This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Drug-induced aplastic anaemia
DRUGADVERS_APLAST_ANAEM
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
55 |
4. Check minimum number of eventsNone |
55 |
5. Include endpointsNone |
55 |
6. Filter based on genotype QC (FinnGen only) |
55 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced aplastic anaemia
based on the number of shared cases.
Similar with more cases:
- Other and unspecified aplastic anaemias
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 549 | 296 | 245 |
| Only index persons | 425 | 235 | 190 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 69.55 | 71.11 | 67.73 |
| Only index persons | 68.94 | 70.57 | 66.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 55 | 26 | 29 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 64.77 | 60.83 | 68.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 52
- Matched controls
- 520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D61.1
ICD-10 Finland
Drug-induced aplastic anaemia
+∞
74.4
52
*
WW500
NOMESCO Finland
Blood transfusion
33.3
14.1
18
8
D70.82
ICD-10 Finland
Drug-induced neutropenia
152.4
12.0
12
*
A04AA01
ATC
ondansetron; systemic, rectal
15.1
10.2
17
16
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
25.3
9.0
12
6
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
25.3
9.0
12
6
XW000
NOMESCO Finland
Bone marrow biopsy
25.3
9.0
12
6
R50.9
ICD-10 Finland
Fever, unspecified
8.9
8.9
20
34
H02AB02
ATC
dexamethasone; systemic
8.9
8.2
18
29
L03AA02
ATC
filgrastim; parenteral
53.3
8.0
9
*
D64.9
ICD-10 Finland
Anaemia, unspecified
8.0
7.7
18
32
A03FA01
ATC
metoclopramide; systemic, rectal
5.4
6.8
23
66
D70.89
ICD-10 Finland
Neutropenic splenomegaly
79.2
6.6
7
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3021879) Hepatitis B virus core Ab [Presence] in Serum
15
27
7.26
8.55
1.9
1.9
—
—
—
0
0
(3018418) pH of Serum or Plasma
31
128
4.26
6.60
8.5
5.1
ph
7.4
7.4
—
6
24
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
9
7
15.01
5.81
1.3
1.3
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
16
45
4.60
5.53
2.1
2.0
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
9
8
13.13
5.51
1.3
1.4
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
7
5
15.73
4.71
1.4
1.2
—
—
—
0
0
(4035726)
13
36
4.42
4.52
1.2
1.3
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
8
9
10.15
4.44
2.8
2.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
28
133
3.25
4.41
20.1
5.7
—
—
—
0
0
(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection
7
6
13.10
4.40
3.1
1.3
u/ml
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
24
106
3.24
4.24
8.0
4.5
—
—
—
0
0
(40758558) Short blood count panel - Blood
24
110
3.10
3.94
26.1
6.2
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
19
76
3.29
3.90
2.2
2.1
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
8
13
6.99
3.65
1.4
1.6
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
8
13
6.99
3.65
1.4
1.6
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
14
48
3.57
3.61
1.8
1.8
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
6
6
11.01
3.58
1.5
1.7
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
10
27
4.30
3.53
1.9
1.5
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
21
94
3.00
3.53
11.5
2.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
14
49
3.49
3.50
1.9
1.8
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
26
132
2.84
3.47
8.7
2.1
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
16
62
3.23
3.41
1.7
1.7
—
—
—
0
0
(3000991) Gas panel - Venous blood
11
33
3.92
3.40
8.9
3.4
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
8
15
6.04
3.33
1.6
1.3
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
7
11
7.10
3.29
1.4
1.5
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
34
206
2.70
3.13
11.3
6.3
mmol/l
1.2
1.2
0.20
29
171
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
7
13
5.99
2.97
1.3
2.2
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
19
88
2.77
2.94
4.9
3.8
—
—
—
0
0
(44790049)
5
6
9.00
2.80
1.4
1.7
—
—
—
0
0
(44790047)
5
6
9.00
2.80
1.4
1.7
—
—
—
0
0
(44806118)
5
6
9.00
2.80
1.4
1.7
—
—
—
0
0
(44790048)
5
6
9.00
2.80
1.4
1.7
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
32
200
2.43
2.61
17.6
3.9
—
—
—
0
0
(3012544) pH of Venous blood
12
46
3.06
2.56
6.1
2.6
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
14
59
2.84
2.54
3.6
2.6
umol/l
20.5
13.4
0.77
14
52
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
5
8
6.73
2.42
1.6
1.6
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
12
48
2.92
2.37
3.2
3.0
%
45.8
24.8
0.93
12
40
(3004789) Transferrin [Mass/volume] in Serum or Plasma
13
55
2.79
2.33
3.0
2.7
g/l
1.7
2.3
2.80
13
49
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
15
70
2.57
2.23
2.3
2.0
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
