Other primary thrombocytopenia

D3_OTHPRIMTHROMBOCYTOPENIA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D69.4 Hospital discharge: ICD-9 — 2873 Hospital discharge: excluded ICD-9 — 2873A Cause of death: ICD-10 — D69.4 Cause of death: ICD-9 — 2873 Cause of death: excluded ICD-9 — 2873A 2 out of 7 registries used, show all original rules.	138
4. Check minimum number of events None	138
5. Include endpoints None	138
6. Filter based on genotype QC (FinnGen only)	138

Control definitions (FinnGen only)

Control exclude: D3_COAGDEF_PURPUR_HAEMORRHAGIC

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D69
Name in latin: Alia thrombocytopenia primaria

NAME	D3_OTHPRIMTHROMBOCYTOPENIA
CONTROL_EXCLUDE	D3_COAGDEF_PURPUR_HAEMORRHAGIC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D694
HD_ICD_9	2873
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL	2873A
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D694
COD_ICD_9	2873
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL	2873A
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other primary thrombocytopenia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1180	637	530
Only index persons	901	512	389
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.01
Median age at first event (years)
Whole population	52.63	48.40	57.23
Only index persons	45.98	40.32	53.43

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	138	82	56
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	49.90	39.64	64.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
125: Matched controls
1249

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D69.4

ICD-10 Finland

Other primary thrombocytopenia

+∞

146.1

110

D69.6

ICD-10 Finland

Thrombocytopenia, unspecified

1309.6

74.2

D69.3

ICD-10 Finland

Idiopathic thrombocytopenic purpura

+∞

54.2

XW000

NOMESCO Finland

Bone marrow biopsy

19.2

20.3

129

Kela drug reimbursment

Idiopathic thrombocytopaenia or granulocytopenia

+∞

16.0

B02AA02

ATC

tranexamic acid; systemic

5.7

13.6

109

O99.1

ICD-10 Finland

Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium

71.9

11.8

2873X

ICD-9 Finland

Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]

+∞

11.6

D69.9

ICD-10 Finland

Haemorrhagic condition, unspecified

+∞

11.6

D64.9

ICD-10 Finland

Anaemia, unspecified

6.9

11.3

2873A

ICD-9 Finland

Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]

+∞

9.5

D69.1

ICD-10 Finland

Qualitative platelet defects

+∞

8.4

6753

FHL

Transabdominal splenectomy

+∞

8.4

WW500

NOMESCO Finland

Blood transfusion

8.2

8.3

D50.0

ICD-10 Finland

Iron deficiency anaemia secondary to blood loss (chronic)

11.2

8.3

D70.89

ICD-10 Finland

Neutropenic splenomegaly

23.9

8.2

JMA11

NOMESCO Finland

Laparoscopic total splenectomy

+∞

7.4

B02BX05

ATC

eltrombopag; oral

+∞

7.4

ZX120

NOMESCO Finland

Intravenous

4.6

7.0

Z31.5

ICD-10 Finland

Genetic counselling

7.2

6.9

Z2221

NOMESCO Finland

Medical doctor

3.0

6.9

229

A02BC01

ATC

omeprazole; systemic

3.0

6.5

193

2873C

ICD-9 Finland

Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA ALIA DEFINITA]

+∞

6.3

28719

ICD-8 Finland

Purpura and other haemorrhagic conditions, Thrombocytopenia NUD

+∞

6.3

D69.0

ICD-10 Finland

Allergic purpura

+∞

6.3

M04AA01

ATC

allopurinol; systemic

4.2

6.2

R04.0

ICD-10 Finland

Epistaxis

5.4

6.2

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3023520) Reticulocytes [#/volume] in Blood

6.73

21.90

5.5

2.5

e9/l

79.7

66.7

1.03

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

10.59

17.79

5.0

1.9

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

159

4.94

17.77

3.3

2.1

g/l

2.5

0.02

138

(42870588) Differential panel, method unspecified - Blood

365

4.46

16.80

12.9

5.8

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

11.98

15.85

1.8

1.9

—

(3005719) IgG [Mass/volume] in Serum or Plasma

5.60

15.53

5.5

2.3

g/l

10.1

0.04

(3003458) Phosphate [Moles/volume] in Serum or Plasma

134

4.50

14.26

5.5

6.3

mmol/l

1.1

0.19

122

(3001604) Monocytes [#/volume] in Blood

104

559

4.49

14.14

14.4

6.0

e9/l

0.6

0.38

496

(3006315) Basophils [#/volume] in Blood

104

560

4.48

14.08

14.4

6.0

e9/l

0.0

1.69

501

(3019198) Lymphocytes [#/volume] in Blood

103

576

4.11

12.61

14.5

6.0

e9/l

2.1

2.0

0.22

529

(3028026) IgM [Mass/volume] in Serum or Plasma

4.84

11.04

2.1

1.6

g/l

0.9

1.3

1.12

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

496

3.45

11.01

9.7

7.8

mmol/l

1.2

1.41

419

(3013650) Neutrophils [#/volume] in Blood by Automated count

107

661

3.75

10.24

18.6

9.7

e9/l

4.3

4.1

0.24

102

588

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

6.11

9.23

1.1

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

130

3.52

8.93

1.3

1.5

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

5.15

8.92

2.1

g/l

1.2

1.4

0.28

(3000093) Morphology [Interpretation] in Blood Narrative

17.76

8.74

1.3

1.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

280

2.93

8.53

3.9

3.1

umol/l

342.9

4155.9

1.05

236

(21494434) Karyotype in Bone marrow

15.77

8.39

1.7

1.0

—

(3045142) Bone marrow Pathology biopsy report

18.59

8.23

1.6

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

23.70

8.15

5.3

3.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

23.70

8.15

5.3

3.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

7.64

8.13

1.0

1.1

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

6.38

8.03

2.1

3.2

g/l

0.0

0.00

(3004588) Protein electrophoresis panel - Serum or Plasma

4.41

7.76

2.7

2.9

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

7.88

7.67

1.0

1.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

266

2.78

7.51

3.3

1.8

mg/l

3.2

3.0

0.18

232

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.19

7.37

2.1

2.6

—

(3037522) Nuclear Ab [Titer] in Serum

147

3.07

7.20

1.6

1.5

titre

1113.3

725.4

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

14.79

7.02

3.1

1.6

—

(3032080) INR in Blood by Coagulation assay

402

2.58

6.94

10.9

7.8

inr

1.1

1.2

0.78

138

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.66

6.80

1.1

1.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

568

2.60

6.66

10.6

6.0

umol/l

14.2

12.6

0.31

538

(3000991) Gas panel - Venous blood

3.56

6.54

12.7

9.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.72

6.46

15.0

7.1

mmol/l

23.7

25.0

0.82

(43055222) Platelet function.collagen + Adenosine diphosphate induced and EPINEPHrine induced panel - Blood

+∞

6.29

1.2

0.0

—

(3018418) pH of Serum or Plasma

311

2.49

6.21

5.1

3.5

7.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

188

2.68

6.04

1.5

1.6

—

(40758558) Short blood count panel - Blood

307

2.46

6.01

12.5

5.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

424

2.39

5.92

8.3

4.8

g/l

35.1

36.0

0.68

400

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

403

2.36

5.72

2.7

1.9

pmol/l

96.5

96.0

0.03

203

(3044640) Blood type and Crossmatch panel - Blood

329

2.39

5.70

4.5

2.2

—

(3021589) Normoblasts [#/volume] in Blood

516

2.31

5.43

24.6

9.7

e9/l

0.0

0.06

430

(40760888) Immunoglobulin light chains.free panel - Serum

5.91

5.40

3.2

5.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

4.96

5.37

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

250

2.41

5.35

4.3

2.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

164

2.62

5.31

3.1

2.5

e6/l

3.3

1.5

0.60

(3012544) pH of Venous blood

2.99

5.16

7.8

4.6

—

(3003396) Base excess in Arterial blood by calculation

104

2.85

4.90

8.2

12.6

mmol/l

-0.5

2.1

1.27

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

252

2.31

4.84

2.1

mg/l

1.4

1.0

0.50

196

(3023368) Bacteria identified in Blood by Culture

270

2.26

4.72

7.2

4.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

5.06

4.61

1.0

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

176

2.41

4.53

3.1

2.4

e6/l

3.9

0.8

0.72

100

(3002179) Metamyelocytes/100 leukocytes in Blood

3.00

4.49

9.9

4.0

0.4

0.3

0.05

(3042936) Bacteria identified in Isolate by Culture

136

2.54

4.43

2.9

2.3

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.14

4.36

1.9

1.7

—

(3030467) Casts [#/volume] in Urine by Automated count

310

2.15

4.35

4.4

2.8

e6/l

1.6

0.4

0.61

227

(3007164) IgA [Mass/volume] in Serum or Plasma

239

2.23

4.34

2.1

1.5

g/l

2.0

2.7

1.04

132

(3037467) Urinalysis macro (dipstick) panel - Urine

102

768

2.26

4.28

6.5

4.3

—

(3018095) Leukocytes [#/volume] in Urine

396

2.09

4.27

5.6

3.4

e6/l

109.6

52.7

0.48

271

(36304419) Bacteria [Presence] in Urine

305

2.13

4.22

4.3

2.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.60

4.17

12.5

21.2

—

(3052851) Hemolysis interference index of Serum or Plasma

4.61

4.16

2.8

3.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

192

2.27

4.04

2.9

3.2

ng/l

52.1

165.7

1.02

138

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.67

4.01

2.1

2.0

g/l

0.2

0.13

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.41

3.96

1.1

1.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

7.64

3.91

2.5

1.6

32.0

31.6

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

12.45

3.80

1.0

6.4

116.3

103.4

—

(3005895) Myoglobin [Mass/volume] in Serum or Plasma

3.90

3.72

2.4

2.2

ug/l

555.4

339.4

0.23

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.78

3.64

3.5

4.1

ng/l

144.2

68.1

0.54

(3017181) Myelocytes/100 leukocytes in Blood

2.64

3.60

10.4

4.0

0.8

0.9

0.04

(4062490)

8.12

3.60

1.4

1.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.40

3.60

2.1

2.0

g/l

1.1

1.2

0.31

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.07

3.59

2.7

1.8

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.68

3.58

10.4

4.1

0.1

0.15

(3025159) Blasts/100 leukocytes in Blood

2.68

3.58

10.3

4.0

0.4

0.01

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

498

1.93

3.55

7.1

4.2

—

(3011648) Oxygen content in Venous blood

10.37

3.53

9.0

9.8

10.8

11.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

3.46

3.43

1.2

1.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.99

3.38

1.7

1.6

—

(3002582) Erythrocytes [#/volume] in Urine

345

1.93

3.32

4.5

2.9

e6/l

33.8

237.8

0.53

256

(3016650) Hepatitis A virus Ab [Presence] in Serum

4.99

3.30

1.0

1.1

—

(3037756) Immunofixation for Serum or Plasma

4.99

3.30

1.3

1.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

259

1.96

3.12

10.5

5.0

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

3.64

3.11

2.5

2.6

mmol/l

22.4

23.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

381

1.85

2.99

5.0

2.9

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.78

2.99

1.5

1.2

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

4.92

2.96

1.6

1.8

—

(3000475) Leukocytes [#/volume] in Synovial fluid

4.92

2.96

1.5

1.8

e6/l

12955.6

7764.7

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.30

2.94

2.7

1.5

—

(3044941) Cell count panel - Synovial fluid

6.91

2.90

1.7

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

6.91

2.90

1.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

5.20

2.76

15.0

5.0

66.9

62.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

104

849

1.91

2.73

4.2

3.9

pmol/l

14.6

14.8

0.33

768

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

6.21

2.72

1.0

1.3

—

(1616796) Gas panel - Central venous blood

3.94

2.72

2.4

2.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

237

1.90

2.72

1.7

1.8

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

356

1.79

2.69

4.7

3.1

u/l

41.5

29.1

0.48

342

(3007853) Bacteria identified in Skin by Aerobe culture

123

2.15

2.66

2.1

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.78

2.62

1.1

1.3

—

(3024928) Oxygen saturation in Venous blood

4.18

2.61

14.0

5.5

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.18

2.61

8.0

3.9

66.3

54.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.18

2.61

7.5

3.8

e9/l

5.4

3.8

—

(3021788) Differential panel - Synovial fluid

5.64

2.57

1.7

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

113

2.13

2.42

2.5

1.6

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

4.28

2.39

1.4

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

115

2.09

2.32

2.5

1.7

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

732

1.71

2.31

3.4

3.0

u/l

59.0

43.7

0.78

690

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

4.04

2.28

1.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.64

2.25

1.0

1.1

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

5.71

2.23

1.4

1.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

2.51

2.19

8.8

4.0

g/l

118.1

130.2

1.40

(40761511) CBC panel - Blood by Automated count

128

1153

2.52

2.18

25.6

12.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

172

1.87

2.15

2.4

1.8

—

(3026782) Osmolality of Urine

208

1.77

2.01

3.8

2.6

mosm/kgh2o

493.4

565.0

0.88

170

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

116

1019

1.87

1.95

26.6

12.1

ml/min/173m2

79.2

83.3

0.88

100

820

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

2.16

1.94

3.4

5.5

kpa

4.8

5.0

0.89

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

3.29

1.90

2.4

1.5

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.51

1.90

10.4

3.6

1.5

1.2

0.26

(3049717) Cytology report of Urine Cyto stain

2.97

1.89

2.0

3.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.97

1.89

1.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

102

2.00

1.87

3.3

4.7

ug/l

2.7

6.6

0.96

(3026008) Bacteria identified in Urine by Culture

316

1.63

1.84

4.1

2.8

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

4.28

1.84

1.2

1.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

2.15

1.83

3.1

5.7

mmol/l

0.4

1.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

115

1016

1.79

1.78

36.5

14.1

39.2

40.1

0.93

763

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.12

1.77

2.9

1.5

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

2.77

1.75

2.1

1.4

—

(40768797) Stomach Pathology biopsy report

168

1.75

1.72

1.9

1.2

—

(3000494) Fungus identified in Specimen by Culture

114

1.88

1.67

1.7

1.6

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.89

1.67

1.3

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

122

1103

1.91

1.66

30.1

13.3

mg/l

21.5

21.7

0.03

109

868

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

2.59

1.62

2.1

1.4

—

(3012516) Albumin [Mass/volume] in Urine

284

1.58

1.54

4.5

3.3

mg/l

39.2

71.7

0.84

181

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

3.42

1.53

1.2

1.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

3.42

1.53

1.0

1.1

—

(4035726)

1.90

1.51

1.4

1.5

—

(40768804) Tissue Pathology biopsy report

450

1.50

1.49

2.2

2.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.40

1.46

2.6

2.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.80

1.45

2.2

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

112

1.81

1.44

1.6

1.9

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.68

1.38

1.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.68

1.38

1.0

1.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.22

1.36

2.9

2.2

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.84

1.29

2.8

1.6

—

(3021901) Oxygen saturation in Capillary blood

2.84

1.29

2.6

2.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

304

1.50

1.29

5.2

4.1

mg/mmol

5.5

9.8

0.86

192

(3015377) Calcium [Moles/volume] in Serum or Plasma

359

1.47

1.28

4.3

3.1

mmol/l

2.3

2.4

1.36

313

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

2.30

1.26

1.1

1.7

ug/l

0.6

1.5

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

315

1.48

1.24

3.5

2.0

u/l

1016.0

236.5

0.51

297

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.69

1.22

2.0

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

185

1.57

1.20

1.3

u/ml

1.9

7.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.97

1.15

1.5

1.2

—

(3022217) INR in Platelet poor plasma by Coagulation assay

121

1.66

1.13

27.3

23.2

—

1.3

—

(36660697) Celiac disease serology panel - Serum

1.73

1.12

1.3

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

538

1.39

1.11

5.0

3.7

estimate

0.0

0.00

113

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

111

1012

1.49

1.06

4.2

3.9

mmol/l

1.4

1.3

0.83

106

929

(3003327) Ova and parasites identified in Stool by Light microscopy

2.02

1.06

1.3

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

200

1.50

1.04

1.4

1.3

iu/ml

74.6

31.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

2.11

1.04

1.4

1.5

—

(40767503) Oxygen content in Capillary blood by calculation

2.32

1.04

2.4

2.5

15.5

16.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

115

1058

1.52

1.03

4.4

4.3

mmol/l

4.4

4.6

1.45

109

980

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

401

1.39

1.01

4.7

3.6

ng/l

58.8

35.9

0.50

262

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.05

1.01

1.1

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.89

1.01

1.2

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

545

1.36

1.00

5.0

3.7

estimate

0.0

0.00

109

(3011397) Hemoglobin [Presence] in Urine by Test strip

238

1.45

0.98

5.3

3.7

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

186

1.49

0.96

3.0

3.1

mmol/l

2.4

2.5

0.68

160

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.94

0.95

2.0

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

539

1.35

0.95

7.1

5.0

estimate

0.0

0.00

114

(42529406) Shigella sp [Presence] in Stool by Culture

2.19

0.92

1.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.19

0.92

1.0

1.2

—

(3027315) Oxygen [Partial pressure] in Blood

2.19

0.92

4.8

2.5

kpa

8.3

8.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.19

0.92

1.2

1.1

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.19

0.92

4.8

2.5

kpa

4.9

5.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.19

0.92

1.0

1.2

—

(3020891) Body temperature

1.96

0.90

3.9

4.7

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.87

0.87

2.5

3.6

38.1

47.9

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.62

0.82

3.6

3.7

mmol/l

1.2

0.16

(3010421) pH of Blood

1.85

0.80

4.8

2.6

7.4

—

(3019060) Gas panel - Arterial blood

1.70

0.77

3.9

10.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

113

1053

1.40

0.77

4.5

4.2

mmol/l

1.3

1.5

3.03

107

965

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.22

0.77

1.8

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.68

0.75

1.2

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

307

1.33

0.72

3.8

3.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

116

0.58

0.71

7.7

7.2

—

(21494755) Public health laboratory ask at order entry panel

116

0.58

0.71

1.6

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.66

0.67

1.2

—

(1761868) Lipid panel - Serum or Plasma

403

0.76

0.65

2.5

2.9

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.63

0.63

1.6

1.9

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.69

0.62

2.4

1.6

—

(3022145) Colonoscopy Study observation

124

1.42

0.59

1.5

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.75

0.58

1.8

1.5

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

1.51

0.58

3.8

6.6

mmol/l

23.1

24.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

123

0.63

0.58

1.4

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.60

0.55

1.3

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.56

0.53

1.2

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.52

0.52

1.5

1.8

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.55

0.49

1.6

2.9

mmol/l

25.5

25.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.52

0.48

1.7

2.1

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.42

0.44

2.3

1.7

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.61

0.43

1.0

1.5

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

2.7

—

4.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

2.7

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

2.7

—

106.6

—

(3011288) Drugs identified in Urine by Screen method

1.49

0.41

1.8

1.7

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

105

998

1.22

0.40

6.4

5.6

mmol/mol

39.0

39.7

0.33

100

939

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.40

0.0

1.7

—

(3044889) 12 lead EKG panel

723

1.18

0.40

4.1

3.6

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

1.44

0.39

1.6

1.2

u/l

12.6

10.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

107

1.34

0.39

4.1

3.4

—

(3019225) pH of Specimen

1.37

0.37

6.0

4.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.29

0.37

1.4

1.5

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.29

0.37

2.2

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

163

1.27

0.36

3.0

ug/l

0.7

0.07

113

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.35

0.34

1.5

2.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

137

1.27

0.34

1.8

1.6

—

(3016879) Cocaine [Presence] in Urine

1.32

0.33

1.2

1.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

251

1.20

0.32

1.9

1.6

—

(3008898) HLA-B27 [Presence]

1.26

0.30

1.0

1.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.27

0.28

1.4

4.0

pmol/l

4.7

4.6

—

(3019150) Specific gravity of Urine by Refractometry

227

1.18

0.26

4.4

4.1

kg/l

1.0

—

(4010399)

1.25

0.26

1.2

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

145

1.20

0.22

1.7

2.1

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.20

0.21

1.6

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.20

0.21

1.6

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.20

0.21

1.6

1.5

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.20

0.21

1.6

1.5

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

3.8

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

11.7

—

1220.9

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

7.9

—

818.2

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

1.1

—

(3027008) Opiates [Presence] in Urine

1.23

0.20

1.2

1.4

—

(3028300) Cannabinoids [Presence] in Urine

1.23

0.20

1.2

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

1.23

0.20

1.2

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.21

0.20

1.2

1.4

—

(3003694) ABO and Rh group [Type] in Blood

315

1.11

0.15

1.8

1.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

131

1.16

0.15

1.4

1.5

—

(3000492) Spirometry study

0.83

0.14

2.4

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

785

1.08

0.13

3.9

3.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.17

0.10

1.6

—

(1002224) Polysomnography panel

1.04

0.09

1.0

1.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

105

1032

1.07

0.09

5.0

4.4

mmol/l

5.8

5.9

0.50

941

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.09

0.09

1.2

1.0

—

(3002256) Pathology report gross observation

127

1.11

0.08

1.1

1.2

—

(40761536) Microorganisms panel - Urine sediment

109

1.11

0.06

6.8

3.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

201

0.94

0.05

1.4

—

(3013512) EKG study

286

1.02

0.00

4.6

4.1

—

(3029937) Albumin [Presence] in Urine by Test strip

299

1.00

0.00

6.2

3.9

estimate

0.0

0.00

109

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

421

1.00

0.00

5.1

3.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

232

0.99

0.00

3.9

4.2

22.1

21.9

—

123

(40768443) Skin Pathology biopsy report

0.92

0.00

1.4

1.1

—

(3004451) EKG impression Narrative

0.00

0.0

1.4

—

(3001684) Respiratory syncytial virus Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3027901) Hemoglobin [Mass/volume] in Arterial cord blood

0.00

0.0

1.0

—

178.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.1

—

(3012741) Chlamydophila pneumoniae IgA Ab [Titer] in Serum

0.00

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.2

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.6

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.2

—

(4198724)

0.00

0.0

1.0

—

(44806420)

0.00

0.0

2.0

—

(3022621) pH of Urine by Test strip

0.92

0.00

2.7

2.4

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.0

7.7

—

0.6

—

(3022313) Gas panel - Capillary blood

0.95

0.00

4.5

5.7

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3027231) Wheat IgE Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

2.4

—

1.2

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(40761535) Cells panel - Urine sediment

1.01

0.00

4.8

3.6

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(4211845)

0.00

0.0

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

130

1.00

0.00

1.6

1.9

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_OTHPRIMTHROMBOCYTOPENIA and mortality.

Females

Parameter	HR [95% CI]	p-value
D3_OTHPRIMTHROMBOCYTOPENIA	2.493 [1.72, 3.61]	< 0.001
Birth year	0.994 [0.99, 1.0]	0.153

During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 392 females with D3_OTHPRIMTHROMBOCYTOPENIA died.

Males

Parameter	HR [95% CI]	p-value
D3_OTHPRIMTHROMBOCYTOPENIA	2.598 [1.6, 4.21]	< 0.001
Birth year	0.985 [0.98, 0.99]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 333 males with D3_OTHPRIMTHROMBOCYTOPENIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_OTHPRIMTHROMBOCYTOPENIA.

N-year risk	Females	Males
1	0.238%	0.479%
5	1.336%	2.855%
10	3.226%	6.937%
15	6.591%	13.331%
20	11.845%	21.59%

Relationships between endpoints

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Index endpoint: D3_OTHPRIMTHROMBOCYTOPENIA – Other primary thrombocytopenia

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other primary thrombocytopenia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints