This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Disorder of amino-acid metabolism, other/unspecified
E4_AMINONAS
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
42 |
4. Check minimum number of eventsNone |
42 |
5. Include endpointsNone |
42 |
6. Filter based on genotype QC (FinnGen only) |
42 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorder of amino-acid metabolism, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of amino-acid metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 457 | 216 | 237 |
| Only index persons | 323 | 153 | 170 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.69 | 61.68 | 55.77 |
| Only index persons | 59.92 | 63.72 | 56.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 42 | 20 | 22 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 58.46 | 61.08 | 56.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3019309) Folate [Moles/volume] in Red Blood Cells
18
50
5.55
6.63
3.2
1.7
nmol/l
2151.7
1257.5
0.95
13
39
(3023183) Ammonium ion [Moles/volume] in Plasma
6
6
11.37
3.61
10.2
1.3
umol/l
41.7
30.0
—
6
6
(3000991) Gas panel - Venous blood
10
27
4.55
3.60
16.0
4.7
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
18
80
3.19
3.17
8.4
3.7
—
—
—
0
0
(3005895) Myoglobin [Mass/volume] in Serum or Plasma
6
9
7.55
2.97
2.7
2.1
ug/l
319.7
700.0
—
6
9
(3022313) Gas panel - Capillary blood
8
18
5.22
2.96
2.8
5.8
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
8
18
5.22
2.96
14.0
3.9
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
5
6
9.23
2.82
11.8
1.0
kpa
9.2
8.9
—
5
6
(3013290) Carbon dioxide [Partial pressure] in Blood
5
6
9.23
2.82
11.8
1.0
kpa
4.8
4.5
—
5
6
(3001604) Monocytes [#/volume] in Blood
26
151
2.89
2.76
4.2
5.0
e9/l
0.7
0.6
0.85
26
133
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
12
45
3.33
2.73
1.5
1.7
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
26
152
2.87
2.71
4.2
5.1
e9/l
0.0
0.0
0.15
26
135
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
21
111
2.78
2.63
2.9
1.8
pmol/l
92.0
105.2
0.35
14
49
(3044290) Cell count panel - Cerebral spinal fluid
5
8
6.90
2.44
1.2
1.0
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
26
158
2.69
2.43
4.9
5.2
e9/l
0.2
0.2
0.19
26
144
(3019198) Lymphocytes [#/volume] in Blood
26
158
2.69
2.43
4.2
5.1
e9/l
2.0
1.8
0.73
26
141
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
7
21
3.78
2.07
1.9
1.4
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
7
21
3.78
2.07
12.9
7.2
mmol/l
25.4
24.8
—
7
21
(3042936) Bacteria identified in Isolate by Culture
11
46
2.88
2.05
3.3
2.5
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
12
53
2.77
2.03
2.6
1.8
pmol/l
458.8
419.1
0.16
12
46
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
7
23
3.44
1.89
1.9
1.8
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
26
171
2.37
1.89
11.6
4.8
umol/l
15.4
14.2
0.08
26
161
(3022096) Basophils/100 leukocytes in Blood
23
144
2.32
1.86
6.1
5.1
%
0.6
0.6
0.00
23
136
(3019069) Monocytes/100 leukocytes in Blood
23
146
2.27
1.78
6.1
5.4
%
9.5
8.8
0.58
23
138
(3006504) Eosinophils/100 leukocytes in Blood
23
146
2.27
1.78
5.4
5.2
%
2.7
2.9
0.17
23
137
(40760892) CBC W Ordered Manual Differential panel - Blood
12
58
2.50
1.69
4.9
4.7
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
18
108
2.17
1.55
6.1
5.2
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
8
34
2.66
1.38
2.6
1.9
—
—
—
0
0
(3015736) pH of Urine
17
104
2.07
1.37
5.2
3.8
—
—
—
0
0
(3018418) pH of Serum or Plasma
14
81
2.09
1.29
17.1
3.1
ph
7.4
7.4
—
5
13
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
8
38
2.36
1.27
14.8
6.6
—
—
—
0
0
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
5
19
2.84
1.25
4.2
5.3
mmol/l
25.5
25.3
—
5
19
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
18
117
1.94
1.20
7.9
4.0
ng/l
111.8
69.1
0.19
18
85
(3025941) Bacteria identified in Stool by Culture
5
20
2.69
1.18
1.6
1.5
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
7
33
2.34
1.12
1.4
1.7
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
7
33
2.34
1.12
1.4
1.7
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
12
70
2.00
1.06
8.9
2.0
e6/l
4.2
5.3
0.27
12
60
(46235355) HIV 1 and 2 tests - Meaningful Use set
9
50
2.01
1.05
2.7
2.0
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
11
63
2.01
1.02
3.5
4.0
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
17
114
1.83
1.00
25.3
7.5
inr
1.1
1.2
—
8
23
(3013650) Neutrophils [#/volume] in Blood by Automated count
24
179
1.80
1.00
6.8
8.5
e9/l
4.0
4.0
0.00
24
159
(40761536) Microorganisms panel - Urine sediment
6
27
2.42
0.98
11.5
3.7
—
—
—
0
0
(3026782) Osmolality of Urine
11
64
1.97
0.97
8.8
2.4
mosm/kgh2o
460.1
556.2
1.26
11
53
(3017143) Hepatitis C virus Ab [Presence] in Serum
6
28
2.33
0.96
3.3
1.7
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
14
90
1.83
0.93
8.6
3.0
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
14
91
1.81
0.90
9.5
3.3
u/l
41.6
30.4
0.55
14
86
(3044640) Blood type and Crossmatch panel - Blood
14
91
1.81
0.90
4.5
1.8
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
20
146
1.71
0.86
19.9
4.7
mmol/l
1.2
1.2
0.33
15
127
(36660697) Celiac disease serology panel - Serum
0
24
0.00
0.82
0.0
1.3
—
—
—
0
0
(3022621) pH of Urine by Test strip
0
26
0.00
0.81
0.0
3.4
—
—
—
0
0
(4010399)
0
27
0.00
0.80
0.0
1.4
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
17
123
1.64
0.74
8.1
3.0
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
31
263
1.68
0.69
25.0
13.6
%
38.1
39.5
0.37
16
190
(21494755) Public health laboratory ask at order entry panel
0
20
0.00
0.62
0.0
1.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
6
35
1.83
0.61
3.3
1.8
—
—
—
0
0
(3033658) Prothrombin time (PT) actual/Normal
11
75
1.63
0.58
10.0
2.9
%
66.6
90.1
1.28
11
75
(3003694) ABO and Rh group [Type] in Blood
5
80
0.57
0.52
2.4
1.5
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
24
201
1.45
0.49
7.5
4.5
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
34
307
1.56
0.45
35.5
13.1
mg/l
29.2
23.1
0.39
29
237
(40768797) Stomach Pathology biopsy report
5
31
1.69
0.45
1.2
1.2
—
—
—
0
0
(3002256) Pathology report gross observation
5
33
1.58
0.43
1.0
1.1
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
15
0.00
0.42
0.0
1.1
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
16
0.00
0.42
0.0
2.3
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
9
67
1.44
0.42
3.9
1.6
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
0
17
0.00
0.41
0.0
2.2
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
0
18
0.00
0.41
0.0
3.8
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
36
1.44
0.39
2.0
1.3
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
17
139
1.37
0.37
8.2
5.7
estimate
0.0
0.0
—
5
29
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
21
178
1.36
0.37
4.0
2.9
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
34
313
1.45
0.34
40.0
12.3
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
16
131
1.36
0.34
11.7
3.7
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
17
141
1.35
0.33
7.3
4.0
estimate
0.0
0.0
—
5
30
(3009261) Glucose [Presence] in Urine by Test strip
17
143
1.32
0.30
7.3
4.1
estimate
0.0
0.0
—
5
28
(3019150) Specific gravity of Urine by Refractometry
8
65
1.28
0.29
5.9
4.4
—
1.0
—
0
10
(1761868) Lipid panel - Serum or Plasma
10
79
1.35
0.25
4.8
2.9
—
—
—
0
0
(3010726) Horse dander IgE Ab [Units/volume] in Serum
0
11
0.00
0.21
0.0
1.0
—
2.7
—
0
6
(3008401) Mugwort IgE Ab [Units/volume] in Serum
0
11
0.00
0.21
0.0
1.0
—
5.3
—
0
11
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
12
0.00
0.21
0.0
2.0
—
7.5
—
0
7
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
12
0.00
0.21
0.0
2.0
—
3.4
—
0
7
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
13
0.00
0.21
0.0
4.0
—
—
—
0
0
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
12
102
1.25
0.17
4.6
2.9
—
—
—
0
0
(3013512) EKG study
11
93
1.25
0.16
5.2
3.7
—
—
—
0
0
(3019550) Sodium [Moles/volume] in Serum or Plasma
33
312
1.27
0.15
45.8
14.1
mmol/l
139.6
139.6
0.06
33
304
(3023103) Potassium [Moles/volume] in Serum or Plasma
33
312
1.27
0.15
47.3
14.2
mmol/l
4.1
4.0
0.81
33
303
(3044889) 12 lead EKG panel
21
192
1.19
0.15
5.2
3.7
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
12
107
1.17
0.10
9.0
4.5
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
7
80
0.85
0.08
12.1
3.8
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
34
327
1.21
0.07
17.8
9.0
u/l
23.3
24.5
0.26
34
319
(3003338) MCHC [Mass/volume]
27
260
1.11
0.05
31.1
16.5
g/l
326.8
332.3
2.84
27
260
(40768804) Tissue Pathology biopsy report
11
108
1.03
0.00
1.3
1.8
—
—
—
0
0
(40758558) Short blood count panel - Blood
8
79
1.02
0.00
5.3
4.9
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
4.6
—
107.2
—
0
5
(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3000963) Hemoglobin [Mass/volume] in Blood
35
344
1.10
0.00
49.6
18.7
g/l
124.6
136.3
3.18
35
338
(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood
0
8
0.00
0.00
0.0
4.5
—
1.8
—
0
8
(44790048)
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
262.2
—
0
5
(3023430) Cat dander IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
1.7
—
0
5
(44790047)
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3035941) MCH [Entitic mass]
35
344
1.10
0.00
48.9
18.5
pg
30.0
30.1
0.06
35
339
(3035637) Corticotropin [Mass/volume] in Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(44806118)
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
4.6
—
4.0
—
0
5
(40768800) Prostate Pathology biopsy report
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(4094501)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
4.6
—
24.7
—
0
7
(3014133) Dog dander IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
2.3
—
0
5
(40768793) Breast Pathology biopsy report
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
(3024731) MCV [Entitic volume]
35
344
1.10
0.00
49.1
18.6
fl
91.6
90.5
0.43
35
339
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.3
—
32.6
—
0
7
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
4.6
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
6.2
—
7.3
—
0
5
(44790049)
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3007930) Methemoglobin/Hemoglobin.total in Blood
0
8
0.00
0.00
0.0
4.5
—
0.9
—
0
8
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
6.2
—
1.5
—
0
5
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3047181) Lactate [Moles/volume] in Blood
0
6
0.00
0.00
0.0
6.7
—
1.1
—
0
6
(3023511) Choriogonadotropin [Units/volume] in Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMINONAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMINONAS | 1.813 [1.19, 2.77] | 0.006 |
| Birth year | 0.997 [0.99, 1.01] | 0.458 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 158 females with E4_AMINONAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMINONAS | 3.184 [1.91, 5.31] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 174 males with E4_AMINONAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_AMINONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.178% | 0.628% |
| 5 | 1.062% | 3.808% |
| 10 | 2.809% | 9.333% |
| 15 | 5.638% | 17.533% |
| 20 | 9.606% | 28.165% |
Relationships between endpoints
↥Index endpoint: E4_AMINONAS – Disorder of amino-acid metabolism, other/unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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