25
148
2.26
2.22
1.3
2.0
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
18
93
2.39
2.17
12.0
6.7
—
—
—
0
0
(3015736) pH of Urine
26
160
2.19
2.07
5.8
3.0
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
9
33
3.06
2.04
1.7
2.8
—
—
—
0
0
(3014111) Lactate [Moles/volume] in Serum or Plasma
9
33
3.06
2.04
8.1
2.8
mmol/l
1.0
1.2
—
9
33
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
5
11
4.88
1.98
11.6
2.5
%
51.2
61.6
—
5
11
(3030905) Polymorphonuclear cells [#/volume] in Blood
5
11
4.88
1.98
9.4
2.5
e9/l
2.4
5.6
—
5
11
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
26
164
2.11
1.91
5.7
2.8
—
—
—
0
0
(3022145) Colonoscopy Study observation
10
41
2.76
1.88
1.6
1.3
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
7
23
3.33
1.87
6.6
2.8
%
95.1
92.6
—
7
23
(3052851) Hemolysis interference index of Serum or Plasma
5
12
4.46
1.86
4.4
4.6
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
21
123
2.14
1.86
4.2
2.7
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
17
93
2.20
1.77
1.9
1.8
mg/l
1.2
1.2
0.01
11
75
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
5
13
4.11
1.75
6.2
5.4
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
6
19
3.41
1.71
2.2
1.9
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
25
162
2.00
1.66
5.0
3.5
e6/l
54.2
44.0
0.13
18
116
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
6
20
3.24
1.63
1.8
1.7
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
25
166
1.93
1.52
2.4
2.1
pmol/l
86.7
94.9
0.40
17
85
(3000963) Hemoglobin [Mass/volume] in Blood
41
475
0.46
1.51
68.3
20.9
g/l
118.1
135.5
5.02
41
464
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
6
22
2.93
1.48
7.5
2.6
%
0.7
0.8
—
6
22
(3024731) MCV [Entitic volume]
41
474
0.47
1.46
67.9
20.8
fl
93.9
91.3
2.29
41
463
(3035941) MCH [Entitic mass]
41
474
0.47
1.46
67.8
20.7
pg
31.2
30.4
1.78
41
463
(3021601) Nitrite [Presence] in Urine by Test strip
30
215
1.87
1.43
7.7
4.7
estimate
0.0
0.0
—
5
48
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
6
23
2.80
1.41
7.5
2.6
%
1.5
1.9
—
6
23
(4010399)
0
38
0.00
1.40
0.0
1.2
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
30
216
1.86
1.40
6.4
3.5
estimate
0.0
0.0
—
5
47
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
5
19
2.79
1.24
2.4
2.0
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
19
2.79
1.24
2.2
2.3
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
29
213
1.76
1.22
6.6
3.5
estimate
0.0
0.0
—
5
51
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
26
185
1.77
1.22
3.8
3.9
ng/l
46.7
33.0
0.27
20
128
(3016502) Oxygen saturation in Arterial blood
8
39
2.23
1.21
6.0
3.1
%
97.3
94.5
—
8
39
(3007164) IgA [Mass/volume] in Serum or Plasma
14
82
1.95
1.19
1.7
1.4
g/l
2.5
2.2
—
8
44
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
5
20
2.64
1.17
15.2
5.6
mmol/l
23.0
24.2
—
5
20
(40761511) CBC panel - Blood by Automated count
38
443
0.54
1.17
29.6
13.4
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
25
179
1.73
1.13
4.1
6.3
inr
1.0
1.2
—
9
51
(40768797) Stomach Pathology biopsy report
11
60
2.04
1.12
1.1
1.2
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
5
21
2.51
1.11
1.0
1.2
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
9
46
2.14
1.10
1.1
1.3
—
—
—
0
0
(3002173) Hemoglobin [Mass/volume] in Arterial blood
7
33
2.28
1.10
6.7
3.2
g/l
106.6
125.0
—
7
33
(3042936) Bacteria identified in Isolate by Culture
10
55
2.00
1.00
1.6
2.0
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
6
27
2.37
0.97
3.2
2.5
%
50.8
48.9
—
6
27
(36660697) Celiac disease serology panel - Serum
6
28
2.28
0.95
1.2
1.1
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
37
304
1.66
0.93
5.8
4.2
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
23
168
1.63
0.93
3.0
2.4
nmol/l
67.7
76.3
0.88
23
146
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
8
46
1.86
0.87
6.0
2.9
kpa
4.8
5.0
—
8
46
(3027801) Oxygen [Partial pressure] in Arterial blood
8
46
1.86
0.87
5.9
2.9
kpa
12.6
12.0
—
8
46
(3020891) Body temperature
5
23
2.29
0.78
5.2
3.3
—
—
—
0
0
(40761535) Cells panel - Urine sediment
7
39
1.91
0.76
7.4
2.4
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
7
41
1.81
0.73
1.3
1.7
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
7
41
1.81
0.73
7.4
4.6
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
5
27
1.93
0.70
6.8
2.6
%
1.2
1.5
—
5
27
(3004119) Hemoglobin [Mass/volume] in Venous blood
5
29
1.79
0.65
6.8
2.5
g/l
117.6
126.7
—
5
29
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
11
72
1.66
0.65
4.4
4.4
ng/l
14448.4
93.7
0.50
11
61
(3019150) Specific gravity of Urine by Refractometry
14
99
1.56
0.62
6.3
3.3
—
1.0
—
0
9
(3048689) Calprotectin [Mass/mass] in Stool
8
53
1.59
0.62
8.0
1.4
ug/g
743.1
199.8
—
8
36
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
9
59
1.63
