Carcinoma in situ of prostate

CD2_INSITU_PROSTATE_EXALLC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule only males	-
2. Check conditions not C3_PROSTATE	-
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D07.5& Hospital discharge: ICD-9 — 2334 Cause of death: ICD-10 — D07.5& Cause of death: ICD-9 — 2334 Cancer registry: Topography ICD-O-3 — C61 Cancer registry: Morphology ICD-O-3 — ANY Cancer registry: Behaviour codes — 2 3 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF9
Parent code in ICD-10: D07
Name in latin: Carcinoma in situ oculi

NAME	CD2_INSITU_PROSTATE_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	1
INCLUDE
PRE_CONDITIONS
CONDITIONS	!C3_PROSTATE
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D075
HD_ICD_9	2334
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D075
COD_ICD_9	2334
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO	C61
CANC_TOPO_EXCL
CANC_MORPH	ANY
CANC_MORPH_EXCL
CANC_BEHAV	2

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of prostate based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Carcinoma in situ of prostate

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	42	-	42
Only index persons	20	-	20
Unadjusted period prevalence (%)
Whole population	0.00	-	0.00
Only index persons	0.00	-	0.00
Median age at first event (years)
Whole population	-	-	74.45
Only index persons	-	-	69.37

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	190	-	190
Unadjusted period prevalence (%)	0.08	-	0.08
Median age at first event (years)	68.07	-	68.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
180: Matched controls
1800

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

8148/2-C61.9

ICD-O-3

Glandular intraepithelial neoplasia, high grade of prostate gland

+∞

200.5

153

KE1AT

NOMESCO Finland

Biopsy of prostata with ultrasoudnguidance

59.3

76.5

R74.8

ICD-10 Finland

Abnormal levels of other serum enzymes

31.0

58.4

C61

ICD-10 Finland

Malignant neoplasm of prostate

738.0

56.9

R86.0

ICD-10 Finland

Abnormal findings in specimens from male genital organs, abnormal level of enzymes

55.5

44.6

8140/3-C61.9

ICD-O-3

Adenocarcinoma, NOS, of prostate gland

+∞

40.1

XKD00

NOMESCO Finland

Uroflowmetry

7.8

35.1

111

308

N40

ICD-10 Finland

Hyperplasia of prostate

6.4

28.4

136

586

KC1EE

NOMESCO Finland

Ultrasound measurement of residual urine

6.6

28.3

250

TKE00

NOMESCO Finland

Needle biopsy of prostate

18.7

25.8

8140/2-C61.9

ICD-O-3

Adenocarcinoma in situ, NOS, of prostate gland

+∞

24.5

KEC01

NOMESCO Finland

Percutaneous endoscopic radical prostatectomy

+∞

23.4

KEB00

NOMESCO Finland

Biopsy of prostate

96.2

23.3

KE1DG

NOMESCO Finland

Very extensive MRI of prostate

62.2

19.4

KE1BE

NOMESCO Finland

Rectal ultrasound examinaiton of prostata

4.9

16.7

178

ZXC96

NOMESCO Finland

Robot assisted procedure

+∞

15.9

XJH00

NOMESCO Finland

Transanal ultrasonography

6.2

14.2

KDE20

NOMESCO Finland

Removal of foreign body from urethra

34.8

12.8

KC1GB

NOMESCO Finland

Cystography with X-ray

+∞

10.5

8090/3-C44.9

ICD-O-3

Basal cell carcinoma, NOS, of skin, NOS

+∞

10.5

Z03.1

ICD-10 Finland

Observation for suspected malignant neoplasm

12.3

10.3

WF002

NOMESCO Finland

Radical radiotherapy

105.3

9.5

UKC02

NOMESCO Finland

Cystoscopy

3.2

8.8

215

C44.31

ICD-10 Finland

Basocellular carcinoma of the skin on another or unspecified part of the face

94.2

8.5

130

Kela drug reimbursment

Malignant tumour

+∞

8.4

KE3AT

NOMESCO Finland

Transrectal gold marker implantation in prostate under ultrasound guidance

+∞

7.3

YL1BD

NOMESCO Finland

Extensive CT examination of pelvis for dose design of radiotherapy

+∞

7.3

ZX070

NOMESCO Finland

Intensity modified radiotherapy

+∞

7.3

JN2CG

NOMESCO Finland

Extensive MRI examination of lower part of abdoment with high intensity magnet

31.4

7.2

R39.1

ICD-10 Finland

Other difficulties with micturition

6.8

7.1

308

Kela drug reimbursment

Alprostadil, sildenafil and combination product containing aviptadil and phentolamine

41.6

6.8

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

12.9

6.7

WD125

NOMESCO Finland

Demanding cystostatic therapy of methastized malignancy

+∞

6.3

C67.8

ICD-10 Finland

Malignant neoplasm: Overlapping lesion of bladder

+∞

6.3

WF049

NOMESCO Finland

Radiotherapy of metastasis

+∞

6.3

R33

ICD-10 Finland

Retention of urine

3.2

6.0

119

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(40768800) Prostate Pathology biopsy report

59.43

139.23

1.8

1.1

—

(3026782) Osmolality of Urine

288

5.48

30.24

4.4

2.5

mosm/kgh2o

620.0

601.5

0.33

229

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

149

737

5.73

24.89

6.3

2.8

ug/l

0.9

0.7

3.30

136

516

(3002582) Erythrocytes [#/volume] in Urine

111

469

4.29

22.02

4.9

3.0

e6/l

280.9

202.2

0.10

360

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

121

569

4.10

20.05

4.9

3.0

—

(3018095) Leukocytes [#/volume] in Urine

115

525

4.02

19.84

5.9

3.4

e6/l

25.2

87.4

1.60

100

379

(4035726)

7.20

19.63

1.3

—

(3030467) Casts [#/volume] in Urine by Automated count

101

425

3.94

19.59

4.5

2.9

e6/l

0.2

0.4

1.31

310

(3041096) Erythrocytes [Presence] in Urine by Automated

357

3.97

19.56

4.6

2.9

—

(40761536) Microorganisms panel - Urine sediment

109

5.25

19.13

6.0

2.7

—

(3026008) Bacteria identified in Urine by Culture

342

3.61

16.56

3.8

2.6

—

(3021589) Normoblasts [#/volume] in Blood

124

660

3.53

15.65

11.5

8.4

e9/l

0.0

0.50

109

544

(3000850) Epithelial cells [#/volume] in Urine

306

3.55

15.61

3.5

2.2

e6/l

1.9

2.7

1.30

258

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

111

557

3.39

15.34

4.7

3.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

6.27

15.28

3.5

4.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

165

1079

5.02

14.80

8.2

3.9

15.5

24.0

26.89

141

516

(40768804) Tissue Pathology biopsy report

400

3.24

14.07

2.5

1.5

—

(36304419) Bacteria [Presence] in Urine

395

3.02

12.33

4.6

2.8

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

259

3.22

12.17

4.4

2.9

e6/l

0.3

0.7

1.09

148

(3021601) Nitrite [Presence] in Urine by Test strip

123

718

3.02

12.04

6.0

4.5

estimate

0.0

0.00

112

(3009261) Glucose [Presence] in Urine by Test strip

124

731

3.00

11.85

4.5

3.3

estimate

0.0

0.00

101

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

180

1340

7.52

11.78

10.4

4.0

ug/l

6.2

2.0

25.89

173

1202

(3035350) Ketones [Presence] in Urine by Test strip

122

716

2.97

11.70

4.6

3.3

estimate

0.0

0.00

105

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

165

3.46

11.17

4.8

2.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

275

2.73

8.77

3.5

2.7

e6/l

0.7

0.9

0.42

163

(3029937) Albumin [Presence] in Urine by Test strip

408

2.55

8.71

4.8

3.3

estimate

0.0

0.50

102

(3015736) pH of Urine

563

2.43

8.25

4.0

3.2

—

(3000330) Specific gravity of Urine by Test strip

3.69

8.17

3.9

3.4

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

180

1462

5.39

7.68

17.8

12.4

ml/min/173m2

74.8

76.3

0.54

168

1193

(1761868) Lipid panel - Serum or Plasma

529

2.33

7.51

4.3

3.3

—

(40767503) Oxygen content in Capillary blood by calculation

5.34

7.31

3.7

2.6

18.5

16.2

—

(3049717) Cytology report of Urine Cyto stain

3.88

6.81

3.2

1.9

—

(3013512) EKG study

521

2.24

6.77

4.9

4.3

—

(1616796) Gas panel - Central venous blood

5.13

6.56

4.4

2.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

100

646

2.16

6.31

4.7

3.7

—

(3002179) Metamyelocytes/100 leukocytes in Blood

3.08

6.03

3.5

4.1

1.0

0.2

—

(40761511) CBC panel - Blood by Automated count

182

1595

4.35

5.93

17.0

13.2

—

(3021440) Promyelocytes/100 leukocytes in Blood

107

2.90

5.61

3.6

3.9

0.0

0.1

—

(3037467) Urinalysis macro (dipstick) panel - Urine

135

1008

2.17

5.53

5.0

3.6

—

(3002256) Pathology report gross observation

121

2.76

5.45

1.4

1.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

182

1609

4.11

5.42

5.5

5.7

mmol/l

2.5

0.02

167

1472

(3025159) Blasts/100 leukocytes in Blood

2.88

5.24

3.6

4.1

0.0

—

(3017181) Myelocytes/100 leukocytes in Blood

113

2.73

5.07

3.8

1.6

0.9

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

4.97

4.58

1.7

2.6

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

183

1652

3.92

4.43

19.3

17.1

mmol/l

139.4

139.7

0.96

183

1608

(3003694) ABO and Rh group [Type] in Blood

365

1.99

4.41

1.5

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

126

962

1.92

4.29

4.1

4.7

mmol/l

7.0

6.9

0.07

117

911

(3023103) Potassium [Moles/volume] in Serum or Plasma

183

1657

3.83

4.27

19.3

17.2

mmol/l

4.0

0.56

183

1616

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

178

1561

3.22

4.11

4.9

5.1

mmol/l

6.2

0.15

164

1406

(40760892) CBC W Ordered Manual Differential panel - Blood

289

1.99

3.94

5.9

4.2

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

174

1519

2.73

3.84

4.4

4.5

mmol/l

1.3

0.07

159

1382

(3032080) INR in Blood by Coagulation assay

703

1.78

3.70

14.3

10.9

inr

1.4

0.03

181

(3033705) Calcium.ionized [Moles/volume] in Venous blood

4.00

3.57

1.4

2.5

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

5.19

3.41

5.9

3.1

61.1

52.0

—

(3041354) Potassium [Moles/volume] in Venous blood

3.85

3.40

1.4

2.4

mmol/l

4.1

4.2

—

(3035285) Chloride [Moles/volume] in Venous blood

3.85

3.40

1.4

2.4

mmol/l

105.1

104.9

—

(3021901) Oxygen saturation in Capillary blood

3.59

3.39

3.1

3.0

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

171

1510

2.32

3.16

15.8

13.4

mg/l

27.2

26.2

0.12

152

1185

(3010421) pH of Blood

3.37

3.11

7.1

2.8

7.4

0.15

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

175

1566

2.49

3.03

5.0

mmol/l

1.3

0.03

160

1427

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

176

1581

2.54

2.98

5.1

5.0

mmol/l

4.3

0.00

161

1454

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.86

2.95

4.0

2.9

e9/l

4.9

3.5

—

(3035637) Corticotropin [Mass/volume] in Plasma

6.84

2.89

1.0

1.2

—

(3044889) 12 lead EKG panel

139

1159

1.74

2.89

4.6

4.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

744

1.62

2.73

5.4

4.5

umol/l

12.1

14.4

1.41

708

(3018418) pH of Serum or Plasma

401

1.68

2.66

4.2

3.8

7.4

0.05

(40758558) Short blood count panel - Blood

332

1.69

2.44

3.3

4.2

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

169

1523

1.99

2.35

6.7

7.0

mmol/mol

40.7

41.2

0.38

158

1407

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

2.79

2.32

1.3

2.5

mg/l

1.5

1.7

0.65

(3006184) Hemoglobin [Mass/volume] in Capillary blood

2.80

2.14

3.2

2.2

g/l

146.2

129.6

—

(3028271) Lactate [Moles/volume] in Capillary blood

3.59

2.07

4.4

1.7

mmol/l

1.7

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

797

1.51

2.06

6.9

6.3

e9/l

4.4

4.5

0.14

706

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

489

1.54

2.02

1.8

2.2

u/l

56.7

58.7

0.24

457

(3022806) Fractional oxyhemoglobin in Capillary blood

3.84

1.95

3.8

1.6

86.4

89.9

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

209

1.70

1.90

4.0

6.0

mmol/l

0.9

1.0

0.98

194

(3023368) Bacteria identified in Blood by Culture

454

1.51

1.80

5.4

4.1

—

(3044640) Blood type and Crossmatch panel - Blood

446

1.50

1.78

2.3

—

(40768443) Skin Pathology biopsy report

2.26

1.71

1.0

1.2

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

128

1.81

1.69

2.3

1.5

nmol/l

444.4

374.2

0.54

117

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.23

1.67

1.3

1.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

130

1133

1.47

1.65

3.8

3.9

mm/h

9.9

11.3

0.61

120

1033

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

177

1.68

1.63

1.5

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

3.64

1.62

2.0

1.4

ug/l

30.1

16.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

1.94

1.55

5.3

1.4

ug/l

12.2

6.4

0.35

(3002030) Lymphocytes/100 leukocytes in Blood

674

1.41

1.52

5.4

5.9

24.5

25.6

0.46

627

(40760888) Immunoglobulin light chains.free panel - Serum

2.56

1.46

1.9

1.3

—

(3013115) Eosinophils [#/volume] in Blood

736

1.39

1.45

4.8

5.6

e9/l

0.2

0.01

645

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

2.78

1.44

4.0

2.2

33.0

34.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

147

1331

1.46

1.37

13.9

14.8

38.2

40.2

0.80

844

(3019069) Monocytes/100 leukocytes in Blood

664

1.38

1.37

5.4

6.0

9.7

9.3

0.47

620

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

1.34

0.0

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

118

1034

1.37

1.29

3.1

2.9

pmol/l

15.0

15.1

0.06

103

912

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

2.82

1.29

1.4

1.6

—

(3003327) Ova and parasites identified in Stool by Light microscopy

2.44

1.25

1.7

1.6

—

(3018010) Neutrophils/100 leukocytes in Blood

672

1.36

1.25

4.8

5.7

59.5

58.1

0.43

630

(3021447) Carbon dioxide [Partial pressure] in Venous blood

174

1.57

1.23

4.0

3.3

kpa

5.9

5.8

0.18

168

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

722

1.35

1.22

4.7

6.5

mmol/l

1.2

0.24

630

(3027801) Oxygen [Partial pressure] in Arterial blood

221

0.56

1.22

6.7

7.4

kpa

12.6

11.6

0.38

216

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

221

0.56

1.22

6.8

7.4

kpa

5.3

5.1

0.40

215

(42870588) Differential panel, method unspecified - Blood

478

1.37

1.19

5.3

5.6

—

(3006504) Eosinophils/100 leukocytes in Blood

661

1.33

1.13

5.4

5.7

3.4

3.2

0.27

617

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

702

1.32

1.10

4.3

3.8

ng/l

40.0

50.7

0.39

541

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.42

1.09

3.0

2.0

—

(3001604) Monocytes [#/volume] in Blood

712

1.32

1.09

4.9

5.5

e9/l

0.7

0.6

0.45

616

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.23

1.09

1.1

1.3

—

(3019225) pH of Specimen

148

0.52

1.09

1.9

3.7

—

(3019198) Lymphocytes [#/volume] in Blood

723

1.32

1.07

4.9

5.6

e9/l

1.8

0.18

631

(3019832) Treponema pallidum Ab [Presence] in Serum

2.00

1.05

1.1

1.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

506

1.33

1.04

2.0

2.1

nmol/l

82.1

74.7

1.21

438

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.10

1.04

1.1

1.3

—

(3024354) Oxygen [Partial pressure] in Venous blood

148

1.55

1.03

3.0

2.6

kpa

4.4

4.6

0.20

141

(3014111) Lactate [Moles/volume] in Serum or Plasma

148

1.55

1.03

4.0

7.1

mmol/l

1.3

1.4

0.13

143

(3019060) Gas panel - Arterial blood

131

0.52

1.03

5.0

5.3

—

(3022096) Basophils/100 leukocytes in Blood

649

1.31

1.03

5.4

5.6

0.8

0.7

1.90

611

(3006315) Basophils [#/volume] in Blood

717

1.31

1.02

4.9

5.5

e9/l

0.0

1.16

628

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

147

1357

1.37

1.01

3.8

mu/l

2.0

2.1

0.32

136

1214

(4146454)

0.00

0.97

0.0

3.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

693

1.29

0.96

1.5

2.0

pmol/l

86.9

92.4

0.55

404

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

118

1.58

0.95

1.1

1.2

—

(3022145) Colonoscopy Study observation

135

1.54

0.93

1.4

1.3

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.18

0.92

1.2

2.0

—

(3022313) Gas panel - Capillary blood

105

0.46

0.91

5.8

3.9

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

170

1.47

0.91

3.8

2.4

u/l

497.4

255.2

1.03

157

(3004588) Protein electrophoresis panel - Serum or Plasma

1.63

0.90

1.6

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

314

1.35

0.86

1.3

1.6

mg/l

2.0

1.2

0.62

249

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.59

0.84

1.6

2.1

0.9

1.2

1.36

(3020630) Protein [Mass/volume] in Serum or Plasma

122

1.53

0.83

2.6

2.0

g/l

68.9

67.0

0.47

106

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

440

1.28

0.77

1.6

1.7

mmol/l

1.5

1.4

0.51

359

(3005322) IgE [Units/volume] in Serum or Plasma

1.64

0.77

1.1

1.2

u/ml

208.0

198.5

0.04

(3025941) Bacteria identified in Stool by Culture

1.67

0.74

1.1

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

1.87

0.74

1.7

1.5

—

(3048689) Calprotectin [Mass/mass] in Stool

109

1.51

0.73

2.7

2.4

ug/g

133.6

136.2

—

(3000991) Gas panel - Venous blood

152

1.43

0.73

6.5

8.2

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

1.65

0.67

1.9

1.4

—

0.9

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

1.81

0.66

2.2

2.0

u/ml

9.6

230.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

563

1.23

0.66

2.1

2.6

ug/l

208.1

204.6

0.03

514

(3002173) Hemoglobin [Mass/volume] in Arterial blood

187

0.67

0.65

6.7

8.2

g/l

125.8

125.5

0.03

181

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.74

0.64

3.0

1.9

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.74

0.64

3.0

1.9

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

106

968

1.21

0.64

2.6

3.3

u/l

58.9

60.5

0.04

896

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

230

0.71

0.61

4.7

7.3

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.60

0.0

1.1

—

(3026493) Urate [Moles/volume] in Serum or Plasma

482

1.23

0.60

2.6

2.8

umol/l

9219.4

10619.6

0.05

424

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.59

0.0

1.0

—

2.4

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.53

0.59

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

193

0.70

0.57

1.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.64

0.56

1.0

1.1

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.49

0.56

1.8

nmol/l

46.1

45.3

0.05

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

192

0.71

0.55

1.3

u/ml

1.1

17.2

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

294

1.23

0.47

1.6

1.9

32.3

29.8

1.61

282

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

504

1.19

0.46

2.3

u/l

161.6

362.2

0.76

469

(40761535) Cells panel - Urine sediment

157

1.31

0.45

3.4

2.9

—

(3020682) Albumin/Creatinine [Ratio] in Urine

633

1.17

0.43

4.3

mg/mmol

3.6

8.7

2.06

431

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

1.63

0.43

1.8

7.3

—

139.2

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

1.53

0.41

1.0

1.4

mmol/l

3.7

4.0

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.0

—

(21494434) Karyotype in Bone marrow

0.00

0.41

0.0

1.2

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.41

0.0

2.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.40

0.0

1.7

—

(3017569) Oxygen content in Arterial blood

0.00

0.40

0.0

1.8

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.40

0.39

2.9

2.4

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.39

0.0

3.7

—

47.8

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

590

1.15

0.38

2.5

3.2

ng/l

1417.2

1441.4

0.01

512

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.41

0.35

1.0

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

127

1.28

0.35

1.9

2.2

ml/min/173m2

71.4

63.1

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.69

0.34

1.8

1.2

g/l

1.0

1.1

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

655

1.13

0.33

4.4

4.0

g/l

35.0

35.2

0.07

607

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.72

0.31

2.0

1.4

—

(3022621) pH of Urine by Test strip

0.70

0.31

1.7

2.5

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

384

1.15

0.31

1.6

2.0

mg/l

3.1

2.8

0.38

324

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

106

0.74

0.30

1.6

1.8

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.26

0.30

1.0

1.4

—

(3000494) Fungus identified in Specimen by Culture

193

0.81

0.28

1.3

1.5

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

114

1.25

0.26

1.9

2.0

u/l

40.6

34.5

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.24

0.26

1.0

1.4

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

1.32

0.23

1.0

1.4

e6/l

2.2

3016.5

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.76

0.23

1.6

2.0

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

1.20

0.21

3.8

3.9

mg/l

14.6

24.1

—

(3005719) IgG [Mass/volume] in Serum or Plasma

105

0.75

0.21

3.3

2.0

g/l

9.8

11.3

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(3027923) C peptide [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

1.3

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3003129) Base excess in Capillary blood by calculation

0.00

0.21

0.0

1.2

—

2.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

1.0

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.21

0.0

1.9

—

7.3

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

2.3

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

0.4

—

(3017704) Immunofixation for Urine

0.00

0.21

0.0

1.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

0.5

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.20

0.0

1.3

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.0

—

1.2

—

(3009508) Creatinine [Moles/volume] in Urine

605

1.09

0.18

2.9

3.4

mmol/l

9.7

8.6

1.22

505

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

706

1.08

0.17

2.1

2.2

—

(40768797) Stomach Pathology biopsy report

187

1.14

0.16

1.4

1.2

—

(3012516) Albumin [Mass/volume] in Urine

588

1.08

0.16

2.9

3.5

mg/l

44.0

66.7

0.79

395

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

178

1.14

0.16

1.9

2.0

—

(3009343) pH of Capillary blood

131

1.16

0.15

4.4

3.9

7.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

237

1.11

0.15

1.3

1.2

g/l

2.9

3.3

0.63

145

(36660697) Celiac disease serology panel - Serum

0.77

0.14

1.1

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

118

0.84

0.14

1.1

1.6

—

(3000492) Spirometry study

148

0.87

0.13

1.5

—

(3042936) Bacteria identified in Isolate by Culture

261

0.91

0.12

1.6

1.9

—

(3021960) Folate [Moles/volume] in Serum or Plasma

428

1.07

0.11

1.4

1.5

nmol/l

22.3

19.3

0.47

367

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.11

0.10

1.0

1.2

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.04

0.09

1.0

1.4

g/l

11.3

11.6

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

243

1.08

0.09

6.9

6.4

mmol/l

104.6

104.5

0.03

235

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.09

0.09

1.2

1.5

—

(3045414) Leukocytes [Presence] in Urine

1.05

0.08

1.2

1.7

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.14

0.08

5.9

3.8

mmol/l

23.7

24.2

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

100

0.90

0.06

6.8

11.0

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.12

0.05

6.9

10.2

mmol/l

24.7

24.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

100

1.11

0.05

1.2

1.4

—

(4010399)

