Risteys · CD2_INSITU_FEM_GENITAL_NOS

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule only females	-
2. Check conditions None
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D07.3& Hospital discharge: ICD-9 — 2333X Cause of death: ICD-10 — D07.3& Cause of death: ICD-9 — 2333X 2 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	18	18	-
Unadjusted period prevalence (%)	0.01	0.01	-
Median age at first event (years)	47.85	47.85	-

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3044640) Blood type and Crossmatch panel - Blood

5.12

2.81

1.6

1.8

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

5.82

2.09

3.2

1.5

u/ml

46.8

108.1

—

(3042936) Bacteria identified in Isolate by Culture

4.88

1.85

2.0

2.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.90

1.40

5.1

3.7

—

(1761868) Lipid panel - Serum or Plasma

2.52

1.19

2.6

3.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.08

0.72

1.4

1.6

—

(40768804) Tissue Pathology biopsy report

1.99

0.71

4.4

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

111

0.50

0.68

7.0

3.4

—

(3018418) pH of Serum or Plasma

1.86

0.62

2.0

2.5

—

7.4

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.70

0.54

3.1

1.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

1.67

0.48

7.5

3.6

umol/l

9.4

10.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.84

0.48

1.6

2.1

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.43

0.0

1.4

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.43

0.0

2.6

—

(3009508) Creatinine [Moles/volume] in Urine

1.69

0.42

3.0

2.5

mmol/l

8.6

7.5

—

(3044889) 12 lead EKG panel

100

1.60

0.34

3.4

3.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

1.49

0.33

3.1

3.7

mmol/l

6.3

6.6

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.30

0.24

1.2

1.8

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.33

0.23

1.5

2.0

u/l

52.0

54.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

1.30

0.23

6.3

2.3

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

4.5

—

4.8

—

(3020630) Protein [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.2

—

66.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.22

0.0

1.0

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.22

0.0

2.0

—

(3017732) Neutrophils [#/volume] in Blood

0.00

0.22

0.0

2.3

—

3.3

—

(3000492) Spirometry study

0.00

0.22

0.0

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

1.37

0.21

10.4

6.7

e9/l

3.9

4.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

111

0.78

0.21

3.3

4.0

—

(3001604) Monocytes [#/volume] in Blood

1.29

0.21

4.0

5.7

e9/l

0.6

0.5

—

(3003694) ABO and Rh group [Type] in Blood

1.26

0.11

2.6

1.3

—

(3021589) Normoblasts [#/volume] in Blood

0.79

0.10

6.2

6.6

e9/l

0.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.3

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.5

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

52.8

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

8.9

—

(3015736) pH of Urine

1.10

0.00

2.3

2.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.6

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

3.3

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.0

1.2

—

91.7

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.00

0.0

1.8

—

1.2

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

1.2

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

4.4

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

12.7

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

3.4

—

24.4

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

35.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.4

—

8.5

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

0.00

0.0

6.0

—

195.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

0.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

5.0

—

57.8

—

(4034850)

0.00

0.0

5.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

1.1

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.0

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.4

—

5.0

—

(3026008) Bacteria identified in Urine by Culture

0.97

0.00

6.8

3.2

—

(4094501)

0.00

0.0

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(3023520) Reticulocytes [#/volume] in Blood

0.00

0.0

7.7

—

74.6

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.10

0.00

3.6

2.7

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

1.8

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_FEM_GENITAL_NOS_EXALLC – Carcinoma in situ of other/unspecified female genital organs

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

NAME	CD2_INSITU_FEM_GENITAL_NOS_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D073
HD_ICD_9	2333X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D073
COD_ICD_9	2333X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Carcinoma in situ of other/unspecified female genital organs

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints