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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Major histocompatibility complex class I deficiency

Endpoint Browser

D3_COMPXI

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D81.6
  • Cause of death: ICD-10 — D81.6

2 out of 7 registries used, show all original rules.

7

4. Check minimum number of events

None

7

5. Include endpoints

None

7

6. Filter based on genotype QC (FinnGen only)

7

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D81
Name in latin
Deficientia complexus histocompatibilitatis majoris classis primae

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21 17 -
Only index persons 20 17 -
Unadjusted period prevalence (%)
Whole population 0.00 0.00 -
Only index persons 0.00 0.00 -
Median age at first event (years)
Whole population - 48.04 -
Only index persons 48.86 48.04 -

-FinnGen-

Key figures

All Female Male
Number of individuals 7 6 -
Unadjusted period prevalence (%) 0.00 0.00 -
Median age at first event (years) 45.01 42.98 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

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OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
7
26
+∞
2.75
4.3
1.3
nmol/l
68.4
81.0
—
7
21
(3003694) ABO and Rh group [Type] in Blood
0
25
0.00
1.05
0.0
1.5
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
7
43
+∞
1.05
5.9
5.3
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
0
16
0.00
0.48
0.0
5.6
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
0
15
0.00
0.48
0.0
1.7
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
0
11
0.00
0.23
0.0
1.4
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
0
11
0.00
0.23
0.0
1.7
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
0
10
0.00
0.23
0.0
1.3
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
0
12
0.00
0.23
0.0
2.0
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
7
57
+∞
0.23
5.9
4.2
mmol/l
5.9
5.8
—
7
52
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
7
63
+∞
0.00
33.0
17.1
mg/l
17.1
18.2
—
7
51
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
8.4
—
16.4
—
0
7
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3014576) Chloride [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
9.8
—
104.5
—
0
6
(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.2
—
8.1
—
0
6
(40761511) CBC panel - Blood by Automated count
7
63
+∞
0.00
30.4
14.1
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

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Association

Association between endpoint D3_COMPXI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_COMPXI.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: D3_COMPXI – Major histocompatibility complex class I deficiency

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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