Carcinoma in situ of endometrium

CD2_INSITU_ENDOMETRIUM_EXALLC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule only females	-
2. Check conditions None
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D07.0& Hospital discharge: ICD-9 — 2332 Cause of death: ICD-10 — D07.0& Cause of death: ICD-9 — 2332 2 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D07
Name in latin: Carcinoma in situ endometrii (corporis uteri)

NAME	CD2_INSITU_ENDOMETRIUM_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D070
HD_ICD_9	2332
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D070
COD_ICD_9	2332
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Carcinoma in situ of endometrium based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Carcinoma in situ of endometrium

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	669	669	-
Only index persons	611	611	-
Unadjusted period prevalence (%)
Whole population	0.02	0.02	-
Only index persons	0.02	0.02	-
Median age at first event (years)
Whole population	-	64.51	-
Only index persons	-	63.61	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	157	157	-
Unadjusted period prevalence (%)	0.05	0.05	-
Median age at first event (years)	62.28	62.28	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
140: Matched controls
1399

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D07.0

ICD-10 Finland

Carcinoma in situ: Endometrium

+∞

199.1

139

C54.11

ICD-10 Finland

Adenocarcinoma of the endometrium

+∞

85.4

LCD01

NOMESCO Finland

Total laparoscopic hysterectomy

229.6

73.2

LAF11

NOMESCO Finland

Laparoscopic bilateral salpingo-oophorectomy

53.7

70.9

8380/3-C54.1

ICD-O-3

Endometrioid adenocarcinoma, NOS, of endometrium

+∞

59.7

PJA01

NOMESCO Finland

Laparoscopic sentinel node excision

+∞

56.1

N95.0

ICD-10 Finland

Postmenopausal bleeding

11.1

30.1

101

N85.1

ICD-10 Finland

Endometrial adenomatous hyperplasia

36.7

28.4

B01AB10

ATC

tinzaparin; parenteral

18.3

27.1

ZXC96

NOMESCO Finland

Robot assisted procedure

115.7

26.8

JN4BD

NOMESCO Finland

Extensive body CT

11.6

19.2

LCB25

NOMESCO Finland

Hysteroscopic excision of lesion

9.6

18.2

WF003

NOMESCO Finland

Adjuvant radiotherapy

+∞

18.1

JN2CG

NOMESCO Finland

Extensive MRI examination of lower part of abdoment with high intensity magnet

+∞

17.0

N84.0

ICD-10 Finland

Polyp of corpus uteri

6.5

16.8

107

8380/3-C54.9

ICD-O-3

Endometrioid adenocarcinoma, NOS, of corpus uteri

+∞

14.8

B01AB05

ATC

enoxaparin; parenteral

4.3

14.4

262

WZC20

NOMESCO Finland

Multidisciplinary treatment meeting

20.9

13.8

128

Kela drug reimbursment

Cancers of female genital organs

+∞

13.8

N85.0

ICD-10 Finland

Endometrial glandular hyperplasia

16.2

13.3

PJA12

NOMESCO Finland

Sentinel node biopsy

+∞

12.7

115

Kela drug reimbursment

Breast cancer

+∞

11.6

ZX040

NOMESCO Finland

Intracavity HDR radiotherapy

+∞

11.6

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

+∞

10.5

C54.10

ICD-10 Finland

Malignant tumor of endometrium without histology

+∞

10.5

YX9AD

NOMESCO Finland

Other CT eamination for dose design of radiotherapy

+∞

10.5

H02AB02

ATC

dexamethasone; systemic

20.8

10.5

SPAT1292

SPAT

Other function in accordance with SHToL (Finnish classification of nursing interventions)

