This is a non-core endpoint: only basic statistics are computed.
Functional disorders of polymorphonuclear neutrophils
D3_FUNCPOLYMORPHONUCNEUTRO
obsolete_chronic granulomatous disease: ['A recessive X-linked defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
30 |
4. Check minimum number of eventsNone |
30 |
5. Include endpointsNone |
30 |
6. Filter based on genotype QC (FinnGen only) |
30 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D70-D77
- Name in latin
- Dysfunctiones granulocytorum neutrophilorum segmentonuclearium
Similar endpoints
↥List of similar endpoints to
Functional disorders of polymorphonuclear neutrophils
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 189 | 97 | 90 |
| Only index persons | 142 | 76 | 66 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 43.39 | 50.56 | 34.71 |
| Only index persons | 40.96 | 48.51 | 32.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 30 | 19 | 11 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | 45.09 | 47.87 | 40.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(42870588) Differential panel, method unspecified - Blood
20
76
5.89
5.25
20.7
6.0
—
—
—
0
0
(3018677) aPTT in Platelet poor plasma by Coagulation assay
11
30
5.21
4.07
3.8
2.2
s
34.8
29.4
0.43
11
30
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
6
6
12.05
3.67
3.0
2.8
—
—
—
0
0
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
9
19
6.28
3.58
30.2
7.5
u/l
324.1
226.5
—
9
19
(4035726)
9
20
5.94
3.44
1.6
1.2
—
—
—
0
0
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
6
8
9.00
3.21
5.3
4.6
g/l
3.8
3.5
—
6
8
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
5
5
11.61
3.09
1.2
1.0
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
21
124
3.30
2.47
15.9
5.7
e9/l
0.1
0.0
0.62
21
112
(3037756) Immunofixation for Serum or Plasma
5
8
7.21
2.47
1.0
1.5
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
21
125
3.26
2.45
15.8
5.7
e9/l
0.5
0.6
0.42
21
112
(40758558) Short blood count panel - Blood
13
58
3.19
2.31
34.5
10.3
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
21
128
3.12
2.20
15.9
6.1
e9/l
1.8
1.9
0.09
21
115
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
17
94
2.87
2.03
1.9
2.1
pmol/l
77.0
91.7
0.82
12
50
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
11
5.21
2.02
1.4
1.4
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
9
37
3.03
1.66
2.1
3.5
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
16
94
2.50
1.59
2.4
1.8
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
12
178
0.46
1.19
3.4
3.5
—
—
—
0
0
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
7
33
2.45
1.15
2.3
1.3
%
1.4
1.3
—
7
28
(3000494) Fungus identified in Specimen by Culture
7
33
2.45
1.15
2.6
2.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
5
21
2.65
1.13
1.2
3.2
—
—
—
0
0
(3026493) Urate [Moles/volume] in Serum or Plasma
10
55
2.23
1.08
7.5
3.3
umol/l
317.5
6928.7
—
10
49
(3019832) Treponema pallidum Ab [Presence] in Serum
6
27
2.52
1.00
1.7
1.7
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
11
67
2.01
0.91
7.1
3.6
ng/l
608.3
1153.6
1.12
11
59
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
6
32
2.09
0.87
13.7
3.5
umol/l
5.7
4.6
—
6
27
(3033658) Prothrombin time (PT) actual/Normal
10
60
2.00
0.85
6.8
4.1
%
68.1
87.7
—
10
60
(3044640) Blood type and Crossmatch panel - Blood
13
87
1.87
0.81
13.3
2.5
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
11
70
1.90
0.79
9.6
4.2
—
—
—
0
0
(3002256) Pathology report gross observation
5
24
2.29
0.79
1.2
1.1
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
10
65
1.81
0.66
12.7
2.5
—
—
—
0
0
(3004119) Hemoglobin [Mass/volume] in Venous blood
0
20
0.00
0.63
0.0
3.8
—
133.6
—
0
20
(4010399)
0
20
0.00
0.63
0.0
1.2
—
—
—
0
0
(3000991) Gas panel - Venous blood
0
19
0.00
0.63
0.0
11.2
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
16
123
1.64
0.57
16.1
5.3
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
14
106
1.60
0.52
22.9
9.1
e9/l
0.0
0.0
0.38
14
87
(46235355) HIV 1 and 2 tests - Meaningful Use set
8
57
1.55
0.47
2.0
1.8
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
11
80
1.59
0.47
2.9
1.6
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
5
30
1.80
0.46
2.0
2.0
—
—
—
0
0
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
0
15
0.00
0.42
0.0
2.5
—
0.8
—
0
15
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
16
0.00
0.42
0.0
1.4
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
0
16
0.00
0.42
0.0
3.4
—
49.0
—
0
16
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
17
0.00
0.42
0.0
1.5
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
0
17
0.00
0.42
0.0
2.4
—
2.0
—
0
17
(1761868) Lipid panel - Serum or Plasma
6
88
0.60
0.40
2.2
2.7
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
6
42
1.53
0.38
2.3
1.4
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
7
53
1.42
0.34
2.4
1.5
—
—
—
0
0
(3013512) EKG study
8
60
1.45
0.32
7.5
4.9
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
8
64
1.34
0.31
4.4
4.6
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
0
11
0.00
0.22
0.0
1.0
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
10
0.00
0.22
0.0
1.1
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
0
10
0.00
0.22
0.0
3.2
—
6.3
—
0
10
(3008037) Lactate [Moles/volume] in Venous blood
0
10
0.00
0.22
0.0
3.2
—
1.2
—
0
10
(40768443) Skin Pathology biopsy report
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
0
13
0.00
0.21
0.0
51.5
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
0
14
0.00
0.20
0.0
3.6
—
24.9
—
0
14
(3018418) pH of Serum or Plasma
10
82
1.33
0.20
13.4
4.0
—
7.4
—
0
13
(3041096) Erythrocytes [Presence] in Urine by Automated
9
78
1.22
0.18
1.8
3.1
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
11
95
1.25
0.14
4.7
2.7
—
—
—
0
0
(3026782) Osmolality of Urine
6
53
1.16
0.10
3.3
2.6
mosm/kgh2o
537.2
504.4
—
6
46
(3009508) Creatinine [Moles/volume] in Urine
6
54
1.14
0.09
3.2
2.7
mmol/l
5.4
7.3
—
6
42
(3011397) Hemoglobin [Presence] in Urine by Test strip
5
60
0.80
0.09
1.6
2.7
—
—
—
0
0
(3000850) Epithelial cells [#/volume] in Urine
5
62
0.77
0.09
3.2
2.1
e6/l
2.6
4.6
—
5
57
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
7
62
1.17
0.09
1.9
1.6
mmol/l
2.5
1.3
—
7
52
(3002582) Erythrocytes [#/volume] in Urine
9
83
1.12
0.08
5.1
2.7
e6/l
10.3
14.7
—
9
63
(3026008) Bacteria identified in Urine by Culture
9
86
1.07
0.08
2.3
3.0
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
19
179
1.17
0.07
4.3
3.9
—
—
—
0
0
(3015736) pH of Urine
10
108
0.89
0.03
1.8
2.8
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
10
104
0.94
0.00
1.8
3.2
—
—
—
0
0
(3044889) 12 lead EKG panel
17
169
1.01
0.00
4.5
3.5
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
17
169
1.01
0.00
6.2
4.3
—
40.6
—
0
5
(3035285) Chloride [Moles/volume] in Venous blood
0
7
0.00
0.00
0.0
3.4
—
108.0
—
0
7
(3010421) pH of Blood
0
8
0.00
0.00
0.0
2.5
—
7.4
—
0
8
(3002523) Influenza virus A Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
23
231
0.98
0.00
42.4
18.1
%
40.8
40.1
0.10
16
176
(3003181) Sodium [Moles/volume] in Urine
0
5
0.00
0.00
0.0
1.2
—
51.0
—
0
5
(3027315) Oxygen [Partial pressure] in Blood
0
8
0.00
0.00
0.0
2.4
—
8.7
—
0
8
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
743.4
—
0
5
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3043238) Trisomy 21 risk [Likelihood] in Fetus
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
0
5
0.00
0.00
0.0
6.4
—
—
—
0
0
(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
5.4
—
14.1
—
0
5
(3037121) Protein [Mass/volume] in Urine
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
23
227
1.06
0.00
32.2
13.5
ml/min/173m2
92.4
84.0
0.85
23
184
(3047007) Chlamydophila sp Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
8
85
0.92
0.00
3.3
2.0
u/l
2513.1
154.3
—
8
80
(3047352) Trisomy 18 risk [Likelihood] in Fetus
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(4034850)
0
7
0.00
0.00
0.0
30.6
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
8
80
1.00
0.00
4.9
2.4
e6/l
0.4
0.3
—
8
60
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
0
9
0.00
0.00
0.0
1.6
—
24.9
—
0
9
(36304419) Bacteria [Presence] in Urine
8
78
1.03
0.00
4.9
2.3
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
25
249
1.02
0.00
37.8
18.7
mmol/l
3.9
4.0
0.08
25
244
(3008898) HLA-B27 [Presence]
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(1616796) Gas panel - Central venous blood
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
3.0
—
4.2
—
0
6
(3041354) Potassium [Moles/volume] in Venous blood
0
7
0.00
0.00
0.0
3.4
—
3.9
—
0
7
(3003740) Influenza virus B Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3013290) Carbon dioxide [Partial pressure] in Blood
0
8
0.00
0.00
0.0
2.4
—
4.9
—
0
8
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
4.7
—
29.0
—
0
6
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(21494890) Protein electrophoresis panel - 24 hour Urine
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
(3005033) Fetal Nuchal fold Thickness US
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_FUNCPOLYMORPHONUCNEUTRO and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_FUNCPOLYMORPHONUCNEUTRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_FUNCPOLYMORPHONUCNEUTRO – Functional disorders of polymorphonuclear neutrophils
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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