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Carcinoma in situ of liver, gallbladder and bile ducts

CD2_INSITU_LIVER_GALLBLADDER_BILE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_LIVER_INTRAHEPATIC_BILE_DUCTS
  • or not C3_GALLBLADDER
  • or not C3_BILIARY_TRACT
518527

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D01.5&
  • Hospital discharge: ICD-9 2308
  • Cause of death: ICD-10 D01.5&
  • Cause of death: ICD-9 2308
  • Cancer registry: Topography ICD-O-3 C2[2-4]
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

25

4. Check minimum number of events

None

25

5. Include endpoints

None

25

6. Filter based on genotype QC (FinnGen only)

25

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D01
Name in latin
Carcinoma in situ tracheae

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 25 16 9
Unadjusted period prevalence (%) 0.00 0.01 0.00
Median age at first event (years) 60.23 56.85 66.25

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3033658) Prothrombin time (PT) actual/Normal
15
47
6.48
5.06
11.4
2.6
%
85.8
95.3
0.66
15
47
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
14
42
6.30
4.93
6.4
2.3
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
16
54
6.40
4.67
6.0
2.4
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
10
25
6.00
4.16
2.9
2.4
—
—
—
0
0
(3002256) Pathology report gross observation
9
17
7.61
3.95
1.3
1.3
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
10
29
5.08
3.46
1.4
1.2
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
6
7
10.76
3.46
1.8
1.1
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
17
86
4.03
2.74
8.2
4.4
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
16
91
3.09
2.03
11.5
9.6
mmol/l
1.2
1.2
0.46
16
74
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
8
30
3.43
1.93
1.6
1.6
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
11
50
3.14
1.91
5.4
3.8
—
—
—
0
0
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
15
85
2.91
1.74
10.0
8.1
mmol/l
1.2
1.2
0.09
15
76
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
13
74
2.58
1.42
2.7
2.0
pmol/l
112.7
96.9
—
8
32
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
13
75
2.53
1.37
2.2
2.8
nmol/l
62.5
75.1
1.09
13
63
(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma
12
67
2.52
1.34
9.1
2.2
u/l
59.4
56.3
0.14
12
60
(3018418) pH of Serum or Plasma
11
59
2.54
1.33
2.5
6.2
—
7.4
—
0
15
(3044889) 12 lead EKG panel
20
148
2.75
1.28
4.9
4.0
—
—
—
0
0
(3014111) Lactate [Moles/volume] in Serum or Plasma
5
20
2.86
1.21
16.6
6.6
mmol/l
2.0
2.0
—
5
20
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
5
20
2.86
1.21
2.4
4.7
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
13
79
2.34
1.18
3.7
2.0
—
—
—
0
0
(3015377) Calcium [Moles/volume] in Serum or Plasma
11
62
2.38
1.18
2.8
3.7
mmol/l
2.4
2.4
0.08
11
55
(3019150) Specific gravity of Urine by Refractometry
10
55
2.36
1.12
2.1
4.5
—
1.0
—
0
7
(3003694) ABO and Rh group [Type] in Blood
9
51
2.19
1.10
1.4
1.5
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
10
57
2.26
1.02
10.1
5.1
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
9
54
2.04
0.88
2.7
4.6
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
0
24
0.00
0.84
0.0
3.7
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
5
23
2.46
0.81
2.0
1.7
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
24
2.34
0.80
1.2
1.7
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
5
24
2.34
0.80
1.2
1.5
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
16
124
1.80
0.68
13.6
2.7
u/l
80.9
38.7
0.80
16
114
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
5
29
1.90
0.67
2.2
1.7
—
—
—
0
0
(40758558) Short blood count panel - Blood
8
54
1.70
0.50
2.8
7.2
—
—
—
0
0
(3015736) pH of Urine
11
80
1.67
0.49
2.2
4.3
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
14
111
1.59
0.43
3.1
5.3
—
0.0
—
0
26
(3035350) Ketones [Presence] in Urine by Test strip
14
111
1.59
0.43
2.2
4.4
—
0.0
—
0
24
(21494755) Public health laboratory ask at order entry panel
0
17
0.00
0.42
0.0
1.2
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
0
18
0.00
0.41
0.0
1.7
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
14
114
1.52
0.36
2.4
4.3
—
0.0
—
0
22
(3021960) Folate [Moles/volume] in Serum or Plasma
7
52
1.48
0.35
1.7
1.6
nmol/l
28.7
17.4
—
7
43
(3029937) Albumin [Presence] in Urine by Test strip
5
73
0.61
0.31
3.0
4.6
—
0.0
—
0
24
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
9
70
1.44
0.31
1.7
3.4
ng/l
1825.8
1482.1
—
9
56
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
14
120
1.38
0.24
2.4
2.5
—
—
—
0
0
(3027273) Bicarbonate [Moles/volume] in Venous blood
0
11
0.00
0.22
0.0
3.6
—
23.6
—
0
11
(4010399)
0
11
0.00
0.22
0.0
1.2
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
0
11
0.00
0.22
0.0
4.2
—
48.0
—
0
11
(3004588) Protein electrophoresis panel - Serum or Plasma
0
13
0.00
0.21
0.0
4.5
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
7
58
1.29
0.21
2.7
2.6
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
8
66
1.31
0.20
2.3
3.1
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
9
77
1.26
0.19
5.0
3.3
—
—
—
0
0
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
5
43
1.20
0.11
1.2
1.3
—
0.5
—
0
9
(1761868) Lipid panel - Serum or Plasma
5
60
0.79
0.09
1.8
2.7
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
5
63
0.74
0.09
1.4
3.6
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
10
92
1.14
0.04
2.1
4.5
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
15
144
1.10
0.01
5.3
4.6
—
—
—
0
0
(3020961) Endomysium IgA Ab [Titer] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(1001926) Buprenorphine [Presence] in Urine by Screen method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
0.2
—
0
5
(40768800) Prostate Pathology biopsy report
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3037756) Immunofixation for Serum or Plasma
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3027008) Opiates [Presence] in Urine
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
2.4
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
0
6
0.00
0.00
0.0
6.8
—
—
—
0
0
(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.8
—
544.0
—
0
6
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
0
8
0.00
0.00
0.0
5.3
—
—
—
0
0
(3023150) Myeloperoxidase Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3016879) Cocaine [Presence] in Urine
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
0
7
0.00
0.00
0.0
5.3
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3024891) Influenza virus A+B Ag [Presence] in Specimen
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
5
0.00
0.00
0.0
7.2
—
289.9
—
0
5
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
1.2
—
0
5
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_LIVER_GALLBLADDER_BILE – Carcinoma in situ of liver, gallbladder and bile ducts

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).