No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
417 |
4. Check minimum number of eventsNone |
417 |
5. Include endpointsNone |
417 |
6. Filter based on genotype QC (FinnGen only) |
417 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Thrombocytopenia secundaria
Similar endpoints
↥List of similar endpoints to
Secondary thrombocytopenia
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3098 | 1537 | 1524 |
| Only index persons | 2347 | 1177 | 1170 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 61.19 | 61.53 | 60.87 |
| Only index persons | 60.76 | 60.97 | 60.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 417 | 218 | 199 |
| Unadjusted period prevalence (%) | 0.08 | 0.07 | 0.09 |
| Median age at first event (years) | 61.30 | 60.07 | 62.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 387
- Matched controls
- 3869
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.5
ICD-10 Finland
Secondary thrombocytopenia
+∞
323.0
360
*
WW500
NOMESCO Finland
Blood transfusion
35.7
107.6
141
61
D70.82
ICD-10 Finland
Drug-induced neutropenia
73.3
105.3
118
23
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
528.7
87.8
84
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
19.3
75.5
120
88
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
21.7
66.4
100
61
A49.9
ICD-10 Finland
Bacterial infection, unspecified
9.1
55.6
130
203
XW000
NOMESCO Finland
Bone marrow biopsy
15.7
51.9
88
71
H02AB02
ATC
dexamethasone; systemic
7.4
46.3
124
231
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
13.1
45.8
84
80
A03FA01
ATC
metoclopramide; systemic, rectal
5.3
44.7
171
499
ZX120
NOMESCO Finland
Intravenous
7.8
44.6
113
193
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
18.0
43.5
69
46
JN4BD
NOMESCO Finland
Extensive body CT
7.1
43.1
119
229
N02AA05
ATC
oxycodone; systemic
5.9
41.3
135
322
L03AA13
ATC
pegfilgrastim; parenteral
13.8
40.6
72
63
L03AA14
ATC
lipegfilgrastim; parenteral
24.9
39.7
56
26
L03AA02
ATC
filgrastim; parenteral
18.3
38.9
61
39
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
38.2
36
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
42.2
36.5
45
12
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.3
36.5
132
347
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.8
34.8
79
110
Z51.5
ICD-10 Finland
Palliative care
8.8
33.7
76
104
A04AA01
ATC
ondansetron; systemic, rectal
7.3
32.1
83
140
R50.9
ICD-10 Finland
Fever, unspecified
4.9
29.9
112
297
M04AA01
ATC
allopurinol; systemic
5.0
28.1
101
255
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.4
27.3
192
873
A04AA02
ATC
granisetron; systemic, transdermal
7.2
26.7
68
111
JN4AD
NOMESCO Finland
Body CT examination
5.9
25.9
78
159
D64.9
ICD-10 Finland
Anaemia, unspecified
5.4
25.3
83
187
H02AB06
ATC
prednisolone; systemic
3.1
24.3
228
1235
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.0
24.1
223
1193
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
18.2
22.7
35
21
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
9.2
21.6
46
56
WW300
NOMESCO Finland
Transfer of autologic stem cells
53.2
21.4
25
5
B01AB10
ATC
tinzaparin; parenteral
5.9
21.4
63
124
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.6
19.3
59
121
128
Kela drug reimbursment
Cancers of female genital organs
15.2
18.9
31
22
28711
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia symptomatica
+∞
18.9
18
*
B03XA02
ATC
darbepoetin alfa; parenteral
12.3
18.9
34
30
JN6AD
NOMESCO Finland
CT of torso and neck
13.8
18.8
32
25
C83.1
ICD-10 Finland
Mantle cell lymphoma
105.2
18.7
20
*
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
23.1
18.4
26
12
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
21.3
18.0
26
13
A41.9
ICD-10 Finland
Sepsis, unspecified
8.2
17.4
39
52
ZX112
NOMESCO Finland
Subcutaneous
12.4
17.3
31
27
130
Kela drug reimbursment
Malignant tumour
4.5
17.0
64
164
A02BC02
ATC
pantoprazole; systemic
2.6
16.7
282
1957
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
16.2
115
487
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
18.2
15.8
24
14
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
15.6
158
823
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
17.0
15.4
24
15