130

0.92

0.05

1.3

1.5

—

(3023520) Reticulocytes [#/volume] in Blood

161

1.06

0.03

3.6

2.2

e9/l

63.6

67.2

0.14

123

(3011397) Hemoglobin [Presence] in Urine by Test strip

369

0.97

0.02

3.8

3.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

163

1.05

0.01

1.2

1.6

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

253

1.03

0.01

2.1

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

346

0.98

0.00

2.6

2.2

—

(3019309) Folate [Moles/volume] in Red Blood Cells

339

1.00

0.00

2.2

1.8

nmol/l

1618.7

1153.8

1.84

269

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

392

0.99

0.00

1.7

1.9

pmol/l

450.3

17485048.1

0.50

326

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

118

1.02

0.00

1.1

1.5

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

248

1.01

0.00

1.4

1.2

u/ml

10.7

1.4

0.48

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

182

0.99

0.00

2.0

1.9

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.1

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.1

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3028772) Osteocalcin [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.3

—

(3024471) HLA-A [Type]

0.00

0.0

1.0

—

(3024932) HLA-DR beta [Type]

0.00

0.0

1.3

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

1.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3039443) Prostate specific Ag panel - Serum or Plasma

1.02

0.00

2.4

1.6

—

(4024509)

0.00

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.9

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

(3038071) Oxygen [Partial pressure] in Mixed venous blood

0.00

0.0

6.9

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.2

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

807.2

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

0.0

1.0

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.96

0.00

1.1

1.2

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture

0.00

0.0

2.2

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(3000285) Sodium [Moles/volume] in Blood

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.2

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.4

—

(4133840)

0.00

0.0

1.2

—

(3044007) Cell count panel - Peritoneal fluid

0.00

0.0

2.1

—

(3018921) Toxoplasma gondii IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

1.8

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

12.2

—

1513.8

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.3

—

(3009871) Measles virus Ab [Titer] in Serum

0.00

0.0

1.2

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

0.00

0.0

2.1

—

570.9

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(4281824)

0.00

0.0

1.2

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.0

—

210.5

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3013803) Aspergillus fumigatus IgG Ab [Mass/volume] in Serum

0.00

0.0

1.0

—

(3042733) HLA Ab [Presence] in Serum

0.00

0.0

6.0

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.2

—

(21494755) Public health laboratory ask at order entry panel

0.91

0.00

1.1

1.5

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

2.1

—

13.6

—

(3012215) Mononuclear cells/100 leukocytes in Synovial fluid

0.00

0.0

1.0

—

27.8

—

(3021513) Carbon dioxide [Partial pressure] in Mixed venous blood

0.00

0.0

6.7

—

(3042602) Urea [Moles/volume] in Serum or Plasma --post dialysis

0.00

0.0

4.4

—

5.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.96

0.00

1.0

1.3

—

(3035880) pH of Pleural fluid

0.00

0.0

1.6

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.0

—

(3028371) Actinomyces sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3020891) Body temperature

0.91

0.00

6.0

4.1

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3034037) Hematocrit [Volume Fraction] of Mixed venous blood

0.00

0.0

7.7

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

2.0

—

0.3

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_INSITU_PROSTATE_EXALLC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_PROSTATE_EXALLC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_PROSTATE_EXALLC – Carcinoma in situ of prostate

GWS hits: 2

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Carcinoma in situ of prostate

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints