Other benign neoplasms of uterus

CD2_BENIGN_UTERUS_OTH

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D26 Cause of death: ICD-10 — D26 2 out of 7 registries used, show all original rules.	414
4. Check minimum number of events None	414
5. Include endpoints CD2_BENIGN_CERVIX_UTERI CD2_BENIGN_CORPUS_UTERI CD2_BENIGN_UTERUS_NOS	1936
6. Filter based on genotype QC (FinnGen only)	1936

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: 2
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D10-D36
Name in latin: Alia neoplasmata benigna uteri

NAME	CD2_BENIGN_UTERUS_OTH
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE	CD2_BENIGN_CERVIX_UTERI\|CD2_BENIGN_CORPUS_UTERI\|CD2_BENIGN_UTERUS_NOS
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D26
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D26
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other benign neoplasms of uterus based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	24514	24514	-
Only index persons	19081	19081	-
Unadjusted period prevalence (%)
Whole population	0.70	0.70	-
Only index persons	0.70	0.70	-
Median age at first event (years)
Whole population	-	47.18	-
Only index persons	-	45.30	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	1936	1936	-
Unadjusted period prevalence (%)	0.66	0.66	-
Median age at first event (years)	41.38	41.38	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1758: Matched controls
17580

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

21900

ICD-8 Finland

Other benign neoplasm of uterus, Papiloma, polyp

+∞

323.0

1066

D26.1

ICD-10 Finland

Other benign neoplasm: Corpus uteri

1831.7

168.5

161

D26.0

ICD-10 Finland

Other benign neoplasm: Cervix uteri

+∞

145.9

138

2191A

ICD-9 Finland

Other benign neoplasm of uterus, Corpus uteri

+∞

73.4

21920

ICD-8 Finland

+∞

72.4

21901

ICD-8 Finland

+∞

69.2

D26.9

ICD-10 Finland

Other benign neoplasm: Uterus, unspecified

+∞

57.6

2190A

ICD-9 Finland

Other benign neoplasm of uterus, Cervix uteri

+∞

49.2

8113

FHL

Fractional scraping

2.8

47.0

360

1502

21998

ICD-8 Finland

Other benign neoplasm of uterus, Loco alio definito

+∞

37.6

62660

ICD-8 Finland

Disorders of menstruation, Intermenstrual bleeding

3.2

34.0

190

635

21999

ICD-8 Finland

Other benign neoplasm of uterus, Other and unspecified

+∞

32.4

21899

ICD-8 Finland

Uterine fibroma

2.5

30.6

271

1203

6227A

ICD-9 Finland

Noninflammatory disorders of cervix, Mucous polyp of cervix

5.0

19.3

127

62620

ICD-8 Finland

Disorders of menstruation, Excessive

3.0

18.1

106

365

8111

FHL

Taking a biopsy from the mouth of the uterus at the operating room or under anesthesia (vulvabiopsia 8474, vaginabiopsia 8411)

10.2

17.4

21910

ICD-8 Finland

Other benign neoplasm of uterus, Benign cyst

+∞

15.6

62699

ICD-8 Finland

Disorders of menstruation, Other

2.3

14.0

134

612

N84.1

ICD-10 Finland

Polyp of cervix uteri

3.0

13.4

263

62650

ICD-8 Finland

Disorders of menstruation, Irregular

3.1

12.7

242

62670

ICD-8 Finland

Disorders of menstruation, Postmenopausal bleeding

3.3

12.0

182

8339

FHL

Other measure in this category

9.0

11.7

LDB00

NOMESCO Finland

Excision of lesion of cervix uteri

4.0

11.7

118

62800

ICD-8 Finland

Sterility, female, Sterilitas primaria

3.3

9.3

144

6266A

ICD-9 Finland

Disorders of menstruation and other abnormal bleeding from female genital tract, Metrorrhagia

2.0

9.3

117

602

LCD00

NOMESCO Finland

Hysterectomy

1.9

9.1

128

689

00000

ICD-8 Finland

3.8

9.0

100

62110

ICD-8 Finland

Other diseases of cervix, Erythroplasia of cervix

7.9

8.4

8305

FHL

Supravaginal amputation or resection

2.4

8.1

274

LCB25

NOMESCO Finland

Hysteroscopic excision of lesion

1.9

7.9

109

586

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

1.7

7.7

174

1092

62000

ICD-8 Finland

Infective diseases of cervix uteri, Cervicitis chronica

3.8

7.6

62521

ICD-8 Finland

Other diseases of uterus, Hyperplasia glandularis cystica endometrii

3.7

7.4

D26.7

ICD-10 Finland

Other benign neoplasm: Other parts of uterus

+∞

7.3

N84.0

ICD-10 Finland

Polyp of corpus uteri

1.6

6.7

168

1087

ICD-10 Finland

0.2

6.4

261

2198X

ICD-9 Finland

Other benign neoplasm of uterus, Other specified parts of uterus

+∞

6.3

Y0609

ICD-8 Finland

Examination of the urinary and genital organs, Genital organs

2.4

6.2

195

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_UTERUS_OTH and mortality.

Females

Parameter	HR [95% CI]	p-value
CD2_BENIGN_UTERUS_OTH	1.198 [1.02, 1.4]	0.025
Birth year	0.999 [0.99, 1.01]	0.86

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 2089 females with CD2_BENIGN_UTERUS_OTH died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_UTERUS_OTH.

N-year risk	Females	Males
1	0.115%	No data
5	0.738%	No data
10	1.962%	No data
15	3.867%	No data
20	6.731%	No data

Relationships between endpoints

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Index endpoint: CD2_BENIGN_UTERUS_OTH – Other benign neoplasms of uterus

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other benign neoplasms of uterus

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints