obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
D3_CVID_BCELL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
84 |
4. Check minimum number of eventsNone |
84 |
5. Include endpointsNone |
84 |
6. Filter based on genotype QC (FinnGen only) |
84 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D83
- Name in latin
- Deficientia immunalis variabilis communis praecipue cum abnormalitatibus numeri et functionis cellularum B
Similar endpoints
↥List of similar endpoints to
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
based on the number of shared cases.
Similar with more cases:
- Common variable immunodeficiency
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 312 | 164 | 146 |
| Only index persons | 287 | 154 | 133 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.79 | 49.97 | 49.50 |
| Only index persons | 47.93 | 48.90 | 46.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 84 | 51 | 33 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 45.94 | 46.37 | 45.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 79
- Matched controls
- 787
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
113.6
79
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
66.2
54
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
57.4
48
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
45.2
39
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
67.8
31.4
35
9
ZX120
NOMESCO Finland
Intravenous
16.4
21.4
37
40
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
20.7
19
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
18.8
19.6
31
26
6BA02
NOMESCO Finland
NA
245.7
19.4
19
*
J47
ICD-10 Finland
Bronchiectasis
70.2
19.0
21
*
C01CA24
ATC
epinephrine; parenteral
20.0
18.9
29
22
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
17.3
16
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
17.3
16
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
17.3
16
*
WW200
NOMESCO Finland
Immunization
37.4
16.1
20
7
J01MA12
ATC
levofloxacin; systemic
9.9
16.0
36
61
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.9
15.5
38
74
TDM10
NOMESCO Finland
Puncture of maxillary antrum
18.5
14.9
23
17
J01MA14
ATC
moxifloxacin; systemic
10.8
13.0
26
34
Z3231
NOMESCO Finland
Registered nurse
5.8
11.8
43
134
D83.8
ICD-10 Finland
Other common variable immunodeficiencies
+∞
11.7
11
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.5
11.7
52
203
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
33.4
11.2
14
5
Z2221
NOMESCO Finland
Medical doctor
5.3
11.0
44
150
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.4
11.0
42
136
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
38.2
10.7
13
*
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
10.6
10
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
10.6
10
*
H02AB06
ATC
prednisolone; systemic
4.9
10.1
54
242
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
11.0
10.0
19
22
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
13.2
9.9
17
16
J01.0
ICD-10 Finland
Acute maxillary sinusitis
5.0
9.5
37
118
H02AB07
ATC
prednisone; oral
6.5
9.1
25
52
UGC12
NOMESCO Finland
Flexible bronchoscopy
8.5
9.1
20
30
Z01.8
ICD-10 Finland
Other specified special examinations
5.2
9.0
32
91
TPH04
NOMESCO Finland
Cathetrisation of vein
5.2
8.8
31
87
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
6.8
8.8
23
45
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
100.2
8.6
9
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
9.0
8.6
18
25
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.0
8.6
18
25
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
8.5
8
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
8.3
8.2
18
27
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.2
8.1
39
147
J01MA02
ATC
ciprofloxacin; systemic
4.0
7.9
44
188
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.3
7.8
17
25
J01FA06
ATC
roxithromycin; oral
3.9
7.8
48
224
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.6
7.6
23
54
SPAT1262
SPAT
Handing over of treatment supplies
4.9
7.6
27
76
M05BA04
ATC
alendronic acid; oral
8.4
7.5
16
23
J01FF01
ATC
clindamycin; systemic
4.1
7.4
36
134
