No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
90 |
4. Check minimum number of eventsNone |
90 |
5. Include endpointsNone |
90 |
6. Filter based on genotype QC (FinnGen only) |
90 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D59
- Name in latin
- Syndroma haemolytico-uraemicum
Similar endpoints
↥List of similar endpoints to
Haemolytic-uraemic syndrome
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 569 | 325 | 242 |
| Only index persons | 445 | 258 | 187 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 25.46 | 26.20 | 24.21 |
| Only index persons | 25.69 | 26.59 | 24.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 90 | 50 | 40 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 38.71 | 31.64 | 47.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 81
- Matched controls
- 808
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
61.5
51
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
54.4
46
*
TK800
NOMESCO Finland
Hemodialysis
574.9
37.1
34
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
191.1
34.8
34
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
518.3
34.7
32
*
A11CC03
ATC
alfacalcidol; systemic
210.1
28.7
28
*
Z94.0
ICD-10 Finland
Kidney transplant status
376.0
27.5
26
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
355.2
26.3
25
*
127
Kela drug reimbursment
Transplant complication
99.3
25.7
27
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
335.1
25.1
24
*
Z49.1
ICD-10 Finland
Extracorporeal dialysis
315.7
24.0
23
*
L04AA06
ATC
mycophenolic acid; systemic
75.2
23.8
26
5
A12AA04
ATC
calcium carbonate; oral
111.6
23.1
24
*
N18.0
ICD-10 Finland
End-stage renal disease
+∞
23.0
21
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
158.0
22.9
23
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
31.4
22.0
29
14
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
278.8
21.7
21
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
92.9
19.8
21
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
244.3
19.4
19
*
WW400
NOMESCO Finland
Plasmaferesis
+∞
17.3
16
*
B03XA02
ATC
darbepoetin alfa; parenteral
211.9
17.2
17
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.9
17.0
39
69
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
106.2
16.3
17
*
V03AE01
ATC
polystyrene sulfonate; oral
106.2
16.3
17
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
106.2
16.3
17
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
16.2
15
*
137
Kela drug reimbursment
Uraemia requiring dialysis
196.4
16.1
16
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
15.6
16.1
27
25
N18.8
ICD-10 Finland
Other chronic renal failure
45.5
15.2
18
5
B03XA01
ATC
erythropoietin; parenteral
181.4
15.0
15
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
26.0
14.7
20
10
C09AA02
ATC
enalapril; systemic
8.4
14.1
35
67
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
166.8
13.9
14
*
C08CA01
ATC
amlodipine; oral
6.5
13.5
45
130
KA1AE
NOMESCO Finland
Kidney ultrasound examination
60.5
13.4
15
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
+∞
12.8
12
*
V03AE02
ATC
sevelamer; oral
+∞
12.8
12
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
28.0
12.1
16
7
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
11.7
11
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
11.7
11
*
C02AC05
ATC
moxonidine; oral
30.1
11.6
15
6
C03CA01
ATC
furosemide; systemic
6.2
11.6
37
97
Z3231
NOMESCO Finland
Registered nurse
5.5
11.5
45
150
L04AA01
ATC
[U] ciclosporin; systemic
33.3
11.1
14
5
205
Kela drug reimbursment
Chronic hypertension
6.1
11.0
35
90
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.2
11.0
48
178
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
69.4
10.9
12
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
12.7
10.7
19
19
B05DB
ATC
Hypertonic solutions
125.6
10.7
11
*
B05DA
ATC
Isotonic solutions
125.6
10.7
11
*
Z2446
NOMESCO Finland
Social worker
8.1
10.7
25
42
L04AD01
ATC
ciclosporin; systemic
27.7
10.7
14
6
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
+∞
10.6
10
*
H02AB04
ATC
methylprednisolone; systemic
6.6
10.3
29
63
WX408
NOMESCO Finland
General anesthesy, balanced
4.9
10.1
42
145
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.6
9.8
27
57
Z3226
NOMESCO Finland
Physiotherapist
5.6
9.6
32
85
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
9.6
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
4.6
9.5
45
173
ZXD05
NOMESCO Finland
Urgent procedure
4.6
9.5
43
159
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
18.4
9.4
14
9
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
10.2
9.2
18
22
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
5.0
9.0
33
97
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
100.0
8.6
9
*
Z49.2
ICD-10 Finland
Other dialysis
100.0
8.6
9
*
H05BX01
ATC
cinacalcet; oral
+∞
8.5
8
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
8.5
8
*
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
8.5
8
*
L04AA05
ATC
[U] tacrolimus; systemic
+∞
8.5
8
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
19.8
8.4
12
7
ZXE00
NOMESCO Finland
One hour or less
4.1
8.4
50
229
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
20.9
7.8
11
6
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
87.8
7.6
8
*
C02CA01
ATC
prazosin; oral
87.8
7.6
8
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
7.1
7.5
18
31
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
7.4
7
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
7.4
7
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
+∞
7.4
7
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
7.4
7
*
C07AG02
ATC
carvedilol; oral
11.6
7.3
13
13
Z2221
NOMESCO Finland
Medical doctor
3.8
7.3
38
151
C08CA02
ATC
felodipine; oral
9.1
7.0
14
18
ZXE20
NOMESCO Finland
More than three and less than five hours
5.1
6.8
22
55
ZXA00
NOMESCO Finland
Right side
3.9
6.6
30
105
R4110
NOMESCO Finland
Physiotherapy
3.7
6.6
36
144
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
75.6
6.5
7
*
V03AE03
ATC
lanthanum carbonate; oral
+∞
6.3
6
*
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
+∞
6.3
6
*
TK810
NOMESCO Finland
Hemofiltration
+∞
6.3
6
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
6.3
6
*
L04AX01
ATC
azathioprine; systemic
9.8
6.3
12
14
RD210
NOMESCO Finland
NA
11.3
6.3
11
11
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
8.4
6.2
13
18
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.9
6.0
13
19
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
10.4
6.0
11
12
Mortality – FinRegistry
↥Association
Association between endpoint D3_NONAIHA_OTHER and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_NONAIHA_OTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_NONAIHA_OTHER – Haemolytic-uraemic syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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