone; systemic
15.0
6.5
10
7
G40.59
ICD-10 Finland
Other special epileptic syndromes
72.2
6.5
7
*
N03AE01
ATC
clonazepam; systemic
5.2
6.4
19
40
R40.2
ICD-10 Finland
Coma, unspecified
9.8
6.4
12
13
SPAT1265
SPAT
Breathalyser
18.8
6.3
9
5
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
13.1
6.2
10
8
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
9.1
6.2
12
14
S00.0
ICD-10 Finland
Superficial injury of scalp
10.5
6.1
11
11
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
6.1
33
118
Mortality – FinRegistry
↥Association
Association between endpoint EPISEIZALCO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 9.296 [7.52, 11.49] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.38 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 611 females with EPISEIZALCO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 6.956 [6.12, 7.91] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1235 out of 2499 males with EPISEIZALCO died.
Mortality risk
Mortality risk for people of age
years, who have EPISEIZALCO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.35% | 1.289% |
| 5 | 5.042% | 6.949% |
| 10 | 12.988% | 16.759% |
| 15 | 22.412% | 29.851% |
| 20 | 38.968% | 47.135% |
Relationships between endpoints
↥Index endpoint: EPISEIZALCO – Epileptic seizures related to alcohol
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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