No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
134 |
4. Check minimum number of eventsNone |
134 |
5. Include endpointsNone |
134 |
6. Filter based on genotype QC (FinnGen only) |
134 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Defectus qualitativi thrombocytorum
Similar endpoints
↥List of similar endpoints to
Qualitative platelet defects
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 867 | 530 | 331 |
| Only index persons | 724 | 456 | 268 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.02 | 48.30 | 49.74 |
| Only index persons | 46.38 | 45.50 | 47.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 134 | 89 | 45 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 48.98 | 43.31 | 60.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 128
- Matched controls
- 1281
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
169.1
122
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
247.6
36.9
36
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
35.0
32
*
B02AA02
ATC
tranexamic acid; systemic
7.6
19.7
53
109
D68.9
ICD-10 Finland
Coagulation defect, unspecified
+∞
11.6
11
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
11.6
11
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
+∞
10.6
10
*
D75.2
ICD-10 Finland
Essential thrombocytosis
59.6
9.8
11
*
XW000
NOMESCO Finland
Bone marrow biopsy
10.8
9.6
18
19
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
9.5
9
*
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
+∞
8.4
8
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
8.3
8.0
17
23
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
48.0
7.8
9
*
H02AB06
ATC
prednisolone; systemic
2.8
7.6
73
408
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
7.4
7
*
126
Kela drug reimbursment
Chronic coagulation defects
+∞
7.4
7
*
WW500
NOMESCO Finland
Blood transfusion
6.8
7.1
17
28
D45
ICD-10 Finland
Polycythaemia vera
42.4
6.8
8
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
73.4
6.5
7
*
D69.0
ICD-10 Finland
Allergic purpura
+∞
6.3
6
*
D68.8
ICD-10 Finland
Other specified coagulation defects
+∞
6.3
6
*
B02BX05
ATC
eltrombopag; oral
+∞
6.3
6
*
L04AD01
ATC
ciclosporin; systemic
13.4
6.2
10
8
L04AX01
ATC
azathioprine; systemic
7.9
6.1
13
18
Mortality – FinRegistry
↥Association
Association between endpoint D3_QUALIPATELETDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_QUALIPATELETDEF | 2.075 [1.4, 3.07] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.246 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 401 females with D3_QUALIPATELETDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_QUALIPATELETDEF | 2.304 [1.61, 3.31] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 278 males with D3_QUALIPATELETDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_QUALIPATELETDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.492% |
| 5 | 1.265% | 2.769% |
| 10 | 3.326% | 6.831% |
| 15 | 6.02% | 12.131% |
| 20 | 9.835% | 20.27% |
Relationships between endpoints
↥Index endpoint: D3_QUALIPATELETDEF – Qualitative platelet defects
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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