Henoch-Schoenlein purpura: A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1181 |
4. Check minimum number of eventsNone |
1181 |
5. Include endpointsNone |
1181 |
6. Filter based on genotype QC (FinnGen only) |
1181 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D69
- Name in latin
- Purpura allergica
Similar endpoints
↥List of similar endpoints to
Allergic purpura
based on the number of shared cases.
Similar with more cases:
- Purpura and other haemorrhagic conditions
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11658 | 5675 | 5938 |
| Only index persons | 10225 | 5070 | 5155 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.16 | 0.17 |
| Only index persons | 0.19 | 0.19 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 19.15 | 23.45 | 14.73 |
| Only index persons | 18.96 | 23.33 | 14.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1181 | 691 | 490 |
| Unadjusted period prevalence (%) | 0.23 | 0.24 | 0.22 |
| Median age at first event (years) | 39.68 | 34.31 | 47.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1071
- Matched controls
- 10708
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D69.0
ICD-10 Finland
Allergic purpura
16384.0
323.0
789
*
28700
ICD-8 Finland
Purpura and other haemorrhagic conditions, Allergic purpura
+∞
161.6
151
*
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
122.3
115
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.2
98.0
263
462
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
127.8
97.9
104
9
2870A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Allergic purpura[PURPURA HENOCH-SCHÖNLEIN]
+∞
90.9
86
*
H02AB06
ATC
prednisolone; systemic
3.2
69.6
614
3188
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
68.0
66.4
76
12
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
51.0
48.5
58
12
L95.8
ICD-10 Finland
Other vasculitis limited to skin
104.8
46.2
50
5
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
+∞
43.0
41
*
M36.4*D69.0
ICD-10 Finland
Arthropathy in Henoch(-Schönlein) purpura
423.2
41.4
41
*
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
207.5
39.1
40
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
14.1
34.4
59
44
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
62.0
31.2
36
6
L04AX01
ATC
azathioprine; systemic
5.2
30.3
98
203
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
29.8
338
1764
J04BA02
ATC
dapsone; oral
45.1
28.8
35
8
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.9
27.3
183
705
D07AC01
ATC
betamethasone; topical
2.1
26.3
385
2230
D69
ICD-10 Finland
Purpura and other haemorrhagic conditions
266.7
25.8
26
*
C03CA01
ATC
furosemide; systemic
2.3
25.3
274
1378
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
66.5
22.9
26
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.0
22.7
142
520
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
22.4
438
2802
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
21.9
21
*
A02BC02
ATC
pantoprazole; systemic
1.9
20.8
643
4792
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
49.0
20.2
24
5
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.3
19.4
74
183
H02AB07
ATC
prednisone; oral
2.5
18.8
167
749
L95.0
ICD-10 Finland
Livedoid vasculitis
193.2
18.6
19
*
R23.3
ICD-10 Finland
Spontaneous ecchymoses
7.5
18.4
43
59
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.6
17.9
82
238
E0000UV
ATC
NA
1.8
17.2
432
2942
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
16.6
202
1050
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.5
16.3
48
90
H02AB04
ATC
methylprednisolone; systemic
2.3
15.5
156
744
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.1
15.2
41
69
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
15.1
154
737
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
14.9
119
502
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
14.9
270
1631
L04AA01
ATC
[U] ciclosporin; systemic
7.3
14.9
35
49
TK800
NOMESCO Finland
Hemodialysis
6.0
14.6
40
69
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.6
14.6
31
37
L04AA06
ATC
mycophenolic acid; systemic
6.6
14.5
37
58
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
14.2
111
462
L04AD01
ATC
ciclosporin; systemic
5.7
14.0
40
73
M31.9
ICD-10 Finland
Necrotizing vasculopathy, unspecified
30.5
13.9
18
6
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.6
13.9
40
74
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.1
13.6
30
38
127
Kela drug reimbursment
Transplant complication
6.6
13.5
34
53
A12AA04
ATC
calcium carbonate; oral
7.0
13.2
32
47
N18.8
ICD-10 Finland
Other chronic renal failure
4.6
13.1
45
101
A46
ICD-10 Finland
Erysipelas
2.2
13.1
140
681
E000001
ATC
NA
1.9
13.0
230
1369
R50.9
ICD-10 Finland
Fever, unspecified
2.1
12.8
157
813
Z94.0
ICD-10 Finland
Kidney transplant status
8.0
12.6
28
36
A11CC03
ATC
alfacalcidol; systemic
5.1
12.6
39
79
A02BC01
ATC
omeprazole; systemic
1.8
12.4
259
1630
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
12.3
64
207
N02AX02
ATC
tramadol; systemic, rectal
1.6
12.2
383
2709
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
11.9
232
1422
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
11.7
361
2537
M36.4
ICD-10 Finland
Arthropathy in hypersensitivity reactions classified elsewhere
+∞
11.5
11
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
11.4
194
1134
R31
ICD-10 Finland
Unspecified haematuria
2.4
11.3
96
417
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
11.3
61
204
D07AB08
ATC
desonide; topical
2.1
11.0
128
649
D07AC13
ATC
mometasone; topical
1.7
10.7
272
1803
J01MA02
ATC
ciprofloxacin; systemic
1.6
10.7
351
2494
V03AE01
ATC
polystyrene sulfonate; oral
7.4
10.5
24
33
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
10.4
10
*
205
Kela drug reimbursment
Chronic hypertension
1.8
10.4
214
1330
TQW80
NOMESCO Finland
Local dermatologic skincare
4.2
10.3
38
93
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.9
10.3
62
223
N03.3
ICD-10 Finland
Chronic nephritic syndrome, diffuse mesangial proliferative glomerulonephritis
23.6
10.3
14
6
M04AA01
ATC
allopurinol; systemic
2.1
9.9
110
547
E000006
ATC
NA
2.5
9.9
79
334
D68.8
ICD-10 Finland
Other specified coagulation defects
26.3
9.8
13
5
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
9.7
66
257
J01AA02
ATC
doxycycline; systemic
1.5
9.7
733
6269
P01BA02
ATC
hydroxychloroquine; oral
2.4
9.5
82
361
ZX120
NOMESCO Finland
Intravenous
2.2
9.5
95
451
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
4.7
9.4
31
68
137
Kela drug reimbursment
Uraemia requiring dialysis
7.6
9.4
21
28
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
100.9
9.4
10
*
J01DA01
ATC
[U] cefalexin; systemic
1.5
9.3
617
5098
B03XA02
ATC
darbepoetin alfa; parenteral
5.1
9.3
28
56
C03DA01
ATC
spironolactone; oral
2.2
9.3
94
448
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.2
9.2
93
441
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
13.8
9.2
15
11
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.0
9.2
28
57
C08CA01
ATC
amlodipine; oral
1.6
9.1
271
1867
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
9.1
9.0
18
20
B01AA03
ATC
warfarin; systemic
1.8
8.8
153
899
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.2
8.8
26
51
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
8.8
194
1228
R80
ICD-10 Finland
Isolated proteinuria
7.3
8.8
20
28
J01DB01
ATC
cefalexin; oral
1.6
8.7
830
7368
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.3
8.7
43
136
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
4.6
8.7
29
65
M31.3
ICD-10 Finland
Wegener granulomatosis
50.4
8.7
10
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.0
8.6
49
169
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.6
8.6
63
256
R06AE07
ATC
cetirizine; oral
1.5
8.6
438
3401
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
8.6
118
636
L01AA01
ATC
cyclophosphamide; systemic
16.4
8.6
13
8
J01MA12
ATC
levofloxacin; systemic
1.8
8.6
165
1001
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
27.7
8.5
11
*
E000002
ATC
NA
1.9
8.5
123
677
M30.8
ICD-10 Finland
Other conditions related to polyarteritis nodosa
90.7
8.4
9
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
8.3
125
698
A41.9
ICD-10 Finland
Sepsis, unspecified
3.2
8.3
42
136
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
8.1
63
264
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
8.1
86
419
J01FF01
ATC
clindamycin; systemic
1.6
8.1
249
1722
TK820
NOMESCO Finland
Peritoneal dialysis
17.3
8.1
12
7
C09AA02
ATC
enalapril; systemic
1.8
8.1
156
948
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
6.6
7.9
19
29
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
7.9
89
446
B05DA
ATC
Isotonic solutions
8.5
7.8
16
19
V03AE02
ATC
