Other disorders of blood and blood-forming organs in diseases classified elsewhere

D3_BLOODINOTH

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D77, D77A18.8, D77B65.9 Cause of death:* ICD-10 — D77, D77A18.8, D77*B65.9 2 out of 7 registries used, show all original rules.	5
4. Check minimum number of events None	5
5. Include endpoints None	5
6. Filter based on genotype QC (FinnGen only)	5

Control definitions (FinnGen only)

Control exclude: D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	D3_BLOODINOTH
CONTROL_EXCLUDE	D3_BLOODOTHER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D77
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D77
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other disorders of blood and blood-forming organs in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	46	25	21
Only index persons	42	24	18
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	59.39	65.14
Only index persons	59.27	58.94	59.71

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	5	-	-
Unadjusted period prevalence (%)	0.00	-	-
Median age at first event (years)	65.27	-	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.00

0.0

2.6

—

5.0

—

(3002256) Pathology report gross observation

0.00

0.0

1.0

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.0

1.5

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

0.00

0.0

2.6

—

2.0

—

(3009343) pH of Capillary blood

0.00

0.0

2.6

—

(3007853) Bacteria identified in Skin by Aerobe culture

0.00

0.0

1.5

—

(40768797) Stomach Pathology biopsy report

0.00

0.0

1.4

—

(3019060) Gas panel - Arterial blood

0.00

0.0

4.0

—

(3019225) pH of Specimen

0.00

0.0

2.8

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.0

4.8

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.0

7.8

—

25.2

—

(3000492) Spirometry study

0.00

0.0

1.4

—

Mortality – FinRegistry

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Association

Association between endpoint D3_BLOODINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_BLOODINOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: D3_BLOODINOTH – Other disorders of blood and blood-forming organs in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Other disorders of blood and blood-forming organs in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints