info icon

Haemophagocytic lymphohistiocytosis

D3_HAEMOPHAGOLYMPHO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D76.1
  • Cause of death: ICD-10 D76.1

2 out of 7 registries used, show all original rules.

46

4. Check minimum number of events

None

46

5. Include endpoints

None

46

6. Filter based on genotype QC (FinnGen only)

46

Control definitions (FinnGen only)

Control exclude
D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D76
Name in latin
Lymphohistiocytosis haemophagocytica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 229 104 124
Only index persons 190 85 105
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 53.33 53.45 53.32
Only index persons 60.41 60.93 59.99

-FinnGen-

Key figures

All Female Male
Number of individuals 46 19 27
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 58.45 54.69 61.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
24
11
44.53
34.49
2.5
1.5
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
21
10
37.80
29.39
4.5
1.4
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
20
10
34.62
27.33
3.8
1.1
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
21
12
31.36
27.23
2.3
2.2
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
19
10
31.67
25.31
1.5
1.3
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
19
10
31.67
25.31
1.6
1.3
—
—
—
0
0
(4035726)
26
29
19.32
23.63
3.2
1.2
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
23
24
18.17
21.56
3.7
1.5
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
17
10
26.38
21.37
1.8
1.9
—
—
—
0
0
(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method
19
15
20.88
20.75
10.7
2.0
%
83.9
90.2
0.29
19
15
(3021879) Hepatitis B virus core Ab [Presence] in Serum
22
25
15.95
19.36
2.1
1.6
—
—
—
0
0
(3046279) Procalcitonin [Mass/volume] in Serum or Plasma
19
17
18.34
19.28
4.5
1.6
ug/l
2.1
0.3
0.85
19
17
(3017143) Hepatitis C virus Ab [Presence] in Serum
27
42
14.14
19.10
2.3
1.6
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
21
23
15.96
18.87
2.3
1.1
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
28
47
13.67
18.65
2.5
1.6
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
16
12
19.91
17.72
2.0
2.0
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
16
12
19.91
17.72
2.4
1.9
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
16
12
19.91
17.72
2.0
1.5
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
15
10
21.77
17.57
1.7
1.2
—
—
—
0
0
(3020779) Urea [Moles/volume] in Serum or Plasma
23
32
13.38
17.46
11.9
14.4
mmol/l
13.1
9.6
0.84
23
32
(3009445) Proteinase 3 Ab [Units/volume] in Serum
17
15
17.39
17.23
1.8
1.1
—
—
—
0
0
(3037522) Nuclear Ab [Titer] in Serum
26
45
11.99
16.65
2.2
1.3
titre
672.0
330.7
—
5
15
(3015479) Mycobacterium sp identified in Blood by Organism specific culture
15
0
+∞
16.65
2.3
0.0
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
39
104
18.93
16.26
26.9
5.0
—
—
—
0
0
(3012095) Magnesium [Moles/volume] in Serum or Plasma
31
69
11.71
16.03
18.4
5.6
mmol/l
0.8
0.8
1.03
31
62
(46235355) HIV 1 and 2 tests - Meaningful Use set
29
60
11.37
15.94
3.0
2.0
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
19
8
38.94
15.37
4.5
1.0
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
18
6
47.58
15.30
1.8
1.2
—
—
—
0
0
(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma
18
7
40.74
14.77
1.4
1.3
—
—
—
0
0
(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
17
5
52.09
14.76
3.9
3.0
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
28
60
10.37
14.75
5.3
1.5
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
18
8
35.61
14.29
1.4
1.4
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
31
78
10.12
14.02
9.3
1.8
mg/l
4.3
1.3
1.48
31
63
(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma
17
7
37.18
13.70
1.5
1.3
u/ml
93.2
—
—
5
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
22
40
9.63
13.13
3.3
1.5
—
—
—
0
0
(3015171) Extractable nuclear Ab [Units/volume] in Serum
17
9
28.85
12.79
1.4
1.3
—
—
—
0
0
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
15
5
43.18
12.59
1.7
2.4
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
36
118
10.43
12.30
39.1
5.5
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
15
6
35.92
12.07
2.4
1.0
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
39
145
12.04
11.74
21.2
2.9
ug/l
3701.8
115.4
3.88
39
133
(3004789) Transferrin [Mass/volume] in Serum or Plasma
25
59
8.09
11.62
2.6
3.1
g/l
1.9
2.4
2.36
25
54
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
15
7
30.73
11.60
2.2
1.0
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
25
60
7.94
11.40
2.3
2.7
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
21
42
8.36
11.34
3.6
1.4
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
15
8
26.87
11.17
1.7
1.3
—
—
—
0
0
(3022948) Iron [Moles/volume] in Serum or Plasma
25
62
7.64
10.98
2.7
3.0
umol/l
13.9
13.1
0.14
25
57
(3019832) Treponema pallidum Ab [Presence] in Serum
16
24
9.69
10.98
2.9
1.8
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
33
109
8.17
10.81
7.6
2.8
umol/l
300.6
8331.1
0.80
33
92
(3044640) Blood type and Crossmatch panel - Blood
34
118
8.21
10.50
13.9
2.3
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
13
5
35.18
10.49
2.5
1.2
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
11
11
12.83
9.94
13.4
2.5
%
217.5
204.6
0.11
11
11
(3017962) TCRG gene rearrangements [Presence] in Blood or Tissue by Molecular genetics method
9
0
+∞
9.70
1.4
0.0
—
—
—
0
0
(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells
9
0
+∞
9.70
1.6
0.0
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
9
0
+∞
9.70
1.2
0.0
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
23
60
6.67
9.37
2.7
3.2
%
30.4
22.0
1.02
23
52
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
12
15
10.47
9.31
2.8
1.0
—
—
—
0
0
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
13
8
21.92
9.20
1.9
1.3
mg/l
11.5
8.4
—
13
8
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
12
6
26.26
9.03
1.3
1.0
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
13
9
19.45
8.84
1.8
1.2
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
13
9
19.45
8.84
2.2
1.6
—
—
—
0
0
(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells
8
0
+∞
8.59
1.6
0.0
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
11
5
28.11
8.48
1.5
1.2
—
—
—
0
0
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
19
46
6.33
8.23
6.8
4.1
umol/l
21.2
11.5
0.82
19
39
(3016650) Hepatitis A virus Ab [Presence] in Serum
11
7
20.04
7.67
1.2
1.0
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
19
49
5.90
7.63
2.7
2.0
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
39
196
7.48
7.51
35.8
9.6
mmol/l
1.2
1.2
0.01
29
166
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
7
0
+∞
7.48
1.1
0.0
—
—
—
0
0
(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection
10
7
17.73
6.75
1.8
1.3
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
10
7
17.73
6.75
1.3
1.4
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
36
173
5.97
6.66
18.4
4.4
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
24
84
4.88
6.62
12.9
2.3
—
—
—
0
0
(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay
9
5
21.80
6.55
1.2
1.0
—
—
—
0
0
(3039162) Centromere protein B Ab [Units/volume] in Serum
9
5
21.80
6.55
1.2
1.2
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
17
45
5.41
6.52
1.6
1.4
—
—
—
0
0
(3024471) HLA-A [Type]
6
0
+∞
6.38
1.0
0.0
—
—
—
0
0
(3048879) Bone marrow aspiration report
6
0
+∞
6.38
1.7
0.0
—
—
—
0
0
(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection
6
0
+∞
6.38
1.7
0.0
—
—
—
0
0
(21491868) Cryoglobulin [Mass/volume] in Serum
6
0
+∞
6.38
1.3
0.0
g/l
—
—
—
0
0
(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection
6
0
+∞
6.38
1.7
0.0
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
10
16
7.71
6.24
5.6
13.2
%
95.1
94.1
—
10
16
(3008757) Leukocyte morphology finding [Identifier] in Blood
9
6
18.15
6.19
8.0
4.3
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
9
7
15.54
5.86
1.2
1.4
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
26
106
4.34
5.70
5.7
3.3
ng/l
1565.6
967.8
0.77
26
92
(40768806) Pleura Pathology biopsy report
8
5
18.88
5.63
1.0
2.6
—
—
—
0
0
(3044290) Cell count panel - Cerebral spinal fluid
8
5
18.88
5.63
1.4
1.6
—
—
—
0
0
(3033658) Prothrombin time (PT) actual/Normal
24
93
4.30
5.62
22.5
4.5
%
84.8
90.1
0.52
24
93
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
31
147
4.40
5.45
6.7
3.8
—
—
—
0
0
(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection
5
0
+∞
5.30
1.8
0.0
—
—
—
0
0
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
5
0
+∞
5.30
1.0
0.0
—
—
—
0
0
(3024932) HLA-DR beta [Type]
5
0
+∞
5.30
2.0
0.0
—
—
—
0
0
(3013862) HLA-DP [Type]
5
0
+∞
5.30
1.0
0.0
—
—
—
0
0
(40760410) HLA-B [Type] by High resolution
5
0
+∞
5.30
1.0
0.0
—
—
—
0
0
(40765096) Chromosome analysis panel by Banding
5
0
+∞
5.30
1.2
0.0
—
—
—
0
0
(46236302) HLA-C [Type] by High resolution typing
5
0
+∞
5.30
1.0
0.0
—
—
—
0
0
(40760409) HLA-A [Type] by High resolution
5
0
+∞
5.30
1.0
0.0
—
—
—
0
0
(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection
5
0
+∞
5.30
1.8
0.0
—
—
—
0
0
(40763590) HLA-DQ beta [Type]
5
0
+∞
5.30
1.0
0.0
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
8
6
15.72
5.29
1.8
1.2
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
9
9
12.06
5.29
2.2
1.8
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
23
91
4.05
5.15
19.7
4.7
—
—
—
0
0
(3022313) Gas panel - Capillary blood
11
24
5.71
5.09
7.8
4.1
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
9
10
10.83
5.04
1.2
1.1
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
30
146
4.03
4.93
15.0
8.6
inr
1.1
1.2
—
10
42
(3018418) pH of Serum or Plasma
25
108
3.88
4.88
21.3
4.1
ph
7.4
7.4
—
10
18
(3003694) ABO and Rh group [Type] in Blood
23
94
3.89
4.87
2.7
1.3
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
9
11
9.83
4.81
3.2
1.0
g/l
0.1
0.0
—
9
11
(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection
7
5
16.13
4.74
1.9
1.0
—
—
—
0
0
(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection
7
5
16.13
4.74
1.9
1.0
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
11
26
5.25
4.65
9.4
6.1
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
27
127
3.73
4.58
2.7
2.0
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
39
246
4.83
4.49
7.4
4.4
—
12.3
—
0
10
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
8
9
10.44
4.48
1.5
1.6
mg/l
419.5
538.0
—
8
9
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
10
23
5.28
4.33
8.0
4.2
mmol/l
25.6
23.8
—
10
23
(3026008) Bacteria identified in Urine by Culture
24
108
3.56
4.29
4.3
3.0
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
8
10
9.39
4.25
3.1
1.0
g/l
0.0
0.0
—
8
10
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
8
10
9.39
4.25
3.1
1.0
g/l
0.0
0.0
—
8
10
(3020044) Glucose [Moles/volume] in Cerebral spinal fluid
7
7
11.49
4.16
1.6
1.1
mmol/l
3.7
3.6
—
7
7
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
13
39
4.25
4.12
4.5
20.7
kpa
4.2
5.1
3.68
13
34
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
9
15
7.16
4.04
2.8
1.3
—
—
—
0
0
(3014148) Varicella zoster virus Ab [Titer] in Serum
6
5
13.49
3.87
1.5
1.2
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
6
5
13.49
3.87
1.5
1.2
—
—
—
0
0
(3029634) Reagin Ab [Titer] in Serum by VDRL
6
5
13.49
3.87
1.7
2.2
—
—
—
0
0
(3010421) pH of Blood
7
9
8.91
3.70
5.6
7.6
ph
7.4
7.4
—
7
9
(3013290) Carbon dioxide [Partial pressure] in Blood
7
9
8.91
3.70
5.6
7.3
kpa
4.5
5.0
—
7
9
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
7
9
8.91
3.70
2.9
1.2
—
—
—
0
0
(3027315) Oxygen [Partial pressure] in Blood
7
9
8.91
3.70
5.6
7.3
kpa
8.5
8.9
—
7
9
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
11
32
4.20
3.59
31.3
8.4
mmol/l
23.1
24.9
0.89
11
32
(3000991) Gas panel - Venous blood
12
39
3.81
3.37
8.5
9.3
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
7
11
7.27
3.32
1.1
1.2
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
7
11
7.27
3.32
1.1
1.6
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
9
21
5.06
3.19
3.7
1.5
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
11
35
3.82
3.17
8.8
2.7
—
—
—
0
0
(3013512) EKG study
22
109
2.95
3.15
6.6
4.2
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
5
5
10.98
3.05
7.2
3.8
%
51.8
60.6
—
5
5
(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay
5
5
10.98
3.05
1.0
1.0
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
7
13
6.13
2.99
7.7
1.9
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
7
13
6.13
2.99
1.4
1.4
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
25
136
2.84
2.98
3.2
3.4
mmol/l
2.2
2.3
2.03
25
116
(36304419) Bacteria [Presence] in Urine
22
112
2.85
2.96
7.0
3.7
—
—
—
0
0
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
17
76
2.96
2.88
1.4
1.2
iu/ml
60.5
29.3
—
6
22
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
5
6
9.14
2.82
1.8
1.0
—
—
—
0
0
(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination
5
6
9.14
2.82
1.8
2.3
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
20
99
2.80
2.81
8.0
4.1
estimate
0.0
0.0
0.00
11
35
(1616796) Gas panel - Central venous blood
6
10
6.70
2.79
2.7
9.0
—
—
—
0
0
(3019060) Gas panel - Arterial blood
9
26
4.04
2.65
2.6
21.6
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
5
7
7.83
2.61
5.0
3.7
—
—
—
0
0
(3002032) Base excess in Venous blood by calculation
12
46
3.18
2.60
35.8
5.2
mmol/l
1.0
1.9
0.47
12
33
(3025941) Bacteria identified in Stool by Culture
8
21
4.38
2.60
1.9
1.2
—
—
—
0
0
(3019225) pH of Specimen
9
28
3.74
2.46
16.3
3.9
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
30
192
2.62
2.43
8.2
3.9
estimate
0.0
0.0
0.00
11
36
(3021601) Nitrite [Presence] in Urine by Test strip
30
192
2.62
2.43
11.3
5.6
estimate
0.0
0.0
0.00
11
33
(3012544) pH of Venous blood
12
48
3.03
2.42
35.8
5.5
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
30
193
2.59
2.39
8.4
4.0
estimate
0.0
0.0
0.00
11
33
(3020891) Body temperature
6
13
5.13
2.35
4.3
4.0
—
—
—
0
0
(3015736) pH of Urine
24
147
2.32
2.03
6.4
3.6
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
6
17
3.89
1.90
27.2
4.9
%
30.8
55.3
—
6
17
(3004119) Hemoglobin [Mass/volume] in Venous blood
7
23
3.40
1.88
51.3
4.3
g/l
115.6
128.7
—
7
23
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
14
70
2.44
1.83
1.2
1.2
u/ml
53.3
3.0
—
5
25
(40758558) Short blood count panel - Blood
18
101
2.29
1.83
47.9
5.8
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
6
18
3.67
1.81
15.3
3.7
mmol/l
25.7
24.5
—
6
18
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
19
110
2.24
1.79
2.8
2.0
u/l
63.3
173.5
2.29
19
102
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
26
174
2.14
1.69
3.3
2.7
nmol/l
76.2
71.9
0.49
26
158
(21494755) Public health laboratory ask at order entry panel
0
45
0.00
1.60
0.0
1.4
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
23
149
2.09
1.60
8.5
4.1
—
—
—
0
0
(3022145) Colonoscopy Study observation
9
40
2.55
1.50
1.2
1.3
—
—
—
0
0
(3002256) Pathology report gross observation
9
40
2.55
1.50
1.6
1.2
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
11
54
2.36
1.47
1.5
1.4
—
—
—
0
0
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
14
77
2.18
1.45
3.9
3.6
mmol/l
2.4
2.5
0.32
14
63
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
13
72
2.12
1.32
5.4
3.2
ng/l
54.8
122.0
0.42
13
60
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
8
37
2.40
1.29
1.9
2.8
u/l
20.8
28.7
—
8
29
(40761535) Cells panel - Urine sediment
6
25
2.60
1.29
3.8
3.1
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
31
371
0.50
1.27
4.9
5.8
mmol/mol
38.2
39.9
0.29
25
348
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
36
290
2.11
1.23
3.6
3.7
pmol/l
14.4
14.9
0.59
36
255
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
41
353
2.48
1.21
4.1
4.4
mu/l
1.8
1.9
0.32
41
317
(3037121) Protein [Mass/volume] in Urine
5
20
2.68
1.18
1.8
5.4
g/l
0.2
0.1
—
5
13
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
5
20
2.68
1.18
55.6
2.9
%
0.7
0.7
—
5
20
(3000330) Specific gravity of Urine by Test strip
5
20
2.68
1.18
7.4
6.0
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
5
21
2.54
1.12
55.6
2.9
%
1.2
1.0
—
5
21
(3041096) Erythrocytes [Presence] in Urine by Automated
17
113
1.80
1.01
9.1
4.2
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
13
87
1.69
0.73
2.2
1.7
pmol/l
553.1
486.6
0.22
13
75
(3030981) Hyaline casts [#/volume] in Urine by Automated count
5
28
1.88
0.68
4.8
3.7
e6/l
0.5
0.1
—
5
28
(3011397) Hemoglobin [Presence] in Urine by Test strip
13
91
1.60
0.61
6.8
2.9
—
—
—
0
0
(3044889) 12 lead EKG panel
32
277
1.51
0.55
6.6
3.4
—
—
—
0
0
(3003338) MCHC [Mass/volume]
32
355
0.68
0.48
80.1
17.6
g/l
331.3
334.2
0.88
32
355
(3001019) Free T4 and TSH panel - Serum or Plasma
0
15
0.00
0.42
0.0
1.7
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
18
0.00
0.41
0.0
1.6
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
10
73
1.47
0.38
1.7
1.6
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
6
42
1.49
0.37
1.5
1.6
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
6
44
1.42
0.36
19.5
6.9
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
0
12
0.00
0.21
0.0
2.9
—
—
—
0
0
(4094501)
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
39
374
1.28
0.16
63.1
15.3
%
29.9
40.5
3.39
25
288
(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma
5
43
1.18
0.10
2.2
4.8
%
21.0
29.5
—
5
26
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
26
248
1.11
0.07
4.4
3.0
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
15
156
0.94
0.01
3.3
2.8
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
41
409
1.02
0.00
58.1
13.6
—
—
—
0
0
(1002224) Polysomnography panel
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000034) Microalbumin [Mass/volume] in Urine
0
5
0.00
0.00
0.0
3.8
—
31.9
—
0
5
(3040151) Glucose [Moles/volume] in Capillary blood
0
9
0.00
0.00
0.0
19.7
—
6.8
—
0
9
(4146454)
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
97.0
—
0
6
(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint D3_HAEMOPHAGOLYMPHO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMOPHAGOLYMPHO.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: D3_HAEMOPHAGOLYMPHO – Haemophagocytic lymphohistiocytosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data