This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Other combined immunodeficiencies
D3_OCID
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
49 |
4. Check minimum number of eventsNone |
49 |
5. Include endpointsNone |
49 |
6. Filter based on genotype QC (FinnGen only) |
49 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D81
- Name in latin
- Aliae deficientiae immunales mixtae specificatae
Similar endpoints
↥List of similar endpoints to
Other combined immunodeficiencies
based on the number of shared cases.
Similar with more cases:
- Combined immunodeficiencies
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 294 | 155 | 138 |
| Only index persons | 247 | 137 | 110 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 57.07 | 57.06 | 57.39 |
| Only index persons | 56.21 | 56.30 | 56.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 49 | 28 | 21 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 54.81 | 54.56 | 55.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum
5
0
+∞
5.29
2.2
0.0
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
13
34
4.84
4.90
4.4
2.4
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
13
35
4.69
4.73
3.0
1.5
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
12
34
4.35
4.06
3.0
1.6
—
—
—
0
0
(3020779) Urea [Moles/volume] in Serum or Plasma
12
36
4.09
3.76
7.3
5.1
mmol/l
10.6
8.5
0.37
12
36
(3023368) Bacteria identified in Blood by Culture
21
96
3.08
3.47
12.0
3.3
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
12
39
3.75
3.35
4.4
6.1
u/l
202.7
246.1
1.90
12
39
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
14
51
3.44
3.32
3.6
1.8
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
11
34
3.88
3.29
3.1
1.4
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
32
190
2.97
3.24
10.5
6.0
mmol/l
1.2
1.2
0.57
27
159
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
6
8
8.34
3.15
4.2
2.3
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
29
173
2.66
2.77
4.3
4.0
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
17
78
2.81
2.70
1.5
1.9
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
23
124
2.61
2.67
19.7
5.9
—
—
—
0
0
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
9
27
3.84
2.54
3.4
1.7
ng/l
102.1
113.0
—
9
22
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
7
17
4.61
2.46
1.3
1.2
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
21
117
2.39
2.20
2.0
1.9
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
11
44
2.93
2.19
2.3
1.5
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
5
10
5.42
2.12
1.6
1.1
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
5
10
5.42
2.12
2.8
1.8
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
5
10
5.42
2.12
2.8
1.8
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
6
15
4.40
2.11
2.3
1.5
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
23
136
2.30
2.09
2.6
1.8
pmol/l
80.0
98.0
1.09
14
61
(3033658) Prothrombin time (PT) actual/Normal
18
96
2.38
2.05
4.2
2.8
%
91.3
85.8
0.46
18
96
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
6
16
4.12
2.00
2.7
2.0
—
—
—
0
0
(40758558) Short blood count panel - Blood
18
98
2.32
1.95
11.9
8.2
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
11
47
2.73
1.94
1.3
1.2
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
7
24
3.23
1.80
2.1
1.4
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
5
13
4.15
1.76
1.2
1.1
—
—
—
0
0
(3018010) Neutrophils/100 leukocytes in Blood
27
185
2.02
1.57
19.1
5.6
%
59.0
55.5
0.74
27
175
(3037467) Urinalysis macro (dipstick) panel - Urine
35
264
2.14
1.56
8.2
4.7
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
15
3.58
1.56
1.8
1.1
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
23
150
2.01
1.53
7.3
2.7
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
5
16
3.35
1.47
1.0
1.2
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
26
179
1.96
1.47
21.1
5.7
%
3.3
2.8
0.64
26
167
(3019069) Monocytes/100 leukocytes in Blood
26
180
1.95
1.43
22.0
5.9
%
9.1
8.5
0.48
26
170
(3022096) Basophils/100 leukocytes in Blood
25
172
1.93
1.39
21.3
5.7
%
0.7
0.7
0.01
25
160
(3021960) Folate [Moles/volume] in Serum or Plasma
14
80
2.05
1.30
1.7
1.4
nmol/l
21.7
23.1
0.15
14
68
(3025941) Bacteria identified in Stool by Culture
5
19
2.81
1.24
2.2
1.1
—
—
—
0
0
(3012544) pH of Venous blood
8
40
2.19
1.18
2.3
6.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
17
111
1.81
1.06
4.5
2.4
—
—
—
0
0
(3015736) pH of Urine
21
150
1.70
0.96
4.0
3.8
—
—
—
0
0
(3000991) Gas panel - Venous blood
8
42
2.08
0.94
2.0
4.3
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
18
124
1.71
0.93
3.6
3.1
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
11
65
1.89
0.91
1.5
2.0
—
—
—
0
0
(3003396) Base excess in Arterial blood by calculation
8
44
1.97
0.91
3.4
4.8
mmol/l
1.7
1.3
—
8
35
(3032080) INR in Blood by Coagulation assay
20
143
1.67
0.90
10.6
7.3
inr
1.2
1.3
—
7
50
(3009542) Hematocrit [Volume Fraction] of Blood
40
345
1.87
0.87
25.8
14.0
%
39.1
39.8
0.30
27
245
(4035726)
6
32
1.99
0.85
3.3
1.2
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
10
59
1.87
0.83
3.1
1.8
umol/l
13.2
14.7
—
10
53
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
24
0.00
0.81
0.0
1.0
—
—
—
0
0
(3004789) Transferrin [Mass/volume] in Serum or Plasma
9
54
1.81
0.80
3.2
1.7
g/l
2.0
2.5
—
9
48
(3004716) Salmonella sp identified in Stool by Organism specific culture
5
23
2.30
0.78
1.4
1.3
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
7
38
1.98
0.77
1.3
1.4
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
5
24
2.20
0.77
6.4
2.4
e6/l
0.4
0.1
—
5
24
(40768804) Tissue Pathology biopsy report
19
139
1.60
0.76
2.5
2.0
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
32
265
1.60
0.76
6.1
4.5
—
22.4
—
0
5
(3002256) Pathology report gross observation
7
40
1.87
0.75
1.6
1.2
—
—
—
0
0
(3021447) Carbon dioxide [Partial pressure] in Venous blood
7
42
1.78
0.72
2.3
6.1
kpa
5.6
5.7
—
7
42
(3017143) Hepatitis C virus Ab [Presence] in Serum
8
49
1.75
0.66
1.9
1.7
—
—
—
0
0
(3022217) INR in Platelet poor plasma by Coagulation assay
8
49
1.75
0.66
29.6
29.5
—
1.7
—
0
6
(3019225) pH of Specimen
5
29
1.80
0.65
8.8
2.8
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
16
116
1.56
0.65
2.8
4.1
ng/l
2602.5
1602.5
0.18
11
100
(3011397) Hemoglobin [Presence] in Urine by Test strip
13
90
1.60
0.63
4.5
3.7
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
27
221
1.49
0.63
4.0
2.8
—
—
—
0
0
(3009508) Creatinine [Moles/volume] in Urine
17
126
1.53
0.63
4.3
2.7
mmol/l
6.7
8.1
0.62
17
110
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
8
53
1.61
0.62
4.0
1.6
%
24.6
26.6
—
8
42
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
6
34
1.87
0.61
3.3
8.7
mmol/l
26.3
25.3
—
6
34
(3024354) Oxygen [Partial pressure] in Venous blood
6
39
1.61
0.55
1.3
6.5
kpa
4.5
4.2
—
6
39
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
5
83
0.56
0.51
1.4
1.5
—
—
—
0
0
(3022621) pH of Urine by Test strip
5
31
1.68
0.44
1.2
2.7
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
5
31
1.68
0.44
7.4
5.0
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
5
32
1.62
0.44
2.2
1.7
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
15
0.00
0.42
0.0
1.7
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
6
44
1.41
0.36
12.3
8.9
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
13
103
1.36
0.32
7.4
4.3
—
—
—
0
0
(3013512) EKG study
9
119
0.70
0.32
4.1
3.9
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
11
85
1.38
0.31
16.5
5.0
—
—
—
0
0
(3044889) 12 lead EKG panel
30
272
1.27
0.27
6.1
3.8
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
11
0.00
0.21
0.0
1.6
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
11
0.00
0.21
0.0
6.1
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay
0
10
0.00
0.21
0.0
1.0
—
3.0
—
0
5
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
14
0.00
0.20
0.0
2.0
—
37.9
—
0
14
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
17
149
1.22
0.19
8.0
4.7
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
8
97
0.79
0.15
2.5
1.8
pmol/l
606.1
474.9
—
8
85
(3003694) ABO and Rh group [Type] in Blood
10
112
0.87
0.08
1.3
1.4
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
11
120
0.89
0.05
2.0
3.2
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
16
154
1.06
0.01
4.8
4.5
ng/l
23.0
24.0
—
10
110
(40761511) CBC panel - Blood by Automated count
41
404
1.09
0.00
31.1
12.3
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(40768441) Liver Pathology biopsy report
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
6.0
—
105.6
—
0
5
(3002523) Influenza virus A Ag [Presence] in Specimen
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3003181) Sodium [Moles/volume] in Urine
0
6
0.00
0.00
0.0
1.2
—
41.3
—
0
6
(21494890) Protein electrophoresis panel - 24 hour Urine
0
5
0.00
0.00
0.0
7.6
—
—
—
0
0
(4306422)
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
2.3
—
0
7
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
6
68
0.87
0.00
1.2
1.2
—
11.2
—
0
26
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
6
68
0.87
0.00
1.5
1.7
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
52
0.96
0.00
1.6
1.3
—
—
—
0
0
(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
84.3
—
0
6
(3003740) Influenza virus B Ag [Presence] in Specimen
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016244) Insulin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
13.2
—
0
5
(4268621)
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3035285) Chloride [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
2.0
—
110.0
—
0
5
(40768800) Prostate Pathology biopsy report
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
7
0.00
0.00
0.0
2.7
—
8.3
—
0
7
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
35
350
1.00
0.00
34.9
12.7
ml/min/173m2
83.5
78.4
0.34
29
266
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008037) Lactate [Moles/volume] in Venous blood
0
8
0.00
0.00
0.0
2.5
—
1.4
—
0
8
(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
0.00
0.0
1.0
—
118.9
—
0
8
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3032773) Endomysium IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
2.0
—
4.1
—
0
5
(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
11.9
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint D3_OCID and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OCID | 2.764 [1.72, 4.44] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 122 males with D3_OCID died.
Mortality risk
Mortality risk for people of age
years, who have D3_OCID.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.54% |
| 5 | No data | 3.146% |
| 10 | No data | 7.953% |
| 15 | No data | 14.981% |
| 20 | No data | 24.348% |
Relationships between endpoints
↥Index endpoint: D3_OCID – Other combined immunodeficiencies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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