blood coagulation disease: A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1856 |
4. Check minimum number of eventsNone |
1856 |
5. Include endpointsNone |
1856 |
6. Filter based on genotype QC (FinnGen only) |
1856 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified coagulation defects
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11374 | 7399 | 3902 |
| Only index persons | 10454 | 6997 | 3457 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.11 |
| Only index persons | 0.22 | 0.26 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 41.80 | 37.06 | 50.90 |
| Only index persons | 41.92 | 37.10 | 51.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1856 | 1290 | 566 |
| Unadjusted period prevalence (%) | 0.38 | 0.44 | 0.25 |
| Median age at first event (years) | 45.73 | 40.98 | 56.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1627
- Matched controls
- 16269
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.9
ICD-10 Finland
Coagulation defect, unspecified
1062.7
323.0
402
5
D68.8
ICD-10 Finland
Other specified coagulation defects
5305.6
323.0
1312
12
B01AA03
ATC
warfarin; systemic
11.1
323.0
756
1177
B01AB05
ATC
enoxaparin; parenteral
9.2
323.0
1064
2778
B01AB04
ATC
dalteparin; parenteral
15.1
183.6
320
260
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
14.1
142.5
254
211
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
10.2
126.4
265
304
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
436.1
123.5
122
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
5.8
119.4
382
819
I80.29
ICD-10 Finland
Phlebitis and thrombophlebitis of other deep vessels of lower extremities
13.7
112.4
201
165
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
22.2
110.0
163
81
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
38.2
97.1
124
35
Z2221
NOMESCO Finland
Medical doctor
3.2
95.4
710
3185
XF400
NOMESCO Finland
ECG with 12 standard connections
4.1
88.9
408
1235
D68.0
ICD-10 Finland
Von Willebrand disease
883.5
86.4
84
*
R4110
NOMESCO Finland
Physiotherapy
3.0
77.0
579
2526
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
74.5
769
4066
I82.88
ICD-10 Finland
Embolism and thrombosis of other specified veins
16.0
71.7
119
80
I80.1
ICD-10 Finland
Phlebitis and thrombophlebitis of femoral vein
23.1
71.5
104
48
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.4
64.0
362
1264
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
63.3
703
3768
ZXE00
NOMESCO Finland
One hour or less
2.4
62.2
803
4644
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
6.6
61.0
166
276
Z3226
NOMESCO Finland
Physiotherapist
3.0
59.7
418
1689
ZXD10
NOMESCO Finland
Scheduled procedure
2.4
59.1
746
4231
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.6
56.9
213
514
Z3231
NOMESCO Finland
Registered nurse
2.6
56.8
563
2792
R06.0
ICD-10 Finland
Dyspnoea
2.7
54.5
473
2163
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.3
54.2
312
1090
K94
ICPC
Phlebitis/thrombophlebitis
13.2
53.7
96
77
I82.9
ICD-10 Finland
Embolism and thrombosis of unspecified vein
12.5
52.4
96
81
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
186.0
52.2
54
*
B01AB10
ATC
tinzaparin; parenteral
4.6
52.0
196
474
M79.6
ICD-10 Finland
Pain in limb
2.3
50.7
669
3788
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
50.0
422
1884
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
3.2
47.9
280
982
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
6.5
47.3
129
214
N02AX02
ATC
tramadol; systemic, rectal
2.1
44.1
718
4392
126
Kela drug reimbursment
Chronic coagulation defects
+∞
42.9
41
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
42.7
519
2772
ZXD05
NOMESCO Finland
Urgent procedure
2.2
42.3
611
3527
WX892
NOMESCO Finland
Monitored bed care
3.9
39.1
173
483
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.8
38.7
175
498
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
38.5
496
2695
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
38.5
508
2790
N02BE01
ATC
paracetamol; systemic, rectal
2.4
36.8
1400
11741
ZXE20
NOMESCO Finland
More than three and less than five hours
2.8
36.7
262
1038
K99
ICPC
Cardiovascular disease other
7.2
35.9
89
129
I80.8
ICD-10 Finland
Phlebitis and thrombophlebitis of other sites
9.0
35.3
76
88
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
9.1
34.5
74
85
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.3
34.5
134
331
I80.9
ICD-10 Finland
Phlebitis and thrombophlebitis of unspecified site
10.2
34.5
69
70
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
34.0
195
665
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
33.4
402
2094
H02AB07
ATC
prednisone; oral
2.5
31.9
275
1211
R4120
NOMESCO Finland
Occupational therapy
3.7
31.8
150
440
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
89.4
31.8
35
*
ZX120
NOMESCO Finland
Intravenous
3.0
31.8
199
720
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.9
31.8
776
5322
Z2446
NOMESCO Finland
Social worker
3.4
31.5
164
521
4511A
ICD-9 Finland
Phlebitis and thrombophlebitis, Of deep vessels of lower extremities
13.6
31.1
54
41
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
31.0
190
678
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
30.9
286
1303
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
12.9
30.9
55
44
C03CA01
ATC
furosemide; systemic
2.2
30.4
361
1860
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
30.3
237
986
WX002
NOMESCO Finland
Sedation and analgesia
2.2
30.2
340
1710
K78
ICPC
Atrial fibrillation/flutter
3.7
29.7
135
384
B01AX05
ATC
fondaparinux; parenteral
19.2
29.7
45
24
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
29.0
409
2265
I87.0
ICD-10 Finland
Postthrombotic syndrome
34.4
28.8
37
11
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.8
28.6
126
349
H02AB06
ATC
prednisolone; systemic
1.8
28.5
742
5137
J01DB01
ATC
cefalexin; oral
2.0
28.4
1344
11378
I26
ICD-10 Finland
Pulmonary embolism
17.0
27.2
43
26
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.7
27.1
197
783
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
26.8
641
4286
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.6
26.5
215
908
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.4
26.0
132
410
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.0
25.7
416
2415
AA1AD
NOMESCO Finland
CT of head and brain
2.1
25.7
352
1912
R60.0
ICD-10 Finland
Localized oedema
2.7
25.7
195
793
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.6
25.4
120
352
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.1
25.1
148
512
C07AB07
ATC
bisoprolol; oral
1.8
24.9
622
4188
ZXA00
NOMESCO Finland
Right side
1.9
24.5
405
2365
A02BC02
ATC
pantoprazole; systemic
1.7
24.3
991
7726
ZXA05
NOMESCO Finland
Left side
2.0
24.3
377
2145
PG9AC
NOMESCO Finland
Arteriography with X-ray not elsewhere classified
38.2
24.0
30
8
I80.20
ICD-10 Finland
Phlebitis and thrombophlebitis in the iliac vein
23.1
23.9
34
15
Z71.8
ICD-10 Finland
Other specified counselling
1.9
23.8
438
2655
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.5
23.7
114
340
L04AX01
ATC
azathioprine; systemic
3.8
23.3
101
276
N02AJ06
ATC
codeine and paracetamol; systemic
1.8
23.3
611
4157
XF404
NOMESCO Finland
Ambulatory ECG
2.7
23.2
164
639
J01MA12
ATC
levofloxacin; systemic
2.1
22.9
280
1442
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
121.7
22.6
24
*
L17
ICPC
Foot/toe symptom/complaint
1.9
22.4
411
2479
N03AX16
ATC
pregabalin; oral
1.9
22.2
373
2179
B01AF01
ATC
rivaroxaban; oral
2.6
22.2
171
700
K93
ICPC
Pulmonary embolism
10.5
22.1
43
42
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
63.4
21.9
25
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
21.8
318
1756
J01MA02
ATC
ciprofloxacin; systemic
1.7
21.6
571
3868
R51.80
ICD-10 Finland
Headache
2.1
21.6
291
1561
A02BC01
ATC
omeprazole; systemic
1.8
21.3
428
2657
XA800
NOMESCO Finland
Neuropsychological investigation
3.6
21.1
99
290
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
20.7
188
840
315
Kela drug reimbursment
Clopidogrel
13.1
20.7
36
28
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
20.6
136
505
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.7
20.6
148
581
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
20.6
545
3684
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
20.6
424
2650
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
20.6
289
1572
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
20.4
190
857
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
48.6
20.2
24
5
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
19.9
180
802
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.6
19.7
152
619
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
9.3
19.4
40
44
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.3
19.4
196
921
3AC01
NOMESCO Finland
NA
7.6
19.2
45
61
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
19.1
256
1364
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.7
18.8
83
231
L04AA06
ATC
mycophenolic acid; systemic
5.7
18.8
54
97
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.1
18.8
234
1210
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
6.8
18.4
46
69
O22.3
ICD-10 Finland
Deep phlebothrombosis in pregnancy
16.4
18.3
29
18
TKC20
NOMESCO Finland
Catheterisation of bladder
2.9
18.2
118
432
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
4.3
18.2
68
163
R50.9
ICD-10 Finland
Fever, unspecified
2.1
18.2
229
1186
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
18.1
297
1707
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.1
18.0
104
356
A02BC05
ATC
esomeprazole; systemic
1.6
17.8
606
4352
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.8
17.5
114
419
XF402
NOMESCO Finland
ECG with work load test
2.4
17.5
151
657
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.4
17.4
64
151
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.9
17.4
110
399
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.6
17.0
511
3535
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.2
17.0
91
296
I74.3
ICD-10 Finland
Embolism and thrombosis of arteries of lower extremities
8.7
17.0
36
42
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.4
17.0
85
263
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.9
16.9
71
190
P01BA02
ATC
hydroxychloroquine; oral
2.4
16.9
152
674
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.0
16.9
239
1297
28698
ICD-8 Finland
Coagulation defects, Other
+∞
16.7
16
*
J01MA14
ATC
moxifloxacin; systemic
2.4
16.5
145
635
A46
ICD-10 Finland
Erysipelas
2.1
16.5
188
932
R04.0
ICD-10 Finland
Epistaxis
2.8
16.5
110
414
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
16.3
220
1171
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
5.7
16.2
46
82
XF620
NOMESCO Finland
Examination of circulation with color method
18.7
16.0
24
13
R03AC02
ATC
salbutamol; inhalant
1.5
15.9
828
6539
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
15.9
126
522
Z01.7
ICD-10 Finland
Laboratory examination
2.1
15.8
188
949
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.7
15.8
112
436
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
11.3
15.8
29
26
XW000
NOMESCO Finland
Bone marrow biopsy
3.7
15.7
68
187
L28
ICPC
Limited function/disability (L)
2.0
15.7
205
1075
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
15.6
15
*
B01AF02
ATC
apixaban; oral
2.5
15.5
127
537
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
15.2
333
2094
JN4BD
NOMESCO Finland
Extensive body CT
2.2
15.2
155
731
WX402
NOMESCO Finland
General anaesthesia
1.8
15.2
272
1605
I80
ICD-10 Finland
Phlebitis and thrombophlebitis
7.2
15.1
36
51
C10AA05
ATC
atorvastatin; oral
1.6
15.0
434
2954
45100
ICD-8 Finland
Phlebitis and thrombophlebitis, Of lower extremities
10.2
15.0
29
29
J01FF01
ATC
clindamycin; systemic
1.7
14.9
415
2793
M05BA04
ATC
alendronic acid; oral
2.6
14.7
107
424
O28.0
ICD-10 Finland
Abnormal haematological finding on antenatal screening of mother
21.2
14.7
21
10
E0000UV
ATC
NA
1.5
14.6
609
4535
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.8
14.6
267
1583
B83
ICPC
Purpura/coagulation defect
+∞
14.6
14
*
ZXA10
NOMESCO Finland
Bilateral
1.8
14.6
272
1624
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
12.0
14.6
26
22
WX110
NOMESCO Finland
Local anesthesy
1.5
14.5
1108
9455
J01FA06
ATC
roxithromycin; oral
1.5
14.4
610
4555
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
14.4
137
626
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
14.3
146
690
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.0
14.2
182
944
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.3
14.1
52
124
R42
ICD-10 Finland
Dizziness and giddiness
1.7
14.0
295
1830
J45.1
ICD-10 Finland
Nonallergic asthma
2.4
13.9
119
514
K92.1
ICD-10 Finland
Melaena
3.0
13.8
80
275
D69.0
ICD-10 Finland
Allergic purpura
53.8
13.8
16
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
13.8
265
1597
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.4
13.7
121
529
D68.4
ICD-10 Finland
Acquired coagulation factor deficiency
+∞
13.6
13
*
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
+∞
13.6
13
*
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
13.6
13
*
R03BA02
ATC
budesonide; inhalant
1.8
13.5
280
1724
N02AA05
ATC
oxycodone; systemic
2.0
13.5
181
960
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
16.3
13.5
21
13
B99
ICPC
Blood/lymph/spleen disease other
16.3
13.5
21
13
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
2.9
13.4
83
298
XF600
NOMESCO Finland
Bloodpressure measurement
2.5
13.3
108
455
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
13.3
125
568
R03DC03
ATC
montelukast; oral
1.8
13.3
267
1626
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.2
13.2
141
678
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.4
13.2
116
509
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.6
13.2
100
404
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.4
13.2
115
501
R02
ICPC
Shortness of breath/dyspnoea
2.0
13.2
173
909
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.7
13.1
272
1674
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
13.1
153
764
TK800
NOMESCO Finland
Hemodialysis
4.8
13.1
43
92
B02AA02
ATC
tranexamic acid; systemic
1.8
13.0
258
1566
Z3229
NOMESCO Finland
Other healthcare associate professional
2.3
12.9
127
589
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.6
12.9
98
396
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.7
