Other autoimmune haemolytic anaemias

D3_AIHA_OTHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D59.1
  • Hospital discharge: ICD-9 2830
  • Hospital discharge: ICD-8 28390
  • Hospital discharge: excluded ICD-9 2830B
  • Cause of death: ICD-10 D59.1
  • Cause of death: ICD-9 2830
  • Cause of death: ICD-8 28390
  • Cause of death: excluded ICD-9 2830B

2 out of 7 registries used, show all original rules.

363

4. Check minimum number of events

None

363

5. Include endpoints

None

363

6. Filter based on genotype QC (FinnGen only)

348

Control definitions (FinnGen only)

Control exclude
D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D59
Name in latin
Aliae anaemiae autoimmunes haemolyticae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3078 1652 1390
Only index persons 2344 1276 1068
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.04
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 68.37 69.80 66.65
Only index persons 67.43 68.54 66.11

-FinnGen-

Key figures

All Female Male
Number of individuals 348 175 173
Unadjusted period prevalence (%) 0.08 0.07 0.09
Median age at first event (years) 63.82 60.34 67.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
363
Matched controls
3629
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
323.0
344
*
XW000
NOMESCO Finland
Bone marrow biopsy
25.1
78.2
113
64
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
67.9
63
*
D64.9
ICD-10 Finland
Anaemia, unspecified
9.8
63.8
147
235
H02AB06
ATC
prednisolone; systemic
5.5
48.0
271
1267
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
14.8
45.5
79
67
WW500
NOMESCO Finland
Blood transfusion
13.0
40.4
74
70
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
42.3
38.9
48
13
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.9
32.6
198
851
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
42.2
30.9
38
10
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
19.1
30.7
47
28
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
26.3
29.0
40
17
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.8
28.8
111
305
ZX120
NOMESCO Finland
Intravenous
5.4
28.3
94
219
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
46.7
28.3
34
8
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
17.4
20.5
32
20
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.8
19.9
59
117
M04AA01
ATC
allopurinol; systemic
3.8
19.0
92
300
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
18.9
18
*
JN4BD
NOMESCO Finland
Extensive body CT
4.0
18.4
80
237
H02AB07
ATC
prednisone; oral
3.6
18.4
94
320
L03AA02
ATC
filgrastim; parenteral
9.6
17.1
35
40
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
94.5
16.7
18
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
12.0
16.6
30
27
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
15.9
207
1255
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
15.6
128
597
1XC02
NOMESCO Finland
NA
30.1
15.4
20
7
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
14.7
14
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
13.7
75
264
TPH04
NOMESCO Finland
Cathetrisation of vein
2.8
13.5
103
452
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
12.8
136
718
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
12.6
12
*
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
12.6
12
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
12.6
12
*
L04AX01
ATC
azathioprine; systemic
5.3
12.3
38
79
A02BC02
ATC
pantoprazole; systemic
2.3
12.3
256
1848
L01AA02
ATC
chlorambucil; oral
48.4
12.0
14
*
L01AA01
ATC
cyclophosphamide; systemic
17.1
11.8
18
11
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
19.7
11.7
17
9
R50.9
ICD-10 Finland
Fever, unspecified
2.9
11.6
79
319
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
11.5
11
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.8
11.4
50
148
A04AA01
ATC
ondansetron; systemic, rectal
4.2
11.2
43
113
M05BA04
ATC
alendronic acid; oral
3.4
11.1
55
179
6BA02
NOMESCO Finland
NA
44.8
11.0
13
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.1
10.8
42
111
H02AB09
ATC
hydrocortisone; systemic
8.4
10.8
23
29
L03AA13
ATC
pegfilgrastim; parenteral
6.5
10.7
27
44
J05AB11
ATC
valaciclovir; oral
2.9
9.8
63
246
JN4AD
NOMESCO Finland
Body CT examination
3.5
9.5
45
142
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
6.2
9.2
24
41
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
24.7
9.0
12
5
J01MA12
ATC
levofloxacin; systemic
2.4
8.8
86
422
UJF32
NOMESCO Finland
Coloscopy
2.1
8.7
113
631
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
51.3
8.7
10
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.2
8.7
26
53
JMA10
NOMESCO Finland
Transabdominal total splenectomy
20.6
8.5
12
6
L01XX52
ATC
venetoclax; oral
92.1
8.4
9
*
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
8.4
8
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.9
8.3
33
90
PJA10
NOMESCO Finland
Exploration of lymph nodes
14.9
8.3
13
9
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
34.2
8.1
10
*
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.1
8.1
21
36
D64.8
ICD-10 Finland
Other specified anaemias
8.0
8.0
17
22
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
7.9
88
457
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.5
7.9
27
64
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
15.5
7.8
12
8
L01BB05
ATC
fludarabine; systemic
46.0
7.7
9
*
399
Kela drug reimbursment
Venetoclax
46.0
7.7
9
*
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
8.3
7.7
16
20
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
8.3
7.7
16
20
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
6.0
7.6
20
35
B03BA03
ATC
hydroxocobalamin; parenteral
3.2
7.5
38
127
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.9
7.5
23
49
6753
FHL
Transabdominal splenectomy
81.7
7.4
8
*
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
7.3
7
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.9
7.3
29
80
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
30.7
7.2
9
*
A41.9
ICD-10 Finland
Sepsis, unspecified
4.2
7.1
26
66
GD1AD
NOMESCO Finland
Thorax CT examination
4.2
7.1
26
66
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
9.1
7.1
14
16
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
7.2
7.1
16
23
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.8
7.0
22
48
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.0
7.0
39
138
TGC00
NOMESCO Finland
Bronchial lavation
5.2
6.9
20
40
1AA09
NOMESCO Finland
NA
40.8
6.8
8
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
40.8
6.8
8
*
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
23.0
6.7
9
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.3
6.6
32
104
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
6.5
32
105
ZX112
NOMESCO Finland
Subcutaneous
5.1
6.5
19
39
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
6.4
60
287
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
5.7
6.4
17
31
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
4.3
6.3
22
54
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
6.3
6
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
6.3
6
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
6.3
6
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
6.3
6
*
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
27.2
6.3
8
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
27.2
6.3
8
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
4.0
6.2
23
60
J01MA14
ATC
moxifloxacin; systemic
2.8
6.2
39
149
B82
ICPC
Anaemia other/unspecified
5.1
6.1
18
37
WW200
NOMESCO Finland
Immunization
4.3
6.1
21
51
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
6.1
90
522

Mortality – FinRegistry

Association

Association between endpoint D3_AIHA_OTHER and mortality.

Females

Parameter HR [95% CI] p-value
D3_AIHA_OTHER 2.299 [1.91, 2.77] < 0.001
Birth year 1.0 [0.99, 1.01] 0.982

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1170 females with D3_AIHA_OTHER died.

Males

Parameter HR [95% CI] p-value
D3_AIHA_OTHER 2.82 [2.2, 3.62] < 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 976 males with D3_AIHA_OTHER died.

Mortality risk

Mortality risk for people of age

years, who have D3_AIHA_OTHER.

N-year risk Females Males
1 0.296% 0.505%
5 1.48% 3.21%
10 3.848% 8.18%
15 7.384% 13.968%
20 13.26% 22.862%

Relationships between endpoints

Index endpoint: D3_AIHA_OTHER – Other autoimmune haemolytic anaemias

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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