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Colitis due to radiation

COLITRAD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K52.0
  • Cause of death: ICD-10 K52.0

2 out of 7 registries used, show all original rules.

350

4. Check minimum number of events

None

350

5. Include endpoints

None

350

6. Filter based on genotype QC (FinnGen only)

350

Control definitions (FinnGen only)

Control exclude
K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K52
Name in latin
Gastroenteritis e radiatione

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 350 108 242
Unadjusted period prevalence (%) 0.09 0.04 0.11
Median age at first event (years) 68.70 59.70 72.72

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
317
Matched controls
3170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
+∞
323.0
317
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
11.3
78.8
185
348
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
11.5
78.7
182
333
UJF32
NOMESCO Finland
Coloscopy
9.2
70.8
205
525
116
Kela drug reimbursment
Prostate cancer
12.6
69.3
140
187
A07EC02
ATC
mesalazine; oral, rectal
75.0
67.2
75
13
A07EA02
ATC
hydrocortisone; rectal
79.6
57.8
64
10
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
11.3
53.4
110
142
L02AE02
ATC
leuprorelin; implant, parenteral
11.3
49.5
101
126
K62.7
ICD-10 Finland
Radiation proctitis
82.3
44.4
49
7
L02BB03
ATC
bicalutamide; oral
10.9
34.9
70
80
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
8.9
28.7
64
87
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
36.7
28.4
36
11
Y77
ICPC
Malignant neoplasm prostate
9.1
27.7
61
81
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
27.5
26
*
A07EA06
ATC
budesonide; oral, local oral
68.3
27.5
31
5
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
294.5
27.1
27
*
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
98.0
25.1
27
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
270.2
25.0
25
*
J01MA02
ATC
ciprofloxacin; systemic
3.5
25.0
190
945
TKE00
NOMESCO Finland
Needle biopsy of prostate
6.4
22.6
63
118
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
38.2
22.4
28
8
JFA55
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in colon
41.9
22.1
27
7
WF002
NOMESCO Finland
Radical radiotherapy
6.4
21.9
61
114
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
7.8
20.2
48
71
ZX090
NOMESCO Finland
Other technic of radiotherapy
11.8
20.0
37
35
C10AC01
ATC
colestyramine; oral
21.8
19.4
28
14
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
10.1
19.0
38
42
XKD00
NOMESCO Finland
Uroflowmetry
3.1
17.8
123
532
XX3DW
NOMESCO Finland
Time consuming IT work
4.4
17.2
67
181
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.3
16.7
101
394
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.9
16.5
140
682
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
16.4
190
1121
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
4.4
16.3
63
168
K51.5
ICD-10 Finland
Left sided colitis
+∞
15.7
15
*
A03FA01
ATC
metoclopramide; systemic, rectal
3.2
15.4
97
386
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
15.2
130
633
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
9.2
14.9
31
37
JN4BD
NOMESCO Finland
Extensive body CT
3.6
14.8
74
248
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
3.9
13.6
59
174
A06AC01
ATC
ispaghula (psylla seeds); oral
2.8
13.2
105
479
NK6AN
NOMESCO Finland
Total body bone isotope imaging
6.8
13.1
33
53
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
8.8
12.8
27
33
UKC02
NOMESCO Finland
Cystoscopy
2.7
12.8
105
487
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
12.6
124
639
JGA28
NOMESCO Finland
Endoscopic contact coagulation in rectum
+∞
12.6
12
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
8.7
12.3
26
32
ZX070
NOMESCO Finland
Intensity modified radiotherapy
9.3
12.3
25
29
UJF30
NOMESCO Finland
Ileoscopy through colon
4.3
12.0
46
121
WB223
NOMESCO Finland
Demanding adjuvant hormone therapy of malignancy
31.3
11.7
15
5
L02AE03
ATC
goserelin; implant
10.6
11.7
22
22
K51.8
ICD-10 Finland
Other ulcerative colitis
+∞
11.5
11
*
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
+∞
11.5
11
*
128
Kela drug reimbursment
Cancers of female genital organs
11.8
11.2
20
18
C05AA08
ATC
fluocortolone; rectal, topical
3.0
10.9
68
263
XJH00
NOMESCO Finland
Transanal ultrasonography
3.3
10.8
59
207
A07DA03
ATC
loperamide; oral
6.0
10.7
29
52
R31
ICD-10 Finland
Unspecified haematuria
2.9
10.7
71
286
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.3
10.6
58
203
LCD30
NOMESCO Finland
Radical hysterectomy
+∞
10.5
10
*
K50.8
ICD-10 Finland
Other Crohn disease
+∞
10.5
10
*
N02AX02
ATC
tramadol; systemic, rectal
2.2
10.3
156
966
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.9
10.2
66
261
H02AB06
ATC
prednisolone; systemic
2.2
10.1
163
1036
G03HA01
ATC
cyproterone; systemic
14.0
9.8
16
12
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
7.5
9.7
22
31
ZX080
NOMESCO Finland
Image guided radiotherapy
9.5
9.7
19
21
ZX120
NOMESCO Finland
Intravenous
3.4
9.6
47
153
JGA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in rectum
102.9
9.5
10
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
+∞
9.4
9
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
9.4
9
*
JGA35
NOMESCO Finland
Other endoscopic haemostatic procedure in rectum
+∞
9.4
9
*
G04CA02
ATC
tamsulosin; oral
2.1
9.3
145
899
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
12.0
9.2
16
14
D16
ICPC
Rectal bleeding
6.9
9.1
22
34
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.5
9.1
78
363
WF003
NOMESCO Finland
Adjuvant radiotherapy
5.6
8.8
25
48
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
6.9
8.8
21
32
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
5.0
8.7
27
58
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.1
8.6
148
946
UJG02
NOMESCO Finland
Proctoscopy
7.0
8.5
20
30
WF049
NOMESCO Finland
Radiotherapy of metastasis
5.6
8.5
24
46
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
3.2
8.3
43
146
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.1
117
689
L02BX03
ATC
abiraterone; oral
12.1
8.1
14
12
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.2
8.1
92
491
P01AB01
ATC
metronidazole; oral, rectal
2.1
8.0
119
710
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
8.0
145
937
A02BA02
ATC
ranitidine; systemic
2.3
7.9
84
433
R50.9
ICD-10 Finland
Fever, unspecified
2.6
7.7
57
242
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
7.7
57
242
K59.1
ICD-10 Finland
Functional diarrhoea
4.4
7.7
27
66
L04AX01
ATC
azathioprine; systemic
6.0
7.7
20
35
JN4AD
NOMESCO Finland
Body CT examination
3.2
7.6
40
138
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
7.4
7.6
17
24
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.9
7.5
47
181
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
7.5
47
182
J01DB01
ATC
cefalexin; oral
2.1
7.4
251
2035
N02BE01
ATC
paracetamol; systemic, rectal
2.3
7.4
271
2272
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
7.3
7
*
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.1
7.2
38
132
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
10.4
7.1
13
13
UJH02
NOMESCO Finland
Anoscopy
4.3
7.1
25
62
A02BC01
ATC
omeprazole; systemic
2.0
7.0
108
645
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.1
7.0
37
128
163
Kela drug reimbursment
Abiraterone and enzalutamide
7.0
6.9
16
24
SPAT1263
SPAT
Sampling
1.9
6.8
141
944
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
5.1
6.8
20
41
J01EA01
ATC
trimethoprim; systemic
2.1
6.7
81
440
352
Kela drug reimbursment
Abiraterone and enzalutamide
9.0
6.6
13
15
H02AB02
ATC
dexamethasone; systemic
2.7
6.6
46
190
TPH07
NOMESCO Finland
Cathetrisation of artery
2.6
6.6
48
202
L03AA13
ATC
pegfilgrastim; parenteral
5.2
6.6
19
38
L02BX02
ATC
degarelix; parenteral
6.4
6.5
16
26
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.9
6.5
20
43
JN3AD
NOMESCO Finland
Abdominal CT examination
3.1
6.5
34
117
G04BE03
ATC
sildenafil; oral
7.6
6.5
14
19
A02BC02
ATC
pantoprazole; systemic
1.8
6.5
200
1521
D64.9
ICD-10 Finland
Anaemia, unspecified
2.4
6.4
53
240
J02AC01
ATC
fluconazole; systemic
2.0
6.4
99
589
N13.3
ICD-10 Finland
Other and unspecified hydronephrosis
6.8
6.4
15
23
N02AA05
ATC
oxycodone; systemic
2.2
6.3
67
341
ZXD05
NOMESCO Finland
Urgent procedure
1.9
6.3
110
688
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
6.3
6
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
6.3
6
*
ZX020
NOMESCO Finland
HDR radiotherapy within tissue
+∞
6.3
6
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
+∞
6.3
6
*
C53.02
ICD-10 Finland
Adenocarcinoma of the endocervix
+∞
6.3
6
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
6.3
6
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
3.9
6.2
24
65
N02AJ06
ATC
codeine and paracetamol; systemic
1.9
6.1
106
660
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
2.4
6.1
51
234
G04BD08
ATC
solifenacin; oral
2.9
6.0
35
129

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: COLITRAD – Colitis due to radiation

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).