info icon

This is a non-core endpoint: only basic statistics are computed.

Iodine-deficiency-related thyroid disorders and allied conditions

E4_IODTHYR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E01.8
  • Cause of death: ICD-10 E01.8

2 out of 7 registries used, show all original rules.

36

4. Check minimum number of events

None

36

5. Include endpoints

None

36

6. Filter based on genotype QC (FinnGen only)

36

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E01
Name in latin
Aliae morbositates glandulae thyreoideae ex deficientia iodi et status cognati

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 284 217 65
Only index persons 220 176 44
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 65.85 65.17 67.92
Only index persons 59.04 60.79 52.06

-FinnGen-

Key figures

All Female Male
Number of individuals 36 30 6
Unadjusted period prevalence (%) 0.01 0.01 0.00
Median age at first event (years) 56.43 53.67 70.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
19
85
3.62
3.49
2.4
2.1
u/l
49.3
49.4
0.01
19
77
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
8
15
6.51
3.41
6.5
6.4
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
22
121
3.10
2.70
2.2
1.7
pmol/l
99.8
98.4
0.06
11
48
(3019060) Gas panel - Arterial blood
9
28
3.93
2.52
5.2
3.0
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
21
120
2.80
2.30
3.7
2.2
ug/l
96.8
106.5
0.13
21
110
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
6
14
4.91
2.25
2.0
2.1
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
14
65
2.89
2.24
2.3
1.7
nmol/l
1136.8
1315.2
0.51
14
47
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
30
214
3.40
2.20
8.4
2.7
pmol/l
15.8
14.6
2.88
30
188
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
15
73
2.81
2.20
1.8
1.9
pmol/l
456.1
501.1
0.22
15
58
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
6
16
4.27
2.03
1.2
1.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
17
96
2.46
1.80
5.4
5.0
—
—
—
0
0
(4010399)
7
25
3.22
1.75
1.9
1.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
6
20
3.38
1.66
1.2
1.2
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
16
92
2.33
1.59
1.9
1.7
mmol/l
1.3
1.4
0.09
16
79
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
0
38
0.00
1.44
0.0
4.1
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
21
142
2.15
1.36
9.4
5.5
%
2.6
2.5
0.04
21
132
(3037467) Urinalysis macro (dipstick) panel - Urine
27
206
2.24
1.30
9.6
4.5
—
—
—
0
0
(3019069) Monocytes/100 leukocytes in Blood
21
144
2.10
1.29
10.3
5.7
%
7.9
8.3
0.28
21
134
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
8
38
2.41
1.28
1.1
1.5
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
21
145
2.08
1.26
10.9
5.4
%
60.3
57.6
0.51
21
136
(3020779) Urea [Moles/volume] in Serum or Plasma
5
19
2.88
1.26
3.8
5.9
mmol/l
10.7
11.3
—
5
19
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
19
2.88
1.26
1.4
1.3
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
8
39
2.35
1.25
1.1
1.6
—
—
—
0
0
(3019225) pH of Specimen
7
31
2.55
1.18
7.3
3.4
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
20
138
2.01
1.18
8.3
5.6
%
0.7
0.6
0.10
20
126
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
10
53
2.23
1.15
1.2
1.6
—
—
—
0
0
(3002030) Lymphocytes/100 leukocytes in Blood
21
149
1.98
1.13
9.5
5.6
%
27.3
27.7
0.06
21
136
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
7
34
2.31
1.10
2.0
3.4
u/l
175.0
250.0
—
7
29
(40761536) Microorganisms panel - Urine sediment
0
28
0.00
1.03
0.0
4.9
—
—
—
0
0
(3004789) Transferrin [Mass/volume] in Serum or Plasma
8
47
1.90
0.88
2.4
1.9
g/l
2.5
2.4
—
8
40
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
0
27
0.00
0.81
0.0
3.3
—
74.7
—
0
9
(3004588) Protein electrophoresis panel - Serum or Plasma
5
25
2.16
0.76
1.4
1.5
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
5
25
2.16
0.76
1.4
4.1
u/ml
20.6
71.5
—
5
25
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
22
174
1.68
0.70
2.9
2.7
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
7
44
1.73
0.70
1.3
1.5
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
26
216
1.73
0.68
9.4
5.1
—
467.3
—
0
8
(1761868) Lipid panel - Serum or Plasma
6
99
0.53
0.63
2.0
2.8
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
18
138
1.61
0.63
6.3
4.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
15
110
1.62
0.62
5.7
2.9
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
20
0.00
0.62
0.0
1.4
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
0
19
0.00
0.62
0.0
4.6
—
25.7
—
0
19
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
0
19
0.00
0.62
0.0
6.4
—
1.5
—
0
19
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
0
19
0.00
0.62
0.0
6.4
—
0.9
—
0
19
(3007853) Bacteria identified in Skin by Aerobe culture
6
35
1.85
0.61
1.3
1.4
—
—
—
0
0
(3022621) pH of Urine by Test strip
0
23
0.00
0.60
0.0
2.4
—
—
—
0
0
(3022145) Colonoscopy Study observation
6
36
1.80
0.60
1.3
1.2
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
31
276
1.88
0.53
10.1
3.5
mu/l
1.6
1.9
1.26
31
245
(3022948) Iron [Moles/volume] in Serum or Plasma
7
49
1.53
0.49
3.0
1.8
umol/l
10.6
12.3
—
7
43
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
28
248
1.58
0.47
12.5
6.8
u/l
91.7
77.9
0.39
28
231
(3044889) 12 lead EKG panel
24
207
1.48
0.43
3.5
3.8
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
15
0.00
0.42
0.0
3.0
—
1.0
—
0
15
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
15
0.00
0.42
0.0
1.3
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
0
17
0.00
0.42
0.0
6.9
—
94.5
—
0
17
(3021879) Hepatitis B virus core Ab [Presence] in Serum
0
18
0.00
0.41
0.0
1.2
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
0
18
0.00
0.41
0.0
3.3
—
0.9
—
0
12
(36304419) Bacteria [Presence] in Urine
6
89
0.61
0.39
5.8
3.2
—
—
—
0
0
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
6
41
1.55
0.38
6.7
4.6
%
33.3
36.5
—
6
20
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
13
103
1.41
0.34
1.6
2.8
ng/l
227.5
1490.0
2.10
13
85
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
7
55
1.34
0.32
1.6
1.3
—
13.4
—
0
25
(40760892) CBC W Ordered Manual Differential panel - Blood
5
73
0.63
0.29
2.6
5.5
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
18
154
1.34
0.29
3.4
4.5
—
0.0
—
0
40
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
5
37
1.41
0.25
5.0
4.7
ug/l
67.2
1.8
—
5
31
(40768797) Stomach Pathology biopsy report
5
38
1.37
0.24
1.0
1.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
40
1.29
0.23
1.2
1.3
—
—
—
0
0
(1616796) Gas panel - Central venous blood
0
11
0.00
0.22
0.0
3.6
—
—
—
0
0
(3020891) Body temperature
0
11
0.00
0.22
0.0
2.8
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
11
0.00
0.22
0.0
4.2
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
11
0.00
0.22
0.0
1.3
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
(3024354) Oxygen [Partial pressure] in Venous blood
0
13
0.00
0.21
0.0
3.1
—
3.8
—
0
13
(3011397) Hemoglobin [Presence] in Urine by Test strip
8
67
1.25
0.18
3.3
3.6
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
11
128
0.80
0.17
3.0
4.5
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
8
96
0.79
0.16
3.5
4.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
8
95
0.80
0.16
3.5
2.1
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
10
87
1.21
0.11
3.6
3.7
—
—
—
0
0
(40758558) Short blood count panel - Blood
10
87
1.21
0.11
8.5
7.0
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
14
127
1.17
0.10
3.2
4.3
ng/l
15.6
31.0
—
7
94
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
31
299
1.26
0.09
6.7
5.3
mmol/l
2.5
2.7
0.55
31
267
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
60
0.81
0.09
2.0
1.2
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
10
112
0.85
0.08
4.6
3.2
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
30
291
1.19
0.08
5.8
4.6
mmol/l
1.5
1.6
0.23
30
260
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
27
278
0.89
0.08
4.5
4.1
mmol/l
1.1
1.2
0.54
27
244
(3009542) Hematocrit [Volume Fraction] of Blood
26
259
1.01
0.00
29.9
14.0
%
34.9
38.7
0.53
16
177
(40768804) Tissue Pathology biopsy report
13
127
1.04
0.00
1.7
1.8
—
—
—
0
0
(3015736) pH of Urine
11
115
0.94
0.00
2.9
4.3
—
—
—
0
0
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
0.00
0.0
5.6
—
—
—
0
0
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.2
—
108.8
—
0
5
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
5
0.00
0.00
0.0
1.0
—
91.1
—
0
5
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
6
66
0.89
0.00
3.3
1.9
—
—
—
0
0
(3026782) Osmolality of Urine
6
65
0.91
0.00
3.2
2.8
mosm/kgh2o
458.3
524.3
—
6
57
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4268621)
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
0
9
0.00
0.00
0.0
2.7
—
156.2
—
0
9
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.7
—
1.3
—
0
6
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
9
0.00
0.00
0.0
2.7
—
4.9
—
0
9
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
282.4
—
0
7
(3044290) Cell count panel - Cerebral spinal fluid
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
0
7
0.00
0.00
0.0
3.6
—
37.8
—
0
7
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
0
7
0.00
0.00
0.0
3.1
—
0.6
—
0
7
(3014051) Protein [Presence] in Urine by Test strip
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
0
7
0.00
0.00
0.0
1.9
—
7.0
—
0
7
(40768795) Lymph node Pathology biopsy report
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
9
0.00
0.00
0.0
4.4
—
119.1
—
0
9
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
0
7
0.00
0.00
0.0
4.3
—
66.4
—
0
7
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
0
9
0.00
0.00
0.0
1.7
—
3.3
—
0
9
(1761482) Bacteria [#/volume] in Urine by Culture
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
0
6
0.00
0.00
0.0
5.3
—
—
—
0
0
(3013512) EKG study
9
91
0.99
0.00
5.6
4.3
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
30
293
1.14
0.00
5.5
4.7
mmol/l
4.5
4.6
0.36
30
263
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
0
8
0.00
0.00
0.0
1.6
—
100.8
—
0
8
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(4034850)
0
9
0.00
0.00
0.0
26.9
—
—
—
0
0
(4281824)
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
0
9
0.00
0.00
0.0
2.7
—
7.8
—
0
9
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
29
288
1.04
0.00
7.5
5.9
mmol/mol
38.4
40.2
1.38
29
265
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
0
7
0.00
0.00
0.0
3.1
—
0.7
—
0
7
(3021901) Oxygen saturation in Capillary blood
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.7
—
7.5
—
0
6
(1617658) Protocol used for examination of sentinel lymph nodes
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint E4_IODTHYR and mortality.

Females

Parameter HR [95% CI] p-value
E4_IODTHYR 1.831 [1.35, 2.48] < 0.001
Birth year 0.993 [0.98, 1.0] 0.117

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 194 females with E4_IODTHYR died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_IODTHYR.

N-year risk Females Males
1 0.144% No data
5 0.997% No data
10 2.579% No data
15 4.928% No data
20 8.476% No data

Relationships between endpoints

Index endpoint: E4_IODTHYR – Iodine-deficiency-related thyroid disorders and allied conditions

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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