autoimmune thrombocytopenic purpura: An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1103 |
4. Check minimum number of eventsNone |
1103 |
5. Include endpointsNone |
1103 |
6. Filter based on genotype QC (FinnGen only) |
1103 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Purpura idiopathica thrombocytopenica
Similar endpoints
↥List of similar endpoints to
Idiopathic thrombocytopenic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9562 | 4823 | 4657 |
| Only index persons | 8094 | 4155 | 3939 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.13 | 0.14 | 0.13 |
| Only index persons | 0.15 | 0.15 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 50.61 | 48.79 | 52.21 |
| Only index persons | 47.50 | 45.05 | 50.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1103 | 587 | 516 |
| Unadjusted period prevalence (%) | 0.21 | 0.20 | 0.23 |
| Median age at first event (years) | 50.33 | 41.61 | 60.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1001
- Matched controls
- 10008
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
1532.8
323.0
522
7
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
4503599627370496.0
323.0
889
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
207.7
192
*
XW000
NOMESCO Finland
Bone marrow biopsy
21.9
169.7
257
155
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
127.9
120
*
H02AB06
ATC
prednisolone; systemic
4.1
94.9
652
3146
B02BX05
ATC
eltrombopag; oral
819.7
78.5
76
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.2
56.0
248
734
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
55.7
53
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.1
55.1
419
1894
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
556.7
54.1
53
*
ZX120
NOMESCO Finland
Intravenous
5.0
52.3
185
434
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
98.8
51.4
56
6
1517
Kela drug reimbursment
NA
512.3
49.8
49
*
3039
Kela drug reimbursment
NA
512.3
49.8
49
*
H02AB07
ATC
prednisone; oral
3.9
47.7
228
711
WW500
NOMESCO Finland
Blood transfusion
7.9
45.5
108
150
6BA02
NOMESCO Finland
NA
76.8
39.2
44
6
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.5
38.0
147
372
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
36.7
35
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
49.8
35.9
43
9
28710
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia essentialis (Morbus Werlhof)
+∞
34.6
33
*
L04AX01
ATC
azathioprine; systemic
6.3
34.4
95
163
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
34.1
483
2879
6753
FHL
Transabdominal splenectomy
337.7
33.1
33
*
D69.5
ICD-10 Finland
Secondary thrombocytopenia
175.8
32.9
34
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
29.2
31.3
42
15
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
88.0
30.9
34
*
28719
ICD-8 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia NUD
+∞
27.2
26
*
B02BX04
ATC
romiplostim; parenteral
+∞
27.2
26
*
A02BC02
ATC
pantoprazole; systemic
2.0
24.6
642
4703
D68.8
ICD-10 Finland
Other specified coagulation defects
55.4
23.1
27
5
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
26.6
22.7
31
12
1XC02
NOMESCO Finland
NA
19.5
22.7
34
18
3038
Kela drug reimbursment
NA
+∞
22.0
21
*
1516
Kela drug reimbursment
NA
+∞
22.0
21
*
B02AA02
ATC
tranexamic acid; systemic
2.8
21.5
155
623
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
19.4
21.4
32
17
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.7
21.3
75
171
D70.89
ICD-10 Finland
Neutropenic splenomegaly
12.3
20.7
37
31
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
8.0
20.2
46
60
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
20.0
266
1455
A02BC01
ATC
omeprazole; systemic
2.0
19.0
288
1657
L04AD01
ATC
ciclosporin; systemic
7.5
18.7
44
61
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
11.3
18.3
34
31
M05BA04
ATC
alendronic acid; oral
3.2
17.9
100
338
D69.0
ICD-10 Finland
Allergic purpura
67.9
17.8
20
*
R50.9
ICD-10 Finland
Fever, unspecified
2.3
17.4
175
838
D64.9
ICD-10 Finland
Anaemia, unspecified
2.8
17.4
120
468
J01MA12
ATC
levofloxacin; systemic
2.2
17.3
191
957
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.5
16.7
79
237
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
16.5
289
1743
P01BA02
ATC
hydroxychloroquine; oral
3.0
16.4
97
341
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
15.3
221
1232
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
15.0
123
529
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
10.3
15.0
29
29
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
36.6
14.5
18
5
B01AB05
ATC
enoxaparin; parenteral
1.8
13.4
275
1733
120
Kela drug reimbursment
Hypogammaglobulinaemia
40.6
13.2
16
*
H02AB09
ATC
hydrocortisone; systemic
4.9
13.1
42
88
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
19.3
12.9
19
10
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.5
12.6
100
422
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.4
12.6
61
187
R04.0
ICD-10 Finland
Epistaxis
2.7
12.0
86
342
L04AA06
ATC
mycophenolic acid; systemic
6.1
12.0
32
54
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.9
12.0
29
43
C03CA01
ATC
furosemide; systemic
1.8
11.9
264
1697
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
47.2
11.9
14
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
11.8
475
3601
A46
ICD-10 Finland
Erysipelas
2.1
11.7
135
682
B99
ICPC
Blood/lymph/spleen disease other
19.2
11.6
17
9
H02AB02
ATC
dexamethasone; systemic
2.3
11.5
108
495
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
10.7
11.3
21
20
JN4BD
NOMESCO Finland
Extensive body CT
2.2
11.0
117
571
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
43.8
10.9
13
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
6.6
10.8
27
42
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
28.4
10.7
14
5
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
9.3
10.5
21
23
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
9.3
10.5
21
23
J05AB01
ATC
aciclovir; systemic
1.8
10.5
194
1169
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
10.5
177
1034
D61.3
ICD-10 Finland
Idiopathic aplastic anaemia
111.1
10.4
11
*
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
111.1
10.4
11
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
10.4
10
*
2875A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Thrombocytopenia, unspecified
+∞
10.4
10
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.7
10.4
34
74
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
19.0
10.3
15
8
M04AA01
ATC
allopurinol; systemic
2.0
10.2
130
682
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
11.4
10.1
18
16
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
10.0
78
327
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
7.3
10.0
23
32
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
10.0
258
1722
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
9.7
112
563
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
9.4
9
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.6
9.3
66
262
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
6.5
9.3
23
36
A41.9
ICD-10 Finland
Sepsis, unspecified
3.4
9.2
44
135
J01DB01
ATC
cefalexin; oral
1.6
9.2
766
6720
TGC00
NOMESCO Finland
Bronchial lavation
3.7
9.2
39
109
M35.1
ICD-10 Finland
Other overlap syndromes
13.8
9.2
15
11
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.8
9.2
57
208
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
8.4
9.1
19
23
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
24.2
8.9
12
5
J01FF01
ATC
clindamycin; systemic
1.6
8.7
239
1612
ZX112
NOMESCO Finland
Subcutaneous
3.8
8.6
35
95
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
8.5
84
399
WW200
NOMESCO Finland
Immunization
3.6
8.4
37
107
D68.9
ICD-10 Finland
Coagulation defect, unspecified
90.8
8.4
9
*
122
Kela drug reimbursment
Aplastic anaemia
90.8
8.4
9
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
8.4
298
2140
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
8.3
8
*
J01AA02
ATC
doxycycline; systemic
1.5
8.2
684
5900
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.6
8.2
27
60
R23.3
ICD-10 Finland
Spontaneous ecchymoses
4.4
8.2
28
65
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
8.1
162
998
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
9.0
8.1
16
18
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
22.2
8.0
11
5
N02BE01
ATC
paracetamol; systemic, rectal
1.6
8.0
791
7070
D07AB08
ATC
desonide; topical
2.0
8.0
104
552
B01AA03
ATC
warfarin; systemic
1.7
8.0
183
1173
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.7
8.0
51
192
AA1AD
NOMESCO Finland
CT of head and brain
1.6
7.8
206
1370
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
7.6
156
965
H26.3
ICD-10 Finland
Drug-induced cataract
12.0
7.6
13
11
L01AA01
ATC
cyclophosphamide; systemic
12.0
7.6
13
11
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
7.6
95
499
L04AA01
ATC
[U] ciclosporin; systemic
5.8
7.5
20
35
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.1
7.5
39
129
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
6.5
7.4
18
28
D73.1
ICD-10 Finland
Hypersplenism
80.7
7.4
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
7.3
101
550
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
30.2
7.2
9
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.3
7.1
33
101
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
12.1
7.1
12
10
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.4
7.1
24
56
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
7.0
676
7547
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
6.9
136
832
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
6.9
145
905
9101
FHL
Bone biopsy
40.3
6.8
8
*
C81.0
ICD-10 Finland
Nodular lymphocyte predominant Hodgkin lymphoma
40.3
6.8
8
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
6.7
305
2298
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.4
6.7
387
3058
J01MA14
ATC
moxifloxacin; systemic
2.0
6.7
86
456
C03DA01
ATC
spironolactone; oral
1.9
6.6
97
536
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.1
6.6
75
376
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.9
6.6
95
524
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
4.8
6.6
20
42
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.9
6.5
25
66
A05AA02
ATC
ursodeoxycholic acid; oral
4.4
6.4
21
48
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
6.3
129
799
UJF32
NOMESCO Finland
Coloscopy
1.5
6.3
216
1529
2873X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[THROMBOCYTOPENIA PRIMARIA NUD]
+∞
6.3
6
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
6.3
147
948
XF600
NOMESCO Finland
Bloodpressure measurement
2.2
6.2
61
289
K92.1
ICD-10 Finland
Melaena
2.4
6.2
50
215
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
6.2
82
439
A03
ICPC
Fever
1.6
6.1
150
974
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
6.1
55
250
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
6.1
183
1252
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.1
384
3066
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.1
352
2766
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
12.6
6.1
10
8
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
12.6
6.1
10
8
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
10.1
6.0
11
11
R53
ICD-10 Finland
Malaise and fatigue
1.6
6.0
182
1246
K76.9
ICD-10 Finland
Liver disease, unspecified
5.2
6.0
17
33
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.4
6.0
47
201
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.7
6.0
39
149
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
4.0
6.0
22
56
Mortality – FinRegistry
↥Association
Association between endpoint D3_ITP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.136 [1.84, 2.48] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 792 out of 3356 females with D3_ITP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ITP | 2.157 [1.83, 2.54] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 954 out of 3358 males with D3_ITP died.
Mortality risk
Mortality risk for people of age
years, who have D3_ITP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.16% | 0.403% |
| 5 | 0.979% | 2.627% |
| 10 | 2.315% | 6.513% |
| 15 | 4.587% | 11.842% |
| 20 | 8.251% | 20.907% |
Relationships between endpoints
↥Index endpoint: D3_ITP – Idiopathic thrombocytopenic purpura
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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