No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
305 |
4. Check minimum number of eventsNone |
305 |
5. Include endpointsNone |
305 |
6. Filter based on genotype QC (FinnGen only) |
305 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Purpura non thrombocytopenica
Similar endpoints
↥List of similar endpoints to
Other nonthrombocytopenic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2281 | 1241 | 1022 |
| Only index persons | 1995 | 1125 | 870 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 61.62 | 63.49 | 59.23 |
| Only index persons | 59.44 | 61.58 | 56.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 305 | 177 | 128 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 58.97 | 57.20 | 61.43 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 278
- Matched controls
- 2778
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
4503599627370496.0
323.0
262
*
D69.0
ICD-10 Finland
Allergic purpura
420.7
38.0
37
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.7
33.8
87
155
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.0
19.5
92
306
H02AB06
ATC
prednisolone; systemic
3.2
19.0
170
917
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
71.5
18.0
20
*
2872B
ICD-9 Finland
Purpura and other haemorrhagic conditions, Other nonthrombocytopenic purpuras
+∞
17.9
17
*
D07AC01
ATC
betamethasone; topical
2.9
15.1
132
664
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
33.8
12.7
16
5
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
48.9
12.0
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
12.0
144
836
A46
ICD-10 Finland
Erysipelas
3.4
11.8
63
221
L04AX01
ATC
azathioprine; systemic
6.9
11.8
29
46
C03CA01
ATC
furosemide; systemic
2.7
11.6
103
505
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
11.5
11
*
E0000UV
ATC
NA
2.5
11.5
136
776
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
10.7
55
188
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
10.3
114
621
D07AB08
ATC
desonide; topical
3.4
9.5
48
161
L95.8
ICD-10 Finland
Other vasculitis limited to skin
+∞
9.4
9
*
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.5
9.4
27
53
R50.9
ICD-10 Finland
Fever, unspecified
3.0
9.1
56
217
R60.0
ICD-10 Finland
Localized oedema
3.3
8.9
46
158
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.6
8.3
38
118
A02BC02
ATC
pantoprazole; systemic
2.1
7.8
185
1359
XQ848
NOMESCO Finland
Dermatological photography
8.0
7.5
16
21
J01CF05
ATC
flucloxacillin; systemic
5.7
7.4
20
37
XW000
NOMESCO Finland
Bone marrow biopsy
5.6
7.2
20
38
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.9
6.8
42
161
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
6.8
42
162
N03AX12
ATC
gabapentin; oral
2.6
6.7
51
222
L17
ICPC
Foot/toe symptom/complaint
2.2
6.7
80
435
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
6.6
48
205
WW200
NOMESCO Finland
Immunization
6.5
6.6
16
26
ZX120
NOMESCO Finland
Intravenous
3.2
6.4
33
113
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
6.3
6
*
TQW80
NOMESCO Finland
Local dermatologic skincare
6.5
6.3
15
24
D07AC13
ATC
mometasone; topical
2.1
6.2
87
504
C08CA13
ATC
lercanidipine; oral
2.6
6.2
46
198
J01FF01
ATC
clindamycin; systemic
2.1
6.2
82
466
P01BA02
ATC
hydroxychloroquine; oral
3.1
6.1
32
111
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHNONTHROMBOCYTOPENPURPURA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHNONTHROMBOCYTOPENPURPURA | 1.597 [1.33, 1.92] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.101 |
During the follow-up period (1.1.1998 — 31.12.2019), 289 out of 1034 females with D3_OTHNONTHROMBOCYTOPENPURPURA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHNONTHROMBOCYTOPENPURPURA | 2.141 [1.7, 2.7] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 268 out of 813 males with D3_OTHNONTHROMBOCYTOPENPURPURA died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHNONTHROMBOCYTOPENPURPURA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.141% | 0.389% |
| 5 | 0.854% | 2.614% |
| 10 | 2.273% | 6.654% |
| 15 | 4.128% | 12.93% |
| 20 | 7.356% | 21.529% |
Relationships between endpoints
↥Index endpoint: D3_OTHNONTHROMBOCYTOPENPURPURA – Other nonthrombocytopenic purpura
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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