R01AD09
ATC
mometasone; nasal
3.8
7.3
53
277
J32.4
ICD-10 Finland
Chronic pansinusitis
33.3
7.3
9
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
33.3
7.3
9
*
J01FA15
ATC
telithromycin; oral
5.6
7.3
22
51
ZXE00
NOMESCO Finland
One hour or less
3.6
7.0
45
211
ZXD10
NOMESCO Finland
Scheduled procedure
3.6
6.9
43
197
Z3226
NOMESCO Finland
Physiotherapist
4.3
6.8
27
84
R50.9
ICD-10 Finland
Fever, unspecified
4.7
6.7
24
67
A02BC01
ATC
omeprazole; systemic
4.0
6.6
30
105
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
16.1
6.6
10
7
J01FA09
ATC
clarithromycin; systemic
3.5
6.5
39
170
TGC00
NOMESCO Finland
Bronchial lavation
12.5
6.5
11
10
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
20.0
6.4
9
5
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
6.6
6.4
16
29
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
6.3
6
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
6.3
6
*
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
6.3
6
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
6.3
6
*
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
+∞
6.3
6
*
132
Kela drug reimbursment
Sarcoidosis
+∞
6.3
6
*
C03CA01
ATC
furosemide; systemic
4.3
6.2
24
72
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma
39
0
+∞
44.87
3.1
0.0
u/l
18.0
—
—
39
0
(3007164) IgA [Mass/volume] in Serum or Plasma
66
153
16.46
33.87
5.7
1.4
g/l
0.8
2.3
10.61
34
108
(3011412) CD3 cells [#/volume] in Blood
33
6
88.79
30.92
1.8
1.2
e9/l
1.0
—
—
27
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
21
15
18.33
23.65
1.6
1.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
68
223
11.76
23.31
18.8
4.8
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
20
14
18.44
22.70
2.6
2.2
—
—
—
0
0
(4062490)
22
5
58.47
19.35
1.5
1.0
—
—
—
0
0
(3000492) Spirometry study
37
76
7.91
19.29
4.8
1.3
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
15
10
18.04
17.19
1.6
1.5
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
26
47
7.56
14.91
2.2
1.3
—
—
—
0
0
(40758558) Short blood count panel - Blood
51
178
5.75
14.44
19.2
6.9
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
35
96
5.54
12.90
2.6
2.2
ug/g
130.0
102.0
0.29
29
77
(3023368) Bacteria identified in Blood by Culture
43
146
4.99
12.17
7.5
4.7
—
—
—
0
0
(3005260) Streptococcus pneumoniae Danish serotype 9V IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
0.1
—
—
6
0
(36203922) Streptococcus pneumoniae Danish serotype 14 IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
1.0
—
—
5
0
(36204005) Streptococcus pneumoniae Danish serotype 19F IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
2.2
—
—
6
0
(3005665) Streptococcus pneumoniae Danish serotype 6B IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
0.2
—
—
5
0
(3006665) Streptococcus pneumoniae Danish serotype 18C IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
0.3
—
—
6
0
(3000899) Streptococcus pneumoniae Danish serotype 7F IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
1.6
—
—
5
0
(36204187) Streptococcus pneumoniae Danish serotype 4 IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
0.4
—
—
5
0
(36204094) Streptococcus pneumoniae Danish serotype 23F IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
0.2
—
—
5
0
(36204286) Streptococcus pneumoniae Danish serotype 5 IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
0.1
—
—
5
0
(36203821) Streptococcus pneumoniae Danish serotype 1 IgG Ab [Mass/volume] in Serum
11
0
+∞
11.73
1.8
0.0
mg/l
0.7
—
—
6
0
(3042936) Bacteria identified in Isolate by Culture
33
94
5.14
11.48
4.2
2.9
—
—
—
0
0
(3004789) Transferrin [Mass/volume] in Serum or Plasma
28
71
5.42
11.12
3.8
2.0
g/l
2.5
2.5
0.09
28
65
(3052851) Hemolysis interference index of Serum or Plasma
17
26
7.94
11.10
2.9
2.9
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
30
81
5.21
11.08
2.6
1.7
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
15
8
22.42
10.72
3.8
2.8
—
—
—
0
0
(3033658) Prothrombin time (PT) actual/Normal
44
165
4.50
10.69
7.2
3.9
%
94.7
95.7
0.12
44
165
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
32
94
4.88
10.63
2.9
1.5
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
26
71
4.86
9.33
2.8
1.4
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
29
91
4.34
8.67
1.7
1.7
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
15
26
6.81
8.67
3.1
1.4
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
26
76
4.51
8.51
2.8
1.4
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
15
29
6.08
7.78
1.3
1.1
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
16
33
5.75
7.77
2.2
1.2
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
12
9
15.29
7.65
1.5
1.2
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
56
294
3.71
7.64
9.1
8.9
mmol/l
1.2
1.2
0.38
48
252
(3014373) Corynebacterium diphtheriae Ab [Units/volume] in Serum
7
0
+∞
7.39
1.4
0.0
—
—
—
0
0
(3013924) Clostridium tetani IgG Ab [Units/volume] in Serum
7
0
+∞
7.39
1.6
0.0
—
—
—
0
0
(3018418) pH of Serum or Plasma
42
188
3.47
7.30
5.6
4.0
ph
7.4
7.4
—
5
28
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
10
13
8.60
7.28
1.7
1.2
—
—
—
0
0
(3012544) pH of Venous blood
19
49
4.72
7.17
4.4
3.1
—
—
—
0
0
(3021447) Carbon dioxide [Partial pressure] in Venous blood
19
49
4.72
7.17
4.4
2.7
kpa
5.7
5.8
0.21
19
49
(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection
10
6
18.65
6.93
1.4
1.5
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
10
14
7.97
6.85
1.7
1.1
—
—
—
0
0
(3033799) Differential panel - Peritoneal fluid
6
0
+∞
6.32
3.2
0.0
—
—
—
0
0
(3002179) Metamyelocytes/100 leukocytes in Blood
18
49
4.40
6.32
8.7
4.3
%
0.4
0.3
—
5
11
(36304419) Bacteria [Presence] in Urine
38
181
3.01
5.66
4.4
2.6
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
24
87
3.46
5.63
1.3
1.2
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
38
182
2.99
5.59
4.4
2.6
e6/l
0.2
0.4
0.41
32
138
(3017181) Myelocytes/100 leukocytes in Blood
18
55
3.89
5.39
11.2
4.3
%
0.6
0.8
—
5
19
(3016228) CD19 cells/100 cells in Blood
5
0
+∞
5.25
1.6
0.0
%
28.4
—
—
5
0
(21494814) CD8 cells/100 lymphocytes in Specimen
5
0
+∞
5.25
1.6
0.0
—
—
—
0
0
(3020073) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Specimen
5
0
+∞
5.25
1.6
0.0
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
10
19
5.84
5.18
1.6
1.7
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
36
174
2.87
5.13
1.6
2.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
14
37
4.34
5.05
1.2
1.6
—
—
—
0
0
(3024354) Oxygen [Partial pressure] in Venous blood
15
42
4.13
5.03
3.4
2.3
kpa
4.3
4.6
0.27
15
42
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
12
28
4.83
5.01
1.3
1.1
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
8
7
12.45
4.89
1.5
1.1
—
—
—
0
0
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
8
7
12.45
4.89
1.1
1.7
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
8
7
12.45
4.89
1.5
1.3
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
42
228
2.68
4.70
9.5
5.5
inr
1.1
1.1
0.43
11
73
(3034770) Mitochondria Ab [Titer] in Serum
10
21
5.27
4.66
1.0
1.3
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
42
229
2.67
4.65
4.8
3.0
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
44
246
2.66
4.62
4.9
3.4
e6/l
599.6
49.1
0.49
32
176
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
11
26
4.72
4.51
2.9
1.5
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
35
177
2.68
4.47
14.9
4.8
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
12
31
4.35
4.43
9.3
6.3
mmol/l
24.1
25.1
0.28
12
31
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
8
9
9.67
4.38
1.6
1.1
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
30
144
2.69
4.21
1.6
1.8
—
—
—
0
0
(3000991) Gas panel - Venous blood
14
43
3.71
4.12
11.0
10.8
—
—
—
0
0
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
7
8
9.41
3.85
3.9
3.1
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
7
8
9.41
3.85
1.7
1.1
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
9
16
6.16
3.77
1.7
1.4
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
38
214
2.42
3.75
4.4
2.8
e6/l
48.3
24.8
0.37
31
169
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
9
17
5.79
3.62
1.4
2.1
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
23
104
2.67
3.57
3.0
2.5
e6/l
0.8
0.7
0.09
14
63
(44790049)
6
6
10.63
3.55
1.5
1.2
—
—
—
0
0
(44790048)
6
6
10.63
3.55
1.5
1.2
—
—
—
0
0
(44790047)
6
6
10.63
3.55
1.5
1.2
—
—
—
0
0
(44806118)
6
6
10.63
3.55
1.5
1.2
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
36
202
2.37
3.54
2.8
1.9
pmol/l
89.0
99.2
0.61
24
99
(3002385) Erythrocyte distribution width [Ratio]
77
631
3.64
3.44
50.9
14.8
%
14.2
13.6
2.66
77
623
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
28
142
2.46
3.43
3.4
2.2
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
17
67
2.93
3.38
1.5
1.6
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
36
207
2.29
3.31
3.6
2.2
—
—
—
0
0
(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing
7
11
6.82
3.25
1.3
1.6
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
9
20
4.91
3.21
1.1
1.3
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
10
29
3.78
3.15
2.5
2.8
mmol/l
24.7
24.4
—
10
29
(3021440) Promyelocytes/100 leukocytes in Blood
14
52
3.03
3.07
13.6
4.4
%
0.0
0.1
—
5
17
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
5
5
10.51
3.01
1.2
1.2
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
8
17
5.08
3.00
2.0
1.4
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
8
17
5.08
3.00
2.0
1.4
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
47
311
2.16
2.98
4.9
4.3
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
41
260
2.13
2.87
2.0
1.8
—
—
—
0
0
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
8
18
4.79
2.87
1.1
1.3
—
—
—
0
0
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
5
6
8.75
2.78
1.2
2.0
nmol/l
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
21
102
2.41
2.77
3.0
2.5
e6/l
1.8
2.6
0.30
12
61
(3031040) Bacteria [#/volume] in Urine by Automated count
59
434
2.21
2.77
7.1
4.2
—
53.6
—
0
10
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
6
10
6.36
2.74
1.8
1.1
—
—
—
0
0
(4035726)
12
44
3.02
2.67
1.3
1.3
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
8
20
4.30
2.64
1.8
1.7
—
—
—
0
0
(3019060) Gas panel - Arterial blood
10
33
3.30
2.62
1.4
19.0
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
6
11
5.78
2.59
7.8
3.4
%
47.5
54.6
—
6
11
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
5
7
7.50
2.58
1.6
1.0
—
—
—
0
0
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
5
7
7.50
2.58
1.6
1.0
—
—
—
0
0
(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection
5
7
7.50
2.58
2.0
1.3
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
8
21
4.10
2.53
1.9
1.2
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
78
672
3.25
2.52
46.2
13.2
%
40.2
40.7
0.32
59
531
(3025941) Bacteria identified in Stool by Culture
11
40
3.01
2.48
2.3
1.2
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
8
22
3.90
2.43
1.9
1.2
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
8
22
3.90
2.43
1.9
1.2
—
—
—
0
0
(3003396) Base excess in Arterial blood by calculation
15
66
2.55
2.41
7.7
17.3
mmol/l
-1.5
1.4
—
10
50
(3037756) Immunofixation for Serum or Plasma
5
8
6.56
2.40
1.0
1.3
—
—
—
0
0
(3038177) Helicobacter pylori Ab [Presence] in Serum
5
8
6.56
2.40
1.0
1.1
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
9
28
3.47
2.39
2.9
3.4
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
32
196
2.02
2.37
3.8
2.6
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
7
18
4.14
2.30
1.3
1.3
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
27
158
2.04
2.25
3.9
3.3
—
—
—
0
0
(1616796) Gas panel - Central venous blood
5
9
5.82
2.24
5.0
1.3
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
5
9
5.82
2.24
1.6
2.6
—
—
—
0
0
(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
5
9
5.82
2.24
1.2
1.6
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
5
9
5.82
2.24
1.0
1.7
—
—
—
0
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
5
9
5.82
2.24
1.2
1.7
—
—
—
0
0
(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum
9
30
3.23
2.22
1.3
1.3
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
42
290
1.90
2.16
4.6
2.4
ug/l
108.0
93.0
0.22
42
274
(1761868) Lipid panel - Serum or Plasma
16
287
0.45
2.15
2.7
2.5
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
14
63
2.47
2.15
1.3
1.1
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
7
20
3.72
2.10
1.1
1.2
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
9
32
3.02
2.07
11.0
14.3
%
91.3
92.5
—
9
32
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
9
32
3.02
2.07
3.8
2.9
%
50.3
56.4
—
9
32
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
8
27
3.16
1.99
2.3
2.0
%
3.1
1.5
—
8
27
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
6
16
3.95
1.97
1.2
2.4
—
—
—
0
0
(3023183) Ammonium ion [Moles/volume] in Plasma
5
11
4.76
1.97
4.2
2.1
umol/l
44.4
34.8
—
5
11
(3030905) Polymorphonuclear cells [#/volume] in Blood
5
11
4.76
1.97
7.4
3.1
e9/l
3.8
3.4
—
5
11
(3014051) Protein [Presence] in Urine by Test strip
5
11
4.76
1.97
3.4
1.6
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
20
111
2.05
1.89
1.4
1.6
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
65
532
1.98
1.84
3.5
3.5
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
28
177
1.87
1.83
3.8
3.9
mg/mmol
1.8
11.0
1.98
18
116
(44816559) Phosphatidylethanol [Mass/volume] in Blood
7
24
3.09
1.76
1.1
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
5
13
4.02
1.74
6.6
2.4
u/ml
0.3
0.3
—
5
7
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
8
32
2.65
1.64
12.1
24.9
—
—
—
0
0
(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection
5
14
3.73
1.64
1.8
1.2
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
26
168
1.79
1.57
3.2
3.3
mg/l
15.2
56.0
1.99
16
112
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
7
27
2.73
1.55
2.7
1.9
—
—
—
0
0
(3038515) Glucose [Moles/volume] in Venous blood
5
15
3.47
1.54
3.4
2.7
mmol/l
5.2
7.5
—
5
15
(3021601) Nitrite [Presence] in Urine by Test strip
45
343
1.67
1.49
5.6
4.8
estimate
0.0
0.0
—
9
62
(3008037) Lactate [Moles/volume] in Venous blood
5
16
3.25
1.46
3.4
2.6
mmol/l
1.8
1.4
—
5
16
(3009261) Glucose [Presence] in Urine by Test strip
45
345
1.66
1.44
4.2
3.5
estimate
0.0
0.0
—
8
63
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
7
29
2.54
1.42
1.3
2.1
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
9
41
2.34
1.42
1.8
1.3
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
45
346
1.65
1.42
4.6
3.5
estimate
0.0
0.0
—
9
65
(3045414) Leukocytes [Presence] in Urine
6
23
2.73
1.39
3.0
1.5
—
—
—
0
0
(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid
5
17
3.06
1.38
2.0
1.1
e6/l
5.8
162.1
—
5
12
(3020044) Glucose [Moles/volume] in Cerebral spinal fluid
5
17
3.06
1.38
2.0
1.2
mmol/l
3.3
3.8
—
5
17
(3016543) Leukocytes [#/volume] in Cerebral spinal fluid
5
17
3.06
1.38
2.0
1.0
e6/l
4.2
4.6
—
5
11
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
8
34
2.49
1.33
12.3
13.6
%
0.6
0.7
—
8
34
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
8
35
2.42
1.31
12.3
12.5
%
1.6
2.0
—
8
35
(3020891) Body temperature
5
18
2.89
1.30
2.4
4.8
—
—
—
0
0
(3019473) Protein [Mass/volume] in Cerebral spinal fluid
5
18
2.89
1.30
2.0
1.3
mg/l
368.2
397.7
—
5
18
(3022621) pH of Urine by Test strip
8
39
2.16
1.19
4.3
2.6
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
11
58
2.03
1.18
3.0
2.6
—
—
—
0
0
(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay
5
20
2.59
1.17
1.2
1.1
—
7.5
—
0
5
(3013139) Helicobacter pylori Ag [Presence] in Stool
8
41
2.05
1.12
1.4
1.1
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
9
45
2.12
1.09
4.3
3.4
mmol/l
1.2
1.2
—
9
39
(4010399)
9
49
1.94
1.02
1.3
1.3
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
18
118
1.67
1.01
4.5
3.2
ng/l
17.9
86.2
0.73
12
76
(3037467) Urinalysis macro (dipstick) panel - Urine
56
476
1.53
1.01
6.1
3.8
—
—
—
0
0
(3017732) Neutrophils [#/volume] in Blood
8
45
1.86
0.87
2.1
2.8
e9/l
3.5
4.1
—
8
40
(3019832) Treponema pallidum Ab [Presence] in Serum
15
99
1.63
0.82
1.3
1.7
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
8
132
0.56
0.82
1.5
2.0
—
—
—
0
0
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
5
23
2.25
0.77
1.0
1.2
—
—
—
0
0
(3022145) Colonoscopy Study observation
12
77
1.65
0.73
1.6
1.3
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
22
166
1.44
0.68
2.2
1.7
mg/l
1.5
0.8
0.83
17
128
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
18
132
1.46
0.64
1.5
1.4
—
—
—
0
0
(3044889) 12 lead EKG panel
55
488
1.37
0.63
3.9
3.0
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
13
89
1.55
0.62
2.8
2.4
ug/l
0.6
0.6
—
8
44
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
8
121
0.63
0.60
1.5
1.8
—
—
—
0
0
(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma
6
37
1.67
0.57
1.3
2.1
—
4802.7
—
0
12
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
13
178
0.68
0.56
1.2
1.5
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
12
86
1.46
0.47
1.4
1.6
—
—
—
0
0
(4268621)
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
25
209
1.28
0.40
1.4
1.6
—
—
—
0
0
(4094501)
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
(3002256) Pathology report gross observation
11
81
1.41
0.38
1.1
1.2
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
9
70
1.32
0.38
1.8
2.2
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
79
762
1.62
0.37
28.3
10.6
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
6
43
1.43
0.36
1.2
1.0
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
7
54
1.32
0.31
5.0
2.9
—
—
—
0
0
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
8
108
0.71
0.31
1.8
2.0
%
1.8
1.4
—
8
100
(3008898) HLA-B27 [Presence]
5
38
1.34
0.23
1.0
1.1
—
—
—
0
0
(3004616) Nuclear Ab [Presence] in Serum
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(40761535) Cells panel - Urine sediment
6
47
1.30
0.21
7.5
3.3
—
—
—
0
0
(3003888) Timothy IgE Ab [Units/volume] in Serum
0
13
0.00
0.21
0.0
1.1
—
1.5
—
0
6
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
14
119
1.21
0.19
3.6
3.7
%
18.1
21.2
—
8
44
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
7
59
1.20
0.18
1.9
1.9
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
56
534
1.15
0.18
4.8
4.0
pmol/l
15.0
14.8
0.22
51
494
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
5
69
0.71
0.17
21.6
6.7
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
61
627
0.90
0.11
6.2
5.1
mmol/mol
38.1
39.4
0.33
56
592
(3019225) pH of Specimen
5
46
1.09
0.10
3.2
4.6
—
—
—
0
0
(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma
5
47
1.07
0.09
1.6
2.6
ug/l
3.7
4.1
—
5
40
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
15
136
1.13
0.09
1.5
1.3
iu/ml
—
43.8
—
0
44
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
29
274
1.09
0.09
5.1
3.5
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
20
189
1.08
0.05
5.5
3.7
estimate
0.0
0.0
—
7
59
(3013512) EKG study
15
158
0.94
0.02
4.7
3.0
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
20
197
1.02
0.00
4.0
3.3
—
—
—
0
0
(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(3018301) Testosterone Free [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
111.3
—
0
6
(3048469) 10-Hydroxycarbazepine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
64.0
—
0
6
(3042975) Streptococcus sp identified in Isolate by Organism specific culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006442) Creatine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(1617658) Protocol used for examination of sentinel lymph nodes
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3012447) Hantavirus puumala IgG Ab [Titer] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
(3029075) Extractable nuclear Ab panel - Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016244) Insulin [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
12.5
—
0
5
(21491868) Cryoglobulin [Mass/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016616) Dehydroepiandrosterone sulfate (DHEA-S) [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
6.7
—
0
5
(3013727) Leukocytes other/100 leukocytes in Blood
0
5
0.00
0.00
0.0
2.2
—
56.3
—
0
5
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
7
72
0.97
0.00
2.1
1.9
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
0.8
—
0
7
(3035637) Corticotropin [Mass/volume] in Plasma
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
9.7
—
0
6
(4198724)
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_CVID_BCELL and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_CVID_BCELL.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_CVID_BCELL – Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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