sevelamer; oral
10.9
7.8
14
13
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.8
201
1328
J01CA04
ATC
amoxicillin; systemic
1.5
7.7
838
7522
D68.9
ICD-10 Finland
Coagulation defect, unspecified
45.3
7.7
9
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.0
7.7
100
530
M10.9
ICD-10 Finland
Gout, unspecified
2.5
7.6
56
229
J01FA06
ATC
roxithromycin; oral
1.5
7.6
376
2885
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
8.9
7.6
15
17
M05BA04
ATC
alendronic acid; oral
2.2
7.5
70
323
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
7.5
138
826
D07AA02
ATC
hydrocortisone; topical
1.7
7.5
151
929
N18.0
ICD-10 Finland
End-stage renal disease
6.5
7.4
18
28
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
6.5
7.4
18
28
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
6.5
7.4
18
28
C07AB07
ATC
bisoprolol; oral
1.5
7.4
362
2770
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
+∞
7.3
7
*
Z49.2
ICD-10 Finland
Other dialysis
9.4
7.3
14
15
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.0
7.2
92
482
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
7.2
70
329
E000007
ATC
NA
2.4
7.2
60
263
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
7.2
162
1030
M05BA01
ATC
etidronic acid; systemic
20.2
7.1
10
5
D07AD01
ATC
clobetasol; topical
1.8
7.1
133
798
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
7.1
74
357
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.1
7.1
36
118
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
10.1
7.0
13
13
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
7.0
80
401
D09AB01
ATC
zinc bandage without supplements; topical
4.0
7.0
26
66
B03XA01
ATC
erythropoietin; parenteral
5.5
6.9
19
35
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
6.9
250
1788
XW000
NOMESCO Finland
Bone marrow biopsy
2.9
6.8
39
136
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
11.0
6.8
12
11
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
6.7
254
1833
R06.0
ICD-10 Finland
Dyspnoea
1.6
6.7
208
1433
M30.0
ICD-10 Finland
Polyarteritis nodosa
22.7
6.7
9
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
6.6
71
352
N03AX16
ATC
pregabalin; oral
1.6
6.5
192
1309
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
6.5
507
4201
L30.3
ICD-10 Finland
Infective dermatitis
3.1
6.5
33
109
S97
ICPC
Chronic ulcer skin
2.5
6.5
47
193
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.7
6.5
40
150
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
70.3
6.4
7
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.9
6.4
24
62
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.4
156
1014
C02AC05
ATC
moxonidine; oral
2.7
6.3
39
146
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.8
6.3
37
134
2870X
ICD-9 Finland
Purpura and other haemorrhagic conditions, Allergic purpura[PURPURA ALLERGICA NUD]
+∞
6.3
6
*
126
Kela drug reimbursment
Chronic coagulation defects
+∞
6.3
6
*
D69.4
ICD-10 Finland
Other primary thrombocytopenia
+∞
6.3
6
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.2
405
3242
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
6.2
66
325
M13.9
ICD-10 Finland
Arthritis, unspecified
2.1
6.2
68
339
WX892
NOMESCO Finland
Monitored bed care
2.0
6.1
71
360
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.2
6.0
57
265
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.6
6.0
25
71
Z49.0
ICD-10 Finland
Preparatory care for dialysis
6.1
6.0
15
25
Mortality – FinRegistry
↥Association
Association between endpoint D3_ALLERGPURPURA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ALLERGPURPURA | 1.684 [1.48, 1.91] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.726 |
During the follow-up period (1.1.1998 — 31.12.2019), 714 out of 4075 females with D3_ALLERGPURPURA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ALLERGPURPURA | 2.061 [1.77, 2.4] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 715 out of 3988 males with D3_ALLERGPURPURA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ALLERGPURPURA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.196% | 0.383% |
| 5 | 1.231% | 2.411% |
| 10 | 2.985% | 5.958% |
| 15 | 5.514% | 11.65% |
| 20 | 9.794% | 19.138% |
Relationships between endpoints
↥Index endpoint: D3_ALLERGPURPURA – Allergic purpura
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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