This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Immunodeficiency with increased immunoglobulin M [IgM]

Endpoint Browser

D3_IMMUDEF_INCR_IGM

No definition available.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D80.5 Cause of death: ICD-10 — D80.5 2 out of 7 registries used, show all original rules.	12
4. Check minimum number of events None	12
5. Include endpoints None	12
6. Filter based on genotype QC (FinnGen only)	12

Control definitions (FinnGen only)

Control exclude: D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D80
Name in latin: Deficientia immunalis cum incremento immunoglobulini M

NAME	D3_IMMUDEF_INCR_IGM
CONTROL_EXCLUDE	D3_IMMUNEMECHANISM
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D805
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D805
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Immunodeficiency with increased immunoglobulin M [IgM] based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	67	31	34
Only index persons	55	29	26
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	47.58	42.63	51.90
Only index persons	44.55	41.53	47.91

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	12	7	5
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	47.02	41.53	54.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

18.04

4.00

4.2

3.7

u/l

186.2

284.0

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

15.42

3.74

6.3

3.3

mmol/l

0.9

1.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

6.85

2.55

3.0

1.6

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

6.90

2.18

2.0

1.5

g/l

2.5

—

(3022948) Iron [Moles/volume] in Serum or Plasma

5.76

1.93

2.8

1.5

umol/l

7.4

16.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

4.33

1.75

6.0

2.7

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

3.36

1.28

3.4

2.5

nmol/l

74.0

69.9

—

(3026008) Bacteria identified in Urine by Culture

3.40

1.14

15.7

2.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.73

0.99

17.7

4.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

2.98

0.89

5.6

2.8

ng/l

624.2

1865.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.83

0.87

2.0

2.5

—

(3037522) Nuclear Ab [Titer] in Serum

0.00

0.67

0.0

1.5

—

704.0

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

2.23

0.53

3.8

3.1

mmol/l

2.4

2.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

0.47

0.52

9.6

4.6

mu/l

1.4

1.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

2.04

0.51

1.2

1.4

—

3.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

0.44

0.0

2.8

—

0.7

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.22

0.0

1.2

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.22

0.0

1.2

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.22

0.0

1.2

—

(3000492) Spirometry study

0.00

0.22

0.0

1.5

—

(36660697) Celiac disease serology panel - Serum

0.00

0.22

0.0

1.1

—

(3044889) 12 lead EKG panel

1.22

0.11

5.7

2.8

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.3

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.3

—

392.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3009445) Proteinase 3 Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

2.0

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

3.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.9

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

2.6

—

300.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

2.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

2.7

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_IMMUDEF_INCR_IGM and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_IMMUDEF_INCR_IGM.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_IMMUDEF_INCR_IGM – Immunodeficiency with increased immunoglobulin M [IgM]

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Immunodeficiency with increased immunoglobulin M [IgM]

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints