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Drug-induced interstitial lung disorders, unspecified

Endpoint Browser PheWeb

DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J70.4#

1 out of 7 registries used, show all original rules.

60

4. Check minimum number of events

None

60

5. Include endpoints

None

60

6. Filter based on genotype QC (FinnGen only)

60

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 294 177 116
Only index persons 245 147 98
Unadjusted period prevalence (%)
Whole population 0.00 0.01 0.00
Only index persons 0.00 0.01 0.00
Median age at first event (years)
Whole population 70.11 70.84 68.94
Only index persons 68.88 69.62 67.77

-FinnGen-

Key figures

All Female Male
Number of individuals 60 39 21
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 65.52 67.60 61.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
54
Matched controls
539
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J70.4
ICD-10 Finland
Drug-induced interstitial lung disorders, unspecified
+∞
77.3
54
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
23.6
13.4
19
12
H02AB06
ATC
prednisolone; systemic
9.6
11.5
45
185
GD1AA
NOMESCO Finland
Thorax X-ray examination
8.3
10.7
44
186
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
18.3
9.3
14
10
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
9.2
8.7
19
30
JN4AD
NOMESCO Finland
Body CT examination
10.7
8.7
17
22
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
40.0
8.4
10
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
5.8
8.4
30
95
B01AB10
ATC
tinzaparin; parenteral
9.8
7.9
16
22
A03FA01
ATC
metoclopramide; systemic, rectal
5.7
7.9
27
80
N02AA05
ATC
oxycodone; systemic
6.8
7.4
20
43
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.3
7.1
25
75
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
11.0
7.0
13
15
JN4BD
NOMESCO Finland
Extensive body CT
6.2
6.5
18
40
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
8.2
6.4
14
22
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
+∞
6.4
6
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
7.3
6.3
15
27
M04AA01
ATC
allopurinol; systemic
5.4
6.0
19
49

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3012095) Magnesium [Moles/volume] in Serum or Plasma
32
74
8.12
15.13
5.4
3.3
mmol/l
0.8
0.8
0.29
32
67
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
13
10
16.32
13.82
1.7
1.9
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
13
10
16.32
13.82
1.7
1.7
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
15
15
13.00
13.71
1.6
2.0
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
32
83
7.12
13.24
2.5
2.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
27
60
7.36
13.00
2.3
2.1
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
26
59
7.01
12.17
2.3
2.0
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
14
16
11.11
11.60
1.6
1.9
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
21
44
6.80
10.47
6.3
4.0
mmol/l
1.2
1.2
0.09
21
38
(3003458) Phosphate [Moles/volume] in Serum or Plasma
22
51
6.23
9.86
6.3
6.9
mmol/l
1.1
1.0
0.16
22
46
(3004588) Protein electrophoresis panel - Serum or Plasma
18
35
6.92
9.58
2.4
2.9
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
37
138
5.39
9.57
5.8
4.5
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
10
10
11.80
8.89
1.7
1.9
—
—
—
0
0
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
48
232
6.34
8.81
8.4
6.2
mmol/l
1.2
1.2
0.23
48
208
(3006315) Basophils [#/volume] in Blood
49
244
6.50
8.59
12.3
6.1
e9/l
0.0
0.0
0.32
43
208
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
50
255
6.76
8.47
9.2
7.5
mmol/l
1.2
1.2
0.68
37
212
(3018418) pH of Serum or Plasma
39
165
4.90
8.30
6.8
4.2
ph
7.4
7.4
0.93
18
28
(3026782) Osmolality of Urine
30
104
4.77
8.25
2.9
3.0
mosm/kgh2o
531.7
504.9
0.29
24
89
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
19
45
5.72
8.19
5.9
3.4
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
30
105
4.71
8.13
8.0
5.6
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
48
242
5.92
8.09
12.6
6.1
e9/l
0.6
0.6
0.71
43
206
(42870588) Differential panel, method unspecified - Blood
37
153
4.70
8.05
11.5
6.1
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
52
297
6.62
8.03
22.1
10.8
e9/l
4.6
4.2
0.57
47
257
(3019198) Lymphocytes [#/volume] in Blood
49
253
6.11
7.97
12.6
6.0
e9/l
1.6
1.8
0.83
44
223
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
11
6
21.97
7.94
1.8
2.2
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
12
18
8.08
7.93
4.0
12.9
mmol/l
24.0
26.1
0.72
12
18
(3002179) Metamyelocytes/100 leukocytes in Blood
17
38
5.85
7.75
4.9
4.1
%
0.5
0.4
—
8
8
(3000850) Epithelial cells [#/volume] in Urine
32
122
4.48
7.67
3.2
2.6
e6/l
4.7
4.8
0.01
27
108
(40761536) Microorganisms panel - Urine sediment
18
43
5.55
7.64
4.9
3.4
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
36
151
4.46
7.57
4.1
3.0
—
—
—
0
0
(3021440) Promyelocytes/100 leukocytes in Blood
17
39
5.69
7.53
4.9
4.3
%
0.2
0.3
—
9
11
(3021589) Normoblasts [#/volume] in Blood
45
225
5.00
7.41
26.9
10.5
e9/l
0.0
0.0
0.50
38
186
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
10
13
9.03
7.35
1.7
1.9
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
36
155
4.31
7.21
4.1
3.1
e6/l
0.4
0.3
0.14
31
117
(3000991) Gas panel - Venous blood
16
38
5.38
6.78
5.7
10.7
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
40
192
4.25
6.75
4.5
3.2
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
10
15
7.80
6.53
2.3
1.3
—
—
—
0
0
(3017181) Myelocytes/100 leukocytes in Blood
17
44
5.00
6.52
5.1
4.1
%
1.5
1.1
—
10
13
(3025159) Blasts/100 leukocytes in Blood
16
41
4.96
6.18
4.9
4.1
%
0.0
0.0
—
8
10
(3002582) Erythrocytes [#/volume] in Urine
35
163
3.75
5.96
4.5
3.2
e6/l
9.5
433.7
0.56
30
127
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
20
64
4.19
5.84
1.6
1.7
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
9
8
12.94
5.49
5.6
1.9
%
51.2
62.0
—
9
8
(3030905) Polymorphonuclear cells [#/volume] in Blood
9
8
12.94
5.49
4.8
1.9
e9/l
3.0
4.5
—
9
8
(3018095) Leukocytes [#/volume] in Urine
37
187
3.55
5.40
5.6
3.7
e6/l
39.5
48.8
0.15
32
138
(3022948) Iron [Moles/volume] in Serum or Plasma
21
74
3.83
5.32
2.8
2.4
umol/l
10.8
12.3
0.45
21
64
(3021879) Hepatitis B virus core Ab [Presence] in Serum
15
41
4.54
5.32
1.3
1.3
—
—
—
0
0
(3020073) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Specimen
5
0
+∞
5.27
1.6
0.0
—
—
—
0
0
(1616796) Gas panel - Central venous blood
8
6
15.09
5.24
4.3
3.2
—
—
—
0
0
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
8
6
15.09
5.24
1.8
1.8
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
21
75
3.77
5.21
2.3
1.7
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
39
209
3.47
5.09
17.2
8.8
inr
1.2
1.3
0.04
20
59
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
9
10
10.33
4.98
1.8
1.7
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
9
10
10.33
4.98
1.8
1.9
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
10
20
5.80
4.97
3.4
3.0
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
17
55
3.92
4.81
1.5
1.4
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
54
388
4.91
4.65
19.8
7.8
u/l
73.9
78.4
0.59
54
357
(3021901) Oxygen saturation in Capillary blood
7
6
12.96
4.39
4.4
2.3
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
12
32
4.44
4.33
5.5
11.4
%
93.7
94.0
0.05
12
32
(4035726)
15
48
3.83
4.28
1.9
1.3
—
—
—
0
0
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
12
34
4.16
4.00
5.5
10.8
%
0.6
0.8
0.99
12
34
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
12
34
4.16
4.00
5.5
10.8
%
1.6
1.5
0.10
12
34
(3042936) Bacteria identified in Isolate by Culture
20
82
3.16
3.89
2.0
1.9
—
—
—
0
0
(3021447) Carbon dioxide [Partial pressure] in Venous blood
14
47
3.58
3.70
4.5
4.2
kpa
5.9
5.9
0.02
14
47
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
6
6
10.91
3.58
2.5
1.0
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
6
6
10.91
3.58
4.3
5.0
kpa
4.7
5.2
—
6
6
(3027315) Oxygen [Partial pressure] in Blood
6
6
10.91
3.58
4.3
5.0
kpa
8.8
8.5
—
6
6
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
6
6
10.91
3.58
1.2
1.0
—
—
—
0
0
(3002256) Pathology report gross observation
15
55
3.30
3.46
1.3
1.2
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
35
205
2.70
3.45
6.3
3.7
ng/l
18.8
40.7
0.65
27
150
(3029937) Albumin [Presence] in Urine by Test strip
28
147
2.70
3.42
4.6
4.3
estimate
0.0
0.0
0.00
20
48
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
9
19
5.37
3.39
1.1
1.1
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
6
7
9.35
3.34
5.0
9.0
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
22
105
2.73
3.20
1.9
1.5
g/l
2.1
2.2
0.10
17
59
(3003396) Base excess in Arterial blood by calculation
16
64
3.05
3.19
4.9
8.3
mmol/l
0.6
2.1
0.71
16
52
(3024354) Oxygen [Partial pressure] in Venous blood
12
40
3.50
3.18
3.2
2.9
kpa
4.6
4.1
0.40
12
40
(3012544) pH of Venous blood
13
46
3.33
3.15
4.2
4.2
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
5
5
10.73
3.03
1.4
1.2
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
7
13
5.93
2.96
2.1
1.7
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
7
13
5.93
2.96
2.1
1.7
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
6
9
7.25
2.94
4.5
1.4
%
80.8
93.7
—
6
9
(3041096) Erythrocytes [Presence] in Urine by Automated
26
141
2.49
2.88
4.7
3.3
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
31
183
2.44
2.85
4.0
3.1
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
7
14
5.50
2.82
5.4
5.1
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
6
10
6.52
2.77
4.5
2.8
%
238.3
139.6
—
6
10
(3033658) Prothrombin time (PT) actual/Normal
23
120
2.49
2.75
8.3
3.7
%
89.3
92.3
0.31
23
120
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
8
20
4.44
2.67
5.9
3.9
mmol/l
24.1
23.9
—
8
20
(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal
5
7
7.65
2.60
1.8
1.0
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
5
8
6.69
2.42
2.6
1.1
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
32
203
2.24
2.38
2.1
2.1
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
37
250
2.25
2.35
6.6
5.1
estimate
0.0
0.0
0.00
20
50
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
7
18
4.25
2.33
4.1
1.7
—
—
—
0
0
(3044889) 12 lead EKG panel
47
354
2.51
2.27
7.8
4.1
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
37
254
2.19
2.21
5.2
3.9
estimate
0.0
0.0
0.00
20
51
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
8
25
3.53
2.18
1.3
1.2
—
74.6
—
0
8
(3029080) Hemoglobin [Entitic mass] in Reticulocytes
5
10
5.34
2.11
1.8
1.9
pg
29.6
32.7
—
5
10
(3037756) Immunofixation for Serum or Plasma
6
15
4.32
2.09
1.0
1.1
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
8
27
3.26
2.02
1.6
1.6
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
5
11
4.85
1.98
6.8
6.2
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
8
28
3.13
1.94
5.5
9.4
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
8
28
3.13
1.94
1.9
1.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
25
154
2.07
1.91
4.0
2.1
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
36
254
2.04
1.90
5.3
3.9
estimate
0.0
0.0
0.00
20
54
(3052851) Hemolysis interference index of Serum or Plasma
6
17
3.80
1.89
3.5
4.1
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
5
12
4.44
1.86
4.6
2.0
g/l
0.0
0.0
—
5
12
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
5
12
4.44
1.86
2.0
1.6
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
5
12
4.44
1.86
1.2
1.3
—
—
—
0
0
(40758558) Short blood count panel - Blood
22
131
2.07
1.83
12.1
8.8
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
6
18
3.58
1.79
1.3
1.3
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
50
404
2.43
1.79
48.7
19.4
%
14.6
13.9
2.46
50
396
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
33
230
1.97
1.76
6.2
3.9
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
5
13
4.09
1.75
1.0
1.2
—
—
—
0
0
(3020891) Body temperature
7
25
3.03
1.71
6.6
3.5
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
5
14
3.79
1.65
1.8
2.4
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
30
206
1.91
1.64
4.8
4.0
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
35
255
1.89
1.58
3.0
2.7
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
25
166
1.87
1.48
4.9
2.9
u/l
34.4
29.6
0.65
25
156
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
16
91
2.03
1.47
4.2
2.7
e6/l
0.6
0.9
0.35
11
55
(4010399)
10
48
2.30
1.36
1.6
1.4
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
14
80
1.98
1.26
4.6
2.9
e6/l
0.7
2.8
—
9
45
(3037467) Urinalysis macro (dipstick) panel - Urine
44
359
1.85
1.25
8.2
4.5
—
—
—
0
0
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
5
19
2.77
1.24
1.2
1.3
g/l
0.2
0.2
—
5
19
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
19
2.77
1.24
1.6
1.3
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
5
19
2.77
1.24
1.2
1.3
g/l
1.2
1.1
—
5
19
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
10
51
2.15
1.19
1.7
1.5
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
8
41
2.09
1.14
1.4
1.7
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
28
206
1.67
1.11
2.1
2.1
pmol/l
85.2
93.4
0.32
14
93
(3013512) EKG study
23
162
1.68
1.06
5.4
3.8
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
12
70
1.89
1.01
2.1
1.6
—
—
—
0
0
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
14
89
1.75
0.91
1.4
1.3
iu/ml
49.0
38.2
—
5
32
(1761868) Lipid panel - Serum or Plasma
20
142
1.61
0.88
2.4
3.2
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
6
33
1.91
0.81
1.5
1.7
—
—
—
0
0
(3022145) Colonoscopy Study observation
9
55
1.75
0.78
1.2
1.3
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
55
507
2.02
0.74
36.7
14.4
—
—
—
0
0
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
7
41
1.80
0.73
1.0
2.2
g/l
0.3
0.2
—
7
36
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
5
26
2.00
0.72
3.2
3.1
%
54.4
44.9
—
5
26
(3018405) Lactate [Moles/volume] in Arterial blood
5
26
2.00
0.72
6.0
3.0
mmol/l
1.5
1.2
—
5
26
(3027273) Bicarbonate [Moles/volume] in Venous blood
5
28
1.86
0.68
3.0
4.2
mmol/l
24.6
25.0
—
5
28
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
5
28
1.86
0.68
3.0
2.9
%
0.7
0.7
—
5
28
(3019060) Gas panel - Arterial blood
8
49
1.73
0.65
5.3
3.7
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
16
115
1.53
0.65
4.3
2.1
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
5
29
1.79
0.65
3.0
2.9
%
2.2
1.0
—
5
29
(3019309) Folate [Moles/volume] in Red Blood Cells
15
107
1.54
0.63
1.5
1.7
nmol/l
1702.7
1262.5
—
10
82
(3004119) Hemoglobin [Mass/volume] in Venous blood
5
32
1.61
0.43
3.0
4.3
g/l
139.8
131.0
—
5
32
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
32
1.61
0.43
2.4
2.3
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
16
0.00
0.41
0.0
6.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
10
72
1.47
0.40
1.1
1.5
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
10
75
1.40
0.32
1.9
1.5
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
10
75
1.40
0.32
2.2
3.0
ug/l
0.3
0.6
—
5
52
(3003694) ABO and Rh group [Type] in Blood
16
133
1.28
0.28
1.9
1.4
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
6
81
0.71
0.26
1.3
1.4
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
1.3
—
36.2
—
0
11
(3035285) Chloride [Moles/volume] in Venous blood
0
10
0.00
0.21
0.0
2.6
—
106.9
—
0
10
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
10
0.00
0.21
0.0
2.6
—
4.0
—
0
10
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
12
0.00
0.21
0.0
2.9
—
6.7
—
0
12
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
(40761535) Cells panel - Urine sediment
6
49
1.25
0.21
3.0
4.1
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
6
78
0.74
0.16
8.2
8.2
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
44
424
1.14
0.11
37.6
17.2
%
38.9
40.1
0.62
25
287
(3019225) pH of Specimen
5
44
1.15
0.10
7.4
4.7
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
16
153
1.06
0.01
5.2
3.1
mg/l
113.5
50.4
0.34
11
93
(3011397) Hemoglobin [Presence] in Urine by Test strip
12
121
0.99
0.00
5.3
4.1
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
47
469
1.01
0.00
4.9
5.0
mmol/l
6.1
5.9
0.36
41
424
(3020682) Albumin/Creatinine [Ratio] in Urine
16
165
0.96
0.00
6.1
3.8
mg/mmol
28.5
9.4
—
10
96
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
47
474
0.96
0.00
4.6
4.7
mmol/l
5.0
4.6
1.10
42
427
(3017704) Immunofixation for Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
1.6
—
0
5
(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
1146.0
—
0
6
(4146454)
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3029634) Reagin Ab [Titer] in Serum by VDRL
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
116.3
—
0
6
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3016038) Potassium [Moles/volume] in Urine
0
5
0.00
0.00
0.0
1.0
—
29.6
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
146.7
—
0
6
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(3051593) INR in Capillary blood by Coagulation assay
0
5
0.00
0.00
0.0
13.8
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
7
75
0.92
0.00
1.9
1.2
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
2.8
—
113.0
—
0
6
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3016244) Insulin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
11.6
—
0
5
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3026389) Candida sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3001788) Aldosterone [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
274.5
—
0
6
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(4281824)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE and mortality.

Females

Parameter HR [95% CI] p-value
DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE 2.1 [1.45, 3.04] < 0.001
Birth year 0.995 [0.99, 1.0] 0.217

During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 143 females with DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE.

N-year risk Females Males
1 0.214% No data
5 1.23% No data
10 3.312% No data
15 5.661% No data
20 9.969% No data

Relationships between endpoints

↥

Index endpoint: DRUGADVERS_INTERSTITIAL_LUNG_DISORD_UNSPE – Drug-induced interstitial lung disorders, unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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