This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Immunodeficiency associated with other specified major defects, or unspecified
D3_IMMUDEFMAJORDEFNAS
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
25 |
4. Check minimum number of eventsNone |
25 |
5. Include endpointsNone |
25 |
6. Filter based on genotype QC (FinnGen only) |
25 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Immunodeficiency associated with other specified major defects, or unspecified
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency associated with other major defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 163 | 79 | 84 |
| Only index persons | 132 | 66 | 66 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | - | 56.48 | 53.37 |
| Only index persons | 54.48 | 56.74 | 52.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 25 | 12 | 13 |
| Unadjusted period prevalence (%) | 0.00 | 0.00 | 0.01 |
| Median age at first event (years) | 55.95 | 58.30 | 53.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3005719) IgG [Mass/volume] in Serum or Plasma
11
12
15.58
9.73
20.2
2.1
g/l
9.5
9.9
0.09
11
12
(4062490)
5
0
+∞
5.38
2.0
0.0
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
7
6
15.45
4.58
4.4
1.0
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
7
6
15.45
4.58
4.4
1.0
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
19
94
5.22
3.39
5.7
4.2
estimate
0.0
0.0
—
5
14
(3013742) Prealbumin [Mass/volume] in Serum or Plasma
8
16
6.80
3.38
4.3
3.3
g/l
0.2
0.2
—
8
16
(40758558) Short blood count panel - Blood
13
50
4.33
3.14
10.8
8.8
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
5
5
12.00
3.11
5.8
1.0
—
—
—
0
0
(4035726)
8
18
6.00
3.10
1.8
1.2
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
9
24
5.25
3.04
6.9
1.5
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
18
93
4.32
2.98
7.5
6.3
estimate
0.0
0.0
—
5
13
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
8
19
5.66
2.98
6.0
1.6
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
18
94
4.24
2.94
6.0
4.3
estimate
0.0
0.0
—
5
14
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
8
20
5.36
2.86
6.1
1.5
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
5
7
8.54
2.67
3.6
2.3
—
—
—
0
0
(3020779) Urea [Moles/volume] in Serum or Plasma
7
17
5.28
2.57
9.1
5.2
mmol/l
14.3
6.3
—
7
17
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
15
73
3.64
2.46
5.9
2.8
—
—
—
0
0
(3015736) pH of Urine
15
76
3.43
2.26
4.7
3.8
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
7
20
4.43
2.25
3.3
1.6
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
14
69
3.34
2.19
41.2
7.1
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
14
70
3.27
2.12
2.6
2.0
pmol/l
74.2
97.2
—
7
31
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
5
11
5.37
2.04
10.0
3.7
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
7
23
3.81
1.97
1.6
1.3
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
5
13
4.52
1.81
9.0
4.5
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
5
14
4.18
1.70
2.0
1.2
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
9
39
3.03
1.65
22.6
3.7
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
9
41
2.85
1.58
5.0
2.2
e6/l
1.6
6.0
—
9
35
(3011397) Hemoglobin [Presence] in Urine by Test strip
9
42
2.77
1.55
5.8
3.2
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
6
22
3.25
1.54
1.2
1.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
11
56
2.72
1.51
6.9
2.8
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
19
135
2.69
1.44
3.7
4.1
pmol/l
15.1
15.2
0.07
19
119
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
15
92
2.58
1.40
28.8
6.9
mmol/l
1.2
1.2
0.49
15
83
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
18
3.20
1.35
3.4
1.3
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
11
59
2.54
1.33
6.9
2.9
e6/l
0.0
0.1
1.29
11
41
(3000991) Gas panel - Venous blood
6
25
2.83
1.33
10.3
3.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
5
19
3.02
1.28
3.8
1.5
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
7
30
2.84
1.24
10.4
3.2
u/l
295.9
250.1
—
7
30
(3021960) Folate [Moles/volume] in Serum or Plasma
9
45
2.55
1.22
2.0
1.5
nmol/l
19.4
18.9
—
9
37
(3033658) Prothrombin time (PT) actual/Normal
9
46
2.48
1.21
11.1
3.6
%
90.6
89.5
—
9
46
(3009508) Creatinine [Moles/volume] in Urine
11
62
2.38
1.18
3.6
3.3
mmol/l
5.8
8.2
1.61
11
54
(3026782) Osmolality of Urine
9
48
2.36
1.17
4.7
2.9
mosm/kgh2o
472.2
561.1
—
9
41
(3029937) Albumin [Presence] in Urine by Test strip
10
54
2.42
1.17
7.4
3.8
estimate
0.0
0.0
—
5
12
(3042936) Bacteria identified in Isolate by Culture
6
28
2.49
0.99
4.2
1.4
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
12
75
2.15
0.98
6.6
4.3
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
6
30
2.31
0.94
1.7
1.7
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
6
30
2.31
0.94
1.8
3.4
ug/g
77.3
112.9
—
6
24
(3037467) Urinalysis macro (dipstick) panel - Urine
18
136
2.15
0.86
7.9
4.2
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
9
57
1.90
0.83
6.0
4.5
—
—
—
0
0
(3037522) Nuclear Ab [Titer] in Serum
5
24
2.34
0.80
2.2
1.5
—
354.3
—
0
7
(40768797) Stomach Pathology biopsy report
5
25
2.24
0.77
1.2
1.2
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
11
72
1.94
0.75
7.2
2.9
e6/l
8.5
11.9
0.55
11
53
(3002032) Base excess in Venous blood by calculation
5
26
2.15
0.75
61.2
8.1
mmol/l
1.8
1.7
—
5
19
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
15
110
1.91
0.73
4.4
2.9
—
—
—
0
0
(3012544) pH of Venous blood
5
27
2.06
0.73
61.2
7.8
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
13
92
1.86
0.69
59.5
10.8
e9/l
0.0
0.0
0.65
13
78
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
12
84
1.82
0.65
6.3
3.6
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
9
60
1.78
0.65
2.2
3.4
ng/l
2528.8
965.3
—
9
52
(3023368) Bacteria identified in Blood by Culture
9
60
1.78
0.65
33.4
3.2
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
20
0.00
0.63
0.0
1.0
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
20
169
1.91
0.58
5.8
5.6
mmol/mol
38.7
40.6
0.52
20
160
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
7
44
1.82
0.56
1.6
1.8
mmol/l
1.8
1.2
—
7
36
(3032080) INR in Blood by Coagulation assay
11
79
1.70
0.52
18.6
7.8
inr
1.3
1.3
—
6
31
(3019150) Specific gravity of Urine by Refractometry
7
49
1.59
0.51
4.4
4.0
—
1.0
—
0
7
(40768804) Tissue Pathology biopsy report
9
65
1.60
0.46
1.9
1.6
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
20
172
1.81
0.44
4.8
4.7
mu/l
1.9
1.9
0.11
20
154
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
15
121
1.60
0.43
6.7
2.9
u/l
57.3
64.8
0.15
15
111
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
18
157
1.52
0.40
21.4
7.0
u/l
105.7
91.6
0.49
18
146
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
7
54
1.41
0.34
3.0
4.3
ug/l
1.9
2.0
—
7
47
(3044640) Blood type and Crossmatch panel - Blood
7
55
1.38
0.34
4.3
2.2
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
7
55
1.38
0.34
1.7
3.1
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
8
64
1.37
0.32
3.6
3.4
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
11
88
1.45
0.29
6.0
2.7
nmol/l
85.6
69.5
1.03
11
80
(3044889) 12 lead EKG panel
16
138
1.44
0.28
7.7
3.2
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
5
40
1.31
0.24
1.2
1.4
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
5
40
1.31
0.24
7.2
1.8
mg/l
1.2
0.9
—
5
33
(3013512) EKG study
7
58
1.29
0.21
9.0
3.8
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
17
174
0.93
0.08
5.8
4.9
mmol/l
6.0
6.0
0.04
17
161
(1761482) Bacteria [#/volume] in Urine by Culture
0
9
0.00
0.00
0.0
5.3
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
18
182
0.96
0.00
5.1
5.3
mmol/l
2.2
2.7
1.45
18
166
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
5
48
1.05
0.00
1.2
1.4
—
—
—
0
0
(1002224) Polysomnography panel
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
14.3
—
0
5
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
2.7
—
0
5
(42529406) Shigella sp [Presence] in Stool by Culture
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
5
0.00
0.00
0.0
3.6
—
5.8
—
0
5
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
6
0.00
0.00
0.0
2.5
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_IMMUDEFMAJORDEFNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_IMMUDEFMAJORDEFNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_IMMUDEFMAJORDEFNAS – Immunodeficiency associated with other specified major defects, or unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data