No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
138 |
4. Check minimum number of eventsNone |
138 |
5. Include endpointsNone |
138 |
6. Filter based on genotype QC (FinnGen only) |
138 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Alia thrombocytopenia primaria
Similar endpoints
↥List of similar endpoints to
Other primary thrombocytopenia
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1180 | 637 | 530 |
| Only index persons | 901 | 512 | 389 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 52.63 | 48.40 | 57.23 |
| Only index persons | 45.98 | 40.32 | 53.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138 | 82 | 56 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 49.90 | 39.64 | 64.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 125
- Matched controls
- 1249
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
146.1
110
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
1309.6
74.2
65
*
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
54.2
48
*
XW000
NOMESCO Finland
Bone marrow biopsy
19.2
20.3
31
21
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
16.0
15
*
B02AA02
ATC
tranexamic acid; systemic
5.7
13.6
44
109
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
71.9
11.8
13
*
2873X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]
+∞
11.6
11
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
+∞
11.6
11
*
D64.9
ICD-10 Finland
Anaemia, unspecified
6.9
11.3
29
52
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
9.5
9
*
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
8.4
8
*
6753
FHL
Transabdominal splenectomy
+∞
8.4
8
*
WW500
NOMESCO Finland
Blood transfusion
8.2
8.3
18
25
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
11.2
8.3
15
15
D70.89
ICD-10 Finland
Neutropenic splenomegaly
23.9
8.2
11
5
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
7.4
7
*
B02BX05
ATC
eltrombopag; oral
+∞
7.4
7
*
ZX120
NOMESCO Finland
Intravenous
4.6
7.0
24
61
Z31.5
ICD-10 Finland
Genetic counselling
7.2
6.9
16
25
Z2221
NOMESCO Finland
Medical doctor
3.0
6.9
50
229
A02BC01
ATC
omeprazole; systemic
3.0
6.5
44
193
2873C
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA ALIA DEFINITA]
+∞
6.3
6
*
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
6.3
6
*
D69.0
ICD-10 Finland
Allergic purpura
+∞
6.3
6
*
M04AA01
ATC
allopurinol; systemic
4.2
6.2
23
63
R04.0
ICD-10 Finland
Epistaxis
5.4
6.2
18
38
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHPRIMTHROMBOCYTOPENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.493 [1.72, 3.61] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 392 females with D3_OTHPRIMTHROMBOCYTOPENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHPRIMTHROMBOCYTOPENIA | 2.598 [1.6, 4.21] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 111 out of 333 males with D3_OTHPRIMTHROMBOCYTOPENIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHPRIMTHROMBOCYTOPENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.238% | 0.479% |
| 5 | 1.336% | 2.855% |
| 10 | 3.226% | 6.937% |
| 15 | 6.591% | 13.331% |
| 20 | 11.845% | 21.59% |
Relationships between endpoints
↥Index endpoint: D3_OTHPRIMTHROMBOCYTOPENIA – Other primary thrombocytopenia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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