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Carcinoma in situ of oral cavity and pharynx

CD2_INSITU_OROPHARYNX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_OROPHARYNX
519681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

3 out of 7 registries used, show all original rules.

53

4. Check minimum number of events

None

53

5. Include endpoints

None

53

6. Filter based on genotype QC (FinnGen only)

53

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D00

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 53 18 35
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 64.41 70.73 61.15

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
23
88
3.85
5.28
3.0
2.4
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
34
174
3.66
4.94
5.0
3.8
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
26
121
3.25
4.25
3.0
2.5
—
—
—
0
0
(3002256) Pathology report gross observation
13
38
4.21
4.22
1.6
1.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
21
89
3.25
3.96
10.7
7.0
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
28
148
2.89
3.51
3.7
2.1
—
—
—
0
0
(4035726)
12
38
3.79
3.46
1.7
1.3
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
11
33
3.94
3.41
2.0
1.4
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
33
194
2.86
3.34
7.9
6.2
e9/l
0.6
0.6
0.43
28
166
(3006315) Basophils [#/volume] in Blood
33
195
2.83
3.29
7.9
6.3
e9/l
0.0
0.0
0.28
28
169
(3019198) Lymphocytes [#/volume] in Blood
33
197
2.79
3.20
8.0
6.3
e9/l
1.8
1.7
0.12
28
172
(3013115) Eosinophils [#/volume] in Blood
33
201
2.70
3.01
8.0
6.4
e9/l
0.2
0.2
0.50
28
174
(3000991) Gas panel - Venous blood
11
36
3.59
3.01
8.9
9.3
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
6
170
0.27
2.84
3.5
3.0
—
—
—
0
0
(3043109) Cytology report of Tissue fine needle aspirate Cyto stain
5
6
9.03
2.81
1.4
1.5
—
—
—
0
0
(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma
33
211
2.49
2.59
9.6
5.5
umol/l
11.2
10.4
0.17
33
199
(3023368) Bacteria identified in Blood by Culture
23
125
2.48
2.56
4.9
4.6
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
27
159
2.42
2.52
2.2
1.9
pmol/l
95.7
95.0
0.03
13
77
(42870588) Differential panel, method unspecified - Blood
23
127
2.43
2.46
6.4
5.9
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
14
61
2.76
2.39
1.2
1.7
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
15
69
2.64
2.31
2.1
2.3
e6/l
0.3
0.8
—
10
38
(3017143) Hepatitis C virus Ab [Presence] in Serum
12
49
2.87
2.30
1.2
1.7
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
15
70
2.59
2.24
2.1
1.8
—
—
—
0
0
(4010399)
9
31
3.28
2.19
1.6
1.3
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
13
57
2.70
2.18
12.5
10.8
—
—
—
0
0
(3003458) Phosphate [Moles/volume] in Serum or Plasma
14
65
2.57
2.11
4.1
5.9
mmol/l
0.9
1.0
0.91
14
59
(3000494) Fungus identified in Specimen by Culture
12
52
2.69
2.05
2.2
1.5
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
24
146
2.18
1.97
2.5
2.2
nmol/l
84.0
76.1
0.54
18
127
(3019832) Treponema pallidum Ab [Presence] in Serum
7
22
3.50
1.95
1.1
1.6
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
11
48
2.63
1.85
1.4
1.6
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
11
49
2.57
1.78
1.3
1.5
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
35
254
2.11
1.75
4.6
4.6
—
100.3
—
0
6
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
7
25
3.07
1.71
1.9
1.7
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
13
68
2.21
1.49
2.4
1.7
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
5
117
0.37
1.49
2.6
3.8
—
—
—
0
0
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
9
41
2.43
1.46
2.1
3.2
umol/l
5.3
5.8
—
9
36
(36304419) Bacteria [Presence] in Urine
19
117
1.97
1.44
2.5
2.9
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
16
94
2.01
1.37
1.4
1.4
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
8
35
2.51
1.34
1.3
1.5
—
—
—
0
0
(3022313) Gas panel - Capillary blood
5
18
2.95
1.31
3.8
2.1
—
—
—
0
0
(3030467) Casts [#/volume] in Urine by Automated count
19
121
1.89
1.29
2.7
3.0
e6/l
0.4
0.2
0.20
14
84
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
10
50
2.23
1.26
1.4
1.7
—
—
—
0
0
(3036481) Cortisol [Moles/volume] in Serum or Plasma
7
35
2.15
1.04
2.7
2.1
nmol/l
369.6
360.8
—
7
29
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
7
35
2.15
1.04
1.1
1.5
—
—
—
0
0
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
6
27
2.37
0.97
2.0
2.7
%
2.2
1.4
—
6
27
(3007853) Bacteria identified in Skin by Aerobe culture
8
43
2.01
0.92
2.4
2.0
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
6
30
2.12
0.90
1.5
1.3
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
6
31
2.05
0.87
12.7
5.7
mmol/l
24.3
25.2
—
6
31
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
8
47
1.82
0.85
1.3
1.3
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
5
23
2.29
0.78
14.6
7.7
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
5
23
2.29
0.78
1.2
1.8
—
—
—
0
0
(40761535) Cells panel - Urine sediment
7
38
1.97
0.77
4.7
3.1
—
—
—
0
0
(3020891) Body temperature
5
24
2.19
0.77
6.0
4.1
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
5
26
2.02
0.72
1.8
2.5
mmol/l
25.5
24.1
—
5
26
(3002032) Base excess in Venous blood by calculation
7
42
1.77
0.72
2.3
3.7
mmol/l
1.0
2.4
—
7
31
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
5
27
1.94
0.70
2.0
2.6
%
52.8
53.2
—
5
27
(3021589) Normoblasts [#/volume] in Blood
24
188
1.51
0.69
10.0
11.6
e9/l
0.0
0.0
0.00
18
155
(3009343) pH of Capillary blood
5
28
1.87
0.68
4.0
2.4
—
7.4
—
0
6
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
45
406
1.72
0.64
30.0
15.2
mg/l
37.9
21.4
2.11
39
334
(3004119) Hemoglobin [Mass/volume] in Venous blood
6
34
1.86
0.61
2.2
3.0
g/l
130.5
130.6
—
6
34
(3013707) Erythrocyte sedimentation rate by Westergren method
35
302
1.47
0.59
6.3
4.3
mm/h
15.9
12.4
0.69
35
273
(3019225) pH of Specimen
6
38
1.65
0.56
13.8
4.2
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
20
158
1.43
0.52
3.3
3.1
—
—
—
0
0
(3012544) pH of Venous blood
7
46
1.60
0.51
2.3
3.9
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
19
150
1.42
0.50
3.2
3.7
e6/l
8.0
54.9
1.70
12
106
(3011397) Hemoglobin [Presence] in Urine by Test strip
14
104
1.47
0.49
5.3
3.5
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
28
239
1.36
0.46
2.9
2.8
—
—
—
0
0
(3019060) Gas panel - Arterial blood
5
31
1.67
0.44
9.2
3.9
—
—
—
0
0
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
17
134
1.40
0.44
3.9
2.8
u/l
37.4
29.6
0.42
17
124
(3049717) Cytology report of Urine Cyto stain
0
16
0.00
0.42
0.0
2.8
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
40
364
1.40
0.41
29.2
15.6
%
36.7
40.9
1.08
26
247
(3037121) Protein [Mass/volume] in Urine
0
17
0.00
0.41
0.0
3.3
—
0.1
—
0
10
(3044889) 12 lead EKG panel
33
292
1.34
0.41
5.5
4.1
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
13
165
0.72
0.40
5.0
4.1
—
—
—
0
0
(3013512) EKG study
11
143
0.71
0.38
5.5
4.4
—
—
—
0
0
(3022145) Colonoscopy Study observation
6
41
1.52
0.37
1.5
1.4
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
23
196
1.31
0.36
4.0
4.1
ng/l
15.8
31.4
2.25
17
153
(3026008) Bacteria identified in Urine by Culture
14
111
1.36
0.34
2.9
3.1
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
46
435
1.43
0.34
22.6
14.1
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
30
267
1.28
0.33
4.8
2.9
u/l
68.0
49.1
0.52
30
255
(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis
0
11
0.00
0.21
0.0
1.1
—
0.0
—
0
11
(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis
0
11
0.00
0.21
0.0
1.1
—
0.0
—
0
11
(3000570) Elastase.pancreatic [Mass/mass] in Stool
0
12
0.00
0.21
0.0
1.5
—
352.1
—
0
5
(40767503) Oxygen content in Capillary blood by calculation
0
13
0.00
0.21
0.0
3.5
—
16.1
—
0
6
(3012110) Lysozyme [Mass/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
1.6
—
11.4
—
0
13
(3037467) Urinalysis macro (dipstick) panel - Urine
30
276
1.20
0.20
4.3
4.7
—
—
—
0
0
(4094501)
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis
0
14
0.00
0.20
0.0
1.1
—
0.0
—
0
14
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
15
172
0.82
0.19
3.0
3.5
%
13.6
21.7
—
5
76
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
5
67
0.72
0.18
1.4
1.2
—
10.8
—
0
25
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
5
43
1.18
0.10
3.6
4.7
ug/l
2.0
13.4
—
5
38
(3002385) Erythrocyte distribution width [Ratio]
33
342
0.91
0.07
33.0
18.5
%
14.2
13.8
0.94
33
333
(3020564) Creatinine [Moles/volume] in Serum or Plasma
43
440
0.88
0.06
34.0
17.5
umol/l
76.9
84.5
1.13
43
440
(40760892) CBC W Ordered Manual Differential panel - Blood
10
90
1.14
0.06
7.3
6.2
—
—
—
0
0
(3015736) pH of Urine
16
169
0.92
0.04
4.8
3.7
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
39
384
1.06
0.01
22.1
15.1
ml/min/173m2
80.3
77.6
0.33
34
312
(40768806) Pleura Pathology biopsy report
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
2.3
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3021901) Oxygen saturation in Capillary blood
0
8
0.00
0.00
0.0
3.1
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
8
0.00
0.00
0.0
2.8
—
15.5
—
0
8
(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
5
0.00
0.00
0.0
14.8
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3045424) Erythrocytes [Presence] in Urine
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction
0
7
0.00
0.00
0.0
1.1
—
156.9
—
0
7
(3042631) Mycobacterium sp identified in Specimen
0
6
0.00
0.00
0.0
8.3
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3003434) Protein [Mass/volume] in Pleural fluid
0
7
0.00
0.00
0.0
1.1
—
31.9
—
0
7
(3000764) Benzodiazepines [Presence] in Urine
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(3045788) Cell count panel - Pleural fluid
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3022806) Fractional oxyhemoglobin in Capillary blood
0
7
0.00
0.00
0.0
3.1
—
87.6
—
0
7
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
5
59
0.83
0.00
1.0
1.2
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(3035880) pH of Pleural fluid
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3036782) Glucose [Moles/volume] in Pleural fluid
0
7
0.00
0.00
0.0
1.1
—
6.9
—
0
7
(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
14.8
—
0
5
(3028300) Cannabinoids [Presence] in Urine
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
(21494815) CD4 cells/100 lymphocytes in Specimen
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_OROPHARYNX – Carcinoma in situ of oral cavity and pharynx

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).