Carcinoma in situ of vagina

CD2_INSITU_VAGINA_EXALLC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule only females	-
2. Check conditions not C3_VAGINA	-
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D07.2& Hospital discharge: ICD-9 — 2333A Cause of death: ICD-10 — D07.2& Cause of death: ICD-9 — 2333A Cancer registry: Topography ICD-O-3 — C52 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D07
Name in latin: Carcinoma in situ prostatae

NAME	CD2_INSITU_VAGINA_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_VAGINA
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D072
HD_ICD_9	2333A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D072
COD_ICD_9	2333A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C52
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of vagina based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Carcinoma in situ of vagina

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	126	126	-
Only index persons	102	102	-
Unadjusted period prevalence (%)
Whole population	0.00	0.00	-
Only index persons	0.00	0.00	-
Median age at first event (years)
Whole population	-	61.35	-
Only index persons	-	57.68	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	147	147	-
Unadjusted period prevalence (%)	0.05	0.05	-
Median age at first event (years)	57.50	57.50	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
137: Matched controls
1369

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

8077/2-C52.9

ICD-O-3

Squamous intraepithelial neoplasia, high grade of vagina, NOS

+∞

155.4

118

LEB00

NOMESCO Finland

Biopsy of vagina

861.4

130.1

109

ULA02

NOMESCO Finland

Kolposcopy

287.2

116.3

131

LEB30

NOMESCO Finland

Destruction of lesion of vaginal mucosa

2766.1

112.1

N89.2

ICD-10 Finland

Severe vaginal dysplasia, not elsewhere classified

+∞

84.3

XLD00

NOMESCO Finland

Sytologyspecimen from mouth of uterus

48.6

78.5

112

115

R87.6

ICD-10 Finland

Abnormal findings in specimens from female genital organs, abnormal cytological findings

37.8

70.6

104

105

N89.1

ICD-10 Finland

Moderate vaginal dysplasia

+∞

68.6

LDA20

NOMESCO Finland

Biopsy of vaginal cervix

32.9

58.6

LFB00

NOMESCO Finland

Biopsy of vulva or perineum

39.8

35.2

N89.0

ICD-10 Finland

Mild vaginal dysplasia

+∞

33.7

LDC03

NOMESCO Finland

Conisation of cervix uteri using diathermy or laser

18.4

32.1

LDA10

NOMESCO Finland

Curettage of cervix uteri

19.4

31.2

8077/2-C53.9

ICD-O-3

Squamous intraepithelial neoplasia, high grade of cervix uteri

55.5

23.4

N87.0

ICD-10 Finland

Mild cervical dysplasia

21.6

21.8

N90.2

ICD-10 Finland

Severe vulvar dysplasia, not elsewhere classified

245.8

21.2

N87.2

ICD-10 Finland

Severe cervical dysplasia, not elsewhere classified

18.2

18.1

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

4.8

16.9

390

LEB10

NOMESCO Finland

Excision of lesion of vagina

68.5

16.2

D07.2

ICD-10 Finland

Carcinoma in situ: Vagina

+∞

14.9

H02AB02

ATC

dexamethasone; systemic

34.2

14.3

115

Kela drug reimbursment

Breast cancer

+∞

12.7

N90.1

ICD-10 Finland

Moderate vulvar dysplasia

+∞

12.7

LFB10

NOMESCO Finland

Excision of lesion of vulva or perineum

51.6

12.1

8077/2-C51.9

ICD-O-3

Squamous intraepithelial neoplasia, high grade of vulva, NOS

+∞

11.6

PJA12

NOMESCO Finland

Sentinel node biopsy

+∞

11.6

A63.0

ICD-10 Finland

Anogenital (venereal) warts

12.1

11.2

WB103

NOMESCO Finland

Simple adjuvant cytostatic therapy

+∞

10.5

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

+∞

10.5

R87.5

ICD-10 Finland

Abnormal findings in specimens from female genital organs, abnormal microbiological findings

35.6

10.5

LDB20

NOMESCO Finland

Electrocoagulation or laser therapy of cervix uteri

25.7

10.5

WB113

NOMESCO Finland

Multiple adjuvant cytostatic therapy

+∞

9.5

HA003

NOMESCO Finland

Radiotherapy after partial ablation of mammary gland

+∞

9.5

D06BB10

ATC

imiquimod; topical

11.2

8.8

C44.31

ICD-10 Finland

Basocellular carcinoma of the skin on another or unspecified part of the face

+∞

8.4

N87.1

ICD-10 Finland

Moderate cervical dysplasia

8.9

7.9

WX105

NOMESCO Finland

Surface analgesia on skin or mucosa

4.5

7.8

N90.0

ICD-10 Finland

Mild vulvar dysplasia

26.7

7.7

ZXC10

NOMESCO Finland

Use of laser

14.5

7.5

128

Kela drug reimbursment

Cancers of female genital organs

+∞

7.4

C50.99

ICD-10 Finland

Breast, unspecified

+∞

7.4

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

+∞

7.4

8090/3-C44.9

ICD-O-3

Basal cell carcinoma, NOS, of skin, NOS

+∞

7.4

A04AA55

ATC

palonosetron, combinations; systemic

+∞

7.4

LFB20

NOMESCO Finland

Destruction of lesion of vulva or perineum

31.9

7.2

XX3DW

NOMESCO Finland

Time consuming IT work

6.5

7.2

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

7.9

6.9

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.7

6.8

306

L02BG04

ATC

letrozole; oral

15.3

6.5

LFC00

NOMESCO Finland

Partial excision of vulva

73.1

6.5

A04AA02

ATC

granisetron; systemic, transdermal

73.1

6.5

HA1AA

NOMESCO Finland

X-ray mammography

6.9

6.4

PJ5AN

NOMESCO Finland

Localisation of sentinell lymphnode with isotope imaging

+∞

6.3

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

+∞

6.3

L03AA14

ATC

lipegfilgrastim; parenteral

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3025130) Human papilloma virus identified in Specimen

35.57

73.08

4.7

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

12.83

49.14

4.2

1.4

—

(4035726)

