This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Selective deficiency of immunoglobulin M [IgM]
D3_DEF_IGM
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
19 |
4. Check minimum number of eventsNone |
19 |
5. Include endpointsNone |
19 |
6. Filter based on genotype QC (FinnGen only) |
19 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80
- Name in latin
- Deficientia selectiva immunoglobulini M
Similar endpoints
↥List of similar endpoints to
Selective deficiency of immunoglobulin M [IgM]
based on the number of shared cases.
Similar with more cases:
- Immunodeficiency with predominantly antibody defects
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Paracetamol of NSAID medication
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 85 | 54 | 31 |
| Only index persons | 80 | 51 | 29 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | - | 45.96 | 30.70 |
| Only index persons | 39.72 | 44.85 | 30.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 19 | 12 | 7 |
| Unadjusted period prevalence (%) | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | 53.60 | 54.11 | 52.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum
5
0
+∞
5.44
1.2
0.0
—
—
—
0
0
(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum
5
0
+∞
5.44
1.2
0.0
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
6
5
16.53
4.06
2.7
12.2
%
1.0
1.1
—
6
5
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
6
5
16.53
4.06
16.5
13.2
%
50.9
61.5
—
6
5
(3024889) Methemoglobin/Hemoglobin.total in Venous blood
6
5
16.53
4.06
2.7
12.2
%
0.8
0.9
—
6
5
(3027273) Bicarbonate [Moles/volume] in Venous blood
6
6
13.76
3.78
10.8
12.2
mmol/l
25.3
26.1
—
6
6
(3004119) Hemoglobin [Mass/volume] in Venous blood
6
6
13.76
3.78
10.5
10.5
g/l
130.8
113.7
—
6
6
(3007853) Bacteria identified in Skin by Aerobe culture
8
18
6.84
3.23
2.4
1.6
—
—
—
0
0
(3015736) pH of Urine
12
50
4.76
2.61
6.8
3.7
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
10
37
4.55
2.60
7.1
7.6
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
7
18
5.50
2.54
2.3
2.7
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
10
40
4.13
2.37
3.2
2.9
mg/l
102.4
51.5
—
5
28
(3024354) Oxygen [Partial pressure] in Venous blood
6
15
5.31
2.24
10.8
12.1
kpa
4.0
5.6
—
6
15
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
5
10
6.33
2.22
1.8
1.2
—
—
—
0
0
(40761535) Cells panel - Urine sediment
5
11
5.73
2.08
3.2
5.5
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
8
30
3.84
2.02
1.1
1.7
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
10
43
3.77
2.01
4.3
3.3
mg/mmol
14.4
13.9
—
5
28
(3012544) pH of Venous blood
6
18
4.36
1.92
10.8
10.4
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
5
13
4.80
1.84
1.6
1.5
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
6
19
4.11
1.83
1.2
1.6
—
—
—
0
0
(3021447) Carbon dioxide [Partial pressure] in Venous blood
6
19
4.11
1.83
10.8
9.9
kpa
6.3
5.9
—
6
19
(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma
6
19
4.11
1.83
2.5
1.7
mmol/l
2.4
2.5
—
6
13
(3000991) Gas panel - Venous blood
6
19
4.11
1.83
5.7
11.4
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
8
33
3.43
1.80
3.8
4.0
mg/l
2.8
2.7
—
8
33
(3023368) Bacteria identified in Blood by Culture
8
34
3.31
1.53
3.1
4.3
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
8
35
3.20
1.50
7.6
4.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
10
52
2.93
1.48
7.9
3.9
—
—
—
0
0
(3037522) Nuclear Ab [Titer] in Serum
5
18
3.38
1.38
1.4
2.2
—
991.1
—
0
9
(3035350) Ketones [Presence] in Urine by Test strip
12
71
2.86
1.33
6.8
3.8
—
0.0
—
0
18
(3021601) Nitrite [Presence] in Urine by Test strip
12
71
2.86
1.33
8.6
5.1
—
0.0
—
0
18
(3018418) pH of Serum or Plasma
9
45
2.88
1.30
5.8
5.8
—
7.4
—
0
7
(3009261) Glucose [Presence] in Urine by Test strip
12
74
2.67
1.29
6.8
3.7
—
0.0
—
0
16
(3015377) Calcium [Moles/volume] in Serum or Plasma
9
48
2.65
1.25
3.3
4.2
mmol/l
2.3
2.4
—
9
43
(40758558) Short blood count panel - Blood
9
48
2.65
1.25
11.8
12.0
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
5
20
3.01
1.23
1.6
2.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
10
59
2.46
1.14
11.8
10.0
—
—
—
0
0
(3013826) Glucose [Moles/volume] in Serum or Plasma
14
97
2.67
1.05
4.0
5.8
mmol/l
6.9
6.2
0.62
14
91
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
11
71
2.29
1.05
4.5
3.4
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
9
56
2.14
0.91
1.3
1.7
mmol/l
2.0
1.4
—
9
47
(3029937) Albumin [Presence] in Urine by Test strip
7
37
2.40
0.87
8.6
4.5
—
0.0
—
0
15
(3019309) Folate [Moles/volume] in Red Blood Cells
5
24
2.46
0.81
2.0
1.4
nmol/l
975.6
1055.7
—
5
19
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
5
25
2.34
0.79
1.0
1.4
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
0
15
0.00
0.43
0.0
3.2
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
19
175
+∞
0.43
18.4
12.5
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
7
54
1.47
0.36
3.4
2.9
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
8
64
1.43
0.34
2.3
1.7
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
5
36
1.52
0.27
2.2
3.1
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
6
47
1.40
0.24
1.2
1.6
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
6
49
1.33
0.23
2.7
2.9
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
7
57
1.36
0.22
2.1
2.7
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
12
0.00
0.22
0.0
1.8
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
0
13
0.00
0.21
0.0
3.2
—
—
—
0
0
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
0
14
0.00
0.21
0.0
8.5
—
25.1
—
0
14
(3044889) 12 lead EKG panel
11
118
0.84
0.09
2.6
3.8
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
2.4
—
1.8
—
0
7
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
6
60
1.00
0.00
2.7
5.4
—
1.1
—
0
16
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
7
74
0.91
0.00
7.3
4.5
—
—
—
0
0
(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
0.00
0.0
1.0
—
98.8
—
0
5
(4306422)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016244) Insulin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
7.4
—
163.3
—
0
5
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
5
0.00
0.00
0.0
1.0
—
0.0
—
0
5
(40768793) Breast Pathology biopsy report
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3028271) Lactate [Moles/volume] in Capillary blood
0
5
0.00
0.00
0.0
2.4
—
1.3
—
0
5
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
0
5
0.00
0.00
0.0
1.0
—
36.2
—
0
5
(3000093) Morphology [Interpretation] in Blood Narrative
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(40768443) Skin Pathology biopsy report
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells
0
5
0.00
0.00
0.0
4.0
—
—
—
0
0
(3035637) Corticotropin [Mass/volume] in Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
5
0.00
0.00
0.0
1.0
—
0.0
—
0
5
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
4.6
—
367.4
—
0
5
(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting
0
6
0.00
0.00
0.0
2.0
—
0.7
—
0
6
(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection
0
5
0.00
0.00
0.0
6.4
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
5
0.00
0.00
0.0
1.0
—
0.0
—
0
5
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3028707) Methadone [Presence] in Urine by Screen method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.0
—
114.6
—
0
5
(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
0
5
0.00
0.00
0.0
1.0
—
3.2
—
0
5
(3045414) Leukocytes [Presence] in Urine
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
(3014051) Protein [Presence] in Urine by Test strip
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_DEF_IGM and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_DEF_IGM.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_DEF_IGM – Selective deficiency of immunoglobulin M [IgM]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data