hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
57 |
4. Check minimum number of eventsNone |
57 |
5. Include endpointsNone |
57 |
6. Filter based on genotype QC (FinnGen only) |
57 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D59
- Name in latin
- Aliae anaemiae non autoimmunes haemolyticae
Similar endpoints
↥List of similar endpoints to
Other nonautoimmune haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 438 | 222 | 207 |
| Only index persons | 286 | 140 | 146 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 65.19 | 68.72 | 61.30 |
| Only index persons | 61.49 | 62.70 | 60.34 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57 | 29 | 28 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 65.30 | 68.77 | 61.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 54
- Matched controls
- 538
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
69.9
51
*
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
15.3
14
*
D64.9
ICD-10 Finland
Anaemia, unspecified
13.7
14.7
28
39
C03CA01
ATC
furosemide; systemic
9.4
12.9
39
117
XW000
NOMESCO Finland
Bone marrow biopsy
26.7
12.6
17
9
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
33.7
11.9
15
6
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
120.2
9.8
10
*
B01AA03
ATC
warfarin; systemic
6.6
9.1
28
75
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
18.5
8.7
13
9
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
8.5
8
*
I35.0
ICD-10 Finland
Aortic (valve) stenosis
10.9
8.3
16
20
TPH07
NOMESCO Finland
Cathetrisation of artery
9.8
7.9
16
22
B01AB05
ATC
enoxaparin; parenteral
5.3
7.9
33
123
WW500
NOMESCO Finland
Blood transfusion
12.7
7.5
13
13
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.2
7.4
38
169
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
35.2
7.4
9
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
16.8
7.3
11
8
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
46.0
7.0
8
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
17.1
6.7
10
7
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
78.8
6.6
7
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
4.4
6.1
26
93
Mortality – FinRegistry
↥Association
Association between endpoint D3_NOCT_HAEMOGLOBINURIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NOCT_HAEMOGLOBINURIA | 2.556 [1.24, 5.26] | 0.011 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 139 females with D3_NOCT_HAEMOGLOBINURIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_NOCT_HAEMOGLOBINURIA | 3.81 [2.25, 6.45] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 138 males with D3_NOCT_HAEMOGLOBINURIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_NOCT_HAEMOGLOBINURIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.305% | 0.681% |
| 5 | 1.497% | 4.41% |
| 10 | 3.57% | 10.283% |
| 15 | 6.782% | 17.758% |
| 20 | 11.725% | 28.367% |
Relationships between endpoints
↥Index endpoint: D3_NOCT_HAEMOGLOBINURIA – Other nonautoimmune haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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