18.60

49.00

1.3

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

116

349

12.02

43.78

4.4

1.4

—

(40768804) Tissue Pathology biopsy report

118

471

8.63

29.86

6.0

1.7

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

46.69

27.55

5.9

2.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

512

3.74

13.21

4.6

3.5

—

(3044640) Blood type and Crossmatch panel - Blood

313

3.18

10.68

2.0

1.8

—

(3002256) Pathology report gross observation

105

3.62

8.48

1.4

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

245

2.82

7.84

2.1

1.8

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

381

2.67

7.84

4.4

1.8

mmol/l

2.4

0.52

316

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

110

3.17

6.61

3.3

2.5

25.6

24.0

0.23

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

118

891

2.64

5.38

12.2

4.9

u/l

75.6

75.3

0.03

110

811

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

482

2.19

5.18

6.3

4.2

mmol/l

1.2

0.44

425

(3013650) Neutrophils [#/volume] in Blood by Automated count

635

2.20

5.00

14.7

6.3

e9/l

3.7

4.0

0.89

551

(3045424) Erythrocytes [Presence] in Urine

5.29

4.85

1.0

1.7

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

449

2.12

4.77

7.3

3.2

g/l

35.9

36.5

0.46

416

(3026008) Bacteria identified in Urine by Culture

383

2.13

4.67

3.9

2.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

153

2.49

4.63

2.1

1.7

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

140

2.54

4.59

1.7

1.8

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

2.93

4.38

2.6

1.5

u/ml

21.7

31.0

0.33

(3026493) Urate [Moles/volume] in Serum or Plasma

277

2.15

4.32

3.6

2.0

umol/l

306.7

2979.5

0.80

243

(42870588) Differential panel, method unspecified - Blood

360

2.07

4.25

8.6

5.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

386

2.05

4.23

5.7

2.7

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

153

2.40

4.18

1.8

1.9

—

(3019309) Folate [Moles/volume] in Red Blood Cells

189

2.28

4.16

1.7

1.6

nmol/l

1149.6

1148.2

0.00

144

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

524

1.99

4.04

8.5

4.7

mmol/l

1.2

0.59

460

(3032080) INR in Blood by Coagulation assay

394

1.99

3.93

7.4

5.8

inr

1.2

1.1

0.22

107

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

172

2.27

3.90

1.4

1.6

—

(40758558) Short blood count panel - Blood

264

2.08

3.85

10.3

4.9

—

(3013707) Erythrocyte sedimentation rate by Westergren method

118

946

2.25

3.82

5.3

3.9

mm/h

15.8

11.4

1.68

105

862

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

542

1.94

3.77

2.8

2.3

nmol/l

79.3

80.2

0.11

479

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

6.98

3.72

1.1

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.88

3.71

1.6

1.1

—

(3019225) pH of Specimen

113

2.46

3.67

4.6

3.6

—

(36304419) Bacteria [Presence] in Urine

296

1.98

3.53

4.5

2.6

—

(3021589) Normoblasts [#/volume] in Blood

488

1.88

3.46

13.1

7.2

e9/l

0.0

0.63

394

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.97

3.29

2.1

1.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.97

3.29

2.1

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.77

3.16

1.3

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

412

1.82

3.06

3.3

3.1

ng/l

25.2

18.5

0.49

253

(3013115) Eosinophils [#/volume] in Blood

606

1.80

3.04

10.0

5.2

e9/l

0.2

0.49

537

(3013826) Glucose [Moles/volume] in Serum or Plasma

646

1.80

3.01

5.5

3.5

mmol/l

6.3

6.4

0.43

589

(3009261) Glucose [Presence] in Urine by Test strip

618

1.79

2.98

4.6

3.3

estimate

0.0

0.50

105

(3023368) Bacteria identified in Blood by Culture

214

1.97

2.97

6.9

3.4

—

(3052851) Hemolysis interference index of Serum or Plasma

3.50

2.96

3.2

2.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

200

1.98

2.90

1.7

1.8

—

(3019198) Lymphocytes [#/volume] in Blood

594

1.76

2.86

9.4

5.1

e9/l

1.7

1.9

1.99

526

(3000850) Epithelial cells [#/volume] in Urine

225

1.93

2.84

3.2

2.2

e6/l

5.9

7.1

0.37

198

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

187

1.99

2.79

5.0

2.4

e6/l

1.3

1.1

0.08

(3021601) Nitrite [Presence] in Urine by Test strip

616

1.75

2.79

6.3

4.6

estimate

0.0

0.50

103

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

100

2.28

2.75

2.5

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.52

2.66

1.3

—

(3006315) Basophils [#/volume] in Blood

585

1.71

2.61

9.6

5.0

e9/l

0.0

0.03

505

(3030467) Casts [#/volume] in Urine by Automated count

297

1.80

2.61

5.2

2.6

e6/l

0.3

0.5

0.73

211

(3003694) ABO and Rh group [Type] in Blood

291

1.79

2.53

1.4

1.5

—

(3002582) Erythrocytes [#/volume] in Urine

325

1.76

2.53

5.4

2.7

e6/l

34.8

37.6

0.04

237

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

476

1.70

2.53

2.1

1.9

pmol/l

100.9

101.5

0.03

220

(3001604) Monocytes [#/volume] in Blood

580

1.69

2.50

9.7

5.0

e9/l

0.5

0.02

504

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.30

2.47

2.2

2.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.30

2.47

1.8

1.6

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

164

1.96

2.46

3.8

4.6

32.2

33.5

0.27

104

(3022313) Gas panel - Capillary blood

2.89

2.43

4.5

4.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.46

2.40

1.6

1.5

—

(3051611) Lipemic interference index of Serum or Plasma

6.42

2.39

3.6

1.6

—

(3035350) Ketones [Presence] in Urine by Test strip

614

1.66

2.38

4.6

3.3

estimate

0.0

0.00

105

(3017143) Hepatitis C virus Ab [Presence] in Serum

121

2.07

2.37

1.5

1.4

—

(3003396) Base excess in Arterial blood by calculation

100

2.16

2.34

4.7

5.8

mmol/l

1.1

1.4

0.17

(3029937) Albumin [Presence] in Urine by Test strip

316

1.72

2.29

4.6

3.4

estimate

0.0

0.50

105

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

101

2.13

2.28

2.6

1.7

—

(3033658) Prothrombin time (PT) actual/Normal

258

1.76

2.25

7.9

3.0

99.8

97.1

0.33

252

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

5.70

2.23

1.0

1.2

—

(3000991) Gas panel - Venous blood

2.34

2.19

7.7

5.9

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

4.42

2.17

1.0

1.2

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

165

1.86

2.10

5.6

2.6

e6/l

5.0

4.2

0.14

(3012544) pH of Venous blood

2.11

2.05

5.1

3.2

—

(40768443) Skin Pathology biopsy report

2.68

1.96

1.4

1.2

—

(3026389) Candida sp identified in Specimen by Organism specific culture

3.86

1.95

1.7

1.6

—

(3017181) Myelocytes/100 leukocytes in Blood

2.12

1.88

4.8

4.4

0.4

0.6

—

(3025159) Blasts/100 leukocytes in Blood

2.17

1.88

4.7

0.0

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

2.61

1.88

1.5

2.3

u/l

2909.0

9201.5

—

(3042936) Bacteria identified in Isolate by Culture

132

1.88

1.87

2.0

2.1

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

132

1194

2.03

1.87

17.0

8.9

ml/min/173m2

81.2

83.8

0.58

106

957

(3022145) Colonoscopy Study observation

133

1.86

1.83

1.5

1.3

—

(3018418) pH of Serum or Plasma

308

1.61

1.80

5.5

2.6

7.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

158

1.78

1.77

4.7

4.9

—

(40768793) Breast Pathology biopsy report

3.43

1.76

1.3

1.1

—

(3018095) Leukocytes [#/volume] in Urine

408

1.56

1.76

5.7

3.3

e6/l

90.0

81.6

0.05

268

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.48

1.72

1.4

1.6

—

(3021440) Promyelocytes/100 leukocytes in Blood

2.08

1.71

5.0

4.6

0.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

475

1.53

1.70

5.0

3.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

121

1.86

1.69

2.3

1.6

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

136

1252

2.15

1.68

21.9

9.9

mg/l

19.7

17.9

0.29

104

917

(3045414) Leukocytes [Presence] in Urine

2.24

1.66

1.3

1.9

—

(3009508) Creatinine [Moles/volume] in Urine

367

1.55

1.66

4.0

2.8

mmol/l

6.9

0.01

302

(3049717) Cytology report of Urine Cyto stain

2.58

1.62

2.3

1.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

274

1.58

1.56

3.5

2.9

ng/l

1650.0

1020.4

0.29

221