0.59
22.3
8.0
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
7
107
0.60
0.55
1.6
1.6
mmol/l
1.7
1.3
—
7
89
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
41
445
0.69
0.47
35.4
10.1
u/l
26.6
25.1
0.29
41
424
(3020564) Creatinine [Moles/volume] in Serum or Plasma
41
444
0.70
0.45
50.9
16.8
umol/l
91.2
80.3
0.85
41
444
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
16
126
1.38
0.41
9.1
3.7
estimate
0.0
0.0
—
5
45
(1002224) Polysomnography panel
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
15
118
1.37
0.39
1.9
1.4
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
15
124
1.29
0.27
3.5
4.1
mg/mmol
5.7
9.6
—
10
86
(3041096) Erythrocytes [Presence] in Urine by Automated
10
124
0.76
0.25
9.4
3.2
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
16
136
1.25
0.23
5.6
3.0
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3005988) Vibrio sp identified in Specimen by Organism specific culture
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
(3012568) Campylobacter sp identified in Specimen by Organism specific culture
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(3024522) Salmonella sp identified in Specimen by Organism specific culture
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3025468) Yersinia sp identified in Specimen by Organism specific culture
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
6
47
1.31
0.21
2.3
2.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
19
167
1.21
0.20
8.6
3.6
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
6
50
1.22
0.20
2.0
1.4
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
6
52
1.17
0.20
2.7
2.5
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
35
372
0.84
0.19
49.3
14.2
%
35.1
40.1
1.85
27
255
(3013512) EKG study
11
130
0.81
0.18
4.0
4.2
—
—
—
0
0
(3044889) 12 lead EKG panel
32
301
1.15
0.14
3.9
4.1
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
5
44
1.15
0.10
2.2
1.7
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
15
136
1.14
0.10
3.1
4.1
%
16.9
23.7
—
6
67
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
48
1.05
0.09
1.0
1.2
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
11
123
0.87
0.09
3.9
3.1
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
25
246
1.03
0.00
4.5
3.0
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3016724) Homocysteine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
12.3
—
0
6
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3003434) Protein [Mass/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.2
—
28.0
—
0
6
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3036782) Glucose [Moles/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.0
—
7.6
—
0
6
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
0
8
0.00
0.00
0.0
7.1
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction
0
5
0.00
0.00
0.0
1.2
—
135.6
—
0
5
(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate
0
5
0.00
0.00
0.0
10.4
—
—
—
0
0
(3019420) Tryptase [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
5.5
—
0
5
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
105.4
—
0
5
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(4306422)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(4094501)
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3026389) Candida sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3023511) Choriogonadotropin [Units/volume] in Urine
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
7
72
0.97
0.00
1.7
1.7
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
97.4
—
0
5
(3017569) Oxygen content in Arterial blood
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3025130) Human papilloma virus identified in Specimen
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(40768806) Pleura Pathology biopsy report
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3012441) Differential panel - Pleural fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_APLAST_ANAEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_APLAST_ANAEM | 4.979 [2.92, 8.49] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.247 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 248 females with DRUGADVERS_APLAST_ANAEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_APLAST_ANAEM | 6.784 [3.45, 13.35] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 209 males with DRUGADVERS_APLAST_ANAEM died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_APLAST_ANAEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.537% | 0.922% |
| 5 | 3.103% | 7.005% |
| 10 | 7.649% | 16.357% |
| 15 | 14.183% | 29.634% |
| 20 | 22.687% | 44.419% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_APLAST_ANAEM – Drug-induced aplastic anaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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