12.8
43
94
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
5.0
12.8
40
81
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
3.8
12.8
54
147
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.0
12.7
171
909
Z35.1
ICD-10 Finland
Supervision of pregnancy with history of abortive outcome
8.3
12.5
27
33
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
12.5
171
911
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
12.3
738
5880
XX1XW
NOMESCO Finland
Extensive written report from radiologist
4.1
12.3
47
117
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.8
12.3
78
286
PEH57
NOMESCO Finland
Bypass from femoral artery to popliteal artery below knee
14.4
12.3
20
14
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
12.2
369
2518
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.0
12.2
71
246
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
7.5
12.2
28
38
Z2445
NOMESCO Finland
Psychologist
2.6
12.2
87
340
ZXD35
NOMESCO Finland
Usual procedure
3.1
12.1
66
219
H53.1
ICD-10 Finland
Subjective visual disturbances
2.3
12.1
111
499
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
12.1
532
3970
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
12.0
164
873
K22
ICPC
Risk factor cardiovascular disease
2.7
12.0
79
297
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.0
11.9
70
244
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.3
11.9
113
517
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
11.9
379
2620
A28
ICPC
Limited function/disability NOS
2.0
11.9
165
886
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
11.8
112
511
M25.5
ICD-10 Finland
Pain in joint
1.5
11.8
430
3070
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.7
11.8
78
294
N96
ICD-10 Finland
Habitual aborter
6.1
11.7
31
52
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.6
11.6
52
149
S16
ICPC
Bruise/contusion
3.3
11.5
58
182
J01MA06
ATC
norfloxacin; oral
1.8
11.5
204
1194
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
11.5
257
1613
L14
ICPC
Leg/thigh symptom/complaint
2.2
11.4
112
520
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
3.5
11.4
53
157
NF1AA
NOMESCO Finland
Hip X-ray examination
2.3
11.3
109
502
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.6
11.2
291
1907
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.3
11.2
106
484
A02BA02
ATC
ranitidine; systemic
1.7
11.2
259
1640
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.7
11.2
47
128
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.8
11.0
46
125
R06AE07
ATC
cetirizine; oral
1.4
10.9
681
5427
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.9
10.9
43
111
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
10.9
786
6441
Z31.5
ICD-10 Finland
Genetic counselling
2.2
10.9
106
491
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.5
10.9
37
83
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
10.9
293
1938
R06AX27
ATC
desloratadine; oral
1.5
10.9
441
3216
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.1
10.8
58
192
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.9
10.8
152
819
127
Kela drug reimbursment
Transplant complication
4.7
10.7
35
75
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
4.3
10.7
38
89
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.6
10.7
284
1872
I81
ICD-10 Finland
Portal vein thrombosis
13.0
10.6
18
14
WX722
NOMESCO Finland
PEEP
2.8
10.6
70
261
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
10.6
261
1681
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.5
10.6
81
332
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
10.5
272
1776
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
10.5
205
1234
A11CC03
ATC
alfacalcidol; systemic
3.9
10.5
42
110
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.1
10.5
119
587
J01DA01
ATC
[U] cefalexin; systemic
1.4
10.4
936
7956
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
110.7
10.4
11
*
EBA10
NOMESCO Finland
Surgical removal of tooth
1.7
10.4
206
1247
R03BB04
ATC
tiotropium bromide; inhalant
2.1
10.4
116
569
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.1
10.3
112
545
L04AD01
ATC
ciclosporin; systemic
3.9
10.3
41
107
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.7
10.3
72
279
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
10.3
457
3393
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.4
10.3
85
362
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.0
10.2
40
103
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.0
10.2
124
633
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.1
10.2
113
555
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
10.2
110
532
R31
ICD-10 Finland
Unspecified haematuria
2.1
10.2
115
569
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
5.2
10.1
30
58
O36.4
ICD-10 Finland
Maternal care for intrauterine death
6.9
10.1
24
35
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
10.1
601
4729
TAB00
NOMESCO Finland
Lumbar puncture
2.4
10.1
81
341
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
10.1
125
643
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
3.7
10.0
42
115
XCK10
NOMESCO Finland
Photography of fundus of eye
2.0
9.9
130
682
R5110
SPAT
NA
3.7
9.9
42
116
A11
ICPC
Chest pain NOS
2.3
9.9
94
431
C09AA05
ATC
ramipril; oral
1.6
9.8
257
1684
G47.3
ICD-10 Finland
Sleep apnoea
1.6
9.8
269
1787
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
9.8
227
1441
ZXD20
NOMESCO Finland
Day surgery
1.7
9.7
198
1211
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.3
9.7
47
145
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.5
9.7
43
124
J01AA02
ATC
doxycycline; systemic
1.4
9.7
1155
10273
R53
ICD-10 Finland
Malaise and fatigue
1.6
9.6
296
2019
A08
ICPC
Swelling
2.8
9.6
61
225
UJF32
NOMESCO Finland
Coloscopy
1.5
9.6
330
2313
PD5BD
NOMESCO Finland
Extensive CT of aorta
4.2
9.6
35
85
Z32.1
ICD-10 Finland
Pregnancy confirmed
1.7
9.6
187
1128
R4190
NOMESCO Finland
Nutritional therapy
2.7
9.5
62
233
R20.2
ICD-10 Finland
Paraesthesia of skin
2.0
9.5
115
586
I50.0
ICD-10 Finland
Congestive heart failure
2.6
9.5
69
276
XPX08
NOMESCO Finland
Intraoperative flow measurement
9.1
9.5
19
21
H02AB04
ATC
methylprednisolone; systemic
1.7
9.5
204
1264
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.5
9.5
43
126
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.0
9.4
126
665
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.0
9.4
122
637
K84
ICPC
Heart disease other
3.8
9.4
38
101
Z86.7
ICD-10 Finland
Personal history of diseases of the circulatory system
100.6
9.4
10
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.3
9.4
85
379
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
17.6
9.4
14
8
R01AD05
ATC
budesonide; nasal
2.0
9.4
120
625
2869X
ICD-9 Finland
Coagulation defects, Other and unspecified coagulation defects
+∞
9.4
9
*
D68
ICD-10 Finland
Other coagulation defects
+∞
9.4
9
*
I82.80
ICD-10 Finland
Emboli and thrombosis in the subclavian vein
21.8
9.4
13
6
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.4
9.3
44
133
R52.9
ICD-10 Finland
Pain, unspecified
2.0
9.3
125
662
J01DA06
ATC
[U] cefuroxime; systemic
1.7
9.3
210
1322
K29
ICPC
Cardiovascular sympt/complt other
2.7
9.3
62
235
WW500
NOMESCO Finland
Blood transfusion
2.7
9.2
59
220
K90
ICPC
Stroke/cerebrovascular accident
3.6
9.2
40
114
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.4
9.1
78
340
A07AA02
ATC
nystatin; oral
2.3
9.1
83
372
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
9.1
78
341
B01AC04
ATC
clopidogrel; oral
1.8
9.1
157
910
C01CA24
ATC
epinephrine; parenteral
2.0
9.1
113
581
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.5
9.0
68
276
R01AD09
ATC
mometasone; nasal
1.4
9.0
682
5569
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.0
9.0
111
571
R4130
NOMESCO Finland
Speech therapy
3.5
9.0
40
116
M01AG02
ATC
tolfenamic acid; oral, rectal
1.6
8.9
256
1714
H02AB09
ATC
hydrocortisone; systemic
3.2
8.9
44
138
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.2
8.9
85
391
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.7
8.9
29
63
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
8.9
52
183
N30.0
ICD-10 Finland
Acute cystitis
1.7
8.9
206
1306
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
2.2
8.9
85
393
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.4
8.8
73
312
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
8.8
175
1059
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
8.8
138
773
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.9
8.8
52
185
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.1
8.7
102
512
XMA22
NOMESCO Finland
General examination of pregnant woman
1.9
8.7
117
622
Z71.9
ICD-10 Finland
Counselling, unspecified
2.1
8.7
91
437
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.8
8.7
155
909
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.9
8.6
130
720
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
5.1
8.6
26
52
GD1LA
NOMESCO Finland
GD
6.2
8.6
22
36
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.0
8.6
47
159
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
4.2
8.6
31
75
-60
ICPC
Result test/procedure
2.1
8.6
90
433
L05
ICPC
Flank/axilla symptom/complaint
2.3
8.6
80
365
R2110
NOMESCO Finland
Giving the first information
1.9
8.6
123
667
S97
ICPC
Chronic ulcer skin
2.5
8.6
65
266
J01CA04
ATC
amoxicillin; systemic
1.4
8.5
1268
11570
WW400
NOMESCO Finland
Plasmaferesis
27.7
8.5
11
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
20.1
8.5
12
6
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
8.5
305
2155
L04AA01
ATC
[U] ciclosporin; systemic
3.9
8.4
33
86
205
Kela drug reimbursment
Chronic hypertension
1.5
8.4
276
1908
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.1
8.4
45
150
R07.3
ICD-10 Finland
Other chest pain
1.9
8.4
128
711
I82.1
ICD-10 Finland
Thrombophlebitis migrans
90.5
8.4
9
*
R5599
NOMESCO Finland
Other rehabilitation service
3.1
8.4
44
145
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
8.3
287
2005
H53.4
ICD-10 Finland
Visual field defects
3.4
8.2
38
114
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.9
8.2
128
715
J01FA10
ATC
azithromycin; systemic
1.4
8.2
900
7765
M04AA01
ATC
allopurinol; systemic
1.9
8.2
126
704
A01
ICPC
Pain general/multiple sites
1.9
8.1
114
614
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
8.1
80
375
TFP20
NOMESCO Finland
Cardiodefibrillation
2.2
8.1
77
354
R05
ICD-10 Finland
Cough
1.5
8.1
260
1788
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
8.1
1227
13253
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
8.1
237
1596
N06AA09
ATC
amitriptyline; systemic
1.8
8.1
129
730
PB1DE
NOMESCO Finland
Upper extremity arteries ultrasound examination with Doppler method
11.8
8.1
14
12
R04.2
ICD-10 Finland
Haemoptysis
3.0
8.1
46
158
N03AX12
ATC
gabapentin; oral
1.6
8.0
201
1300
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
5.1
8.0
24
48
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
8.0
141
823
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.8
8.0
49
179
A97
ICPC
No disease
1.6
8.0
208
1359
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.5
8.0
35
101
R23.3
ICD-10 Finland
Spontaneous ecchymoses
3.5
8.0
35
101
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
5.6
8.0
22
40
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
1.7
7.9
160
973
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.6
7.9
56
223
R4150
NOMESCO Finland
Neuropsychological rehabilitation
5.2
7.9
23
45
RS221
NOMESCO Finland
NA
3.8
7.9
31
82
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
4.3
7.8
27
63
ZZA00
NOMESCO Finland
Split skin graft
3.2
7.8
38
119
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.1
7.8
41
136
N05CF01
ATC
zopiclone; oral
1.4
7.8
402
3049
6BA02
NOMESCO Finland
NA
9.4
7.8
15
16
SPAT1229
SPAT
Assessment of need for aid
2.0
7.8
95
487
WZC30
NOMESCO Finland
Teaching
1.7
7.7
165
1019
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.7
7.7
170
1061
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.4
7.7
35
104
2BD01
NOMESCO Finland
NA
45.2
7.7
9
*
I74.2
ICD-10 Finland
Embolism and thrombosis of arteries of upper extremities
15.1
7.7
12
8
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
6.4
7.7
19
30
A41.9
ICD-10 Finland
Sepsis, unspecified
2.9
7.7
45
159
N18.8
ICD-10 Finland
Other chronic renal failure
3.5
7.7
34
99
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.1
7.7
28
69
ZY010
NOMESCO Finland
Hospital outpatient
2.1
7.7
84
413
L01XX05
ATC
hydroxycarbamide; oral
5.6
7.7
21
38
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.8
7.7
122
690
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.6
7.7
215
1431
R1260
NOMESCO Finland
Evaluation of communicative skills
4.0
7.7
29
74
C03DA01
ATC
spironolactone; oral
1.9
7.6
116
645
WX780
NOMESCO Finland
Remote monitoring CPAP
2.6
7.6
54
215
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
7.6
189
1218
PD4CM
NOMESCO Finland
Extensive MRI examination of abdominal aorta and vasculature of lower extremities with 3 Tesla magnet
18.4
7.6
11
6
280
Kela drug reimbursment
Clopidogrel
4.9
7.6
23
47
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
7.6
304
2194
R60.9
ICD-10 Finland
Oedema, unspecified
2.3
7.6
66
293
P01AB01
ATC
metronidazole; oral, rectal
1.4
7.6
582
4729
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.7
7.6
50
192
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.3
7.5
66
294
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
8.9
7.5
15
17
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
7.5
122
693
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
4.1
7.5
27
66
WW200
NOMESCO Finland
Immunization
2.7
7.5
48
180
R55
ICD-10 Finland
Syncope and collapse
1.8
7.5
129
749
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
1.8
7.5
122
697
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
7.4
172
1090
WX872
NOMESCO Finland
Intensive care
2.3
7.4
64
281
N02AC04
ATC
dextropropoxyphene; oral
2.8
7.4
45
164
D69.5
ICD-10 Finland
Secondary thrombocytopenia
80.4
7.4
8
*
C10AA01
ATC
simvastatin; oral
1.4
7.4
431
3335
PEH56
NOMESCO Finland
Bypass from femoral to popliteal artery above knee
7.7
7.4
16
21
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
2.7
7.4
48
182
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
5.6
7.4
20
36
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.0
7.4
94
490
M79.1
ICD-10 Finland
Myalgia
1.6
7.4
188
1223
J20
ICD-10 Finland
Acute bronchitis
1.7
7.3
140
838
J01FA09
ATC
clarithromycin; systemic
1.4
7.3
460
3608
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.7
7.3
153
939
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
7.3
134
792
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.5
7.2
20
37
L01
ICPC
Neck symptom/complaint
1.6
7.2
194
1277
N05BA01
ATC
diazepam; systemic, rectal
1.6
7.2
168
1065
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.4
7.2
57
241
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
7.1
196
1294
M32
ICD-10 Finland
Systemic lupus erythematosus
20.1
7.1
10
5
SBB10
NOMESCO Finland
Teeth copy
1.9
7.1
102
554
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
8.0
7.1
15
19
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
3.5
7.1
31
90
N03AX09
ATC
lamotrigine; oral
2.1
7.1
81
403
PH2AE
SPAT
NA
4.0
7.1
26
65
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
4.6
7.1
23
51
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
12.1
7.1
12
10
NGM10
NOMESCO Finland
Fasciotomy of of knee or lower leg
5.6
7.1
19
34
RD210
NOMESCO Finland
NA
2.9
7.0
41
145
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.2
7.0
67
310
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.7
7.0
46
176
C08CA01
ATC
amlodipine; oral
1.4
7.0
363
2747
M02AA07
ATC
piroxicam; topical
1.4
7.0
448
3520
JN4CD
NOMESCO Finland
Very extensive body CT
2.6
7.0
47
183
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.5
7.0
53
220
A07AA09
ATC
vancomycin; oral
4.9
7.0
21
43
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
7.0
624
5170
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
3.3
7.0
32
97
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
4.3
6.9
24
57
ZYB02
NOMESCO Finland
Outreach service at unit of another specialty
7.6
6.9
15
20
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.8
6.9
124
731
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.8
6.9
122
714
G44.2
ICD-10 Finland
Tension-type headache
1.6
6.9
199
1335
S20.2
ICD-10 Finland
Contusion of thorax
2.2
6.8
66
308
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.2
6.8
70
333
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.6
6.8
155
978
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.0
6.8
86
448
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
6.7
6.8
16
24
K60
ICPC
Cardiovascular, Result test/procedure
6.7
6.8
16
24
W84
ICPC
Pregnancy high risk
2.2
6.8
68
322
S18
ICPC
Laceration/cut
1.3
6.8
524
4238
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.8
6.8
105
586
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
9.3
6.8
13
14
WX882
NOMESCO Finland
High dependency care
2.8
6.8
41
150
RS220
NOMESCO Finland
NA
3.6
6.8
28
78
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.9
6.8
26
68
X58
ICD-10 Finland
Exposure to other specified factors
1.6
6.8
195
1304
45001
ICD-8 Finland
Pulmonary embolism and infarction, Embolia
40.2
6.8
8
*
PD4ST
NOMESCO Finland
Endovascular thrombolysis of pelvic and lower extremity arteries
40.2
6.8
8
*
D01
ICPC
Abdominal pain/cramps general
1.6
6.8
162
1037
3A064
NOMESCO Finland
NA
16.8
6.7
10
6
G43.9
ICD-10 Finland
Migraine, unspecified
1.8
6.7
105
591
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.7
6.7
133
807
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.6
6.7
157
999
B01AE07
ATC
dabigatran etexilate; oral
2.5
6.7
48
194
45309
ICD-8 Finland
Other venous embolism and thrombosis, NUD (cerebri, cordis, mesenterii, pulmonis exceptis)
22.6
6.7
9
*
S21
ICPC
Skin texture symptom/complaint
1.6
6.7
158
1009
Z49.1
ICD-10 Finland
Extracorporeal dialysis
4.2
6.6
23
55
ZXE60
NOMESCO Finland
More than 12 and less than 15 hours
5.5
6.6
18
33
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
6.6
205
1398
C09CA06
ATC
candesartan; oral
1.5
6.6
264
1899
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.6
6.6
151
955
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
2.6
6.6
46
181
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.9
6.5
94
515
O02.1
ICD-10 Finland
Missed abortion
1.8
6.5
101
565
KA1AE
NOMESCO Finland
Kidney ultrasound examination
2.9
6.5
38
135
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.5
6.5
195
1317
A60
ICPC
General and Unspecified, Result test/procedure
2.2
6.5
64
303
A99
ICPC
Disease/condition unspecnature/site
1.8
6.5
99
553
TQW99
NOMESCO Finland
Other minor procedure on skin
2.2
6.5
61
282
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.0
6.5
35
120
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
6.5
348
2648
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.5
6.4
203
1388
M54.5
ICD-10 Finland
Low back pain
1.4
6.4
463
3698
2BD06
NOMESCO Finland
NA
70.1
6.4
7
*
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
70.1
6.4
7
*
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
70.1
6.4
7
*
LCA06
NOMESCO Finland
Biopsy of endometrium
1.6
6.4
181
1205
TPX10
NOMESCO Finland
Implantation of vascular injection port
2.6
6.4
45
177
WX203
NOMESCO Finland
Infraclavicular plexus blockade
3.0
6.4
34
115
R52.2
ICD-10 Finland
Other chronic pain
2.4
6.4
50
212
I27.0
ICD-10 Finland
Primary pulmonary hypertension
14.4
6.4
10
7
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
3.7
6.4
26
72
C08CA05
ATC
nifedipine; systemic
2.0
6.4
78
400
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
4.9
6.4
19
39
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.4
6.4
291
2151
318
Kela drug reimbursment
Teriparatide
6.6
6.3
15
23
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
6.6
6.3
15
23
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.8
6.3
38
139
R03AC12
ATC
salmeterol; inhalant
2.3
6.3
54
238
C08CA02
ATC
felodipine; oral
1.9
6.3
92
507
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.5
6.3
27
78
S22.3
ICD-10 Finland
Fracture of rib
2.0
6.3
78
405
I72.8
ICD-10 Finland
Aneurysm and dissection of other specified arteries
9.3
6.3
12
13
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
4.6
6.3
20
44
XX9XW
NOMESCO Finland
NA
4.6
6.3
20
44
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.0
6.3
78
406
C10AA07
ATC
rosuvastatin; oral
1.5
6.3
248
1781
I87.8
ICD-10 Finland
Other specified disorders of veins
18.1
6.3
9
5
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
+∞
6.3
6
*
O991, D688
ICD-10 Finland
NA
+∞
6.3
6
*
PH7YT
NOMESCO Finland
Dilatation of inferior vena cava or lower extremity vein with stent
+∞
6.3
6
*
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
6.3
6
*
B02BD02
ATC
coagulation factor VIII; parenteral, topical, urethral
+∞
6.3
6
*
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
26.8
6.2
8
*
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.3
6.2
51
221
J01DC02
ATC
cefuroxime; systemic
1.9
6.2
93
516
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.5
6.2
183
1231
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.9
6.2
81
428
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
6.2
436
3469
D45
ICD-10 Finland
Polycythaemia vera
5.0
6.2
18
36
N06AX21
ATC
duloxetine; oral
1.6
6.2
145
921
TK810
NOMESCO Finland
Hemofiltration
6.3
6.2
15
24
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.5
6.1
45
185
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.6
6.1
151
973
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.6
6.1
41
160
WX110
SPAT
NA
2.0
6.1
70
352
1XC02
NOMESCO Finland
NA
7.7
6.1
13
17
PG1PT
NOMESCO Finland
Extensive endovascular embolisation for bleeding with radiological guidance not elsewhere classified
7.7
6.1
13
17
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
6.1
380
2962
N03AF02
ATC
oxcarbazepine; oral
2.3
6.1
51
224
A02BC03
ATC
lansoprazole; oral
1.4
6.1
358
2763
K27
ICPC
Fear cardiovascular disease other
4.7
6.1
19
41
N05CF02
ATC
zolpidem; oral
1.5
6.1
239
1712
N06AX12
ATC
bupropion; oral
1.8
6.1
99
563
M13.9
ICD-10 Finland
Arthritis, unspecified
1.8
6.1
94
529
K55.8
ICD-10 Finland
Other vascular disorders of intestine
12.6
6.1
10
8
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.2
6.1
60
282
R06AX22
ATC
ebastine; oral
1.5
6.1
248
1789
WX320
NOMESCO Finland
Spinalanesthesy
1.4
6.1
286
2123
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.3
6.1
55
249
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
8.6
6.1
12
14
PA6AM
NOMESCO Finland
Simple MRI examination of neck vasculature with 3 Tesla magnet
8.6
6.1
12
14
SBA10
NOMESCO Finland
Measurement of excretion of saliva
4.4
6.0
20
46
M01AH02
ATC
rofecoxib; oral
1.6
6.0
150
969
E66.8
ICD-10 Finland
Other obesity
1.9
6.0
86
471
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
10.1
6.0
11
11
B28
ICPC
Limited function/disability (B)
10.1
6.0
11
11
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
6.0
93
521
Mortality – FinRegistry
↥Association
Association between endpoint D3_COAGDEFNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEFNAS | 1.772 [1.5, 2.09] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.663 |
During the follow-up period (1.1.1998 — 31.12.2019), 528 out of 6334 females with D3_COAGDEFNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_COAGDEFNAS | 1.758 [1.5, 2.06] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 579 out of 3194 males with D3_COAGDEFNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_COAGDEFNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.219% | 0.381% |
| 5 | 1.244% | 2.273% |
| 10 | 2.897% | 5.384% |
| 15 | 5.705% | 10.407% |
| 20 | 9.837% | 17.933% |
Relationships between endpoints
↥Index endpoint: D3_COAGDEFNAS – Other and unspecified coagulation defects
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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