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

199

1.64

1.51

2.7

1.8

mmol/l

2.5

2.4

1.13

170

(40761535) Cells panel - Urine sediment

1.89

1.50

4.7

2.9

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

3.20

1.45

1.2

1.3

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

1.35

0.0

1.3

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.11

1.29

1.2

2.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.46

1.25

1.3

2.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.46

1.25

1.5

1.3

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

125

1.69

1.25

2.6

1.6

1.4

1.3

0.06

112

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.12

1.25

3.8

5.2

mmol/l

24.7

25.1

—

(3013512) EKG study

323

1.47

1.25

3.9

3.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.69

1.22

1.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.69

1.22

1.0

1.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

361

1.44

1.22

5.0

3.6

mg/mmol

29.5

3.8

0.53

190

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.55

1.16

1.2

1.7

—

(3012516) Albumin [Mass/volume] in Urine

347

1.43

1.13

4.0

2.9

mg/l

73.4

238.8

0.34

188

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.43

1.10

4.2

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.02

1.06

1.3

2.0

—

(3000492) Spirometry study

1.69

1.05

1.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

270

1.44

1.05

1.7

1.3

g/l

2.2

2.3

0.12

163

(3004616) Nuclear Ab [Presence] in Serum

2.32

1.04

1.6

1.2

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

280

1.43

1.03

1.7

mg/l

0.9

1.0

0.14

213

(3019060) Gas panel - Arterial blood

1.93

1.02

2.6

5.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.91

0.99

1.5

—

(3001019) Free T4 and TSH panel - Serum or Plasma

101

1.66

0.98

1.6

1.7

—

(3021960) Folate [Moles/volume] in Serum or Plasma

267

1.41

0.93

1.6

1.4

nmol/l

22.8

23.6

0.11

227

(3015736) pH of Urine

492

1.33

0.90

4.8

3.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.11

0.90

1.3

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.04

0.88

1.5

1.2

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.04

0.88

1.0

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.82

0.86

11.3

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

281

1.37

0.84

1.6

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.64

0.81

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

338

1.34

0.81

3.8

2.9

—

(1761868) Lipid panel - Serum or Plasma

479

0.75

0.80

2.9

2.7

—

(4010399)

1.57

0.79

1.6

1.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.79

0.0

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.80

0.77

1.0

1.6

—

(3044889) 12 lead EKG panel

841

1.29

0.74

3.9

3.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.88

0.69

1.4

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.62

0.66

6.6

7.3

—

(40761536) Microorganisms panel - Urine sediment

1.54

0.66

2.9

3.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

838

1.26

0.65

4.3

2.8

u/l

78.8

38.0

0.70

787

(3019150) Specific gravity of Urine by Refractometry

283

1.31

0.65

5.6

3.3

kg/l

1.0

—

(3022621) pH of Urine by Test strip

1.57

0.65

2.9

2.3

—

(40761511) CBC panel - Blood by Automated count

138

1330

1.61

0.64

17.8

9.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

321

1.29

0.64

1.3

u/ml

0.8

2.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

870

1.26

0.63

7.3

4.0

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.57

0.60

1.9

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.60

0.0

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.59

0.0

1.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

288

1.28

0.57

5.4

3.3

—

(3037522) Nuclear Ab [Titer] in Serum

197

1.32

0.56

1.7

1.4

titre

648.9

485.3

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.53

0.55

6.4

2.1

e6/l

0.0

0.3

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

384

0.79

0.53

1.9

1.6

mmol/l

1.2

1.4

1.03

335

(3003338) MCHC [Mass/volume]