5.1

10.1

SPAT1312

SPAT

General health counselling

3.2

9.6

348

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

+∞

9.5

LCA06

NOMESCO Finland

Biopsy of endometrium

3.9

9.1

134

XX3DW

NOMESCO Finland

Time consuming IT work

7.5

9.1

ULC02

NOMESCO Finland

Hysteroscopy

6.1

8.8

L02BA01

ATC

tamoxifen; oral

+∞

8.4

WF090

NOMESCO Finland

Profylactic radiotherapy

+∞

8.4

PJD64

NOMESCO Finland

Laparoscopic dissection of iliac lymph nodes

+∞

8.4

SPAT1301

SPAT

No procedures

2.9

8.1

334

LCD11

NOMESCO Finland

Laparoscopically assisted vaginal hysterectomy

14.2

8.1

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

84.4

7.5

SAB01

NOMESCO Finland

Restricted oral and dental health check by dental hygienist or dental assistant

5.4

7.4

SPAT1249

SPAT

Treatment-related counselling outside office

2.7

7.4

457

PJD63

NOMESCO Finland

Laparoscopic dissection of aortic lymph nodes

+∞

7.3

LCA13

NOMESCO Finland

Curettage of cervix and body of uterus

4.2

7.1

TLC00

NOMESCO Finland

Insertion of intrauterine device

6.1

6.9

SPAT1153

SPAT

Removal of sutures

2.6

6.8

338

LCD04

NOMESCO Finland

Laparoscopic hysterectomy

5.9

6.7

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

4.0

6.6

C44.31

ICD-10 Finland

Basocellular carcinoma of the skin on another or unspecified part of the face

+∞

6.3

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

7.8

6.1

SPAT1310

SPAT

Counselling related to known health issue

2.5

6.0

346

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

33.63

92.19

1.2

1.4

pmol/l

76.6

57.6

1.48

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

104

175

15.64

69.92

9.9

6.4

—

(40761535) Cells panel - Urine sediment

114

11.39

51.18

4.3

2.8

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

9.41

38.12

1.4

1.9

g/l

0.2

3.41

(3029937) Albumin [Presence] in Urine by Test strip

110

355

8.01

36.15

5.6

4.4

estimate

0.0

0.00

119

(3020891) Body temperature

10.97

33.36

3.3

4.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

100

335

6.47

30.19

5.9

3.9

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

111

6.70

26.15

2.1

2.5

ml/min/173m2

62.3

60.6

0.12

(3019060) Gas panel - Arterial blood

7.65

26.13

3.0

5.5

—

(3014007) Fractional oxyhemoglobin in Arterial blood

8.18

25.25

3.2

4.9

95.0

94.3

0.81

(3008152) Bicarbonate [Moles/volume] in Arterial blood

7.03

23.67

5.7

8.0

mmol/l

24.6

26.1

1.86

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

113

528

5.07

20.24

5.9

4.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

116

584

4.78

18.03

4.5

3.5

—

(3015736) pH of Urine

109

535

4.39

17.28

6.1

4.0

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

128

4.67

15.82

3.2

5.2

kpa

5.2

5.5

0.73

123

(3027801) Oxygen [Partial pressure] in Arterial blood

128

4.67

15.82

3.2

5.2

kpa

13.3

12.0

0.87

123

(3016502) Oxygen saturation in Arterial blood

114

4.82

15.69

3.2

5.2

97.8

95.8

3.83

108

(3009261) Glucose [Presence] in Urine by Test strip

124

700

4.67

15.41

5.8

4.1

estimate

0.0

0.50

117

(3024561) Albumin [Mass/volume] in Serum or Plasma

106

541

3.95

15.16

3.4

3.3

g/l

37.1

35.8

2.13

497

(3003396) Base excess in Arterial blood by calculation

132

4.51

15.16

3.1

5.0

mmol/l

1.3

2.1

1.19

110

(3035350) Ketones [Presence] in Urine by Test strip

122

691

4.43

14.84

5.9

4.1

estimate

0.0

0.00

120

(3021601) Nitrite [Presence] in Urine by Test strip

121

694

4.24

14.14

6.4

5.7

estimate

0.0

0.00

115

(3014576) Chloride [Moles/volume] in Serum or Plasma

130

4.31

13.86

3.5

3.7

mmol/l

104.2

103.5

0.47

125

(3007853) Bacteria identified in Skin by Aerobe culture

130

3.54

9.47

2.0

1.5

—

(40768804) Tissue Pathology biopsy report

443

2.64

8.23

2.3

1.7

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

297

2.72

8.11

1.4

—

(3044889) 12 lead EKG panel

132

966

3.30

7.45

5.4

3.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

443

2.39

6.63

3.0

3.1

—

(40758558) Short blood count panel - Blood

303

2.45

6.43

5.5

5.3

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

4.02

6.42

1.5

1.4

—

(42870588) Differential panel, method unspecified - Blood

411

0.23

6.36

4.1

5.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

123

935

2.46

5.21

5.4

4.8

—

4356.4

—

(3003694) ABO and Rh group [Type] in Blood

316

2.20

4.99

1.2

1.3

—

(4034850)

3.48

4.77

22.1

7.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

501

2.00

4.36

4.8

3.6

ng/l

18.5

105.5

0.64

337

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

596

1.98

4.24

3.5

4.5

mmol/l

1.2

6.75

522

(3002385) Erythrocyte distribution width [Ratio]

1105

0.52

3.80

10.2

15.2

14.3

13.7

2.50

1083

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.68

3.63

1.3

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

292

1.99

3.63

4.2

3.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

271

1.99

3.51

1.9

—

(40761511) CBC panel - Blood by Automated count

152

1388

3.98

3.39

14.5

11.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

725

1.83

3.33

6.6

6.5

e9/l

4.1

0.05

628

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

422

0.44

3.21

1.5

1.6

mmol/l

1.6

1.3

0.40

356

(3013826) Glucose [Moles/volume] in Serum or Plasma

749

1.77

2.98

4.0

3.8

mmol/l

6.8

6.6

0.42

688

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

645

1.74

2.90

3.8

5.0

mmol/l

1.2

6.62

557

(3044640) Blood type and Crossmatch panel - Blood

345

1.76

2.66

1.9

—

(3026008) Bacteria identified in Urine by Culture

507

1.69

2.60

3.5

3.1

—

(4035726)

3.17

2.57

1.4

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

102

1196

0.58

2.57

8.1

13.8

41.2

39.1

2.66

817

(3022217) INR in Platelet poor plasma by Coagulation assay

170

1.95

2.51

69.0

18.7

—

1.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

131

1139

1.91

2.37

5.5

4.4

pmol/l

15.4

14.8

2.00

122

1040

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

146

1324

2.47

2.28

15.8

12.1

mg/l

26.3

19.5

1.04

123

1001

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

5.69

2.23

4.0

1.3

—

(42529201) Cancer Ag 19-9 [Units/volume] in Serum or Plasma by Immunoassay

5.69

2.23

2.4

1.3

u/ml

1644.3

8.2

—

(4281824)

5.12

2.08

1.0

1.1

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

117

999

1.67

2.07

5.3

5.2

u/l

80.2

75.3

0.47

111

900

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

2.83

1.96

1.8

1.2

—

(3002582) Erythrocytes [#/volume] in Urine

375

0.55

1.93

2.3

3.2

e6/l

22.0

47.0

0.72

283

(3042936) Bacteria identified in Isolate by Culture

170

1.79

1.90

1.5

2.0

—

(3023368) Bacteria identified in Blood by Culture

280

1.63

1.83

3.3

3.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.85

1.82

2.9

2.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

161

0.41

1.79

1.4

1.5

—

(1761868) Lipid panel - Serum or Plasma

430

0.60

1.69

2.9

3.2

—

(3013512) EKG study

400

0.61

1.55

4.1

3.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

1.55

0.0

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

1.54

0.0

1.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.19

1.45

1.0

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

367

0.62

1.37

3.8

3.7

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

1.36

0.0

1.6

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

2.21

1.36

2.0

1.3

—

(3018418) pH of Serum or Plasma

391

1.45

1.32

2.7

2.9

7.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

150

1429

2.11

1.28

18.0

13.9

umol/l

71.2

70.5

0.13

150

1429

(3015377) Calcium [Moles/volume] in Serum or Plasma

460

1.41

1.24

2.9

2.0

mmol/l

2.4

0.74

370

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

302

0.61

1.23

1.3

1.2

u/ml

0.7

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

142

1.64

1.22

1.3

1.7

—

(4010399)

110

1.72

1.21

1.5

—

(3018095) Leukocytes [#/volume] in Urine

465

0.68

1.18

2.4

4.0

e6/l

20.0

106.0

2.89

320

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

140

0.48

1.16

1.4

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

310

1.44

1.13

1.5

1.7

mg/l

0.7

1.0

0.90

241

(3018677) aPTT in Platelet poor plasma by Coagulation assay

162

1.57

1.12

1.4

1.6

26.8

29.4

2.05

154

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

139

1298

1.62

1.11

6.6

5.9

mmol/mol

41.1

39.7

1.01

130

1213

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

114

1.65

1.08

3.0

3.7

u/l

231.0

238.9

0.22

107

(3012516) Albumin [Mass/volume] in Urine

453

1.37

1.04

2.9

mg/l

25.9

348.1

0.82

255

(3033658) Prothrombin time (PT) actual/Normal

289

0.65

1.01

1.8

3.0

85.5

93.8

0.55

279

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

834

0.75

1.01

2.4

2.8

u/l

50.0

39.1

0.50

766

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.97

0.0

1.1

—

(3032080) INR in Blood by Coagulation assay

507

1.33

0.94

13.1

7.3

inr

1.1

1.2

—

143

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.77

0.94

1.3

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.77

0.94

1.3

1.2

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.80

0.92

1.6

2.4

1.3

1.1

0.49

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

625

0.75

0.92

2.2

2.3

nmol/l

78.2

81.9

0.46

546

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

393

0.71

0.92

2.1

2.4

u/l

28.6

27.7

0.16

380

(3002256) Pathology report gross observation

1.67

0.91

1.2

1.0

—

(3020682) Albumin/Creatinine [Ratio] in Urine

473

1.32

0.88

3.4

3.7

mg/mmol

7.0

5.2

0.13

265

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

138

1301

1.50

0.87

4.6

4.3

mmol/l

1.4

1.3

1.06

125

1182

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.97

0.85

2.3

2.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

132

1.50

0.80

1.6

1.8

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.80

0.0

1.5

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.80

0.0

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.80

0.0

1.2

—

(3021788) Differential panel - Synovial fluid

0.00

0.80

0.0

1.7

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

144

1375

1.57

0.78

5.4

4.8

mmol/l

6.2

5.9

2.70

136

1267

(3009508) Creatinine [Moles/volume] in Urine

461

1.30

0.78

2.8

2.9

mmol/l

7.0

6.5

0.43

375

(3044941) Cell count panel - Synovial fluid

0.00

0.78

0.0

1.7

—

(3024928) Oxygen saturation in Venous blood

0.00

0.78

0.0

3.1

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.65

0.77

1.9

1.4

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.74

0.77

1.3

1.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.67

0.75

1.7

1.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.63

0.74

1.4

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.03

0.73

1.8

1.4

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

146

1402

1.59

0.72

5.7

5.4

mmol/l

2.9

2.8

0.25

134

1292

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

617

0.79

0.69

1.9

2.0

pmol/l

95.2

100.2

0.44

257

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.81

0.66

1.0

1.1

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

138

1317

1.40

0.64

6.4

5.4

mu/l

2.7

1.9

0.78

129

1205

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.59

0.64

1.5

1.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

105

1.47

0.62

1.3

1.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

763

0.81

0.62

2.4

2.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

114

0.60

3.9

2.9

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.60

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.60

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.60

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.60

0.0

1.5

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.60

0.0

1.0

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.60

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.60

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.59

0.0

1.3

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.59

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.59

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.59

0.0

1.3

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.42

0.47

1.8

3.2

mmol/l

1.2

1.3

0.40

(3025941) Bacteria identified in Stool by Culture

1.46

0.47

1.6

1.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

315

1.23

0.46

2.1

umol/l

326.1

10404.0

2.54

268

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

142

1376

1.33

0.43

5.1

4.8

mmol/l

4.8

0.25

131

1272

(3017181) Myelocytes/100 leukocytes in Blood

1.39

0.43

2.6

4.4

1.7

0.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.58

0.42

1.2

1.4

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

132

1.32

0.42

1.3

1.8

—

(3000991) Gas panel - Venous blood

1.42

0.42

1.8

4.1

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.41

0.0

1.2

—

(4062490)

0.00

0.41

0.0

1.4

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.41

0.0

1.6

—

6.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.41

0.0

1.4

—

(40761536) Microorganisms panel - Urine sediment

102

0.67

0.41

2.3

3.6

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.41

0.0

1.0

—

(3048689) Calprotectin [Mass/mass] in Stool

158

0.74

0.39

1.2

1.8

ug/g

50.0

103.1

1.51

120

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.39

0.0

1.8

—

5.5

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.39

0.0

2.2

—

14.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.39

0.0

1.2

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.39

0.0

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.39

0.0

2.7

—

64.7

—

(21494755) Public health laboratory ask at order entry panel

0.69

0.34

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.67

0.34

1.2

1.7

—

(3021589) Normoblasts [#/volume] in Blood

582

0.87

0.33

7.9

8.2

e9/l

0.0

0.38

470

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.71

0.32

1.6

1.5

—

(36304419) Bacteria [Presence] in Urine

353

0.85

0.31

2.6

2.9

—

(40768797) Stomach Pathology biopsy report

195

1.21

0.30

1.0

1.2

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

341

1.15

0.27

2.3

mg/l

4.9

3.2

1.77

283

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.26

0.22

1.0

1.1

—

(3022145) Colonoscopy Study observation

135

1.21

0.22

1.4

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

139

1362

1.18

0.21

4.9

4.7

mmol/l

1.5

1.6

1.63

127

1255

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.21

0.0

1.3

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

1.9

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.9

—

8.8

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.21

0.0

1.3

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

1.1

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.21

0.0

1.2

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.2

—

(3014148) Varicella zoster virus Ab [Titer] in Serum

0.00

0.21

0.0

1.3

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

5.8

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.0

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.21

0.0

2.6

—

13.4

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

1.1

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

620.3

—

(43055225) Phosphorylated tau 181 [Mass/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.20

0.0

1.0

—

30.7

—

(40766183) Gliadin peptide IgA Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.1

—

3.1

—

(3000242) Tau protein [Mass/volume] in Cerebral spinal fluid

0.00

0.20

0.0

1.0

—

231.6

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

0.20

0.0

1.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

108

1045

1.11

0.20

4.5

mm/h

15.6

12.9

0.98

958

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

301

1.12

0.19

1.5

1.6

pmol/l

477.2

477.6

0.00

243

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.72

0.17

1.0

—

(3019198) Lymphocytes [#/volume] in Blood

669

1.08

0.16

3.9

5.2

e9/l

1.7

1.9

1.22

587

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.76

0.16

1.2

1.6

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

591

1.08

0.15

2.2

2.9

ug/l

114.9

85.3

0.77

547

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

286

1.10

0.15

1.2

1.3

u/ml

12.3

15.5

0.11

109

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.80

0.14

1.5

1.3

1.5

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

293

0.91

0.14

1.3

1.4

iu/ml

34.3

45.2

—

(3001604) Monocytes [#/volume] in Blood

654

1.07

0.12

3.9

5.1

e9/l

0.5

0.6

0.99

556

(3006315) Basophils [#/volume] in Blood

657

1.06

0.10

3.9

5.1

e9/l

0.0

1.02

557

(3008898) HLA-B27 [Presence]

1.07

0.09

1.0

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.79

0.08

2.6

3.1

mmol/l

24.6

25.5

—

(3012544) pH of Venous blood

123

0.89

0.08

1.5

3.3

—

(3045414) Leukocytes [Presence] in Urine

1.03

0.08

2.1

1.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

1.03

0.08

1.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.06

0.07

2.1

2.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

221

0.94

0.04

1.7

1.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

968

1.03

0.04

4.2

4.6

—

(3000494) Fungus identified in Specimen by Culture

174

1.04

0.00

1.4

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

184

1.04

0.00

1.6

1.7

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

124

0.97

0.00

2.3

1.9

nmol/l

402.7

351.9

1.06

117

(3000492) Spirometry study

101

0.99

0.00

1.1

1.5

—

(3013115) Eosinophils [#/volume] in Blood

677

1.01

0.00

3.9

5.5

e9/l

0.2

0.21

595

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

127

1272

0.99

0.00

7.9

11.1

ml/min/173m2

75.9

76.4

0.10

108

998

(40768443) Skin Pathology biopsy report

0.89

0.00

1.7

1.2

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

1.3

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.0

1.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3025443) Phadiatop IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.0

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

5.9

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

25.3

—

1514.0

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.0

—

(3025149) Bordetella pertussis IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(42868415) European tick borne encephalitis virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.1

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

3.5

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.3

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

3.3

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

70.8

—

(3013180) HIV 1 RNA [Units/volume] (viral load) in Serum or Plasma by Probe with amplification

0.00

0.0

1.0

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.8

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3019977) pH of Arterial blood

0.00

0.0

2.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

23.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.84

0.00

2.0

1.8

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.1

—

10.1

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.0

2.1

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

13.8

—

802.8

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

5.8

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.8

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.3

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.4

—

(4198724)

0.00

0.0

1.2

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.3

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

1.4

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

25.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

1.3

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.0

1.2

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.3

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

0.00

0.0

1.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

0.0

1.5

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.0

—

(3000285) Sodium [Moles/volume] in Blood

0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

0.0

1.6

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

79.6

—

(4211845)

0.00

0.0

5.3

—

(3001964) Herpes simplex virus Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3019225) pH of Specimen

130

1.00

0.00

2.2

3.8

—

(3010375) cycloSPORINE [Mass/volume] in Blood

0.00

0.0

27.8

—

91.0

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.1

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.4

—

(44806420)

0.00

0.0

2.4

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.3

—

(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy

0.00

0.0

1.2

—

(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_INSITU_ENDOMETRIUM_EXALLC and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_INSITU_ENDOMETRIUM_EXALLC	1.441 [1.14, 1.82]	0.002
Birth year	0.995 [0.99, 1.0]	0.296

During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 537 females with CD2_INSITU_ENDOMETRIUM_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_ENDOMETRIUM_EXALLC.

N-year risk	Females	Males
1	0.146%	No data
5	0.753%	No data
10	2.053%	No data
15	3.884%	No data
20	7.04%	No data

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_ENDOMETRIUM_EXALLC – Carcinoma in situ of endometrium

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Carcinoma in situ of endometrium

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints