endocrine system disease: A disease involving the endocrine system.
Disorders of endocrine glands in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
E4_ENDINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
64 |
4. Check minimum number of eventsNone |
64 |
5. Include endpointsNone |
64 |
6. Filter based on genotype QC (FinnGen only) |
64 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Morbositates glandularum endocrinarum in morbis alibi classificatis
Similar endpoints
↥List of similar endpoints to
Disorders of endocrine glands in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other endocrine disorders
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 359 | 201 | 156 |
| Only index persons | 303 | 172 | 131 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 48.72 | 48.00 | 49.57 |
| Only index persons | 47.76 | 46.75 | 49.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 64 | 35 | 29 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 48.06 | 51.56 | 43.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 57
- Matched controls
- 571
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H01AC01
ATC
somatropin; parenteral
236.5
17.5
17
*
H02AB09
ATC
hydrocortisone; systemic
29.2
15.7
21
11
E35.8
ICD-10 Finland
Disorders of other endocrine glands in diseases classified elsewhere
+∞
11.9
11
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
18.1
11.7
18
14
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
36.2
11.4
14
5
ZX120
NOMESCO Finland
Intravenous
10.0
9.7
20
29
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
8.5
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
26.7
8.4
11
5
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
52.5
8.0
9
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.8
7.8
21
45
301
Kela drug reimbursment
Growth hormone
91.5
7.6
8
*
L04AX01
ATC
azathioprine; systemic
11.2
7.6
14
16
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
19.0
7.6
11
7
A11CC03
ATC
alfacalcidol; systemic
19.0
7.6
11
7
127
Kela drug reimbursment
Transplant complication
14.8
7.5
12
10
E35.0
ICD-10 Finland
Disorders of thyroid gland in diseases classified elsewhere
+∞
7.4
7
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.3
7.3
15
21
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
16.6
7.2
11
8
RD210
NOMESCO Finland
NA
19.8
7.0
10
6
A12AA04
ATC
calcium carbonate; oral
45.6
6.9
8
*
602
Kela drug reimbursment
Children's severe malnutrition
14.8
6.9
11
9
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.3
6.8
19
42
K00.40
ICD-10 Finland
Postnatal enamel hypoplasia
16.9
6.7
10
7
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
78.3
6.6
7
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
6.7
6.6
17
34
E35.1
ICD-10 Finland
Disorders of adrenal glands in diseases classified elsewhere
+∞
6.4
6
*
186
Kela drug reimbursment
Growth retardation associated with renal failure (growth hormone)
+∞
6.4
6
*
E34.39
ICD-10 Finland
Short stature, not elsewhere classified
+∞
6.4
6
*
E34.35
ICD-10 Finland
Abnormal growth retardation
+∞
6.4
6
*
D35.0
ICD-10 Finland
Benign neoplasm: Adrenal gland
+∞
6.4
6
*
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
+∞
6.4
6
*
7143C
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[POLYARTHRITIS JUVENILIS SERONEGATIVA]
+∞
6.4
6
*
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
9.8
6.2
12
15
H02AB04
ATC
methylprednisolone; systemic
6.1
6.1
17
37
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.3
6.1
20
53
ZXE20
NOMESCO Finland
More than three and less than five hours
5.3
6.1
20
53
WX408
NOMESCO Finland
General anesthesy, balanced
4.3
6.1
28
105
I35.0
ICD-10 Finland
Aortic (valve) stenosis
13.1
6.1
10
9
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma
23
38
8.89
14.56
13.6
4.6
ng/l
111.7
55.2
0.60
23
33
(3009214) Lutropin [Units/volume] in Serum or Plasma
12
18
7.97
7.91
2.8
1.8
u/l
5.4
8.2
0.37
12
13
(3023323) Follitropin [Units/volume] in Serum or Plasma
11
16
8.09
7.40
2.8
1.9
iu/l
17.2
13.9
—
11
10
(3025159) Blasts/100 leukocytes in Blood
14
29
5.90
6.82
7.9
5.6
%
0.0
0.8
—
5
10
(3023368) Bacteria identified in Blood by Culture
28
105
3.96
6.61
6.9
5.1
—
—
—
0
0
(3002179) Metamyelocytes/100 leukocytes in Blood
14
30
5.69
6.57
5.4
4.8
%
0.0
0.4
—
5
8
(3037121) Protein [Mass/volume] in Urine
12
22
6.48
6.57
9.0
11.3
g/l
0.3
0.5
0.21
12
14
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
11
19
6.78
6.34
3.6
1.4
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
11
19
6.78
6.34
3.7
5.6
%
96.7
99.2
0.12
11
19
(3017181) Myelocytes/100 leukocytes in Blood
14
31
5.50
6.34
8.8
5.3
%
0.3
0.5
—
6
11
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
11
20
6.43
6.04
3.8
1.4
—
—
—
0
0
(40758558) Short blood count panel - Blood
32
143
3.48
5.65
11.8
9.0
—
—
—
0
0
(3021440) Promyelocytes/100 leukocytes in Blood
13
30
5.18
5.59
8.2
5.5
%
0.0
0.0
—
6
11
(3003458) Phosphate [Moles/volume] in Serum or Plasma
22
78
3.77
5.50
42.1
7.3
mmol/l
1.2
1.2
0.36
22
71
(3006245) CD3-CD19+ cells/100 cells in Blood
9
8
12.82
5.48
1.9
5.9
%
8.6
8.1
—
9
8
(3022313) Gas panel - Capillary blood
15
40
4.59
5.46
37.7
7.2
—
—
—
0
0
(3012544) pH of Venous blood
20
67
3.89
5.41
24.9
9.0
—
—
—
0
0
(3026782) Osmolality of Urine
23
86
3.61
5.30
7.8
3.0
mosm/kgh2o
565.3
573.2
0.06
23
72
(3032080) INR in Blood by Coagulation assay
34
168
3.18
4.94
15.3
7.4
inr
1.3
1.3
—
8
50
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
8
7
12.81
4.93
1.3
1.3
—
—
—
0
0
(3035637) Corticotropin [Mass/volume] in Plasma
9
11
9.30
4.73
2.4
1.3
—
—
—
0
0
(44806118)
7
5
15.46
4.69
1.6
2.4
—
—
—
0
0
(44790047)
7
5
15.46
4.69
1.6
2.4
—
—
—
0
0
(44790049)
7
5
15.46
4.69
1.6
2.4
—
—
—
0
0
(44790048)
7
5
15.46
4.69
1.6
2.4
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
43
249
3.22
4.66
23.1
7.4
%
0.7
0.7
0.01
43
230
(3030905) Polymorphonuclear cells [#/volume] in Blood
8
8
11.20
4.66
3.3
4.3
e9/l
3.7
3.2
—
8
8
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
8
8
11.20
4.66
3.1
4.3
%
51.6
51.1
—
8
8
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
26
113
3.19
4.64
4.0
2.4
—
—
—
0
0
(3000991) Gas panel - Venous blood
17
57
3.70
4.53
29.5
10.4
—
—
—
0
0
(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay
9
12
8.51
4.52
1.9
1.3
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
15
46
3.95
4.52
3.7
1.9
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
43
253
3.13
4.46
23.2
7.4
%
3.0
2.8
0.15
43
234
(42870588) Differential panel, method unspecified - Blood
36
192
3.00
4.46
18.7
7.7
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
7
6
12.87
4.38
1.7
1.2
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
7
6
12.87
4.38
73.7
3.7
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
16
53
3.69
4.33
2.1
2.2
—
—
—
0
0
(3019069) Monocytes/100 leukocytes in Blood
43
256
3.07
4.31
24.3
7.6
%
9.0
8.6
0.54
43
239
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
15
48
3.78
4.25
48.4
7.1
kpa
4.8
4.8
0.04
15
42
(3018010) Neutrophils/100 leukocytes in Blood
43
258
3.03
4.22
21.5
7.4
%
54.7
53.9
0.16
43
243
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
22
92
3.12
4.13
5.5
3.5
e6/l
1.4
0.7
0.40
17
55
(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
7
7
11.02
4.11
2.4
5.9
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
25
114
2.96
4.03
13.3
3.2
kg/l
1.0
1.0
—
8
19
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
32
167
2.83
4.02
17.0
3.8
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
11
29
4.37
3.99
10.3
4.7
mmol/l
1.2
1.2
0.02
11
22
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
8
11
8.12
3.99
2.6
1.6
—
—
—
0
0
(3028626) Oxygen [Partial pressure] in Capillary blood
12
34
4.11
3.99
59.3
8.5
kpa
10.5
9.8
0.82
12
29
(3015736) pH of Urine
34
184
2.81
3.98
12.9
3.4
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
9
15
6.78
3.97
4.6
6.2
%
170.6
160.8
—
9
15
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
14
45
3.70
3.93
3.8
1.9
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
30
153
2.81
3.92
9.3
3.5
u/l
27.4
28.1
0.13
30
142
(3035350) Ketones [Presence] in Urine by Test strip
39
228
2.82
3.92
13.1
3.6
estimate
0.0
0.0
—
9
33
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
21
88
3.06
3.91
5.9
3.7
e6/l
8.0
1.2
0.77
16
51
(1175426) CD3 cells/100 lymphocytes in Blood
7
8
9.64
3.87
2.4
5.3
%
79.3
77.3
—
7
8
(3021601) Nitrite [Presence] in Urine by Test strip
39
229
2.80
3.87
16.1
5.1
estimate
0.0
0.0
—
9
34
(3002030) Lymphocytes/100 leukocytes in Blood
43
266
2.88
3.85
23.7
7.5
%
29.3
31.4
0.55
43
250
(3045462) Protein/Creatinine [Ratio] in Urine
6
5
13.03
3.84
4.5
28.4
g/mol
65.0
176.3
—
6
5
(3009261) Glucose [Presence] in Urine by Test strip
39
230
2.78
3.82
13.1
3.6
estimate
0.0
0.0
—
8
32
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
18
70
3.19
3.78
3.3
1.9
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
26
125
2.82
3.77
5.2
3.3
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
15
52
3.46
3.76
31.9
13.9
mmol/l
24.1
25.0
0.63
15
52
(3012095) Magnesium [Moles/volume] in Serum or Plasma
18
71
3.14
3.69
25.8
5.5
mmol/l
0.8
0.8
0.19
18
66
(3037467) Urinalysis macro (dipstick) panel - Urine
49
333
3.01
3.54
15.6
4.4
—
—
—
0
0
(4035726)
11
32
3.94
3.51
1.7
1.3
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
22
100
2.83
3.51
20.5
2.9
e6/l
3.9
5.9
0.52
22
91
(3008757) Leukocyte morphology finding [Identifier] in Blood
7
10
7.69
3.46
4.6
6.1
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
33
186
2.60
3.44
21.3
4.2
e6/l
30.2
67.9
0.74
27
128
(3013826) Glucose [Moles/volume] in Serum or Plasma
43
278
2.67
3.34
12.0
5.0
mmol/l
6.2
6.6
0.66
43
261
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
6
7
9.29
3.33
1.5
1.9
—
—
—
0
0
(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood
6
7
9.29
3.33
1.5
6.0
%
29.0
34.1
—
6
7
(3031040) Bacteria [#/volume] in Urine by Automated count
47
318
2.80
3.32
18.6
4.2
e6/l
7.0
112.4
—
6
5
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
7
11
6.98
3.28
1.7
1.8
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
18
76
2.90
3.25
14.8
2.3
umol/l
12.0
12.8
0.27
18
69
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
9
20
5.05
3.25
4.1
1.6
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
23
111
2.67
3.24
6.6
3.3
umol/l
311.0
10175.0
0.76
23
90
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
37
226
2.51
3.19
10.2
6.7
umol/l
8.3
10.7
1.99
37
212
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
50
353
2.90
3.19
17.2
7.1
u/l
101.7
93.3
0.34
50
323
(3007853) Bacteria identified in Skin by Aerobe culture
15
59
3.01
3.05
4.5
1.8
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
8
17
5.21
3.03
3.4
1.3
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
9
22
4.58
3.01
7.8
5.3
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
9
22
4.58
3.01
1.1
1.7
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
9
22
4.58
3.01
1.1
1.7
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
27
146
2.47
2.98
12.3
3.6
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
7
13
5.90
2.95
2.0
1.7
—
—
—
0
0
(1616796) Gas panel - Central venous blood
6
9
7.21
2.93
12.7
3.7
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
9
23
4.37
2.90
2.8
2.2
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
23
118
2.48
2.82
17.0
3.8
estimate
0.0
0.0
—
9
31
(3044640) Blood type and Crossmatch panel - Blood
27
150
2.38
2.78
5.2
2.5
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
8
19
4.65
2.78
1.1
1.6
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
6
10
6.48
2.76
19.7
16.8
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
51
379
2.70
2.67
7.6
3.8
pmol/l
15.3
14.7
1.19
46
333
(3026008) Bacteria identified in Urine by Culture
25
137
2.35
2.63
4.8
2.8
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
6
11
5.89
2.60
2.3
1.7
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
5
7
7.62
2.59
13.4
3.7
kpa
11.5
8.4
—
5
7
(3010421) pH of Blood
5
7
7.62
2.59
13.6
3.9
ph
7.4
7.4
—
5
7
(3013290) Carbon dioxide [Partial pressure] in Blood
5
7
7.62
2.59
13.4
3.7
kpa
4.8
4.9
—
5
7
(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum
5
7
7.62
2.59
1.2
1.7
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
35
224
2.24
2.54
6.0
3.6
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
6
12
5.39
2.46
2.5
3.0
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
5
8
6.66
2.41
1.4
1.5
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
5
9
5.91
2.25
2.4
3.0
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
28
171
2.13
2.21
15.1
3.6
—
—
—
0
0
(3018418) pH of Serum or Plasma
23
130
2.20
2.20
19.8
3.4
ph
7.4
7.4
—
8
18
(3041096) Erythrocytes [Presence] in Urine by Automated
21
115
2.23
2.16
17.8
3.4
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
7
21
3.61
2.03
4.0
1.4
mu/l
397.1
347.3
—
7
21
(40760892) CBC W Ordered Manual Differential panel - Blood
18
95
2.24
2.01
16.5
3.9
—
—
—
0
0
(3014148) Varicella zoster virus Ab [Titer] in Serum
5
11
4.83
1.98
1.0
1.3
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
12
53
2.56
1.95
1.8
1.5
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
7
22
3.44
1.94
1.6
1.3
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
9
35
2.82
1.89
4.2
3.2
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
10
41
2.71
1.86
4.3
1.4
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
5
12
4.42
1.86
1.0
1.2
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
5
12
4.42
1.86
2.8
1.2
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
5
12
4.42
1.86
1.0
1.0
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
6
18
3.56
1.79
1.2
1.3
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
8
31
2.80
1.72
1.1
1.4
—
—
—
0
0
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
5
14
3.78
1.64
1.6
1.3
—
—
—
0
0
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
6
21
3.04
1.54
18.3
11.0
%
0.5
0.7
—
6
21
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
6
22
2.90
1.47
1.0
1.2
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
22
140
1.87
1.46
2.1
1.9
—
—
—
0
0
(3019060) Gas panel - Arterial blood
7
29
2.58
1.44
4.0
2.4
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
40
0.00
1.38
0.0
1.6
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
8
34
2.54
1.35
9.8
4.1
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
8
35
2.47
1.32
1.3
1.7
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
5
18
2.92
1.31
1.0
1.2
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
49
409
1.84
1.23
31.6
12.3
ml/min/173m2
88.6
85.7
0.22
36
315
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
5
20
2.62
1.17
1.8
1.4
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
16
98
1.84
1.17
4.2
2.9
mg/l
76.0
72.2
—
9
57
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
5
21
2.49
1.11
1.2
1.0
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
5
21
2.49
1.11
1.4
1.2
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
17
110
1.74
1.04
8.4
3.0
ng/l
1835.7
1734.0
0.04
17
94
(3020564) Creatinine [Moles/volume] in Serum or Plasma
56
503
1.91
0.98
48.3
15.2
umol/l
94.0
71.6
0.88
56
503
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
36
290
1.55
0.91
9.9
3.1
u/l
51.1
46.5
0.13
36
274
(3020682) Albumin/Creatinine [Ratio] in Urine
16
107
1.66
0.87
5.0
3.6
mg/mmol
16.9
8.9
—
9
60
(3013139) Helicobacter pylori Ag [Presence] in Stool
6
32
1.96
0.84
1.3
1.2
—
—
—
0
0
(3022621) pH of Urine by Test strip
6
33
1.90
0.81
3.3
2.5
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
26
0.00
0.80
0.0
1.3
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
5
25
2.08
0.74
1.2
1.0
—
—
—
0
0
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
5
26
2.00
0.72
5.8
8.0
%
0.6
1.2
—
5
26
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
5
26
2.00
0.72
5.8
8.0
%
0.7
0.7
—
5
26
(40761511) CBC panel - Blood by Automated count
55
500
1.71
0.70
32.9
12.1
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
7
43
1.70
0.69
1.7
1.5
—
—
—
0
0
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
8
50
1.68
0.64
3.3
2.5
u/l
110.6
29.8
—
8
42
(3017143) Hepatitis C virus Ab [Presence] in Serum
10
64
1.67
0.63
2.2
1.6
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
32
373
0.72
0.60
4.3
3.7
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
6
37
1.68
0.57
1.0
1.1
—
—
—
0
0
(4010399)
6
37
1.68
0.57
1.0
1.3
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
10
66
1.61
0.56
1.2
1.2
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
10
143
0.64
0.56
4.3
2.8
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
21
165
1.41
0.54
3.6
3.1
ng/l
23.7
26.8
0.16
15
102
(3000492) Spirometry study
6
40
1.55
0.53
1.2
1.2
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
56
520
1.61
0.51
25.7
10.2
u/l
24.3
25.7
0.22
56
497
(3007164) IgA [Mass/volume] in Serum or Plasma
19
151
1.37
0.45
1.7
1.6
g/l
2.5
2.2
—
9
75
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
12
88
1.45
0.44
1.8
1.8
—
—
—
0
0
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
12
88
1.45
0.44
1.3
1.3
iu/ml
11.2
35.9
—
5
27
(3014133) Dog dander IgE Ab [Units/volume] in Serum
0
15
0.00
0.42
0.0
1.1
—
3.8
—
0
10
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma
0
17
0.00
0.41
0.0
1.8
—
147.4
—
0
5
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
14
108
1.38
0.39
1.8
2.2
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
21
182
1.23
0.26
2.8
2.0
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
7
91
0.74
0.24
1.3
1.8
—
—
—
0
0
(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3050449) Albumin [Mass/time] in Urine collected for unspecified duration
0
10
0.00
0.21
0.0
2.4
—
21.8
—
0
5
(4094501)
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum
0
14
0.00
0.20
0.0
1.1
—
0.6
—
0
9
(3014051) Protein [Presence] in Urine by Test strip
0
14
0.00
0.20
0.0
2.5
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
14
0.00
0.20
0.0
3.1
—
65.9
—
0
14
(3013512) EKG study
14
119
1.23
0.20
5.2
3.9
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
13
150
0.83
0.17
1.5
1.5
—
—
—
0
0
(3044889) 12 lead EKG panel
32
301
1.13
0.13
5.2
3.2
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
18
163
1.15
0.12
1.5
1.8
pmol/l
109.5
100.4
—
6
77
(3009542) Hematocrit [Volume Fraction] of Blood
49
475
1.13
0.10
49.0
15.5
%
35.1
39.7
2.02
37
366
(3035320) C reactive protein [Mass/volume] in Body fluid
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3005988) Vibrio sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
4.8
—
213.0
—
0
5
(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3038026) Centromere Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3012568) Campylobacter sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3025468) Yersinia sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.3
—
11.5
—
0
8
(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay
0
8
0.00
0.00
0.0
1.3
—
102.3
—
0
8
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
5
52
0.96
0.00
5.8
5.4
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3024522) Salmonella sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
7
73
0.95
0.00
1.1
1.2
—
—
—
0
0
(3022145) Colonoscopy Study observation
5
52
0.96
0.00
1.2
1.4
—
—
—
0
0
(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
65
0.92
0.00
1.3
1.4
—
—
—
0
0
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3026285) Alpha 1 antitrypsin [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
1.2
—
0
6
(3045683) HLA typing for celiac disease panel - Blood or Tissue
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4034850)
0
9
0.00
0.00
0.0
4.1
—
—
—
0
0
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
1710.0
—
0
5
(3003985) Beta hydroxybutyrate [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
2.1
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint E4_ENDINOTH and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_ENDINOTH | 2.635 [1.58, 4.39] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 142 males with E4_ENDINOTH died.
Mortality risk
Mortality risk for people of age
years, who have E4_ENDINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.513% |
| 5 | No data | 3.446% |
| 10 | No data | 8.439% |
| 15 | No data | 15.679% |
| 20 | No data | 25.275% |
Relationships between endpoints
↥Index endpoint: E4_ENDINOTH – Disorders of endocrine glands in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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