No definition available.
Disseminated intravascular coagulation [defibrination syndrome]
D3_DISSEINTRAVASCCOAG
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
110 |
4. Check minimum number of eventsNone |
110 |
5. Include endpointsNone |
110 |
6. Filter based on genotype QC (FinnGen only) |
110 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D65-D69
- Name in latin
- Coagulatio intravascularis disseminata
Similar endpoints
↥List of similar endpoints to
Disseminated intravascular coagulation [defibrination syndrome]
based on the number of shared cases.
Similar with more cases:
- Coagulation defects, purpura and other haemorrhagic conditions
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1279 | 631 | 631 |
| Only index persons | 817 | 418 | 399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.83 | 59.55 | 58.04 |
| Only index persons | 56.58 | 56.34 | 56.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 110 | 59 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 53.41 | 47.09 | 60.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 105
- Matched controls
- 1048
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D65
ICD-10 Finland
Disseminated intravascular coagulation [defibrination syndrome]
+∞
114.5
88
*
A41.9
ICD-10 Finland
Sepsis, unspecified
54.8
35.2
41
12
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
15.7
31.8
60
82
N17.9
ICD-10 Finland
Acute renal failure, unspecified
45.1
26.5
32
10
TK800
NOMESCO Finland
Hemodialysis
53.7
24.1
28
7
TK810
NOMESCO Finland
Hemofiltration
214.8
18.1
18
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
39.2
17.9
22
7
Z49.1
ICD-10 Finland
Extracorporeal dialysis
53.7
15.6
18
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
38.1
15.4
19
6
WX872
NOMESCO Finland
Intensive care
16.0
15.4
25
20
A49.9
ICD-10 Finland
Bacterial infection, unspecified
8.7
15.1
35
57
B03XA02
ATC
darbepoetin alfa; parenteral
42.9
15.0
18
5
A11CC03
ATC
alfacalcidol; systemic
32.6
14.9
19
7
L04AA06
ATC
mycophenolic acid; systemic
50.2
14.6
17
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.6
14.5
37
70
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
79.8
12.9
14
*
N08.2*D65
ICD-10 Finland
Glomerular disorders in disseminated intravascular coagulation [defibrination syndrome]
+∞
12.8
12
*
N18.0
ICD-10 Finland
End-stage renal disease
43.2
12.6
15
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.4
12.3
23
25
A12AA04
ATC
calcium carbonate; oral
53.3
12.2
14
*
127
Kela drug reimbursment
Transplant complication
34.6
12.0
15
5
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
10.6
11.8
23
27
A41.8
ICD-10 Finland
Other specified sepsis
39.9
11.6
14
*
V03AE01
ATC
polystyrene sulfonate; oral
28.8
11.5
15
6
J96.0
ICD-10 Finland
Acute respiratory failure
+∞
10.6
10
*
ZXD05
NOMESCO Finland
Urgent procedure
4.1
10.3
54
216
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
44.6
10.2
12
*
WX730
NOMESCO Finland
Conventional respirator
29.3
10.1
13
5
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
15.5
10.1
16
12
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
10.8
10.0
19
21
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
5.1
10.0
35
94
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
33.5
9.6
12
*
Z94.0
ICD-10 Finland
Kidney transplant status
33.5
9.6
12
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
13.2
9.4
16
14
Z2446
NOMESCO Finland
Social worker
7.4
8.9
21
34
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
54.7
8.8
10
*
ZX120
NOMESCO Finland
Intravenous
6.0
8.8
25
52
KA1AE
NOMESCO Finland
Kidney ultrasound examination
18.3
8.8
13
8
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
22.3
8.7
12
6
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
30.4
8.7
11
*
WX882
NOMESCO Finland
High dependency care
11.4
8.3
15
15
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
36.5
8.2
10
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.0
8.2
20
34
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
14.6
8.1
13
10
TPX10
NOMESCO Finland
Implantation of vascular injection port
14.6
8.1
13
10
Z49.0
ICD-10 Finland
Preparatory care for dialysis
48.8
7.8
9
*
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
+∞
7.4
7
*
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
21.9
7.3
10
5
L04AD01
ATC
ciclosporin; systemic
21.9
7.3
10
5
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
32.5
7.3
9
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
32.5
7.3
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.3
7.2
28
82
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
8.6
7.2
15
20
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.9
6.9
19
38
196
Kela drug reimbursment
Paricalcitol and cinacalcet
42.9
6.9
8
*
NDQ20
NOMESCO Finland
Amputation of finger
42.9
6.9
8
*
V03AE02
ATC
sevelamer; oral
42.9
6.9
8
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
42.9
6.9
8
*
R4110
NOMESCO Finland
Physiotherapy
3.3
6.8
42
178
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.7
6.8
13
15
JN4BD
NOMESCO Finland
Extensive body CT
4.7
6.5
22
56
321
Kela drug reimbursment
Paricalcitol and cinacalcet
74.2
6.5
7
*
H05BX01
ATC
cinacalcet; oral
74.2
6.5
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.6
6.4
22
57
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
28.6
6.3
8
*
GBB00
NOMESCO Finland
Tracheostomy
28.6
6.3
8
*
M10.0
ICD-10 Finland
Idiopathic gout
28.6
6.3
8
*
J80
ICD-10 Finland
Adult respiratory distress syndrome
+∞
6.3
6
*
C03CA01
ATC
furosemide; systemic
3.2
6.2
39
165
Z3226
NOMESCO Finland
Physiotherapist
3.5
6.2
32
116
J01MA12
ATC
levofloxacin; systemic
3.5
6.1
32
118
WX408
NOMESCO Finland
General anesthesy, balanced
3.0
6.1
43
195
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
23
11.71
19.45
2.4
1.9
u/ml
0.2
0.4
—
10
13
(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay
18
15
14.15
18.26
1.3
1.7
—
—
—
0
0
(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma
17
21
9.39
13.13
3.0
1.3
—
—
—
0
0
(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum
12
10
13.35
11.94
2.4
2.2
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
18
28
7.49
11.48
1.3
1.6
—
—
—
0
0
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
38
120
4.31
11.18
7.7
2.5
%
22.7
24.2
0.26
33
109
(3023368) Bacteria identified in Blood by Culture
54
228
3.69
10.36
7.8
4.5
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
38
128
4.01
10.13
4.5
2.0
—
—
—
0
0
(3029634) Reagin Ab [Titer] in Serum by VDRL
11
12
10.07
9.13
2.8
1.4
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
31
98
4.01
8.93
4.3
1.7
—
—
—
0
0
(3012095) Magnesium [Moles/volume] in Serum or Plasma
39
146
3.59
8.77
6.7
3.0
mmol/l
0.8
0.8
1.44
39
138
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
14
22
7.15
8.76
1.4
1.2
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
34
119
3.69
8.43
4.2
1.6
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
11
14
8.62
8.14
8.5
3.1
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
14
24
6.54
8.07
3.1
1.3
—
—
—
0
0
(3002032) Base excess in Venous blood by calculation
27
83
3.99
8.02
17.6
4.2
mmol/l
-0.1
2.1
1.70
20
63
(3021879) Hepatitis B virus core Ab [Presence] in Serum
22
58
4.49
7.99
2.5
1.6
—
—
—
0
0
(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum
12
8
16.62
7.92
1.2
1.3
—
—
—
0
0
(3027945) Reticulocytes/100 erythrocytes in Blood
30
102
3.67
7.70
5.6
3.9
%
2.0
1.8
0.54
25
93
(42870588) Differential panel, method unspecified - Blood
58
295
3.04
7.64
10.9
5.2
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
11
7
17.25
7.40
1.1
1.3
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
31
112
3.46
7.23
4.3
1.6
—
—
—
0
0
(3012544) pH of Venous blood
26
85
3.70
7.03
17.2
4.2
—
—
—
0
0
(3000991) Gas panel - Venous blood
23
69
3.95
7.02
32.3
8.3
—
—
—
0
0
(3014148) Varicella zoster virus Ab [Titer] in Serum
10
7
15.53
6.53
1.1
1.1
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
27
95
3.44
6.51
1.7
1.7
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
19
53
4.12
6.36
2.1
1.4
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
34
142
3.02
6.16
1.7
1.9
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
14
32
4.87
5.96
27.0
6.7
—
—
—
0
0
(3023520) Reticulocytes [#/volume] in Blood
23
77
3.51
5.95
5.0
2.8
e9/l
68.9
70.4
0.05
15
62
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
25
89
3.34
5.88
1.6
1.6
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
36
161
2.84
5.72
4.2
1.8
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
57
328
2.53
5.41
9.7
7.0
inr
1.0
1.2
1.99
11
105
(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum
5
0
+∞
5.24
1.0
0.0
—
—
—
0
0
(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay
5
0
+∞
5.24
1.0
0.0
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
10
19
5.69
5.14
1.6
2.1
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
38
189
2.54
4.81
5.4
2.1
—
—
—
0
0
(3019230) Fractional oxyhemoglobin in Venous blood
9
11
8.79
4.66
10.1
2.3
%
77.4
69.9
—
9
11
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
10
21
5.14
4.63
1.3
1.1
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
10
21
5.14
4.63
1.3
1.1
—
—
—
0
0
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
18
61
3.33
4.53
3.7
2.8
ml/min/173m2
31.4
59.3
—
9
28
(3034770) Mitochondria Ab [Titer] in Serum
10
22
4.90
4.40
1.2
1.2
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
22
86
2.95
4.38
5.0
3.4
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
36
183
2.44
4.29
3.6
1.7
mg/l
5.5
1.1
1.49
29
143
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
9
13
7.43
4.25
1.2
1.2
—
—
—
0
0
(3017181) Myelocytes/100 leukocytes in Blood
20
76
2.99
4.17
4.4
5.5
%
0.4
1.1
—
7
26
(3021440) Promyelocytes/100 leukocytes in Blood
19
71
3.03
4.08
4.4
5.7
%
0.0
0.2
—
6
22
(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
7
7
10.57
4.07
2.3
2.4
—
—
—
0
0
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
18
67
3.02
3.88
6.9
4.3
mmol/l
0.0
2.0
—
10
53
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
13
40
3.55
3.76
8.8
2.5
%
0.6
0.7
0.37
13
40
(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
12
35
3.73
3.74
1.7
1.6
g/l
3.5
3.6
—
6
27
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
12
35
3.73
3.74
1.7
1.6
—
—
—
0
0
(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
12
35
3.73
3.74
1.7
1.6
g/l
7.2
7.8
—
6
27
(3013115) Eosinophils [#/volume] in Blood
66
454
2.13
3.64
12.7
6.1
e9/l
0.2
0.2
0.62
59
410
(3022313) Gas panel - Capillary blood
15
52
3.18
3.63
6.6
4.6
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
13
41
3.46
3.63
8.8
2.5
%
0.7
1.4
1.56
13
41
(3051611) Lipemic interference index of Serum or Plasma
7
9
8.21
3.61
5.4
2.2
—
—
—
0
0
(3009343) pH of Capillary blood
18
70
2.88
3.60
6.9
4.2
—
7.4
—
0
7
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
10
27
3.97
3.44
1.4
1.3
—
—
—
0
0
(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
11
32
3.71
3.43
1.7
1.6
g/l
3.2
3.0
—
6
27
(40758558) Short blood count panel - Blood
41
242
2.11
3.32
10.5
7.0
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
9
19
5.06
3.31
2.4
1.2
—
—
—
0
0
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
6
7
8.97
3.30
1.2
1.1
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
63
438
2.03
3.24
12.3
6.0
e9/l
0.7
0.6
1.85
58
385
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
7
11
6.71
3.23
1.4
1.2
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
63
439
2.02
3.21
12.4
6.0
e9/l
0.0
0.0
1.56
58
391
(3013650) Neutrophils [#/volume] in Blood by Automated count
71
517
2.05
3.19
16.1
10.3
e9/l
5.8
4.0
0.75
65
461
(3044640) Blood type and Crossmatch panel - Blood
43
263
2.04
3.14
6.1
2.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
15
57
2.89
3.11
2.5
2.4
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
7
12
6.14
3.07
1.0
1.2
—
—
—
0
0
(3018418) pH of Serum or Plasma
44
274
2.01
3.04
20.1
4.2
ph
7.4
7.4
—
5
49
(3000093) Morphology [Interpretation] in Blood Narrative
5
5
10.38
3.01
1.8
1.0
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
8
17
4.98
2.98
1.4
1.5
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
13
47
3.00
2.93
1.5
1.3
—
—
—
0
0
(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay
6
9
6.97
2.90
2.3
1.1
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
82
950
0.46
2.85
40.8
12.0
—
—
—
0
0
(4035726)
19
86
2.46
2.83
1.8
1.4
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
13
48
2.94
2.83
30.5
8.6
%
93.5
94.6
0.59
13
48
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
50
332
1.93
2.83
8.6
3.3
—
—
—
0
0
(3051651) Icteric interference index of Serum or Plasma
5
6
8.65
2.77
6.4
2.0
—
—
—
0
0
(3011648) Oxygen content in Venous blood
5
6
8.65
2.77
6.8
2.3
%
10.2
12.0
—
5
6
(3052851) Hemolysis interference index of Serum or Plasma
10
32
3.34
2.72
4.5
2.6
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
12
44
2.94
2.64
1.7
1.6
—
—
—
0
0
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
7
15
4.90
2.64
2.4
1.3
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
55
387
1.84
2.53
6.9
3.9
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
41
263
1.89
2.52
7.0
3.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
8
21
4.02
2.51
1.4
1.1
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
67
0.00
2.49
0.0
1.5
—
—
—
0
0
(3020564) Creatinine [Moles/volume] in Serum or Plasma
83
950
0.49
2.49
42.9
15.9
umol/l
141.1
77.1
3.24
83
950
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
9
27
3.54
2.45
2.3
2.5
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
12
46
2.81
2.45
1.3
1.2
—
—
—
0
0
(3008757) Leukocyte morphology finding [Identifier] in Blood
6
12
5.22
2.43
4.2
3.5
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
8
22
3.84
2.41
1.4
1.1
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
8
22
3.84
2.41
1.4
1.1
—
—
—
0
0
(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture
5
8
6.48
2.39
1.4
2.6
—
—
—
0
0
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
5
8
6.48
2.39
1.4
1.6
—
—
—
0
0
(3016650) Hepatitis A virus Ab [Presence] in Serum
6
13
4.81
2.30
1.0
1.2
—
—
—
0
0
(3019060) Gas panel - Arterial blood
13
55
2.55
2.22
15.4
4.2
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
5
10
5.18
2.09
2.6
3.9
—
—
—
0
0
(44816844) Macroprolactin [Units/volume] in Serum or Plasma
5
10
5.18
2.09
1.8
1.7
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
10
38
2.79
2.07
1.3
1.2
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
26
152
1.93
2.07
6.6
2.9
e6/l
11.1
3.1
0.85
20
80
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
27
161
1.90
2.03
5.9
2.6
e6/l
2.0
1.0
0.31
20
87
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
7
21
3.49
2.00
1.0
1.4
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
73
855
0.57
1.99
5.2
4.5
mmol/l
6.1
5.9
0.68
67
779
(3025130) Human papilloma virus identified in Specimen
5
11
4.70
1.96
1.6
1.5
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
47
337
1.69
1.89
10.5
3.9
e6/l
23.8
43.7
0.47
40
240
(3000330) Specific gravity of Urine by Test strip
9
36
2.63
1.78
6.8
2.8
—
—
—
0
0
(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum
8
30
2.79
1.76
1.0
1.4
—
254.2
—
0
16
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
5
13
3.97
1.73
1.0
1.1
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
5
14
3.69
1.63
7.4
1.6
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
8
32
2.61
1.63
2.3
1.6
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
24
148
1.80
1.61
1.7
1.7
nmol/l
853.9
1192.0
1.34
19
119
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
6
20
3.11
1.60
1.2
1.1
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
30
202
1.67
1.49
1.8
1.5
nmol/l
21.3
22.9
0.25
30
170
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
5
17
3.03
1.37
1.0
1.8
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
29
199
1.62
1.33
1.9
1.4
g/l
2.0
2.6
2.01
24
120
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
10
186
0.49
1.33
1.3
1.8
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
17
100
1.83
1.33
2.4
1.4
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
50
392
1.51
1.28
7.6
2.7
ug/l
299.9
110.7
2.50
50
367
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
44
336
1.52
1.27
2.3
1.9
pmol/l
87.7
97.2
0.79
24
169
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
20
298
0.60
1.25
5.0
4.5
ug/l
1.0
3.1
1.19
20
262
(3002256) Pathology report gross observation
18
111
1.74
1.21
1.9
1.2
—
—
—
0
0
(3003338) MCHC [Mass/volume]
66
760
0.67
1.19
57.1
17.2
g/l
330.8
332.1
0.49
66
755
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
5
20
2.57
1.16
6.0
1.8
—
—
—
0
0
(3045414) Leukocytes [Presence] in Urine
7
31
2.34
1.12
5.6
1.5
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
13
74
1.86
1.12
1.2
1.1
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
52
420
1.45
1.11
18.0
9.5
e9/l
0.0
0.0
0.21
46
341
(40760888) Immunoglobulin light chains.free panel - Serum
5
21
2.44
1.10
4.4
6.0
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
26
355
0.65
1.10
2.7
2.9
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
70
600
1.46
1.08
10.9
4.2
—
—
—
0
0
(3022621) pH of Urine by Test strip
9
46
2.04
1.06
5.4
2.1
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
5
22
2.33
1.04
6.0
2.5
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
68
769
0.70
1.00
56.3
16.3
%
14.6
13.7
4.45
68
757
(3011397) Hemoglobin [Presence] in Urine by Test strip
25
181
1.49
0.90
6.8
3.4
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
45
365
1.39
0.90
4.1
2.0
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
30
226
1.45
0.90
1.4
1.4
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
8
43
1.93
0.89
5.0
3.1
%
55.4
54.0
—
8
43
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
6
32
1.92
0.83
2.0
1.7
nmol/l
47.2
40.9
—
6
32
(3044889) 12 lead EKG panel
56
641
0.74
0.78
4.2
3.7
—
—
—
0
0
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
5
24
2.13
0.75
2.6
1.6
—
—
—
0
0
(40761535) Cells panel - Urine sediment
10
60
1.73
0.75
6.5
3.3
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
74
810
0.74
0.73
51.9
13.5
%
35.1
40.5
4.03
53
614
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
5
26
1.97
0.71
2.2
1.9
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
26
1.97
0.71
1.4
1.2
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
5
29
1.76
0.64
1.0
1.1
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
79
850
0.75
0.62
31.0
12.9
ml/min/173m2
65.3
81.7
3.85
71
702
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
7
115
0.58
0.61
1.3
1.5
—
—
—
0
0
(3012501) Base excess in Blood by calculation
0
23
0.00
0.59
0.0
2.3
—
2.7
—
0
12
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
6
36
1.70
0.57
1.5
2.8
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
49
426
1.27
0.56
7.0
3.5
estimate
0.0
0.0
—
8
99
(3026008) Bacteria identified in Urine by Culture
29
236
1.31
0.54
3.8
2.9
—
—
—
0
0
(3022145) Colonoscopy Study observation
14
102
1.43
0.50
1.1
1.3
—
—
—
0
0
(4010399)
10
68
1.52
0.49
1.1
1.3
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
49
432
1.24
0.48
7.1
3.6
estimate
0.0
0.0
—
9
92
(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma
7
48
1.49
0.48
1.0
1.3
—
68.5
—
0
12
(21494755) Public health laboratory ask at order entry panel
5
85
0.57
0.47
1.6
1.3
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
85
895
0.78
0.44
42.0
13.6
mg/l
30.5
22.0
2.02
74
708
(3023430) Cat dander IgE Ab [Units/volume] in Serum
0
15
0.00
0.41
0.0
1.1
—
6.0
—
0
7
(3014133) Dog dander IgE Ab [Units/volume] in Serum
0
16
0.00
0.41
0.0
1.1
—
4.8
—
0
8
(3051387) C reactive protein [Mass/volume] in Capillary blood
0
18
0.00
0.40
0.0
5.2
—
30.3
—
0
13
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
5
35
1.45
0.40
1.6
2.4
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
9
67
1.37
0.39
1.9
1.7
—
—
—
0
0
(3019150) Specific gravity of Urine by Refractometry
15
188
0.77
0.37
10.0
3.7
kg/l
1.0
1.0
—
6
24
(3029937) Albumin [Presence] in Urine by Test strip
20
241
0.79
0.36
7.4
3.8
estimate
0.0
0.0
—
7
93
(3021601) Nitrite [Presence] in Urine by Test strip
47
426
1.18
0.32
10.6
4.7
estimate
0.0
0.0
—
9
99
(3019225) pH of Specimen
10
76
1.35
0.29
8.2
4.6
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
15
122
1.27
0.29
1.1
1.2
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
17
142
1.23
0.26
2.0
1.4
—
—
—
0
0
(3013512) EKG study
28
248
1.17
0.25
2.6
4.0
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
30
334
0.86
0.24
6.9
3.5
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
5
39
1.30
0.23
2.8
2.1
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
(40768806) Pleura Pathology biopsy report
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
23
203
1.17
0.21
8.1
6.0
—
—
—
0
0
(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum
0
13
0.00
0.21
0.0
1.2
—
1.5
—
0
5
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
37
342
1.12
0.18
2.6
4.0
ng/l
72.8
45.4
0.31
30
234
(3005322) IgE [Units/volume] in Serum or Plasma
7
60
1.18
0.18
1.4
1.2
u/ml
59.3
142.4
—
7
51
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
10
86
1.18
0.11
1.5
1.7
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
57
590
0.93
0.10
2.8
3.3
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
5
48
1.04
0.09
1.0
1.4
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
6
73
0.81
0.08
9.2
3.5
mmol/l
1.2
1.2
—
6
63
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
20
213
0.93
0.06
1.6
1.3
u/ml
0.8
0.8
—
5
56
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
10
108
0.92
0.03
2.3
2.0
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
10
98
1.02
0.00
9.3
8.9
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
25
253
0.98
0.00
6.6
3.3
—
—
—
0
0
(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma
27
265
1.03
0.00
2.9
2.0
u/l
300.4
204.1
0.26
27
254
(3018301) Testosterone Free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
(3047189) Immunofixation for 24 hour Urine
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline
0
6
0.00
0.00
0.0
1.2
—
6.2
—
0
6
(3019897) Erythrocyte distribution width [Ratio] by Automated count
0
6
0.00
0.00
0.0
1.7
—
12.8
—
0
6
(40761536) Microorganisms panel - Urine sediment
8
85
0.94
0.00
2.4
3.6
—
—
—
0
0
(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3035320) C reactive protein [Mass/volume] in Body fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3015183) Erythrocyte sedimentation rate
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
6
59
1.02
0.00
2.2
1.9
u/ml
33.3
60.0
—
6
53
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
9
98
0.91
0.00
2.2
1.8
—
—
—
0
0
(3011897) Casein IgE Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.4
—
17.6
—
0
5
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3036071) Salmonella sp Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3045716) Anion gap in Serum or Plasma
0
5
0.00
0.00
0.0
2.2
—
7.4
—
0
5
(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
9.8
—
0.8
—
0
5
(3037556) Urate [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000492) Spirometry study
7
74
0.94
0.00
1.3
1.3
—
—
—
0
0
(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(4024509)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3006653) Thiamine [Moles/volume] in Blood
0
5
0.00
0.00
0.0
1.0
—
130.4
—
0
5
(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
6.6
—
248.2
—
0
5
(3051593) INR in Capillary blood by Coagulation assay
0
5
0.00
0.00
0.0
11.0
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
10.9
—
1593.2
—
0
9
(3008832) Norclozapine [Moles/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
8.7
—
1049.3
—
0
9
(3032773) Endomysium IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
6
59
1.02
0.00
1.0
1.6
—
—
—
0
0
(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_DISSEINTRAVASCCOAG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 3.462 [2.16, 5.55] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.086 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 307 females with D3_DISSEINTRAVASCCOAG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_DISSEINTRAVASCCOAG | 4.371 [2.68, 7.11] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 291 males with D3_DISSEINTRAVASCCOAG died.
Mortality risk
Mortality risk for people of age
years, who have D3_DISSEINTRAVASCCOAG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.317% | 0.77% |
| 5 | 2.11% | 4.787% |
| 10 | 4.958% | 11.208% |
| 15 | 8.941% | 20.685% |
| 20 | 14.772% | 33.351% |
Relationships between endpoints
↥Index endpoint: D3_DISSEINTRAVASCCOAG – Disseminated intravascular coagulation [defibrination syndrome]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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