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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_UVEAMELANOMA_EXALLC for full statistics.

Melanoma of uvea

CD2_UVEAMELANOMA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

342

4. Check minimum number of events

None

342

5. Include endpoints

None

342

6. Filter based on genotype QC (FinnGen only)

342

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 342 158 184
Unadjusted period prevalence (%) 0.07 0.05 0.08
Median age at first event (years) 64.02 61.76 65.96

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
300
Matched controls
3001
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
+∞
323.0
251
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
273.1
236.1
219
29
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
+∞
214.1
179
*
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
+∞
212.6
178
*
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
+∞
181.2
155
*
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
520.8
152.9
140
5
WX140
NOMESCO Finland
Parabulbar anesthesy
51.5
137.0
167
71
XCK10
NOMESCO Finland
Photography of fundus of eye
23.3
112.9
184
191
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
17.6
86.7
152
165
C69.3
ICD-10 Finland
Malignant neoplasm: Choroid
+∞
79.8
73
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
14.5
70.9
133
156
8720/3-C69.3
ICD-O-3
Malignant melanoma, NOS, of choroid
+∞
67.2
62
*
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
57.9
67.0
78
18
8720/3-C69.9
ICD-O-3
Malignant melanoma, NOS, of eye, NOS
+∞
60.5
56
*
C69.39
ICD-10 Finland
Malignant tumor in chorioidea other or unspecified histology
+∞
56.0
52
*
Z3229
NOMESCO Finland
Other healthcare associate professional
11.2
54.4
114
155
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
14.9
53.8
95
90
WX002
NOMESCO Finland
Sedation and analgesia
6.8
47.7
155
407
XCW99
NOMESCO Finland
Other investigative procedure of eye
8.2
46.9
121
227
ZXD10
NOMESCO Finland
Scheduled procedure
5.1
38.3
206
899
Z2221
NOMESCO Finland
Medical doctor
5.1
37.4
167
593
C69.40
ICD-10 Finland
Malignant tumor of ciliary body without histology
+∞
32.9
31
*
ZXA05
NOMESCO Finland
Left side
4.3
29.5
151
572
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
16.8
28.6
46
32
1906B
ICD-9 Finland
Malignant neoplasm of eye, Choroid[MELANOMA CHORIOIDEAE]
+∞
25.4
24
*
ZXA00
NOMESCO Finland
Right side
3.8
25.1
153
649
ZXE00
NOMESCO Finland
One hour or less
3.6
24.1
176
855
ZXE10
NOMESCO Finland
More than one and less than three hours
3.4
22.1
168
822
S01ED51
ATC
timolol, combinations; ophthalmic
5.6
21.9
69
151
CH2S4
NOMESCO Finland
Photography of iris
236.4
21.9
22
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
21.7
96
301
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
26.6
21.3
29
12
C69.02
ICD-10 Finland
Malignant tumor in conjunctival melanoma
+∞
21.1
20
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
213.4
19.8
20
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
6.5
19.1
52
94
C69.42
ICD-10 Finland
Malignant tumor of ciliary melanoma
+∞
18.9
18
*
3770
FHL
Placing a radiating plate on the surface of the eye with additional measures
+∞
18.9
18
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
13.7
18.1
31
25
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
23.6
17.1
24
11
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
12.7
15.9
28
24
8000/3-C69.3
ICD-O-3
Neoplasm, malignant of choroid
+∞
15.8
15
*
3779
FHL
Other operations in this group include disc removal
+∞
15.8
15
*
CF2S4
NOMESCO Finland
Photography of conjunctiva
89.8
15.7
17
*
CD2S4
NOMESCO Finland
Photography of eye
84.3
14.7
16
*
C69.45
ICD-10 Finland
Melanoma of iris
+∞
14.7
14
*
N02AA05
ATC
oxycodone; systemic
3.2
13.4
83
323
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
13.1
174
1065
C69.99
ICD-10 Finland
Malignant tumor in unspecified localization in eye or other unspecified histology
+∞
12.6
12
*
CDC10
NOMESCO Finland
Enucleation of eye with insertion of prosthesis
+∞
12.6
12
*
XCD20
NOMESCO Finland
Photoangiography of eye
9.1
12.6
26
31
CDC00
NOMESCO Finland
Enucleation of eye
135.3
12.5
13
*
D31.4
ICD-10 Finland
Benign neoplasm: Ciliary body
135.3
12.5
13
*
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
48.7
12.0
14
*
130
Kela drug reimbursment
Malignant tumour
3.7
12.0
55
171
Z51.5
ICD-10 Finland
Palliative care
4.3
11.9
45
117
PC2ET
NOMESCO Finland
Extensive embolisation of lesion of liver
124.5
11.5
12
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
36.5
11.4
14
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
11.1
158
970
Z3231
NOMESCO Finland
Registered nurse
2.5
11.0
114
598
180
Kela drug reimbursment
Interferon alfa
62.2
10.7
12
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
5.7
10.6
30
57
XX7GT
NOMESCO Finland
Selective internal radio therapy (SIRT) with Yttrium
+∞
10.5
10
*
L01AX03
ATC
temozolomide; systemic
27.0
9.9
13
5
H33.2
ICD-10 Finland
Serous retinal detachment
27.0
9.9
13
5
S01ED01
ATC
timolol; ophthalmic
4.8
9.8
32
72
H26.2
ICD-10 Finland
Complicated cataract
10.6
9.7
18
18
CA1ME
NOMESCO Finland
Ultrasound oculometry
18.3
9.5
14
8
C69.03
ICD-10 Finland
Malignant tumor of conjunctival carcinoma
+∞
8.4
8
*
C69.20
ICD-10 Finland
Retina
+∞
8.4
8
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
7.9
99
555
H33.0
ICD-10 Finland
Retinal detachment with retinal break
5.9
7.8
21
38
C69.00
ICD-10 Finland
Malignant tumor of the conjunctiva without histology
46.2
7.7
9
*
S01EC01
ATC
acetazolamide; systemic
5.7
7.7
21
39
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
25.7
7.6
10
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
6.8
7.5
18
28
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
7.5
81
422
ZXA10
NOMESCO Finland
Bilateral
2.3
7.5
79
407
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
4.4
7.5
26
63
A04AA02
ATC
granisetron; systemic, transdermal
3.5
7.5
34
105
JN4CD
NOMESCO Finland
Very extensive body CT
4.3
7.1
25
62
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.5
7.0
32
100
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
6.5
60
289
D31.2
ICD-10 Finland
Benign neoplasm: Retina
71.3
6.4
7
*
PC2DT
NOMESCO Finland
Embolisation of lesion of liver
71.3
6.4
7
*
A06AH03
ATC
naloxegol; oral
11.4
6.3
11
10
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
11.4
6.3
11
10
S01EA03
ATC
apraclonidine; ophthalmic
11.4
6.3
11
10
CH3S4
NOMESCO Finland
Photography of iridocorneal angle
+∞
6.3
6
*
C79.41
ICD-10 Finland
Secondary malignant tumor of optic nerve and eye
+∞
6.3
6
*
S01FA01
ATC
atropine; ophthalmic
27.3
6.3
8
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
5.6
6.2
17
32
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
12.9
6.1
10
8
H35.7
ICD-10 Finland
Separation of retinal layers
10.3
6.1
11
11
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.9
6.1
129
864

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_UVEAMELANOMA – Melanoma of uvea

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).