104

1103

0.80

0.52

27.3

13.4

g/l

331.3

330.8

0.23

104

1098

(3005322) IgE [Units/volume] in Serum or Plasma

1.43

0.46

1.2

u/ml

95.1

165.6

0.37

(3024354) Oxygen [Partial pressure] in Venous blood

1.48

0.45

2.3

kpa

4.7

4.5

—

(3048689) Calprotectin [Mass/mass] in Stool

186

1.28

0.44

3.3

1.9

ug/g

79.0

83.9

0.07

142

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.63

0.43

1.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.63

0.43

1.0

1.5

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

1.63

0.43

1.4

1.8

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.63

0.43

1.0

1.5

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.63

0.43

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.63

0.43

1.0

1.5

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.41

0.0

1.1

—

(3000494) Fungus identified in Specimen by Culture

142

1.30

0.41

1.3

1.4

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.40

0.0

1.1

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.40

0.0

1.1

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.39

0.0

1.2

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.39

0.0

1.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

128

1239

1.26

0.36

4.1

3.8

mmol/l

1.3

1.2

1.05

114

1156

(21494755) Public health laboratory ask at order entry panel

143

0.75

0.34

1.5

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

120

1159

1.19

0.31

21.7

11.2

38.9

40.1

0.83

867

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.32

0.27

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

275

1.16

0.26

5.7

4.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

137

0.79

0.25

1.8

1.7

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.36

0.24

2.0

4.6

1.7

1.6

—

(3020891) Body temperature

1.36

0.24

1.4

3.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

132

1292

1.21

0.23

4.7

4.3

mmol/l

1.6

0.29

116

1216

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.33

0.23

2.0

4.5

0.8

1.0

—

(4268621)

0.00

0.21

0.0

1.9

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.21

0.0

1.0

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.4

—

2.0

—

(3024666) Lithium, Blood [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

11.3

—

0.7

—

(3009991) Angiotensin converting enzyme [Enzymatic activity/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

1.1

—

(4146454)

0.00

0.21

0.0

2.5

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.21

0.0

1.2

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

2.2

—

(4027681)

0.00

0.21

0.0

1.1

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.20

0.0

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.23

0.20

1.8

1.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

110

1071

1.11

0.17

4.7

4.2

pmol/l

14.6

14.5

0.14

989

(40768797) Stomach Pathology biopsy report

192

0.87

0.16

1.0

1.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

132

1299

1.16

0.15

4.7

4.3

mmol/l

4.8

4.9

0.29

118

1222

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

288

1.10

0.13

1.3

u/ml

1.2

10.9

1.88

111

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.09

0.09

1.0

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.09

0.09

1.0

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.07

0.09

1.0

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.12

0.09

1.7

2.0

0.8

1.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.12

0.08

1.6

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.87

0.07

1.0

1.4

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

103

0.87

0.06

1.4

—

51.8

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

139

1.09

0.05

1.7

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

854

0.96

0.05

3.3

3.2

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

120

0.91

0.05

3.2

1.7

nmol/l

320.0

361.3

0.29

110

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

140

0.92

0.04

1.4

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

133

1321

1.07

0.03

5.4

4.8

mmol/l

2.8

2.9

0.27

118

1239

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

127

1279

0.95

0.03

4.9

4.3

mmol/l

5.7

5.8

0.06

115

1184

(3013139) Helicobacter pylori Ag [Presence] in Stool

108

0.92

0.03

1.5

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

123

1239

0.96

0.03

5.5

5.0

mu/l

1.7

1.8

1.14

108

1152

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

291

1.04

0.02

1.3

iu/ml

18.2

38.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

117

0.94

0.02

1.5

1.6

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

119

1189

1.00

0.00

6.1

5.3

mmol/mol

38.6

39.0

0.15

104

1116

(36660697) Celiac disease serology panel - Serum

118

1.02

0.00

1.3

1.2

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.90

0.00

1.4

1.5

—

(3025941) Bacteria identified in Stool by Culture

1.00

0.00

1.1

1.2

—

(37020300) Entamoeba histolytica DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(3012565) Volume of 24 hour Urine

0.00

0.0

1.0

—

2354.0

—

(42868499) Enterovirus IgG Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.8

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

3.7

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.3

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.1

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

14.3

—

842.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.92

0.00

1.3

1.1

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

5.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(42868766) Dientamoeba fragilis DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

0.0

1.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

30.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

14.7

—

1519.9

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

66.8

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

120

1.00

0.00

1.3

iu/ml

44.0

141.4

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.3

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(4198724)

0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.1

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

1.7

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.86

0.00

1.0

1.5

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

0.0

1.2

—

(3004451) EKG impression Narrative

0.00

0.0

1.2

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.5

—

(42868417) European tick borne encephalitis virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.5

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.1

—

10.2

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.6

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_INSITU_VAGINA_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_VAGINA_EXALLC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: CD2_INSITU_VAGINA_EXALLC – Carcinoma in situ of vagina

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Carcinoma in situ of vagina

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints