This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Genetic anomalies of leukocytes
D3_LEUKOANOMALIAGEN
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
28 |
4. Check minimum number of eventsNone |
28 |
5. Include endpointsNone |
28 |
6. Filter based on genotype QC (FinnGen only) |
28 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D72
- Name in latin
- Abnormitates geneticae leucocytorum
Similar endpoints
↥List of similar endpoints to
Genetic anomalies of leukocytes
based on the number of shared cases.
Similar with more cases:
- Other disorders of white blood cells
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 211 | 109 | 99 |
| Only index persons | 176 | 96 | 80 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 58.88 | 57.70 | 59.60 |
| Only index persons | 54.84 | 55.22 | 54.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 28 | 17 | 11 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | 55.09 | 51.33 | 60.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3020779) Urea [Moles/volume] in Serum or Plasma
6
12
6.03
2.55
1.5
3.3
mmol/l
6.0
7.4
—
6
12
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
10
45
2.90
1.70
3.4
1.7
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
16
3.56
1.50
1.6
1.5
—
—
—
0
0
(3005719) IgG [Mass/volume] in Serum or Plasma
5
17
3.34
1.42
5.2
1.9
g/l
8.9
10.1
—
5
17
(4035726)
5
19
2.97
1.27
1.0
1.3
—
—
—
0
0
(3022145) Colonoscopy Study observation
5
21
2.67
1.14
1.0
1.6
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
12
71
2.21
1.11
9.0
5.4
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
11
63
2.23
1.10
2.5
2.0
—
—
—
0
0
(3019225) pH of Specimen
5
22
2.54
1.08
2.2
4.2
—
—
—
0
0
(3002256) Pathology report gross observation
6
31
2.18
0.90
1.3
1.3
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
10
61
1.99
0.82
3.5
3.4
ng/l
339.7
1397.6
—
10
53
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
5
25
2.21
0.77
1.4
1.4
—
—
—
0
0
(3006504) Eosinophils/100 leukocytes in Blood
14
98
1.86
0.77
11.4
6.2
%
2.9
2.4
0.24
14
87
(3017143) Hepatitis C virus Ab [Presence] in Serum
5
26
2.12
0.75
1.0
1.3
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
15
109
1.81
0.72
10.0
6.1
e9/l
0.0
0.0
0.17
15
92
(3015377) Calcium [Moles/volume] in Serum or Plasma
5
87
0.48
0.71
1.8
3.9
mmol/l
2.4
2.4
—
5
73
(3026782) Osmolality of Urine
8
49
1.88
0.70
3.4
2.9
mosm/kgh2o
597.1
528.2
—
8
38
(3019069) Monocytes/100 leukocytes in Blood
14
100
1.80
0.70
11.4
6.4
%
8.0
8.6
0.22
14
89
(40768797) Stomach Pathology biopsy report
5
28
1.95
0.70
1.0
1.4
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
13
91
1.80
0.70
3.3
2.8
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
15
111
1.76
0.66
12.0
7.1
e9/l
0.2
0.2
0.26
15
96
(3000850) Epithelial cells [#/volume] in Urine
9
58
1.81
0.64
3.0
2.2
e6/l
3.2
7.3
—
9
51
(40758558) Short blood count panel - Blood
9
59
1.77
0.64
10.9
7.6
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
9
60
1.73
0.63
2.9
3.9
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
20
0.00
0.63
0.0
1.4
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
12
84
1.75
0.63
3.2
2.8
ug/l
81.9
108.2
0.42
12
75
(4010399)
0
19
0.00
0.63
0.0
1.4
—
—
—
0
0
(3022096) Basophils/100 leukocytes in Blood
13
96
1.66
0.55
11.6
6.2
%
0.6
0.5
0.11
13
85
(3042936) Bacteria identified in Isolate by Culture
5
30
1.81
0.47
2.0
3.2
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
5
32
1.68
0.45
1.6
1.1
—
—
—
0
0
(3019060) Gas panel - Arterial blood
0
15
0.00
0.42
0.0
3.5
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
16
0.00
0.42
0.0
1.2
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
0
18
0.00
0.41
0.0
4.8
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
16
132
1.49
0.38
12.9
10.7
e9/l
3.5
4.4
1.20
16
112
(3010813) Leukocytes [#/volume] in Blood
22
236
0.68
0.37
31.2
20.7
e9/l
7.6
6.6
0.36
22
225
(36304419) Bacteria [Presence] in Urine
10
75
1.52
0.36
3.9
2.5
—
—
—
0
0
(3024731) MCV [Entitic volume]
22
235
0.70
0.36
30.9
20.7
fl
93.6
91.2
1.01
22
230
(3026361) Erythrocytes [#/volume] in Blood
22
235
0.70
0.36
31.1
20.8
e12/l
4.5
4.5
0.09
22
225
(3000963) Hemoglobin [Mass/volume] in Blood
22
235
0.70
0.36
31.0
20.9
g/l
133.5
135.1
0.23
22
230
(3007461) Platelets [#/volume] in Blood
22
235
0.70
0.36
31.1
20.8
e9/l
220.9
251.4
0.65
22
226
(3035941) MCH [Entitic mass]
22
235
0.70
0.36
30.9
20.7
pg
31.1
30.3
0.90
22
230
(3003338) MCHC [Mass/volume]
14
166
0.69
0.34
35.4
19.4
g/l
331.1
332.1
0.18
14
166
(3031040) Bacteria [#/volume] in Urine by Automated count
17
144
1.46
0.34
4.5
4.2
—
55.0
—
0
5
(40768804) Tissue Pathology biopsy report
12
95
1.46
0.34
1.9
2.0
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
12
98
1.39
0.27
2.8
3.8
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
22
231
0.78
0.22
12.5
10.6
u/l
27.7
24.8
0.45
22
226
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
0
11
0.00
0.22
0.0
1.7
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
10
0.00
0.22
0.0
3.3
—
6.6
—
0
10
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
0
12
0.00
0.21
0.0
2.0
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
13
0.00
0.21
0.0
6.2
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
0
13
0.00
0.21
0.0
3.2
—
25.0
—
0
13
(3023103) Potassium [Moles/volume] in Serum or Plasma
21
222
0.78
0.20
25.5
15.1
mmol/l
4.1
3.9
1.21
21
217
(3019550) Sodium [Moles/volume] in Serum or Plasma
21
221
0.80
0.20
24.9
15.1
mmol/l
139.3
139.8
0.51
21
216
(3044889) 12 lead EKG panel
13
145
0.81
0.14
3.8
3.4
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
5
42
1.23
0.11
1.4
2.9
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
14
153
0.83
0.10
3.4
4.1
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
5
46
1.11
0.10
12.4
6.2
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
22
225
0.90
0.09
23.1
16.0
umol/l
80.7
76.0
0.54
22
225
(3041096) Erythrocytes [Presence] in Urine by Automated
5
63
0.75
0.09
2.6
3.8
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
7
66
1.08
0.09
5.7
4.0
u/l
32.6
27.9
—
7
61
(3013512) EKG study
8
74
1.11
0.08
3.1
4.0
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
10
89
1.19
0.08
2.4
2.4
nmol/l
72.6
79.3
—
10
79
(3021589) Normoblasts [#/volume] in Blood
12
109
1.18
0.08
13.1
8.5
e9/l
0.0
0.0
0.00
12
91
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
14
130
1.15
0.06
2.9
2.7
—
—
—
0
0
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
18
178
1.03
0.00
7.9
7.4
u/l
86.8
76.7
0.66
18
164
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3020891) Body temperature
0
9
0.00
0.00
0.0
4.0
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
21
203
1.14
0.00
19.7
14.2
ml/min/173m2
78.0
78.6
0.04
16
165
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
7
76
0.90
0.00
2.1
4.0
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
7
68
1.04
0.00
1.7
3.4
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.0
—
298.2
—
0
6
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
7
71
0.98
0.00
1.9
3.0
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
2.6
—
0
6
(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay
0
7
0.00
0.00
0.0
1.9
—
43.4
—
0
7
(3003694) ABO and Rh group [Type] in Blood
5
52
0.95
0.00
1.6
1.2
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3015736) pH of Urine
7
75
0.91
0.00
2.0
3.4
—
—
—
0
0
(3005895) Myoglobin [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.0
—
190.0
—
0
7
(3001019) Free T4 and TSH panel - Serum or Plasma
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
5
0.00
0.00
0.0
3.4
—
4.2
—
0
5
(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method
0
6
0.00
0.00
0.0
2.0
—
1.8
—
0
6
(3027315) Oxygen [Partial pressure] in Blood
0
5
0.00
0.00
0.0
3.4
—
8.4
—
0
5
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
6
0.00
0.00
0.0
1.0
—
0.0
—
0
6
(3035285) Chloride [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.7
—
107.3
—
0
6
(3016879) Cocaine [Presence] in Urine
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(4034850)
0
7
0.00
0.00
0.0
9.4
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
0
5
0.00
0.00
0.0
1.0
—
1.0
—
0
5
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
3.4
—
18.0
—
0
7
(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
0.2
—
0
6
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3045414) Leukocytes [Presence] in Urine
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
6
0.00
0.00
0.0
2.7
—
4.0
—
0
6
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3010421) pH of Blood
0
5
0.00
0.00
0.0
3.8
—
7.5
—
0
5
(40768793) Breast Pathology biopsy report
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(1616796) Gas panel - Central venous blood
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
22
217
1.06
0.00
12.2
13.1
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3009214) Lutropin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
15.5
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint D3_LEUKOANOMALIAGEN and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_LEUKOANOMALIAGEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_LEUKOANOMALIAGEN – Genetic anomalies of leukocytes
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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