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
5.5
15.2
46
93
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
15.2
83
292
TPX10
NOMESCO Finland
Implantation of vascular injection port
6.8
15.0
38
61
WF049
NOMESCO Finland
Radiotherapy of metastasis
7.6
15.0
35
50
YNB10
NOMESCO Finland
Collection of stem cells for transplant
155.6
14.6
15
*
D70.89
ICD-10 Finland
Neutropenic splenomegaly
12.6
14.3
25
21
B01AB05
ATC
enoxaparin; parenteral
2.4
13.4
141
736
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
12.8
13.3
23
19
C03CA01
ATC
furosemide; systemic
2.5
13.2
134
686
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.8
12.6
55
161
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
15.0
12.4
20
14
A04AA55
ATC
palonosetron, combinations; systemic
6.6
12.3
31
50
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
12.2
56
171
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.9
12.2
40
89
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
27.7
12.1
16
6
ZX108
NOMESCO Finland
Inhalation
22.1
12.1
17
8
C56.71
ICD-10 Finland
Serous epithelial malignant tumor of the ovary
14.0
12.1
20
15
TGC00
NOMESCO Finland
Bronchial lavation
7.8
11.9
27
37
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
13.1
11.8
20
16
WW409
NOMESCO Finland
Other aferesis
31.1
11.7
15
5
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.1
11.5
36
76
XX3DW
NOMESCO Finland
Time consuming IT work
3.3
11.4
62
214
C56.00
ICD-10 Finland
Malignant tumor of the ovary without histology
36.2
11.3
14
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
20.8
11.2
16
8
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.9
11.2
47
133
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.1
11.0
65
237
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.1
11.0
34
71
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
11.0
10.9
20
19
J01MA12
ATC
levofloxacin; systemic
2.5
10.8
92
424
R18
ICD-10 Finland
Ascites
13.4
10.8
18
14
TK800
NOMESCO Finland
Hemodialysis
6.7
10.5
26
41
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.2
10.5
32
66
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
10.1
107
548
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
17.3
9.9
15
9
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
17.3
9.9
15
9
JN4CD
NOMESCO Finland
Very extensive body CT
5.1
9.7
30
63
127
Kela drug reimbursment
Transplant complication
9.5
9.6
19
21
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
15.5
9.6
15
10
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
9.5
44
136
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
12.8
9.4
16
13
ZXC40
NOMESCO Finland
Use of ultrasound
22.3
9.4
13
6
WZC30
NOMESCO Finland
Teaching
2.7
9.3
65
266
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.2
9.3
35
90
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
8.6
9.2
19
23
1XC02
NOMESCO Finland
NA
16.1
9.1
14
9
L01AX03
ATC
temozolomide; systemic
19.1
9.0
13
7
LAF16
NOMESCO Finland
Excision of uterus, adnexes and lymph nodes for treatment of ovarian cancer
24.7
9.0
12
5
8461/3-C56.9
ICD-O-3
High grade serous carcinoma of ovary
24.7
9.0
12
5
J05AB11
ATC
valaciclovir; oral
2.7
8.9
64
265
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.7
8.7
24
44
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.8
8.7
60
241
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
8.5
8.7
18
22
212
Kela drug reimbursment
Gout
7.2
8.7
20
29
B01AX05
ATC
fondaparinux; parenteral
16.7
8.6
13
8
L04AA06
ATC
mycophenolic acid; systemic
6.7
8.6
21
33
D68.8
ICD-10 Finland
Other specified coagulation defects
92.0
8.4
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
8.4
43
144
9673/3-C42.1
ICD-O-3
Mantle cell lymphoma of bone marrow
+∞
8.4
8
*
2874X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Secondary thrombocytopenia[THROMBOCYTOPENIA SECUNDARIA NUD]
+∞
8.4
8
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
4.5
8.2
28
66
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
8.2
96
510
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
17.6
8.1
12
7
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
22.6
8.1
11
5
JAL30
NOMESCO Finland
Omentectomy
8.0
8.0
17
22
J01MA14
ATC
moxifloxacin; systemic
2.9
7.9
47
174
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
8.7
7.9
16
19
A06AD11
ATC
lactulose; oral
2.5
7.9
64
284
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.3
7.7
27
66
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
18.8
7.6
11
6
ZXE00
NOMESCO Finland
One hour or less
1.9
7.5
158
1050
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
81.6
7.4
8
*
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
13.7
7.4
12
9
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.8
7.4
48
188
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
7.4
42
151
L04AX01
ATC
azathioprine; systemic
4.1
7.3
27
69
C57.0
ICD-10 Finland
Malignant neoplasm: Fallopian tube
+∞
7.3
7
*
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
7.2
66
312
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
6.8
7.2
17
26
A04AD12
ATC
aprepitant; systemic
6.8
7.2
17
26
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
8.2
7.2
15
19
9680/3-C77.9
ICD-O-3
Diffuse large B-cell lymphoma, NOS, of lymph node, NOS
20.5
7.2
10
5
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.5
7.2
24
56
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
12.3
7.1
12
10
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
10.3
7.1
13
13
ZXD05
NOMESCO Finland
Urgent procedure
1.9
7.0
128
801
N03AX14
ATC
levetiracetam; systemic
4.8
7.0
22
48
JAH00
NOMESCO Finland
Laparotomy
5.7
7.0
19
35
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.7
7.0
19
35
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
6.9
114
689
H02AB07
ATC
prednisone; oral
2.3
6.9
63
296
A02BC01
ATC
omeprazole; systemic
1.9
6.9
109
648
TAB00
NOMESCO Finland
Lumbar puncture
3.6
6.9
29
84
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
6.9
68
334
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
6.8
53
231
E0000UV
ATC
NA
1.8
6.8
151
1011
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
17.1
6.8
10
6
WF004
NOMESCO Finland
Palliative radiotherapy
7.4
6.8
15
21
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.6
6.7
16
25
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.7
6.7
18
33
WX892
NOMESCO Finland
Monitored bed care
3.0
6.7
38
137
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.6
6.4
21
48
C83.3
ICD-10 Finland
Diffuse large B-cell lymphoma
71.0
6.4
7
*
3009
Kela drug reimbursment
Niraparib
71.0
6.4
7
*
PJD53
NOMESCO Finland
Block dissection of aortic lymph nodes
71.0
6.4
7
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.5
6.4
28
84
ZX090
NOMESCO Finland
Other technic of radiotherapy
4.7
6.4
20
44
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.7
6.4
17
31
N05BA06
ATC
lorazepam; systemic, sublingual
3.7
6.3
26
74
JAH01
NOMESCO Finland
Laparoscopy
3.7
6.3
26
74
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.1
6.3
74
390
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
7.2
6.3
14
20
ZX131
NOMESCO Finland
Intrathecal
+∞
6.3
6
*
YNB00
NOMESCO Finland
Excision of bone marrow for transplantation
+∞
6.3
6
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.1
117
739
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.7
6.1
25
71
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
12.8
6.1
10
8
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
5.7
6.1
16
29
Mortality – FinRegistry
↥Association
Association between endpoint D3_SCNDTHROMBOCYTOPENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SCNDTHROMBOCYTOPENIA | 6.962 [5.14, 9.44] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.753 |
During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 941 females with D3_SCNDTHROMBOCYTOPENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SCNDTHROMBOCYTOPENIA | 6.625 [4.83, 9.08] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 505 out of 932 males with D3_SCNDTHROMBOCYTOPENIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_SCNDTHROMBOCYTOPENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.688% | 0.814% |
| 5 | 4.254% | 6.786% |
| 10 | 9.942% | 17.034% |
| 15 | 19.081% | 30.032% |
| 20 | 33.067% | 46.714% |
Relationships between endpoints
↥Index endpoint: D3_SCNDTHROMBOCYTOPENIA – Secondary thrombocytopenia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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