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Haemophagocytic syndrome, infection-associated

D3_HAEMOPHAGOSDR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D76.2
  • Cause of death: ICD-10 D76.2

2 out of 7 registries used, show all original rules.

9

4. Check minimum number of events

None

9

5. Include endpoints

None

9

6. Filter based on genotype QC (FinnGen only)

9

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D76
Name in latin
Syndroma haemophagocyticum infectionem comitans

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 62 27 35
Only index persons 44 15 29
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population - 53.14 51.31
Only index persons 49.57 53.47 47.56

-FinnGen-

Key figures

All Female Male
Number of individuals 9 - 5
Unadjusted period prevalence (%) 0.00 - 0.00
Median age at first event (years) 48.20 - 39.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3012516) Albumin [Mass/volume] in Urine
0
23
0.00
0.95
0.0
3.7
—
51.8
—
0
17
(3029937) Albumin [Presence] in Urine by Test strip
0
23
0.00
0.95
0.0
4.7
—
0.0
—
0
11
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
0
19
0.00
0.70
0.0
3.9
—
20.4
—
0
8
(3042936) Bacteria identified in Isolate by Culture
0
10
0.00
0.23
0.0
1.4
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3022621) pH of Urine by Test strip
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(40761535) Cells panel - Urine sediment
0
5
0.00
0.00
0.0
6.4
—
—
—
0
0
(3019225) pH of Specimen
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
85.0
—
0
5
(3008898) HLA-B27 [Presence]
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
0
9
0.00
0.00
0.0
2.9
—
—
—
0
0
(3022217) INR in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
9.2
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
0
7
0.00
0.00
0.0
7.7
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3002256) Pathology report gross observation
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3022145) Colonoscopy Study observation
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
6.3
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_HAEMOPHAGOSDR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMOPHAGOSDR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: D3_HAEMOPHAGOSDR – Haemophagocytic syndrome, infection-associated

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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